{"id":45630,"date":"2023-05-05T08:00:35","date_gmt":"2023-05-05T00:00:35","guid":{"rendered":"\/\/www.gsbet888.com\/?p=45630"},"modified":"2023-05-03T15:53:41","modified_gmt":"2023-05-03T07:53:41","slug":"jacs%ef%bc%9a22-%e4%ba%8c%e5%8f%96%e4%bb%a3-13-%e4%b8%99%e4%ba%8c%e9%86%87%e5%8f%82%e4%b8%8e%e7%9a%84%e5%82%ac%e5%8c%96%e5%8e%bb%e5%af%b9%e7%a7%b0%e5%8c%96%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2023\/05\/jacs%ef%bc%9a22-%e4%ba%8c%e5%8f%96%e4%bb%a3-13-%e4%b8%99%e4%ba%8c%e9%86%87%e5%8f%82%e4%b8%8e%e7%9a%84%e5%82%ac%e5%8c%96%e5%8e%bb%e5%af%b9%e7%a7%b0%e5%8c%96%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95.html","title":{"rendered":"JACS\uff1a2,2-\u4e8c\u53d6\u4ee3-1,3-\u4e19\u4e8c\u9187\u53c2\u4e0e\u7684\u50ac\u5316\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u7814\u7a76"},"content":{"rendered":"
\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n
\u8fd1\u65e5\uff0c\u5357\u4eac\u5927\u5b66\u7684\u90d1\u6587\u534e\u8bfe\u9898\u7ec4\u5728J. Am. Chem. Soc.<\/i><\/em>\u00a0\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5177\u6709C<\/em>2<\/sub>-\u5bf9\u79f0\u6027\u7684\u624b\u6027\u787c\u9178\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u75282,2-\u4e8c\u53d6\u4ee3-1,3-\u4e19\u4e8c\u9187\u53c2\u4e0e\u7684\u50ac\u5316\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u56db\u7ea7\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u4e8c\u9187\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n Synthesis of a C<\/i><\/em>2<\/sub>\u2011<\/b><\/strong>Symmetric Chiral Borinic Acid and Its Application in Catalytic Desymmetrization of 2,2-Disubstituted-1,3-Propanediols<\/p>\n J.Song, W.Zheng, J. <\/i><\/em>Am. Chem. Soc.<\/i><\/em>\u00a02023<\/strong>, 145<\/em>, 8338. doi: 10.1021\/jacs.3c02331<\/u><\/a>.<\/p><\/blockquote>\n \u8fd1\u5e74\u6765\uff0c\u901a\u8fc7\u787c\u9178\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u5408\u6210\u8f6c\u5316\u65b9\u6cd5\u5b66\u7684\u76f8\u5173\u7814\u7a76\uff0c\u5df2\u7ecf\u9010\u6e10\u53d7\u5230\u6709\u673a\u5408\u6210\u5316\u5b66\u5bb6\u7684\u5e7f\u6cdb\u5173\u6ce8[1]<\/sup>\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u901a\u8fc7\u624b\u6027\u787c\u9178\u50ac\u5316\u5242\u53c2\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u8f6c\u5316\u65b9\u6cd5\u5b66\u7684\u7814\u7a76\uff0c\u76ee\u524d\u5374\u8f83\u5c11\u6709\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053\u00a0<\/sup>(Figure 1)[2]-[4]<\/sup>\u3002\u8fd9\u91cc\uff0c\u53d7\u5230\u524d\u671f\u5bf9\u4e8e\u4e8c\u82b3\u57fa\u787c\u9178\u4ee5\u53caoxaboraanthracene\u50ac\u5316\u6d3b\u6027\u4e0e\u7a33\u5b9a\u6027\u76f8\u5173\u7814\u7a76\u62a5\u9053 (Figure 1c)[5]<\/sup>\u7684\u542f\u53d1\uff0c\u5357\u4eac\u5927\u5b66\u7684\u90d1\u6587\u534e\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5177\u6709C<\/em>2<\/sub>-\u5bf9\u79f0\u6027\u7684\u624b\u6027\u787c\u9178\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u75282,2-\u4e8c\u53d6\u4ee3-1,3-\u4e19\u4e8c\u9187\u53c2\u4e0e\u7684\u50ac\u5316\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002<\/p>\n \u9996\u5148\uff0c\u4f5c\u8005\u6210\u529f\u5408\u6210\u51fa\u56db\u79cd\u5168\u65b0\u7684\u5177\u6709C<\/em>2<\/sub>-\u5bf9\u79f0\u6027\u7684\u624b\u6027\u787c\u9178\u50ac\u5316\u5242 (Scheme 1)\u3002<\/p>\n \u4e4b\u540e\uff0c\u4f5c\u8005\u91c7\u75282-\u82ef\u57fa-2-\u7532\u57fa-1,3-\u4e19\u4e8c\u91871a<\/strong>\u4e0e4-\u7532\u6c27\u57fa\u82ef\u7532\u9170\u6c2f\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528(S<\/i><\/em>, S<\/i><\/em>)-C1<\/strong>\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cDIPEA\u4f5c\u4e3a\u78b1\uff0c4 \u00c5 MS\u4f5c\u4e3a\u6dfb\u52a0\u5242\uff0cMeCN\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a-45 o<\/sup>C\uff0c\u6700\u7ec8\u83b7\u5f9795%\u6536\u7387\u7684\u624b\u6027\u4ea7\u72692a <\/strong>(95.3:4.7\u00a0er)\u3002<\/p>\n \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u52172,2-\u4e8c\u53d6\u4ee3-1,3-\u4e19\u4e8c\u9187\u5e95\u7269(Scheme 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n \u540c\u65f6\uff0c\u4f5c\u8005\u901a\u8fc7\u4e00\u7cfb\u521711<\/sup>B NMR\u5b9e\u9a8c\uff0c\u5bf9\u787c\u9178\u50ac\u5316\u5242\u4e0e\u5e95\u7269\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u8fdb\u884c\u6df1\u5165\u7814\u7a76 (Figure 2)\u3002<\/p>\n \u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\uff0c\u4f5c\u8005\u63d0\u51fa\u4e00\u79cd\u5408\u7406\u7684\u7acb\u4f53\u9009\u62e9\u6027\u63a7\u5236\u6a21\u578b (Figure 3)\u3002<\/p>\n \u5357\u4eac\u5927\u5b66\u7684\u90d1\u6587\u534e\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5177\u6709C<\/em>2<\/sub>-\u5bf9\u79f0\u6027\u7684\u624b\u6027\u787c\u9178\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u75282,2-\u4e8c\u53d6\u4ee3-1,3-\u4e19\u4e8c\u9187\u53c2\u4e0e\u7684\u50ac\u5316\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u56db\u7ea7\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u4e8c\u9187\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u5bf9\u79f0\u5316\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u5357\u4eac\u5927\u5b66\u7684\u90d1\u6587\u534e\u8bfe\u9898\u7ec4\u5728J. Am. Chem. Soc.\u00a0\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5177\u6709C2-\u5bf9\u79f0\u6027\u7684\u624b\u6027\u787c\u9178\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u75282,2-\u4e8c\u53d6\u4ee3-1,3-\u4e19\u4e8c\u9187\u53c2\u4e0e\u7684\u50ac\u5316\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u56db\u7ea7\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u4e8c\u9187\u5206\u5b50\u7684\u6784\u5efa\u3002 Synthesis of a C2\u2011Symmetric Chiral Borinic Acid and Its Application in Catalytic Desymmetrization of 2,2-Disubstituted-1,3-Propanediols J.Song, W.Zheng, J. Am. Chem. Soc.\u00a02023, 145, 8338. doi: 10.1021\/jacs.3c02331. \u6b63\u6587\uff1a \u8fd1\u5e74\u6765\uff0c\u901a\u8fc7\u787c\u9178\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u5408\u6210\u8f6c\u5316\u65b9\u6cd5\u5b66\u7684\u76f8\u5173\u7814\u7a76\uff0c\u5df2\u7ecf\u9010\u6e10\u53d7\u5230\u6709\u673a\u5408\u6210\u5316\u5b66\u5bb6\u7684\u5e7f\u6cdb\u5173\u6ce8[1]\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u901a\u8fc7\u624b\u6027\u787c\u9178\u50ac\u5316\u5242\u53c2\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u8f6c\u5316\u65b9\u6cd5\u5b66\u7684\u7814\u7a76\uff0c\u76ee\u524d\u5374\u8f83\u5c11\u6709\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053\u00a0(Figure 