{"id":4698,"date":"2015-04-30T09:36:19","date_gmt":"2015-04-30T01:36:19","guid":{"rendered":"\/\/www.gsbet888.com\/?p=4698"},"modified":"2019-08-02T18:55:36","modified_gmt":"2019-08-02T10:55:36","slug":"corey-gilman-ganem%e6%b0%a7%e5%8c%96%e5%8f%8d%e5%ba%94corey-gilman-ganem-oxidation","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/%e6%b0%a7%e5%8c%96%e5%8f%8d%e5%ba%94\/2015\/04\/corey-gilman-ganem%e6%b0%a7%e5%8c%96%e5%8f%8d%e5%ba%94corey-gilman-ganem-oxidation.html","title":{"rendered":"Corey-Gilman-Ganem\u6c27\u5316\u53cd\u5e94(Corey-Gilman-Ganem Oxidation)"},"content":{"rendered":"<ul>\n<li><strong>\u6982\u8981\u3001<\/strong><\/li>\n<\/ul>\n<p>\u5229\u7528\u4e8c\u6c27\u5316\u9530\u4e0e\u6c30\u79bb\u5b50\u4f53\u7cfb\u5728\u6e29\u548c\u6761\u4ef6\u4e0b\u9009\u62e9\u6027\u6c27\u5316\u03b1,\u03b2-\u4e0d\u9971\u548c\u919b\u5230\u5bf9\u5e94\u7fa7\u9178\u916f\u7684\u624b\u6cd5\u3002\u76f8\u5bf9\u4e8e\u5176\u4ed6\u65b9\u6cd5\u6765\u8bf4\uff0c\u8be5\u65b9\u6cd5\u4e0d\u4f1a\u5f15\u8d77\u4e0d\u9971\u548c\u53cc\u952e\u7684cis\/trans\u5f02\u6784\u5316\uff0c\u8fd9\u662f\u5b83\u6700\u5927\u7684\u4e00\u4e2a\u4f18\u70b9\u3002\u53e6\u5916\u5bf9\u4e8e\u8be5\u53cd\u5e94\u6700\u5f00\u59cb\u7684\u6761\u4ef6\uff0c\u7532\u57fa\u916f\u57fa\u5316\u4ee5\u5916\u7684\u4ea7\u7269\u4ea7\u7387\u90fd\u504f\u4f4e\u3002<\/p>\n<p>\u800c\u8fd1\u51e0\u5e74\uff0c\u5229\u7528<strong>N-\u6742\u73af\u5361\u5bbe(NHC)<\/strong>\u53d6\u4ee3\u6c30\u79bb\u5b50\u7684\u53cd\u5e94\u6761\u4ef6\u88ab\u76f8\u7ee7\u62a5\u9053\uff0c\u5176\u76f8\u6bd4\u4e8e\u539f\u6761\u4ef6\uff0c\u4e0d\u4ec5\u6536\u7387\u5f97\u5230\u63d0\u9ad8\uff0c\u5e95\u7269\u7684\u4e00\u822c\u6027\u66f4\u5e7f\uff0c\u6240\u4ee5\u5e94\u7528\u4ef7\u503c\u66f4\u5927\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u57fa\u672c\u6587\u732e<\/strong><\/li>\n<\/ul>\n<ul>\n<li>Corey, E. J.; Gilman, N. W.; Ganem, B. E. <em>J. Am. Chem. Soc.<\/em> <strong>1968<\/strong>, <em>90<\/em>, 5616. DOI:<a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1021\/ja01022a059\">10.1021\/ja01022a059<\/a><\/li>\n<li>Gilman, N. W. <em>Chem Commun.<\/em> <strong>1971<\/strong>, 733. DOI:<a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1039\/C29710000733\">10.1039\/C29710000733<\/a><\/li>\n<li>Foota, J. S.; Kannoa, H.; Giblin, G. M.P.; Taylor, R. J. K.<em> Synthesis<\/em> <strong>2003<\/strong>, 1055. DOI:<a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1055\/s-2003-39163\">10.1055\/s-2003-39163<\/a><\/li>\n<\/ul>\n<p>&lt;NHC-catalyzed conditions&gt;<\/p>\n<ul>\n<li>Chan, A.; Scheidt, K. A. <em>Org. Lett.<\/em> <strong>2005<\/strong>, <em>7<\/em>, 905. DOI: <a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1021\/ol050100f\">10.1021\/ol050100f<\/a><\/li>\n<li>Maki, B. E.; Chan, A.; Phillips, E. M.; Scheidt, K. A. <em>Org. Lett.<\/em> <strong>2007<\/strong>, <em>9<\/em>, 371. doi:<a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1021\/ol062940f\">10.1021\/ol062940f<\/a><\/li>\n<li>Maki, B. E.; Scheidt, K. A. <em>Org. Lett.