{"id":46085,"date":"2023-06-08T08:00:37","date_gmt":"2023-06-08T00:00:37","guid":{"rendered":"\/\/www.gsbet888.com\/?p=46085"},"modified":"2023-06-04T19:51:03","modified_gmt":"2023-06-04T11:51:03","slug":"acs-catal-%ef%bc%9a%e5%af%b9%e6%98%a0%e9%80%89%e6%8b%a9%e6%80%a712-amidocyanation%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2023\/06\/acs-catal-%ef%bc%9a%e5%af%b9%e6%98%a0%e9%80%89%e6%8b%a9%e6%80%a712-amidocyanation%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6%e7%a0%94%e7%a9%b6.html","title":{"rendered":"ACS Catal.\uff1a\u5bf9\u6620\u9009\u62e9\u60271,2-Amidocyanation\u53cd\u5e94\u65b9\u6cd5\u5b66\u7814\u7a76"},"content":{"rendered":"<p style=\"text-align: justify;\"><b><i>\u4f5c\u8005\uff1a\u6749\u6749<\/i><\/b><\/p>\n<h4 style=\"text-align: justify;\">\u5bfc\u8bfb\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u8fd1\u65e5\uff0c\u745e\u58ebEcole Polytechnique F\u00e9d\u00e9rale de Lausanne\u7684\u795d\u4ecb\u5e73\u8bfe\u9898\u7ec4\u5728<em><i>ACS Catal.<\/i><\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5149\u6c27\u5316\u8fd8\u539f\u4e0e\u94dc\u50ac\u5316\u4f53\u7cfb\u534f\u540c\u4fc3\u8fdb\u76841,3-\u4e8c\u70ef\u3001<em>N<\/em>-amidopyridinium\u4e0eTMSCN\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u60271,2-amidocyanation\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u6c30\u57fa\u624b\u6027\u4e2d\u5fc3\u7684\u9ad8\u70ef\u4e19\u80fa\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n<blockquote><p>Dual Photoredox and Copper Catalysis: Enantioselective 1,2-Amidocyanation of 1,3-Dienes<\/p>\n<p>D. Forster, W. Guo, Q. Wang, J. Zhu, <em><i>ACS Catal. <\/i><\/em><strong>2023<\/strong>,<em>13<\/em>, 7523. doi: <a href=\"https:\/\/doi.org\/10.1021\/acscatal.3c01782\"><u>10.1021\/acscatal.3c01782<\/u><\/a><\/p><\/blockquote>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-46087 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/cc62d5383a066ba901c5ec3444980005.png\" alt=\"\" width=\"835\" height=\"394\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/cc62d5383a066ba901c5ec3444980005.png 835w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/cc62d5383a066ba901c5ec3444980005-300x142.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/cc62d5383a066ba901c5ec3444980005-680x321.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/cc62d5383a066ba901c5ec3444980005-768x362.png 768w\" sizes=\"(max-width: 835px) 100vw, 835px\" \/><\/p>\n<h4 style=\"text-align: justify;\">\u6b63\u6587\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c1,3-\u4e8c\u70ef\u5206\u5b50\u53cc\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u7684\u76f8\u5173\u7814\u7a76\uff0c\u5df2\u7ecf\u5907\u53d7\u8bf8\u591a\u79d1\u7814\u56e2\u961f\u7684\u5e7f\u6cdb\u5173\u6ce8 (Schemes 1a-c)<sup>[1]-[3]<\/sup>\u3002\u8fd9\u91cc\uff0c\u53d7\u5230\u8fd1\u5e74\u6765\u9009\u62e9\u6742\u539f\u5b50\u4e2d\u5fc3\u81ea\u7531\u57fa\u5f15\u53d1\u7684domino\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[4]<\/sup>\u3001\u91c7\u7528<em>N<\/em>-amidopyridinium\u00a0<strong>2<\/strong>\u4f5c\u4e3aamidinyl\u81ea\u7531\u57fa\u524d\u4f53<sup>[5]<\/sup>\u4ee5\u53ca\u5728\u5149\u8bf1\u5bfc\u6761\u4ef6\u4e0b\uff0c\u901a\u8fc7\u5171\u8f6d\u4e8c\u70ef\u5206\u5b50<strong>1<\/strong>\u53c2\u4e0e\u76841,2-\u80fa\u5316\u53cc\u5b98\u80fd\u56e2\u5316 (1,2-aminative difunctionalization)\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[6]<\/sup>\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u745e\u58ebEcole Polytechnique F\u00e9d\u00e9rale de Lausanne\u7684\u795d\u4ecb\u5e73\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5149\u6c27\u5316\u8fd8\u539f\u4e0e\u94dc\u50ac\u5316\u4f53\u7cfb\u534f\u540c\u4fc3\u8fdb\u76841,3-\u4e8c\u70ef\u3001<em>N<\/em>-amidopyridinium\u4e0eTMSCN\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u60271,2-amidocyanation\u53cd\u5e94\u65b9\u6cd5\u5b66 (Scheme 1d)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-46088 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/3827eb67ca868b9fdaa10ecbd5ebe151.png\" alt=\"\" width=\"900\" height=\"1319\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/3827eb67ca868b9fdaa10ecbd5ebe151.png 900w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/3827eb67ca868b9fdaa10ecbd5ebe151-205x300.png 205w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/3827eb67ca868b9fdaa10ecbd5ebe151-680x997.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/3827eb67ca868b9fdaa10ecbd5ebe151-768x1126.png 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><\/p>\n<p style=\"text-align: justify;\">\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528(<em>E<\/em>) -1-\u82ef\u57fa-1,3-\u4e01\u4e8c\u70ef<strong>1a<\/strong>\u4e0e<em>N<\/em>-Boc-amidopyridinium salt\u00a0<strong>2a<\/strong>\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528<em><i>fac<\/i><\/em>-Ir(ppy)<sub>3<\/sub>\u4f5c\u4e3a\u5149\u50ac\u5316\u5242\uff0cCu(OTf)<sub>2<\/sub>(H<sub>2<\/sub>O)<em><i>x<\/i><\/em>\u4f5c\u4e3a\u91d1\u5c5e\u50ac\u5316\u5242\uff0c<strong>L1<\/strong>\u4f5c\u4e3a\u624b\u6027\u914d\u4f53\uff0cTMSCN\u4f5c\u4e3a\u6c30\u6e90\uff0c\u84dd\u5149LED\u8f90\u5c04\uff0cCHCl<sub>3<\/sub>\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9766%\u6536\u7387\u7684\u624b\u6027\u4ea7\u7269<strong>3a<\/strong><strong>\u00a0<\/strong>(96% ee)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-46089 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/e2e3397b56d45a4a2c99f956d7930064.png\" alt=\"\" width=\"829\" height=\"857\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/e2e3397b56d45a4a2c99f956d7930064.png 829w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/e2e3397b56d45a4a2c99f956d7930064-290x300.png 290w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/e2e3397b56d45a4a2c99f956d7930064-680x703.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/e2e3397b56d45a4a2c99f956d7930064-768x794.png 768w\" sizes=\"(max-width: 829px) 100vw, 829px\" \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u52171,3-\u4e8c\u70ef\u5e95\u7269 (Scheme 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-46090 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/0456acd8a8ce65dd4b0b588d40562533.png\" alt=\"\" width=\"819\" height=\"1862\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/0456acd8a8ce65dd4b0b588d40562533.png 819w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/0456acd8a8ce65dd4b0b588d40562533-132x300.png 132w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/0456acd8a8ce65dd4b0b588d40562533-450x1024.png 450w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/0456acd8a8ce65dd4b0b588d40562533-768x1746.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/0456acd8a8ce65dd4b0b588d40562533-676x1536.png 676w\" sizes=\"(max-width: 819px) 100vw, 819px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-46091 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/119644f942f654f1861595d532d5cda9.png\" alt=\"\" width=\"1108\" height=\"502\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/119644f942f654f1861595d532d5cda9.png 1108w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/119644f942f654f1861595d532d5cda9-300x136.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/119644f942f654f1861595d532d5cda9-680x308.