{"id":48062,"date":"2023-12-18T08:12:00","date_gmt":"2023-12-18T00:12:00","guid":{"rendered":"\/\/www.gsbet888.com\/?p=48062"},"modified":"2023-12-18T08:12:00","modified_gmt":"2023-12-18T00:12:00","slug":"angew%ef%bc%9a%e9%98%bb%e8%bd%ac%e9%80%89%e6%8b%a9%e6%80%a7%e5%90%88%e6%88%90%e5%b9%b3%e9%9d%a2%e6%89%8b%e6%80%a7%e5%90%b2%e5%93%9a%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2023\/12\/angew%ef%bc%9a%e9%98%bb%e8%bd%ac%e9%80%89%e6%8b%a9%e6%80%a7%e5%90%88%e6%88%90%e5%b9%b3%e9%9d%a2%e6%89%8b%e6%80%a7%e5%90%b2%e5%93%9a%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6.html","title":{"rendered":"Angew\uff1a\u963b\u8f6c\u9009\u62e9\u6027\u5408\u6210\u5e73\u9762\u624b\u6027\u5432\u54da\u53cd\u5e94\u65b9\u6cd5\u5b66"},"content":{"rendered":"

\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n

\u5bfc\u8bfb\uff1a<\/h4>\n

\u8fd1\u65e5\uff0c\u6e05\u534e\u5927\u5b66\u7684\u6c6a\u8230\u8bfe\u9898\u7ec4\u5728Angew. Chem. Int. Ed.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684NHC\u50ac\u53163-\u7532\u9170\u57fa\u5432\u54da\/\u5421\u54af\u7684\u5927\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u4e0d\u540c\u94fe\u957f\u5ea6 (10-16\u5143)\u7684\u5432\u54da\/\u5421\u54af\u57fa\u5e73\u9762\u624b\u6027\u5927\u73af\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n

Atroposelective Synthesis of Planar-Chiral Indoles via Carbene Catalyzed Macrocyclization<\/p>\n

G. Yang, Y. He, T. Wang, Z. Li, J. Wang, Angew. Chem. Int. Ed<\/em>. 2023<\/strong>, ASAP. doi: 10.1002\/anie.202316739<\/a>.<\/u><\/p><\/blockquote>\n

\"\"<\/p>\n

\u6b63\u6587\uff1a<\/h4>\n

\u5432\u54da\u57fa\u5e73\u9762\u624b\u6027\u5927\u73af\u9aa8\u67b6\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u7c7b\u5929\u7136\u4ea7\u7269\u4ee5\u53ca\u751f\u7269\u6d3b\u6027\u5206\u5b50\u4e2d (Scheme 1a)\u3002\u5e76\u4e14\uff0c\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u5df2\u7ecf\u6210\u529f\u8bbe\u8ba1\u51fa\u591a\u79cd\u6784\u5efa\u5432\u54da\u57fa\u8f74\u624b\u6027\u5206\u5b50\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565 (Scheme 1b) [1]<\/sup>\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u963b\u8f6c\u9009\u62e9\u6027\u5408\u6210\u5432\u54da\u57fa\u5e73\u9762\u624b\u6027\u5927\u73af\u5206\u5b50\u7684\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u76ee\u524d\u5374\u8f83\u5c11\u6709\u76f8\u5173\u7684\u7814\u7a76\u62a5\u9053[2]<\/sup>\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u50ac\u5316\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u5e73\u9762\u624b\u6027\u5927\u73af\u5206\u5b50\u7684\u53cd\u5e94\u65b9\u6cd5\u5b66 (Scheme 1c) [3]<\/sup>\u4ee5\u53ca\u6709\u673a\u50ac\u5316\u5408\u6210\u963b\u8f6c\u5f02\u6784\u5206\u5b50\u53cd\u5e94\u65b9\u6cd5\u5b66[4]<\/sup>\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u6e05\u534e\u5927\u5b66\u7684\u6c6a\u8230\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684NHC\u50ac\u53163-\u7532\u9170\u57fa\u5432\u54da\/\u5421\u54af\u7684\u5927\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u4e0d\u540c\u94fe\u957f\u5ea6 (10-16\u5143)\u7684\u5432\u54da\/\u5421\u54af\u57fa\u5e73\u9762\u624b\u6027\u5927\u73af\u5206\u5b50\u7684\u6784\u5efa (Scheme 1d)\u3002<\/p>\n

\"\"<\/p>\n

\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u75281-(9-hydroxynonyl)-2-phenyl-1H<\/em>-indole-3-carbaldehyde 1a<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528C2<\/strong>\u4f5c\u4e3a\u9884\u50ac\u5316\u5242\uff0cK2<\/sub>CO3<\/sub>\u4f5c\u4e3a\u78b1\uff0cDQ\u4f5c\u4e3a\u6c27\u5316\u5242\uff0c\u5728THF\/Hexane (1:1)\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a50 o<\/sup>C\uff0c\u6700\u7ec8\u83b7\u5f9775%\u6536\u7387\u7684\u4ea7\u72692a <\/strong>(96% ee<\/em>)\u3002<\/p>\n

\"\" \u00a0\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217N<\/em>-\u53d6\u4ee3\u76843-\u7532\u9170\u57fa\u5432\u54da\u5e95\u7269 (Scheme 2)\u30012-\u53d6\u4ee3\u76843-\u7532\u9170\u57fa\u5432\u54da\u5e95\u7269 (Scheme 3)\u4ee5\u53ca\u82b3\u57fa\u53d6\u4ee3\u5432\u54da\/\u5421\u54af\u5e95\u7269 (Scheme 4)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n

\"\" \"\" \u00a0 \"\" \"\"<\/p>\n

\"\" \"\"<\/p>\n

\u540c\u65f6\uff0c\u8be5\u7b56\u7565\u8fd8\u53ef\u7528\u4e8e\u8f74-\u5e73\u9762\u5432\u54da\u5206\u5b50\u7684\u6784\u5efa (Scheme 5)\u3002<\/p>\n

\"\" \"\"<\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u5927\u73af\u4ea7\u7269\u7684\u70ed\u7a33\u5b9a\u6027\u4ee5\u53ca\u53cd\u5e94\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c\u8fdb\u884c\u4e86\u7814\u7a76\u00a0(Scheme 6)\u3002<\/p>\n

\"\"<\/p>\n

\u603b\u7ed3\uff1a<\/h4>\n

\u6e05\u534e\u5927\u5b66\u7684\u6c6a\u8230\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684NHC\u50ac\u53163-\u7532\u9170\u57fa\u5432\u54da\/\u5421\u54af\u7684\u5927\u73af\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u4e0d\u540c\u94fe\u957f\u5ea6 (10-16\u5143)\u7684\u5432\u54da\/\u5421\u54af\u57fa\u5e73\u9762\u624b\u6027\u5927\u73af\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u3001\u826f\u597d\u7684\u6536\u7387\u4ee5\u53ca\u4f18\u5f02\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n