{"id":47619,"date":"2023-11-24T08:00:30","date_gmt":"2023-11-24T00:00:30","guid":{"rendered":"\/\/www.gsbet888.com\/?p=47619"},"modified":"2023-11-23T19:37:14","modified_gmt":"2023-11-23T11:37:14","slug":"nature-synthesis%e9%85%b6%e5%82%ac%e5%8c%96%e7%9a%84%e7%be%a7%e9%85%b8%e7%9a%84%e5%af%b9%e6%98%a0%e9%80%89%e6%8b%a9%e6%80%a7%ce%b3-c-h%e5%86%85%e9%85%af%e5%8c%96%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2023\/11\/nature-synthesis%e9%85%b6%e5%82%ac%e5%8c%96%e7%9a%84%e7%be%a7%e9%85%b8%e7%9a%84%e5%af%b9%e6%98%a0%e9%80%89%e6%8b%a9%e6%80%a7%ce%b3-c-h%e5%86%85%e9%85%af%e5%8c%96%e5%8f%8d%e5%ba%94.html","title":{"rendered":"Nature Synthesis:\u9176\u50ac\u5316\u7684\u7fa7\u9178\u7684\u5bf9\u6620\u9009\u62e9\u6027\u03b3-C\u2013H\u5185\u916f\u5316\u53cd\u5e94"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/strong><\/p>\n<h4 style=\"text-align: justify;\">\u5bfc\u8bfb\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u8fd1\u65e5\uff0c<strong>\u626c\u5dde\u5927\u5b66\u738b\u559c\u5e86\u6559\u6388<\/strong>\u56e2\u961f\u901a\u8fc7\u5b9a\u5411\u8fdb\u5316\u6539\u9020P450\u9176(P450BS\u03b2)\u89e3\u51b3\u4e86\u8fd9\u4e00\u96be\u9898\uff0c\u5b9e\u73b0\u4e86\u94fe\u72b6\u8102\u80aa\u65cf\u7fa7\u9178\u672a\u6d3b\u5316\u7684C\u2013H\u952e\u7684\u9ad8\u5ea6\u533a\u57df\u548c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u03b3-\u5185\u916f\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5c06\u8102\u80aa\u9178\u76f4\u63a5\u5408\u6210\u4e3a\u76f8\u5e94\u7684\u03b3-\u5185\u916f\u3002\u5b89\u5fbd\u5927\u5b66\u4f55\u8d85\u8bfe\u9898\u7ec4\u89e3\u6790\u4e86\u6539\u9020\u540e\u7684\u9176\u7a81\u53d8\u4f53\u4e0e\u68d5\u6988\u6cb9\u9178\u590d\u5408\u7269\u7684\u6676\u4f53\u7ed3\u6784\uff0c\u5e76\u7ecf\u4e2d\u56fd\u79d1\u5b66\u6280\u672f\u5927\u5b66\u5ed6\u7ed3\u697c\u8bfe\u9898\u7ec4\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u548c\u5bc6\u5ea6\u6cdb\u51fd\u8ba1\u7b97\uff0c\u9610\u660e\u4e86\u8be5\u9176\u53cd\u5e94\u9009\u62e9\u6027\u7684\u7ed3\u6784\u57fa\u7840\u3002<\/p>\n<blockquote><p>\u201cBiocatalytic enantioselective \u03b3-C\u2013H lactonization of aliphatic carboxylic acids<\/p>\n<p>Qian Ma, Wenhao Shan, Xuan Chu, Haochen Xu, Ziyi Chen, Fudong Li, Jie-Lou Liao*, Chao He*, Wen-Ju Bai*, and Xiqing Wang*<\/p>\n<p><em>Nat Synth<\/em>. <strong>2023<\/strong> : doi:<a href=\"https:\/\/doi.org\/10.1038\/s44160-023-00427-y\">10.1038\/s44160-023-00427-y<\/a><u>.