1)[2]-[4]\u3002\u8fd9\u91cc\uff0c\u53d7\u5230\u524d\u671f\u5bf9\u4e8e\u4e8c\u82b3\u57fa\u787c\u9178\u4ee5\u53caoxaboraanthracene\u50ac\u5316\u6d3b\u6027\u4e0e\u7a33\u5b9a\u6027\u76f8\u5173\u7814\u7a76\u62a5\u9053 (Figure 1c)[5]\u7684\u542f\u53d1\uff0c\u5357\u4eac\u5927\u5b66\u7684\u90d1\u6587\u534e\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5177\u6709C2-\u5bf9\u79f0\u6027\u7684\u624b\u6027\u787c\u9178\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u75282,2-\u4e8c\u53d6\u4ee3-1,3-\u4e19\u4e8c\u9187\u53c2\u4e0e\u7684\u50ac\u5316\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u6210\u529f\u5408\u6210\u51fa\u56db\u79cd\u5168\u65b0\u7684\u5177\u6709C2-\u5bf9\u79f0\u6027\u7684\u624b\u6027\u787c\u9178\u50ac\u5316\u5242 (Scheme 1)\u3002 \u4e4b\u540e\uff0c\u4f5c\u8005\u91c7\u75282-\u82ef\u57fa-2-\u7532\u57fa-1,3-\u4e19\u4e8c\u91871a\u4e0e4-\u7532\u6c27\u57fa\u82ef\u7532\u9170\u6c2f\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528(S, S)-C1\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cDIPEA\u4f5c\u4e3a\u78b1\uff0c4 \u00c5 MS\u4f5c\u4e3a\u6dfb\u52a0\u5242\uff0cMeCN\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a-45 oC\uff0c\u6700\u7ec8\u83b7\u5f9795%\u6536\u7387\u7684\u624b\u6027\u4ea7\u72692a (95.3:4.7\u00a0er)\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u52172,2-\u4e8c\u53d6\u4ee3-1,3-\u4e19\u4e8c\u9187\u5e95\u7269(Scheme 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u540c\u65f6\uff0c\u4f5c\u8005\u901a\u8fc7\u4e00\u7cfb\u521711B NMR\u5b9e\u9a8c\uff0c\u5bf9\u787c\u9178\u50ac\u5316\u5242\u4e0e\u5e95\u7269\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u8fdb\u884c\u6df1\u5165\u7814\u7a76 (Figure 2)\u3002 \u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\uff0c\u4f5c\u8005\u63d0\u51fa\u4e00\u79cd\u5408\u7406\u7684\u7acb\u4f53\u9009\u62e9\u6027\u63a7\u5236\u6a21\u578b (Figure 3)\u3002 \u603b\u7ed3\uff1a \u5357\u4eac\u5927\u5b66\u7684\u90d1\u6587\u534e\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5177\u6709C2-\u5bf9\u79f0\u6027\u7684\u624b\u6027\u787c\u9178\u50ac\u5316\u5242\u4fc3\u8fdb\u7684\u91c7\u75282,2-\u4e8c\u53d6\u4ee3-1,3-\u4e19\u4e8c\u9187\u53c2\u4e0e\u7684\u50ac\u5316\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u56db\u7ea7\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u4e8c\u9187\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u5bf9\u79f0\u5316\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] (a) E.\u00a0Dimitrijevic\u0301,\u00a0M. S. Taylor, ACS Catal. 2013, 3,\u00a0945. doi: 10.1021\/cs4000848. (b) I.\u00a0Georgiou, G. Ilyashenko, A. Whiting, Acc. Chem. Res.\u00a02009, 42,\u00a0756. doi: 10.1021\/ar800262v. (c) D. G. Hall, Chem. Soc. Rev.\u00a02019,\u00a048, 3475. doi: 10.1039\/C9CS00191C. (d) B. J. Graham, R. T. Raines, J. Org. Chem. 2022, doi: 10.1021\/acs.joc.2c01695.\u00a0 [2] T.\u00a0Hashimoto, A. O. 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