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/119644f942f654f1861595d532d5cda9-768x348.png 768w\" sizes=\"(max-width: 1108px) 100vw, 1108px\" \/><\/p>\n<p style=\"text-align: justify;\">\u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c1,3-\u4e01\u4e8c\u70ef\u4e0e2,3-\u4e8c\u7532\u57fa-1,3-\u4e01\u4e8c\u70ef\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u5219\u8fdb\u884c\u76f8\u5e94\u7684\u9009\u62e9\u60271,4-amidocyanation\u53cd\u5e94\u8fc7\u7a0b\u00a0(Scheme 3)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-46092 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/65b1cc46251bb59c4fbe98d9bf357a8d.png\" alt=\"\" width=\"900\" height=\"308\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/65b1cc46251bb59c4fbe98d9bf357a8d.png 900w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/65b1cc46251bb59c4fbe98d9bf357a8d-300x103.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/65b1cc46251bb59c4fbe98d9bf357a8d-680x233.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/65b1cc46251bb59c4fbe98d9bf357a8d-768x263.png 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><\/p>\n<p style=\"text-align: justify;\">\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff01,2-amidocyanation\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\u00a0(Scheme 4a)\u3002\u540c\u65f6\uff0c\u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053<sup>[7]<\/sup>\uff0c\u4f5c\u8005\u63d0\u51fa\u4e00\u79cd\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 4b)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-46093 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/00c4b4e7fcc55ac48f8985bc099647d7.png\" alt=\"\" width=\"859\" height=\"1166\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/00c4b4e7fcc55ac48f8985bc099647d7.png 859w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/00c4b4e7fcc55ac48f8985bc099647d7-221x300.png 221w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/00c4b4e7fcc55ac48f8985bc099647d7-680x923.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/00c4b4e7fcc55ac48f8985bc099647d7-768x1042.png 768w\" sizes=\"(max-width: 859px) 100vw, 859px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-46094 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/5512c2183db0a26c416c8659caa9ada7.png\" alt=\"\" width=\"1106\" height=\"464\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/5512c2183db0a26c416c8659caa9ada7.png 1106w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/5512c2183db0a26c416c8659caa9ada7-300x126.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/5512c2183db0a26c416c8659caa9ada7-680x285.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/5512c2183db0a26c416c8659caa9ada7-768x322.png 768w\" sizes=\"(max-width: 1106px) 100vw, 1106px\" \/><\/p>\n<p style=\"text-align: justify;\">\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u60271,2-amidocyanation\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u00a0(Scheme 5)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-46095 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/aef900fe6a98685ac5f2fcbe968988dd.png\" alt=\"\" width=\"803\" height=\"442\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/aef900fe6a98685ac5f2fcbe968988dd.png 803w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/aef900fe6a98685ac5f2fcbe968988dd-300x165.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/aef900fe6a98685ac5f2fcbe968988dd-680x374.