\u201d<\/u><\/p><\/blockquote>\n<h4 style=\"text-align: justify;\"><strong>\u6b63\u6587<\/strong><\/h4>\n<p style=\"text-align: justify;\">\u03b3-\u5185\u916f\u5b58\u5728\u4e8e\u591a\u79cd\u5929\u7136\u4ea7\u7269\u7684\u7ed3\u6784\u4e2d\uff0c\u4e14\u8868\u73b0\u51fa\u4f18\u826f\u7684\u751f\u7269\u6d3b\u6027\uff0c\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u98df\u54c1\u98ce\u5473\u3001\u836f\u7269\u5f00\u53d1\u3001\u751f\u7269\u9632\u6cbb\u548c\u4fdd\u62a4\u4ee5\u53ca\u751f\u7269\u76f8\u5bb9\u6027\u6750\u6599\u7b49\u591a\u4e2a\u9886\u57df\u3002<\/p>\n<p style=\"text-align: justify;\">\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-47624 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image008-1.png\" alt=\"\" width=\"502\" height=\"248\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image008-1.png 502w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image008-1-300x148.png 300w\" sizes=\"(max-width: 502px) 100vw, 502px\" \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u751f\u7269\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\uff0c\u03b3-\u5185\u916f\u7684\u5408\u6210\u4e0e\u8102\u80aa\u9178\u4ee3\u8c22\u76f8\u5173\u3002\u53d7\u81ea\u7136\u5408\u6210\u7b56\u7565\u7684\u542f\u53d1\uff0c<strong>\u738b\u559c\u5e86\u8bfe\u9898\u7ec4\u548c\u767d\u6587\u4e3e\u535a\u58eb\uff08\u65af\u5766\u798f\u5927\u5b66\uff0c\u73b0\u827e\u4f2f\u7ef4\uff09\u8bbe\u60f3\u901a\u8fc7\u4e9a\u7532\u57fa<\/strong><strong>C<\/strong><strong>\u2013<\/strong><strong>H<\/strong><strong>\u952e\u7684\u7f9f\u57fa\u5316\u548c\u5185\u916f\u5316\u76f4\u63a5\u4ece\u81ea\u7136\u754c\u5e7f\u6cdb\u5b58\u5728\u3001\u53ef\u518d\u751f\u7684\u8102\u80aa\u9178\u6765\u9ad8\u6548\u3001\u7eff\u8272\u5408\u6210\u03b3<\/strong><strong>&#8211;<\/strong><strong>\u5185\u916f\u3002<\/strong>\u8be5\u60f3\u6cd5\u5b58\u5728\u7740\u5316\u5b66\u3001\u533a\u57df\u3001\u5bf9\u6620\u9009\u62e9\u6027\u4ee5\u53ca\u5b98\u80fd\u56e2\u5bb9\u5fcd\u6027\u7684\u591a\u91cd\u6311\u6218\uff0c\u6240\u4ee5\uff0c\u4e0d\u8bba\u5229\u7528\u5316\u5b66\u50ac\u5316\u5242\u8fd8\u662f\u751f\u7269\u9176\u90fd\u96be\u4ee5\u5b9e\u73b0\u3002\u8be5\u8bfe\u9898\u7ec4\u901a\u8fc7\u5b9a\u5411\u8fdb\u5316\u6539\u9020P450\u9176(P450BS\u03b2)\u89e3\u51b3\u4e86\u8fd9\u4e00\u96be\u9898\uff0c\u5b9e\u73b0\u4e86\u94fe\u72b6\u8102\u80aa\u65cf\u7fa7\u9178\u672a\u6d3b\u5316\u7684C\u2013H\u952e\u7684\u9ad8\u5ea6\u533a\u57df\u548c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u03b3-\u5185\u916f\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5c06\u8102\u80aa\u9178\u76f4\u63a5\u5408\u6210\u4e3a\u76f8\u5e94\u7684\u03b3-\u5185\u916f\u3002\u5b89\u5fbd\u5927\u5b66\u4f55\u8d85\u8bfe\u9898\u7ec4\u89e3\u6790\u4e86\u6539\u9020\u540e\u7684\u9176\u7a81\u53d8\u4f53\u4e0e\u68d5\u6988\u6cb9\u9178\u590d\u5408\u7269\u7684\u6676\u4f53\u7ed3\u6784\uff0c\u5e76\u7ecf\u4e2d\u56fd\u79d1\u5b66\u6280\u672f\u5927\u5b66\u5ed6\u7ed3\u697c\u8bfe\u9898\u7ec4\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u548c\u5bc6\u5ea6\u6cdb\u51fd\u8ba1\u7b97\uff0c\u9610\u660e\u4e86\u8be5\u9176\u53cd\u5e94\u9009\u62e9\u6027\u7684\u7ed3\u6784\u57fa\u7840\u3002\u8be5\u6210\u679c\u8fd1\u671f\u53d1\u8868\u5728<em>Nature