{"id":48763,"date":"2024-02-07T08:00:22","date_gmt":"2024-02-07T00:00:22","guid":{"rendered":"\/\/www.gsbet888.com\/?p=48763"},"modified":"2024-02-05T23:52:46","modified_gmt":"2024-02-05T15:52:46","slug":"angew%ef%bc%9a%e6%9c%ab%e7%ab%af%e7%83%af%e5%9f%ba%e6%b0%ae%e6%9d%82%e8%8a%b3%e7%83%83%e5%8f%82%e4%b8%8e%e7%9a%84%e5%af%b9%e6%98%a0%e9%80%89%e6%8b%a9%e6%80%a7%e6%b0%a2%e8%86%a6%e5%8c%96%e5%8f%8d-2","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2024\/02\/angew%ef%bc%9a%e6%9c%ab%e7%ab%af%e7%83%af%e5%9f%ba%e6%b0%ae%e6%9d%82%e8%8a%b3%e7%83%83%e5%8f%82%e4%b8%8e%e7%9a%84%e5%af%b9%e6%98%a0%e9%80%89%e6%8b%a9%e6%80%a7%e6%b0%a2%e8%86%a6%e5%8c%96%e5%8f%8d-2.html","title":{"rendered":"Angew\uff1a\u672b\u7aef\u70ef\u57fa\u6c2e\u6742\u82b3\u70c3\u53c2\u4e0e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u81a6\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66"},"content":{"rendered":"<p>\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n<h4>\u5bfc\u8bfb\uff1a<\/h4>\n<p>\u8fd1\u65e5\uff0c\u8377\u5170Groningen\u5927\u5b66\u7684Syuzanna R. Harutyunyan\u8bfe\u9898\u7ec4\u5728<em>Angew. Chem. Int. Ed.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u9530\u50ac\u5316\u672b\u7aef\u70ef\u57fa\u6c2e\u6742\u82b3\u70c3 (terminal alkenyl aza-heteroarenes)\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u81a6\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u6c2e\u6742\u82b3\u57fa\u81a6 (chiral aza-heteroaromatic phosphines)\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n<blockquote><p>Enantioselective Hydrophosphination of Terminal Alkenyl aza-Heteroarenes<\/p>\n<p>E. Sinnema, T. F. Ramspoth, R. Bouma, L. Ge, S. R. Harutyunyan, <em>Angew. Chem. Int. Ed<\/em>. <strong>2023<\/strong>, ASAP. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.202316785\">10.1002\/anie.202316785<\/a><u>.<\/u><\/p><\/blockquote>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-48767 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image002-3.png\" alt=\"\" width=\"1351\" height=\"342\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image002-3.png 1351w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image002-3-300x76.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image002-3-680x172.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image002-3-768x194.png 768w\" sizes=\"(max-width: 1351px) 100vw, 1351px\" \/><\/p>\n<h4>\u6b63\u6587\uff1a<\/h4>\n<p>\u624b\u6027\u542b\u81a6\u9aa8\u67b6\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u7c7b\u751f\u7269\u6d3b\u6027\u836f\u7269\u5206\u5b50\u3001\u519c\u7528\u5316\u5b66\u54c1\u4ee5\u53ca\u4e0d\u5bf9\u79f0\u50ac\u5316\u9886\u57df\u4e2d\u3002\u5e76\u4e14\uff0c\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u5df2\u7ecf\u6210\u529f\u8bbe\u8ba1\u51fa\u591a\u79cd\u5229\u7528\u6c22\u81a6\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u6784\u5efa\u624b\u6027\u542b\u81a6\u5206\u5b50\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565<sup>[1]<\/sup>\u3002\u7136\u800c\uff0c\u6b64\u7c7b\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u5c40\u9650\u4e8eMichael\u53d7\u4f53\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u70ef\u57fa\u6c2e\u6742\u82b3\u70c3\u53d7\u4f53\u53c2\u4e0e\u4e0d\u5bf9\u79f0\u6c22\u81a6\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66(Scheme 1a\u4e0eScheme 1b) <sup>[2]-[3]<\/sup>\u4ee5\u53caMn(I)-(<em>R<\/em><sub>C<\/sub>, <em>S<\/em><sub>P<\/sub>)-Clarke\u50ac\u5316\u5242\u53c2\u4e0e\u4e8c\u82b3\u57fa\u81a6\u4e2dH-P\u952e\u7684\u6d3b\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[4]<\/sup>\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u8377\u5170Groningen\u5927\u5b66\u7684Syuzanna R. Harutyunyan\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u9530\u50ac\u5316\u672b\u7aef\u70ef\u57fa\u6c2e\u6742\u82b3\u70c3\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u81a6\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u6c2e\u6742\u82b3\u57fa\u81a6\u5206\u5b50\u7684\u6784\u5efa (Scheme 1c)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-48768 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image003-10.png\" alt=\"\" width=\"1131\" height=\"1314\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image003-10.png 1131w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image003-10-258x300.png 258w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image003-10-680x790.