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/06\/aef900fe6a98685ac5f2fcbe968988dd-768x423.png 768w\" sizes=\"(max-width: 803px) 100vw, 803px\" \/><\/p>\n<p style=\"text-align: justify;\">\u603b\u7ed3\uff1a\u745e\u58ebEcole Polytechnique F\u00e9d\u00e9rale de Lausanne\u7684\u795d\u4ecb\u5e73\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5149\u6c27\u5316\u8fd8\u539f\u4e0e\u94dc\u50ac\u5316\u4f53\u7cfb\u534f\u540c\u4fc3\u8fdb\u76841,3-\u4e8c\u70ef\u3001<em>N<\/em>-amidopyridinium\u4e0eTMSCN\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u60271,2-amidocyanation\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u6c30\u57fa\u624b\u6027\u4e2d\u5fc3\u7684\u9ad8\u70ef\u4e19\u80fa\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u76841,2-amidocyanation\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u533a\u57df\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n<h4 style=\"text-align: justify;\"><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ul>\n<li style=\"text-align: justify;\">[1] H. M. Huang, P. Bellotti, P. M. Pflu\u0308ger, J. L. Schwarz, B. Heidrich, F. Glorius, <em>J. Am. Chem. Soc.<\/em><strong>2020<\/strong>, 142,10173.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/jacs.0c03239\"><u>10.1021\/jacs.0c03239<\/u><\/a><u>.<\/u><\/li>\n<li style=\"text-align: justify;\">[2] K. P. S.\u00a0Cheung, D. Kurandina, T. Yata, V. Gevorgyan, <em><i>J. Am. Chem. Soc. <\/i><\/em><strong>2020<\/strong>, <em><i>142<\/i><\/em>, 9932.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/jacs.0c03993\"><u>10.1021\/jacs.0c03993<\/u><\/a><u>.<\/u><\/li>\n<li style=\"text-align: justify;\">[3]\u00a0F.\u00a0Lu, L. Lu, G. He, J. Bai, W. Xiao,\u00a0<em><i>J. Am. Chem. Soc.<\/i><\/em>\u00a0<strong>2021<\/strong>, <em><i>143<\/i><\/em>, 4168.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/jacs.1c01260\"><u>10.1021\/jacs.1c01260<\/u><\/a><u>.<\/u><\/li>\n<li style=\"text-align: justify;\">[4] K. P. S.\u00a0Cheung, S.\u00a0Sarkar, V. Gevorgyan, <em><i>Chem. Rev. <\/i><\/em><strong>2022<\/strong>, <em><i>122<\/i><\/em>, 1543.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/acs.chemrev.1c00403\"><u>10.1021\/acs.chemrev.1c00403<\/u><\/a><u>.<\/u><\/li>\n<li style=\"text-align: justify;\">[5] S. L. R\u00f6ssler, B. J. Jelier, E. Magnier, G. Dagousset, E. M. Carreira, A. Togni, <em>Angew. Chem., Int. Ed.<\/em> <strong>2020<\/strong>, 59, 9264.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1002\/anie.201911660\"><u>10.1002\/anie.201911660<\/u><\/a><u>.<\/u><\/li>\n<li style=\"text-align: justify;\">[6] S.\u00a0Shin, S. Lee, W. Choi, N. Kim, S. Hong, <em><i>Angew. Chem., Int. Ed. <\/i><\/em><strong>2021<\/strong>, <em><i>60<\/i><\/em>, 7873.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1002\/anie.202016156\"><u>10.1002\/anie.202016156<\/u><\/a><u>.<\/u><\/li>\n<li style=\"text-align: justify;\">[7] J.\u00a0Li, Z. Zhang, L. Wu, W. Zhang, P. Chen, Z.\u00a0Lin, G. Liu, <em><i>Nature <\/i><\/em><strong>2019<\/strong>, <em><i>574<\/i><\/em>, 516.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41586-019-1655-8\"><u>10.1038\/s41586-019-1655-8<\/u><\/a><u>.<\/u><\/li>\n<\/ul>\n<p style=\"text-align: justify;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u745e\u58ebEcole Polytechnique F\u00e9d\u00e9rale de Lausanne\u7684\u795d\u4ecb\u5e73\u8bfe\u9898\u7ec4\u5728ACS Catal.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5149\u6c27\u5316\u8fd8\u539f\u4e0e\u94dc\u50ac\u5316\u4f53\u7cfb\u534f\u540c\u4fc3\u8fdb\u76841,3-\u4e8c\u70ef\u3001N-amidopyridinium\u4e0eTMSCN\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u60271,2-amidocyanation\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u6c30\u57fa\u624b\u6027\u4e2d\u5fc3\u7684\u9ad8\u70ef\u4e19\u80fa\u5206\u5b50\u7684\u6784\u5efa\u3002 Dual Photoredox and Copper Catalysis: Enantioselective 1,2-Amidocyanation of 1,3-Dienes D. Forster, W. Guo, Q. Wang, J. Zhu, ACS Catal. 