Synthesis<\/em>\u4e0a\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-47625 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image009-1.jpg\" alt=\"\" width=\"546\" height=\"278\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image009-1.jpg 546w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image009-1-300x153.jpg 300w\" sizes=\"(max-width: 546px) 100vw, 546px\" \/><\/p>\n<p style=\"text-align: justify;\">\u57fa\u4e8e\u8fd1\u5e74\u5bf9P450<sub>BS\u03b2<\/sub>\u7684\u5b9a\u5411\u8fdb\u5316\u7814\u7a76\uff08<em>Angew. Chem. Int. Ed. <\/em><strong>2022<\/strong>\uff1b<em>ACS Catal. <\/em><strong>2021<\/strong>\uff1b<em>ACS Catal<\/em>. <strong>2020<\/strong>\uff09\uff0c\u8be5\u5408\u4f5c\u56e2\u961f\u8d4b\u4e88\u4e86\u539f\u672c\u65e0\u03b3-\u5185\u916f\u5316\u6d3b\u6027\u7684\u91ce\u751f\u578bP450BS\u03b2\u65b0\u7684\u03b3-\u5185\u916f\u5316\u6d3b\u6027\uff0c\u5f97\u5230\u4e86\u9ad8\u8f6c\u5316\u7387\u548c\u9ad8\u03b3\u4f4d\u9009\u62e9\u6027\u7684P450<sub>BS\u03b2<\/sub>-L78G\/Q85F\/F173S\/G290I\u7a81\u53d8\u4f53\u3002\u5728\u5b9a\u5411\u8fdb\u5316\u8fc7\u7a0b\u4e2d\uff0c\u5e95\u7269\u8f6c\u5316\u7387\u9010\u6b65\u4ece27%\u589e\u52a0\u81f389%\uff0c\u03b3\u4f4d\u7f9f\u57fa\u5316\u9009\u62e9\u6027\u4ece0%\u63d0\u9ad8\u81f389%\uff0c\u4e14\u59cb\u7ec8\u4fdd\u6301\u8f83\u9ad8\u7684\u5bf9\u6620\u9009\u62e9\u6027\uff08&gt;94:6 e.r.\uff09\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-47626 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image010-3.png\" alt=\"\" width=\"553\" height=\"683\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image010-3.png 553w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image010-3-243x300.png 243w\" sizes=\"(max-width: 553px) 100vw, 553px\" \/><\/p>\n<p style=\"text-align: justify;\">\u4e3a\u63a2\u7a76\u8be5\u7a81\u53d8\u4f53\u9176\u7684\u5408\u6210\u4ef7\u503c\uff0c\u4f5c\u8005\u5bf9\u8be5\u9176\u8fdb\u884c\u4e860.5 mmol\u5236\u5907\u7ea7\u53cd\u5e94\u7684\u5e95\u7269\u7814\u7a76\uff0c\u53d1\u73b0\u8be5\u9176\u6446\u8131\u4e86\u5bf9\u70c3\u94fe\u957f\u5ea6\u7684\u4f9d\u8d56\uff0c\u80fd\u591f\u50ac\u5316C6\u2013C20\u94fe\u957f\u7684\u8102\u80aa\u9178\uff08\u4ea7\u7269<strong>4-13<\/strong>\uff09\uff0c\u540c\u65f6\u5177\u6709\u5f88\u597d\u7684\u5b98\u80fd\u56e2\u8010\u53d7\u6027\uff08\u4ea7\u7269<strong>14-23<\/strong>\uff09\uff0c\u5c55\u73b0\u4e86\u8f83\u597d\u7684\u53cd\u5e94\u6d3b\u6027\u4ee5\u53ca\u9ad8\u5ea6\u7684\u533a\u57df\u548c\u5bf9\u6620\u9009\u62e9\u6027\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8be5\u53cd\u5e94\u4e5f\u53ef\u9002\u7528\u4e8e\u542b\u5404\u79cd\u82b3\u73af\uff08\u4ea7\u7269<strong>24-31<\/strong>\uff09\u548c\u82b3\u6742\u73af\u7684\u8102\u80aa\u65cf\u7fa7\u9178\uff08\u4ea7\u7269<strong>32-42<\/strong>\uff09\uff0c\u56e0\u6b64\uff0c\u5728\u836f\u7269\u5206\u5b50\u7684\u5408\u6210\u4e0e\u5f00\u53d1\u4e0a\u6709\u5f88\u597d\u7684\u5e94\u7528\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-47627 