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image003-10-768x892.png 768w\" sizes=\"(max-width: 1131px) 100vw, 1131px\" \/><\/p>\n<p>\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528alkenyl quinoxaline <strong>1a<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528HPPh<sub>2<\/sub>\u4f5c\u4e3a\u81a6\u6e90\uff0c(<em>R<\/em><sub>C<\/sub>, <em>S<\/em><sub>P<\/sub>)-<strong>Clarke<\/strong>\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cBarton\u2019s base\u4f5c\u4e3a\u78b1\uff0c\u5728\u7532\u82ef\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a0<sup>o<\/sup>C\uff0c\u6700\u7ec8\u83b7\u5f9772%\u6536\u7387\u7684\u4ea7\u7269<strong>2a <\/strong>(84% <em>ee<\/em>)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-48769 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image004-3.png\" alt=\"\" width=\"1192\" height=\"1916\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image004-3.png 1192w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image004-3-187x300.png 187w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image004-3-637x1024.png 637w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image004-3-768x1234.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image004-3-956x1536.png 956w\" sizes=\"(max-width: 1192px) 100vw, 1192px\" \/><\/p>\n<p>\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217\u70ef\u57fa\u6c2e\u6742\u82b3\u70c3\u4e0e\u81a6\u8bd5\u5242\u5e95\u7269 (Scheme 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-48770 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image005-9.png\" alt=\"\" width=\"1192\" height=\"1788\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image005-9.png 1192w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image005-9-200x300.png 200w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image005-9-680x1020.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image005-9-768x1152.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image005-9-1024x1536.png 1024w\" sizes=\"(max-width: 1192px) 100vw, 1192px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-48774 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/48f83f09296fe5c1ecc5d30c8ed7a20f-1.jpg\" alt=\"\" width=\"1125\" height=\"1211\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/48f83f09296fe5c1ecc5d30c8ed7a20f-1.jpg 1125w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/48f83f09296fe5c1ecc5d30c8ed7a20f-1-279x300.jpg 279w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/48f83f09296fe5c1ecc5d30c8ed7a20f-1-680x732.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/48f83f09296fe5c1ecc5d30c8ed7a20f-1-768x827.jpg 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><\/p>\n<p>\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u6c22\u81a6\u5316\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 3)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-48771 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image007-9.png\" alt=\"\" width=\"1192\" height=\"900\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image007-9.png 1192w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image007-9-300x227.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image007-9-680x513.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image007-9-768x580.png 768w\" sizes=\"(max-width: 1192px) 100vw, 1192px\" \/><\/p>\n<p>\u57fa\u4e8e\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053<sup>[4]<\/sup>\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 4)\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-48772 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image008.png\" alt=\"\" width=\"1014\" height=\"956\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image008.png 1014w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image008-300x283.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image008-680x641.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/02\/image008-768x724.png 768w\" sizes=\"(max-width: 1014px) 100vw, 1014px\" \/><\/p>\n<p>\u603b\u7ed3\uff1a\u8377\u5170Groningen\u5927\u5b66\u7684Syuzanna R. Harutyunyan\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u9530\u50ac\u5316\u672b\u7aef\u70ef\u57fa\u6c2e\u6742\u82b3\u70c3\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u81a6\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u6c2e\u6742\u82b3\u57fa\u81a6\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ul>\n<li>[1] C. Wang, K. Huang, J. Ye, W. Duan, <em>J. Am. Chem. Soc. <\/em><strong>2021<\/strong>, <em>143<\/em>, 5685. doi:<a href=\"https:\/\/doi.org\/10.1021\/jacs.1c02772\">10.1021\/jacs.1c02772<\/a><\/li>\n<li>[2] Q. Yang, J. Zhou, J. Wang, <em>Chem. Sci. <\/em><strong>2023<\/strong>, <em>14<\/em>, 4413. doi:<a href=\"https:\/\/doi.org\/10.1039\/D2SC06950D\">10.1039\/D2SC06950D<\/a>.