<\/em> <strong>2008<\/strong>, <em>10<\/em>, 4331. doi:<a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1021\/ol8018488\">10.1021\/ol8018488<\/a><\/li>\n<li>Maki, B. E.; Chan, A.; Phillips, E. A.; Scheidt, K. A. <em>Tetrahedron<\/em> <strong>2009<\/strong>, <em>65<\/em>, 3102. doi:<a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1016\/j.tet.2008.10.033\">10.1016\/j.tet.2008.10.033<\/a><\/li>\n<li>De Sarkar, S.; Grimme, S.; Studer, A. <em>J. Am. Chem. Soc.<\/em> <strong>2010<\/strong>, <em>132<\/em>, 1190. DOI: <a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1021\/ja910540j\">10.1021\/ja910540j<\/a><\/li>\n<li>Mohlmann, L.; Ludwig, S.; Blechert, S. <em>Beilstein J. Org. Chem.<\/em> <strong>2013<\/strong>, <em>9<\/em>, 602. doi:<a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.3762\/bjoc.9.65\">10.3762\/bjoc.9.65<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/li>\n<\/ul>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2015\/04\/corey_gilman_ganem_2.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-4701 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2015\/04\/corey_gilman_ganem_2.gif\" alt=\"corey_gilman_ganem_2\" width=\"328\" height=\"166\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/li>\n<\/ul>\n<p>\u5229\u7528NHC\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c\u5e94\u7528\u4e8e\u9971\u548c\u8102\u80aa\u919b\u4e0e\u66f4\u590d\u6742\u7684\u9187\u7c7b\u5e95\u7269\u4e4b\u95f4\u7684\u6c27\u5316\u916f\u57fa\u5316\u53cd\u5e94\u3002[1]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2015\/04\/corey_gilman_ganem_3.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-4702 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2015\/04\/corey_gilman_ganem_3.gif\" alt=\"corey_gilman_ganem_3\" width=\"461\" height=\"123\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>\u5e94\u7528\u4e8e\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\u5b9e\u4f8b[2]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2015\/04\/corey_gilman_ganem_4.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-4703 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2015\/04\/corey_gilman_ganem_4.gif\" alt=\"corey_gilman_ganem_4\" width=\"483\" height=\"113\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u5b9e\u9a8c\u6280\u5de7<\/strong><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u53c2\u8003\u6587\u732e<\/strong><\/li>\n<\/ul>\n[1] (a) Chan, A.; Scheidt, K. A. <em>Org. Lett.<\/em> <strong>2005<\/strong>, <em>7<\/em>, 905. DOI: <a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1021\/ol050100f\">10.1021\/ol050100f<\/a> (b) Maki, B. E.; Chan, A.; Phillips, E. M.; Scheidt, K. A. <em>Org. Lett.<\/em> <strong>2007<\/strong>, <em>9<\/em>, 371. doi:<a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1021\/ol062940f\">10.1021\/ol062940f<\/a> (c) Maki, B. E.; Scheidt, K. A. <em>Org. Lett.<\/em><strong>2008<\/strong>, <em>10<\/em>, 4331. doi:<a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1021\/ol8018488\">10.1021\/ol8018488<\/a> (d) Maki, B. E.; Chan, A.; Phillips, E. A.; Scheidt, K. A. <em>Tetrahedron<\/em> <strong>2009<\/strong>,<em>65<\/em>, 3102. doi:<a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1016\/j.tet.2008.10.033\">10.1016\/j.tet.2008.10.033<\/a><br \/>\n[2] Keck, G. E.; Wager, T. T.; Rodriquez, J. F. D. <em>J. Am. Chem. Soc.