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image011-4.png\" alt=\"\" width=\"490\" height=\"300\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image011-4.png 490w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image011-4-300x184.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image011-4-233x144.png 233w\" sizes=\"(max-width: 490px) 100vw, 490px\" \/><\/p>\n<p style=\"text-align: justify;\">\u8be5\u9176\u53cd\u5e94\u7684\u4e00\u4e9b\u4ea7\u7269\u6563\u53d1\u51fa\u9999\u8349\u3001\u6930\u6c41\u548c\u6843\u5b50\u7684\u9999\u5473\u800c\u53ef\u4f5c\u4e3a\u98df\u54c1\u53e3\u5473\u6dfb\u52a0\u5242\uff08\u4ea7\u7269<strong>4<\/strong><strong>\uff0c<\/strong><strong>6<\/strong><strong>\uff0c<\/strong><strong>8<\/strong>\uff09\u3002\u8fd9\u4e00\u50ac\u5316\u53cd\u5e94\u4e5f\u5c06\u4e00\u4e9b\u5929\u7136\u4ea7\u7269\u7684\u5408\u6210\u76f4\u63a5\u7f29\u51cf\u52301\u6b65\uff08\u5929\u7136\u4ea7\u7269<strong>10<\/strong><strong>\uff0c<\/strong><strong>15<\/strong>\uff09\uff0c\u5927\u5e45\u63d0\u5230\u4e86\u5408\u6210\u6548\u7387\u3002\u6b64\u5916\uff0c\u6240\u5408\u6210\u7684\u03b3-\u5185\u916f\u53ef\u4ee5\u642d\u914d\u591a\u6837\u7684\u540e\u7eed\u5316\u5b66\u8f6c\u5316\uff0c\u5b9e\u73b0\u5305\u62ec\u5929\u7136\u4ea7\u7269\u5728\u5185\u7684\u4e00\u7cfb\u5217\u5316\u5408\u7269\u7684\u5408\u6210\uff08\u4ea7\u7269<strong>43-50<\/strong>\uff09\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-47628 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image012-1.jpg\" alt=\"\" width=\"540\" height=\"382\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image012-1.jpg 540w, https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image012-1-300x212.jpg 300w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/p>\n<p style=\"text-align: justify;\">\u6700\u540e\uff0c\u5bf9\u6539\u9020\u540e\u7684\u9176\u4e0e\u68d5\u6988\u9178\u590d\u5408\u7269\u7684\u6676\u4f53\u7ed3\u6784\u7684\u89e3\u6790\u4ee5\u53ca\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u548c\u5bc6\u5ea6\u6cdb\u51fd\u8ba1\u7b97\u63ed\u793a\u4e86\u8be5\u9176\u03b3-\u5185\u916f\u5316\u53cd\u5e94\u7684\u9ad8\u533a\u57df\u548c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u673a\u7406\u3002\u8be5\u7814\u7a76\u5c55\u73b0\u4e86\u5b9a\u5411\u8fdb\u5316\u53ef\u4ee5\u8d4b\u4e88\u91ce\u751f\u9176\u81ea\u7136\u754c\u672a\u6709\u7684\u65b0\u529f\u80fd\uff0c\u4ece\u800c\u89e3\u51b3\u5316\u5b66\u5408\u6210\u4e0a\u5177\u6709\u6311\u6218\u6027\u7684\u5316\u5b66\u53cd\u5e94\u3002<\/p>\n<p style=\"text-align: right;\">(<strong>\u738b\u559c\u5e86\u6559\u6388\u4f9b\u7a3f<\/strong>)<\/p>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u626c\u5dde\u5927\u5b66\u738b\u559c\u5e86\u6559\u6388\u56e2\u961f\u901a\u8fc7\u5b9a\u5411\u8fdb\u5316\u6539\u9020P450\u9176(P450BS\u03b2)\u89e3\u51b3\u4e86\u8fd9\u4e00\u96be\u9898\uff0c\u5b9e\u73b0\u4e86\u94fe\u72b6\u8102\u80aa\u65cf\u7fa7\u9178\u672a\u6d3b\u5316\u7684C\u2013H\u952e\u7684\u9ad8\u5ea6\u533a\u57df\u548c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u03b3-\u5185\u916f\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5c06\u8102\u80aa\u9178\u76f4\u63a5\u5408\u6210\u4e3a\u76f8\u5e94\u7684\u03b3-\u5185\u916f\u3002\u5b89\u5fbd\u5927\u5b66\u4f55\u8d85\u8bfe\u9898\u7ec4\u89e3\u6790\u4e86\u6539\u9020\u540e\u7684\u9176\u7a81\u53d8\u4f53\u4e0e\u68d5\u6988\u6cb9\u9178\u590d\u5408\u7269\u7684\u6676\u4f53\u7ed3\u6784\uff0c\u5e76\u7ecf\u4e2d\u56fd\u79d1\u5b66\u6280\u672f\u5927\u5b66\u5ed6\u7ed3\u697c\u8bfe\u9898\u7ec4\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u548c\u5bc6\u5ea6\u6cdb\u51fd\u8ba1\u7b97\uff0c\u9610\u660e\u4e86\u8be5\u9176\u53cd\u5e94\u9009\u62e9\u6027\u7684\u7ed3\u6784\u57fa\u7840\u3002 \u201cBiocatalytic enantioselective \u03b3-C\u2013H lactonization of aliphatic carboxylic acids Qian Ma, Wenhao Shan, Xuan Chu, Haochen Xu, Ziyi Chen, Fudong Li, Jie-Lou Liao*, Chao He*, Wen-Ju Bai*, and Xiqing Wang* Nat Synth. 2023 : doi:10.1038\/s44160-023-00427-y.\u201d \u6b63\u6587 \u03b3-\u5185\u916f\u5b58\u5728\u4e8e\u591a\u79cd\u5929\u7136\u4ea7\u7269\u7684\u7ed3\u6784\u4e2d\uff0c\u4e14\u8868\u73b0\u51fa\u4f18\u826f\u7684\u751f\u7269\u6d3b\u6027\uff0c\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u98df\u54c1\u98ce\u5473\u3001\u836f\u7269\u5f00\u53d1\u3001\u751f\u7269\u9632\u6cbb\u548c\u4fdd\u62a4\u4ee5\u53ca\u751f\u7269\u76f8\u5bb9\u6027\u6750\u6599\u7b49\u591a\u4e2a\u9886\u57df\u3002 \u00a0 \u5728\u751f\u7269\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\uff0c\u03b3-\u5185\u916f\u7684\u5408\u6210\u4e0e\u8102\u80aa\u9178\u4ee3\u8c22\u76f8\u5173\u3002\u53d7\u81ea\u7136\u5408\u6210\u7b56\u7565\u7684\u542f\u53d1\uff0c\u738b\u559c\u5e86\u8bfe\u9898\u7ec4\u548c\u767d\u6587\u4e3e\u535a\u58eb\uff08\u65af\u5766\u798f\u5927\u5b66\uff0c\u73b0\u827e\u4f2f\u7ef4\uff09\u8bbe\u60f3\u901a\u8fc7\u4e9a\u7532\u57faC\u2013H\u952e\u7684\u7f9f\u57fa\u5316\u548c\u5185\u916f\u5316\u76f4\u63a5\u4ece\u81ea\u7136\u754c\u5e7f\u6cdb\u5b58\u5728\u3001\u53ef\u518d\u751f\u7684\u8102\u80aa\u9178\u6765\u9ad8\u6548\u3001\u7eff\u8272\u5408\u6210\u03b3&#8211;\u5185\u916f\u3002\u8be5\u60f3\u6cd5\u5b58\u5728\u7740\u5316\u5b66\u3001\u533a\u57df\u3001\u5bf9\u6620\u9009\u62e9\u6027\u4ee5\u53ca\u5b98\u80fd\u56e2\u5bb9\u5fcd\u6027\u7684\u591a\u91cd\u6311\u6218\uff0c\u6240\u4ee5\uff0c\u4e0d\u8bba\u5229\u7528