2023,13, 7523. doi: 10.1021\/acscatal.3c01782 \u6b63\u6587\uff1a \u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c1,3-\u4e8c\u70ef\u5206\u5b50\u53cc\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u7684\u76f8\u5173\u7814\u7a76\uff0c\u5df2\u7ecf\u5907\u53d7\u8bf8\u591a\u79d1\u7814\u56e2\u961f\u7684\u5e7f\u6cdb\u5173\u6ce8 (Schemes 1a-c)[1]-[3]\u3002\u8fd9\u91cc\uff0c\u53d7\u5230\u8fd1\u5e74\u6765\u9009\u62e9\u6742\u539f\u5b50\u4e2d\u5fc3\u81ea\u7531\u57fa\u5f15\u53d1\u7684domino\u53cd\u5e94\u65b9\u6cd5\u5b66[4]\u3001\u91c7\u7528N-amidopyridinium\u00a02\u4f5c\u4e3aamidinyl\u81ea\u7531\u57fa\u524d\u4f53[5]\u4ee5\u53ca\u5728\u5149\u8bf1\u5bfc\u6761\u4ef6\u4e0b\uff0c\u901a\u8fc7\u5171\u8f6d\u4e8c\u70ef\u5206\u5b501\u53c2\u4e0e\u76841,2-\u80fa\u5316\u53cc\u5b98\u80fd\u56e2\u5316 (1,2-aminative difunctionalization)\u53cd\u5e94\u65b9\u6cd5\u5b66[6]\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u745e\u58ebEcole Polytechnique F\u00e9d\u00e9rale de Lausanne\u7684\u795d\u4ecb\u5e73\u8bfe\u9898\u7ec4\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5149\u6c27\u5316\u8fd8\u539f\u4e0e\u94dc\u50ac\u5316\u4f53\u7cfb\u534f\u540c\u4fc3\u8fdb\u76841,3-\u4e8c\u70ef\u3001N-amidopyridinium\u4e0eTMSCN\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u60271,2-amidocyanation\u53cd\u5e94\u65b9\u6cd5\u5b66 (Scheme 1d)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528(E) -1-\u82ef\u57fa-1,3-\u4e01\u4e8c\u70ef1a\u4e0eN-Boc-amidopyridinium salt\u00a02a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528fac-Ir(ppy)3\u4f5c\u4e3a\u5149\u50ac\u5316\u5242\uff0cCu(OTf)2(H2O)x\u4f5c\u4e3a\u91d1\u5c5e\u50ac\u5316\u5242\uff0cL1\u4f5c\u4e3a\u624b\u6027\u914d\u4f53\uff0cTMSCN\u4f5c\u4e3a\u6c30\u6e90\uff0c\u84dd\u5149LED\u8f90\u5c04\uff0cCHCl3\u4f5c\u4e3a\u53cd\u5e94\u6eb6\u5242\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9766%\u6536\u7387\u7684\u624b\u6027\u4ea7\u72693a\u00a0(96% ee)\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u52171,3-\u4e8c\u70ef\u5e95\u7269 (Scheme 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u540c\u65f6\uff0c\u8be5\u5c0f\u7ec4\u53d1\u73b0\uff0c1,3-\u4e01\u4e8c\u70ef\u4e0e2,3-\u4e8c\u7532\u57fa-1,3-\u4e01\u4e8c\u70ef\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u5219\u8fdb\u884c\u76f8\u5e94\u7684\u9009\u62e9\u60271,4-amidocyanation\u53cd\u5e94\u8fc7\u7a0b\u00a0(Scheme 3)\u3002 \u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff01,2-amidocyanation\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\u00a0(Scheme 4a)\u3002\u540c\u65f6\uff0c\u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053[7]\uff0c\u4f5c\u8005\u63d0\u51fa\u4e00\u79cd\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 4b)\u3002 \u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u60271,2-amidocyanation\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u00a0(Scheme 5)\u3002 \u603b\u7ed3\uff1a\u745e\u58ebEcole Polytechnique F\u00e9d\u00e9rale de Lausanne\u7684\u795d\u4ecb\u5e73\u56e2\u961f\u6210\u529f\u8bbe\u8ba1\u51fa\u4e00\u79cd\u5168\u65b0\u7684\u901a\u8fc7\u5149\u6c27\u5316\u8fd8\u539f\u4e0e\u94dc\u50ac\u5316\u4f53\u7cfb\u534f\u540c\u4fc3\u8fdb\u76841,3-\u4e8c\u70ef\u3001N-amidopyridinium\u4e0eTMSCN\u4e4b\u95f4\u7684\u5bf9\u6620\u9009\u62e9\u60271,2-amidocyanation\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u6c30\u57fa\u624b\u6027\u4e2d\u5fc3\u7684\u9ad8\u70ef\u4e19\u80fa\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u76841,2-amidocyanation\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u5e94\u7528\u8303\u56f4\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u533a\u57df\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] H. M. Huang, P. Bellotti, P. M. Pflu\u0308ger, J. L. Schwarz, B. Heidrich, F. Glorius, J. Am. Chem. Soc.2020, 142,10173.\u00a0doi:\u00a010.1021\/jacs.0c03239. [2] K. P. S.\u00a0Cheung, D. Kurandina, T. Yata, V. Gevorgyan, J. Am. Chem. Soc. 2020, 142, 9932.\u00a0doi:\u00a010.1021\/jacs.0c03993. [3]\u00a0F.\u00a0Lu, L. Lu, G. He, J. 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