<\/em> <strong>1999<\/strong>, <em>121<\/em>, 5176. DOI: <a class=\"ext-link ext-icon-2\" title=\"\" href=\"http:\/\/dx.doi.org\/10.1021\/ja9826688\">10.1021\/ja9826688<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981\u3001 \u5229\u7528\u4e8c\u6c27\u5316\u9530\u4e0e\u6c30\u79bb\u5b50\u4f53\u7cfb\u5728\u6e29\u548c\u6761\u4ef6\u4e0b\u9009\u62e9\u6027\u6c27\u5316\u03b1,\u03b2-\u4e0d\u9971\u548c\u919b\u5230\u5bf9\u5e94\u7fa7\u9178\u916f\u7684\u624b\u6cd5\u3002\u76f8\u5bf9\u4e8e\u5176\u4ed6\u65b9\u6cd5\u6765\u8bf4\uff0c\u8be5\u65b9\u6cd5\u4e0d\u4f1a\u5f15\u8d77\u4e0d\u9971\u548c\u53cc\u952e\u7684cis\/trans\u5f02\u6784\u5316\uff0c\u8fd9\u662f\u5b83\u6700\u5927\u7684\u4e00\u4e2a\u4f18\u70b9\u3002\u53e6\u5916\u5bf9\u4e8e\u8be5\u53cd\u5e94\u6700\u5f00\u59cb\u7684\u6761\u4ef6\uff0c\u7532\u57fa\u916f\u57fa\u5316\u4ee5\u5916\u7684\u4ea7\u7269\u4ea7\u7387\u90fd\u504f\u4f4e\u3002 \u800c\u8fd1\u51e0\u5e74\uff0c\u5229\u7528N-\u6742\u73af\u5361\u5bbe(NHC)\u53d6\u4ee3\u6c30\u79bb\u5b50\u7684\u53cd\u5e94\u6761\u4ef6\u88ab\u76f8\u7ee7\u62a5\u9053\uff0c\u5176\u76f8\u6bd4\u4e8e\u539f\u6761\u4ef6\uff0c\u4e0d\u4ec5\u6536\u7387\u5f97\u5230\u63d0\u9ad8\uff0c\u5e95\u7269\u7684\u4e00\u822c\u6027\u66f4\u5e7f\uff0c\u6240\u4ee5\u5e94\u7528\u4ef7\u503c\u66f4\u5927\u3002 &nbsp; &nbsp; \u57fa\u672c\u6587\u732e Corey, E. J.; Gilman, N. W.; Ganem, B. E. J. Am. Chem. Soc. 1968, 90, 5616. DOI:10.1021\/ja01022a059 Gilman, N. W. Chem Commun. 1971, 733. DOI:10.1039\/C29710000733 Foota, J. S.; Kannoa, H.; Giblin, G. M.P.; Taylor, R. J. K. Synthesis 2003, 1055. DOI:10.1055\/s-2003-39163 &lt;NHC-catalyzed conditions&gt; Chan, A.; Scheidt, K. A. Org. Lett. 2005, 7, 905. DOI: 10.1021\/ol050100f Maki, B. E.; Chan, A.; Phillips, E. M.; Scheidt, K. A. Org. Lett. 2007, 9, 371. doi:10.1021\/ol062940f Maki, B. E.; Scheidt, K. A. Org. Lett. 2008, 10, 4331. doi:10.1021\/ol8018488 Maki, B. E.; Chan, A.; Phillips, E. A.; Scheidt, K. A. Tetrahedron 2009, 65, 3102. doi:10.1016\/j.tet.2008.10.033 De Sarkar, S.; Grimme, [&hellip;]","protected":false},"author":5,"featured_media":4700,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[8],"tags":[819,820,378],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2015\/04\/2014-10-25_23-35-30.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-1dM","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/4698"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=4698"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/4698\/revisions"}],"predecessor-version":[{"id":27937,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/4698\/revisions\/27937"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/4700"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=4698"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=4698"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=4698"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}