<\/li>\n<li>[3] S. Das, Q. Hu, A. kondoh, M. Terada, <em>Angew. Chem. Int. Ed. <\/em><strong>2021<\/strong>, <em>60<\/em>, 1417. doi:<a href=\"https:\/\/doi.org\/10.1002\/anie.202012492\">10.1002\/anie.202012492<\/a>.<\/li>\n<li>[4] L. Ge, S. R. Harutyunyan, <em>Chem. Sci. <\/em><strong>2022<\/strong>, <em>13<\/em>, 1307. doi:<a href=\"https:\/\/doi.org\/10.1039\/D1SC06694C\">10.1039\/D1SC06694C<\/a>.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u8377\u5170Groningen\u5927\u5b66\u7684Syuzanna R. Harutyunyan\u8bfe\u9898\u7ec4\u5728Angew. Chem. Int. Ed.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u9530\u50ac\u5316\u672b\u7aef\u70ef\u57fa\u6c2e\u6742\u82b3\u70c3 (terminal alkenyl aza-heteroarenes)\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u81a6\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u6c2e\u6742\u82b3\u57fa\u81a6 (chiral aza-heteroaromatic phosphines)\u5206\u5b50\u7684\u6784\u5efa\u3002 Enantioselective Hydrophosphination of Terminal Alkenyl aza-Heteroarenes E. Sinnema, T. F. Ramspoth, R. Bouma, L. Ge, S. R. Harutyunyan, Angew. Chem. Int. Ed. 2023, ASAP. doi: 10.1002\/anie.202316785. \u6b63\u6587\uff1a \u624b\u6027\u542b\u81a6\u9aa8\u67b6\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u7c7b\u751f\u7269\u6d3b\u6027\u836f\u7269\u5206\u5b50\u3001\u519c\u7528\u5316\u5b66\u54c1\u4ee5\u53ca\u4e0d\u5bf9\u79f0\u50ac\u5316\u9886\u57df\u4e2d\u3002\u5e76\u4e14\uff0c\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u5df2\u7ecf\u6210\u529f\u8bbe\u8ba1\u51fa\u591a\u79cd\u5229\u7528\u6c22\u81a6\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u6784\u5efa\u624b\u6027\u542b\u81a6\u5206\u5b50\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565[1]\u3002\u7136\u800c\uff0c\u6b64\u7c7b\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u5c40\u9650\u4e8eMichael\u53d7\u4f53\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u70ef\u57fa\u6c2e\u6742\u82b3\u70c3\u53d7\u4f53\u53c2\u4e0e\u4e0d\u5bf9\u79f0\u6c22\u81a6\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66(Scheme 1a\u4e0eScheme 1b) [2]-[3]\u4ee5\u53caMn(I)-(RC, SP)-Clarke\u50ac\u5316\u5242\u53c2\u4e0e\u4e8c\u82b3\u57fa\u81a6\u4e2dH-P\u952e\u7684\u6d3b\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[4]\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u8377\u5170Groningen\u5927\u5b66\u7684Syuzanna R. Harutyunyan\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u9530\u50ac\u5316\u672b\u7aef\u70ef\u57fa\u6c2e\u6742\u82b3\u70c3\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u81a6\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u6c2e\u6742\u82b3\u57fa\u81a6\u5206\u5b50\u7684\u6784\u5efa (Scheme 1c)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528alkenyl quinoxaline 1a\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528HPPh2\u4f5c\u4e3a\u81a6\u6e90\uff0c(RC, SP)-Clarke\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cBarton\u2019s base\u4f5c\u4e3a\u78b1\uff0c\u5728\u7532\u82ef\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a0oC\uff0c\u6700\u7ec8\u83b7\u5f9772%\u6536\u7387\u7684\u4ea7\u72692a (84% ee)\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217\u70ef\u57fa\u6c2e\u6742\u82b3\u70c3\u4e0e\u81a6\u8bd5\u5242\u5e95\u7269 (Scheme 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u6c22\u81a6\u5316\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 3)\u3002 \u57fa\u4e8e\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053[4]\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 4)\u3002 \u603b\u7ed3\uff1a\u8377\u5170Groningen\u5927\u5b66\u7684Syuzanna R. Harutyunyan\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u9530\u50ac\u5316\u672b\u7aef\u70ef\u57fa\u6c2e\u6742\u82b3\u70c3\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u81a6\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u78b3\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u6c2e\u6742\u82b3\u57fa\u81a6\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] C. Wang, K. Huang, J. Ye, W. Duan, J. Am. Chem. Soc. 2021, 143, 5685. doi:10.1021\/jacs.1c02772 [2] Q. Yang, J. Zhou, J. Wang, Chem. Sci. 2023, 14, 4413. doi:10.1039\/D2SC06950D. [3] S. Das, Q. Hu, A. kondoh, M. 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