\u5316\u5b66\u50ac\u5316\u5242\u8fd8\u662f\u751f\u7269\u9176\u90fd\u96be\u4ee5\u5b9e\u73b0\u3002\u8be5\u8bfe\u9898\u7ec4\u901a\u8fc7\u5b9a\u5411\u8fdb\u5316\u6539\u9020P450\u9176(P450BS\u03b2)\u89e3\u51b3\u4e86\u8fd9\u4e00\u96be\u9898\uff0c\u5b9e\u73b0\u4e86\u94fe\u72b6\u8102\u80aa\u65cf\u7fa7\u9178\u672a\u6d3b\u5316\u7684C\u2013H\u952e\u7684\u9ad8\u5ea6\u533a\u57df\u548c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u03b3-\u5185\u916f\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5c06\u8102\u80aa\u9178\u76f4\u63a5\u5408\u6210\u4e3a\u76f8\u5e94\u7684\u03b3-\u5185\u916f\u3002\u5b89\u5fbd\u5927\u5b66\u4f55\u8d85\u8bfe\u9898\u7ec4\u89e3\u6790\u4e86\u6539\u9020\u540e\u7684\u9176\u7a81\u53d8\u4f53\u4e0e\u68d5\u6988\u6cb9\u9178\u590d\u5408\u7269\u7684\u6676\u4f53\u7ed3\u6784\uff0c\u5e76\u7ecf\u4e2d\u56fd\u79d1\u5b66\u6280\u672f\u5927\u5b66\u5ed6\u7ed3\u697c\u8bfe\u9898\u7ec4\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u548c\u5bc6\u5ea6\u6cdb\u51fd\u8ba1\u7b97\uff0c\u9610\u660e\u4e86\u8be5\u9176\u53cd\u5e94\u9009\u62e9\u6027\u7684\u7ed3\u6784\u57fa\u7840\u3002\u8be5\u6210\u679c\u8fd1\u671f\u53d1\u8868\u5728Nature Synthesis\u4e0a\u3002 \u57fa\u4e8e\u8fd1\u5e74\u5bf9P450BS\u03b2\u7684\u5b9a\u5411\u8fdb\u5316\u7814\u7a76\uff08Angew. Chem. Int. Ed. 2022\uff1bACS Catal. 2021\uff1bACS Catal. 2020\uff09\uff0c\u8be5\u5408\u4f5c\u56e2\u961f\u8d4b\u4e88\u4e86\u539f\u672c\u65e0\u03b3-\u5185\u916f\u5316\u6d3b\u6027\u7684\u91ce\u751f\u578bP450BS\u03b2\u65b0\u7684\u03b3-\u5185\u916f\u5316\u6d3b\u6027\uff0c\u5f97\u5230\u4e86\u9ad8\u8f6c\u5316\u7387\u548c\u9ad8\u03b3\u4f4d\u9009\u62e9\u6027\u7684P450BS\u03b2-L78G\/Q85F\/F173S\/G290I\u7a81\u53d8\u4f53\u3002\u5728\u5b9a\u5411\u8fdb\u5316\u8fc7\u7a0b\u4e2d\uff0c\u5e95\u7269\u8f6c\u5316\u7387\u9010\u6b65\u4ece27%\u589e\u52a0\u81f389%\uff0c\u03b3\u4f4d\u7f9f\u57fa\u5316\u9009\u62e9\u6027\u4ece0%\u63d0\u9ad8\u81f389%\uff0c\u4e14\u59cb\u7ec8\u4fdd\u6301\u8f83\u9ad8\u7684\u5bf9\u6620\u9009\u62e9\u6027\uff08&gt;94:6 e.r.\uff09\u3002 \u4e3a\u63a2\u7a76\u8be5\u7a81\u53d8\u4f53\u9176\u7684\u5408\u6210\u4ef7\u503c\uff0c\u4f5c\u8005\u5bf9\u8be5\u9176\u8fdb\u884c\u4e860.5 mmol\u5236\u5907\u7ea7\u53cd\u5e94\u7684\u5e95\u7269\u7814\u7a76\uff0c\u53d1\u73b0\u8be5\u9176\u6446\u8131\u4e86\u5bf9\u70c3\u94fe\u957f\u5ea6\u7684\u4f9d\u8d56\uff0c\u80fd\u591f\u50ac\u5316C6\u2013C20\u94fe\u957f\u7684\u8102\u80aa\u9178\uff08\u4ea7\u72694-13\uff09\uff0c\u540c\u65f6\u5177\u6709\u5f88\u597d\u7684\u5b98\u80fd\u56e2\u8010\u53d7\u6027\uff08\u4ea7\u726914-23\uff09\uff0c\u5c55\u73b0\u4e86\u8f83\u597d\u7684\u53cd\u5e94\u6d3b\u6027\u4ee5\u53ca\u9ad8\u5ea6\u7684\u533a\u57df\u548c\u5bf9\u6620\u9009\u62e9\u6027\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8be5\u53cd\u5e94\u4e5f\u53ef\u9002\u7528\u4e8e\u542b\u5404\u79cd\u82b3\u73af\uff08\u4ea7\u726924-31\uff09\u548c\u82b3\u6742\u73af\u7684\u8102\u80aa\u65cf\u7fa7\u9178\uff08\u4ea7\u726932-42\uff09\uff0c\u56e0\u6b64\uff0c\u5728\u836f\u7269\u5206\u5b50\u7684\u5408\u6210\u4e0e\u5f00\u53d1\u4e0a\u6709\u5f88\u597d\u7684\u5e94\u7528\u3002 \u8be5\u9176\u53cd\u5e94\u7684\u4e00\u4e9b\u4ea7\u7269\u6563\u53d1\u51fa\u9999\u8349\u3001\u6930\u6c41\u548c\u6843\u5b50\u7684\u9999\u5473\u800c\u53ef\u4f5c\u4e3a\u98df\u54c1\u53e3\u5473\u6dfb\u52a0\u5242\uff08\u4ea7\u72694\uff0c6\uff0c8\uff09\u3002\u8fd9\u4e00\u50ac\u5316\u53cd\u5e94\u4e5f\u5c06\u4e00\u4e9b\u5929\u7136\u4ea7\u7269\u7684\u5408\u6210\u76f4\u63a5\u7f29\u51cf\u52301\u6b65\uff08\u5929\u7136\u4ea7\u726910\uff0c15\uff09\uff0c\u5927\u5e45\u63d0\u5230\u4e86\u5408\u6210\u6548\u7387\u3002\u6b64\u5916\uff0c\u6240\u5408\u6210\u7684\u03b3-\u5185\u916f\u53ef\u4ee5\u642d\u914d\u591a\u6837\u7684\u540e\u7eed\u5316\u5b66\u8f6c\u5316\uff0c\u5b9e\u73b0\u5305\u62ec\u5929\u7136\u4ea7\u7269\u5728\u5185\u7684\u4e00\u7cfb\u5217\u5316\u5408\u7269\u7684\u5408\u6210\uff08\u4ea7\u726943-50\uff09\u3002 \u6700\u540e\uff0c\u5bf9\u6539\u9020\u540e\u7684\u9176\u4e0e\u68d5\u6988\u9178\u590d\u5408\u7269\u7684\u6676\u4f53\u7ed3\u6784\u7684\u89e3\u6790\u4ee5\u53ca\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u548c\u5bc6\u5ea6\u6cdb\u51fd\u8ba1\u7b97\u63ed\u793a\u4e86\u8be5\u9176\u03b3-\u5185\u916f\u5316\u53cd\u5e94\u7684\u9ad8\u533a\u57df\u548c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u673a\u7406\u3002\u8be5\u7814\u7a76\u5c55\u73b0\u4e86\u5b9a\u5411\u8fdb\u5316\u53ef\u4ee5\u8d4b\u4e88\u91ce\u751f\u9176\u81ea\u7136\u754c\u672a\u6709\u7684\u65b0\u529f\u80fd\uff0c\u4ece\u800c\u89e3\u51b3\u5316\u5b66\u5408\u6210\u4e0a\u5177\u6709\u6311\u6218\u6027\u7684\u5316\u5b66\u53cd\u5e94\u3002 (\u738b\u559c\u5e86\u6559\u6388\u4f9b\u7a3f) \u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d. &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;","protected":false},"author":26,"featured_media":47620,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2023\/11\/image001-9.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-co3","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/47619"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=47619"}],"version-history":[{"count":1,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/47619\/revisions"}],"predecessor-version":[{"id":47629,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/47619\/revisions\/47629"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/47620"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=47619"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=47619"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=47619"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}