{"id":49284,"date":"2024-03-22T08:00:37","date_gmt":"2024-03-22T00:00:37","guid":{"rendered":"\/\/www.gsbet888.com\/?p=49284"},"modified":"2024-03-22T08:48:29","modified_gmt":"2024-03-22T00:48:29","slug":"jacs%ef%bc%9a%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9-archangiumide%e7%9a%84%e5%85%a8%e5%90%88%e6%88%90","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2024\/03\/jacs%ef%bc%9a%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9-archangiumide%e7%9a%84%e5%85%a8%e5%90%88%e6%88%90.html","title":{"rendered":"JACS\uff1a\u5929\u7136\u4ea7\u7269(+)-Archangiumide\u7684\u5168\u5408\u6210"},"content":{"rendered":"<p style=\"text-align: justify;\">\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/p>\n<h4 style=\"text-align: justify;\">\u5bfc\u8bfb\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u8fd1\u65e5\uff0c\u5fb7\u56fd\u9a6c\u514b\u65af\u666e\u6717\u514b\u7164\u70ad\u7814\u7a76\u6240\u7684Alois F\u00fcrstner\u6559\u6388\u56e2\u961f\u5728<em>J. Am. Chem. Soc.<\/em>\u4e0a\uff0c\u4ee5 \u201cTotal Synthesis of the Allenic Macrolide (+)-Archangiumide\u201d \u4e3a\u9898\uff0c\u62a5\u9053\u4e86\u5929\u7136\u4ea7\u7269(+)-Archangiumide\u7684\u5168\u5408\u6210\u3002\u5176\u4e2d\u5173\u952e\u6b65\u9aa4\u6d89\u53ca\u91d1\u50ac\u5316\u7094\u4e19\u57fa\u82c4\u57fa\u919a\u91cd\u6392\u53cd\u5e94(Gold catalyzed rearrangement of propargyl benzyl ethers pioneered)\u4ee5\u53ca\u95ed\u73af\u7094\u70c3\u590d\u5206\u89e3(ring closing alkyne metathesis (RCAM))<\/p>\n<blockquote><p>\u201cTotal Synthesis of the Allenic Macrolide (+)-Archangiumide<\/p>\n<p>Jack L. Sutro and Alois F\u00fcrstner*<\/p>\n<p><em>J. Am. Chem. Soc.<\/em>, <strong>2024, <\/strong><em>ASAP<\/em>. doi<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.3c13304\">: 10.1021\/jacs.3c13304\u201d<\/a><\/p><\/blockquote>\n<h4 style=\"text-align: justify;\">\u6b63\u6587<\/h4>\n<p style=\"text-align: justify;\">\u542b\u6709\u8054\u70ef\u7ed3\u6784\u7684\u5929\u7136\u4ea7\u7269\u7279\u522b\u7a00\u5c11<sup>[1]<\/sup>\uff0c\u5c24\u5176\u662f\u8054\u70ef\u4f5c\u4e3a\u5927\u73af\u5929\u7136\u4ea7\u7269\u7ec4\u6210\u90e8\u5206\u7684\u4f8b\u5b50\u66f4\u52a0\u7a00\u5c11\u3002\u5927\u73af\u5185\u916f(+)-Archangiumide(<strong>1<\/strong>)\u662f\u7531\u5c71\u4e1c\u5927\u5b66\u5434\u957f\u751f\u6559\u6388\u53ca\u5176\u540c\u4e8b\u4ece\u5c71\u4e1c\u7701\u7684\u7c98\u6746\u83ccArchangium violaceum SDU8\u4e2d\u5206\u79bb\u83b7\u5f97<sup>[2]<\/sup>\uff0c\u5e76\u901a\u8fc7\u57fa\u56e0\u7ec4\u6316\u6398\u548c\u57fa\u4e8e\u6838\u78c1\u5171\u632f\u7684\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\u76f8\u7ed3\u5408\uff0c\u5c06\u5176\u4f5c\u4e3a\u6b21\u7ea7\u4ee3\u8c22\u7269\u7684\u6f5c\u5728\u6765\u6e90\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8be5\u5c0f\u7ec4\u5bf9\u5176\u6297\u83cc\u3001\u6297\u771f\u83cc\u3001\u6297\u764c\u3001\u6297\u6c27\u5316\u548c\u6297\u708e\u6d3b\u6027\u8fdb\u884c\u4e86\u6df1\u5165\u7684\u7814\u7a76\uff0c\u4f46\u5e76\u6ca1\u6709\u53d1\u73b0\u5176\u663e\u8457\u7684\u6548\u679c\u3002\u867d\u7136\u5176\u5728\u751f\u7269\u6d3b\u6027\u65b9\u9762\u5e76\u4e0d\u786e\u5b9a\uff0c\u4f46(+)-Archangiumide(<strong>1<\/strong>)\u4f5c\u4e3a\u4e00\u7c7b\u65b0\u7684\u5fae\u751f\u7269\u6b21\u7ea7\u4ee3\u8c22\u7269\u7684\u539f\u578b\u503c\u5f97\u5173\u6ce8\u3002\u8fd1\u65e5\uff0c\u5fb7\u56fd\u9a6c\u514b\u65af\u666e\u6717\u514b\u7164\u70ad\u7814\u7a76\u6240\u7684Alois F\u00fcrstner\u6559\u6388\u56e2\u961f\u62a5\u9053\u4e86\u5929\u7136\u4ea7\u7269(+)-Archangiumide\u7684\u5168\u5408\u6210\u3002\u5e76\u53d1\u8868\u4e8e<em>J. Am. Chem. Soc.<\/em>\u4e0a\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49286 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/03\/image002-2.gif\" alt=\"\" width=\"1108\" height=\"1287\" \/><\/p>\n<p style=\"text-align: justify;\">(+)-Archangiumide(<strong>1<\/strong>)\u662f\u4e00\u79cd\u8054\u70ef\u7ed3\u6784\u768417\u5143\u5927\u73af\u5185\u916f\uff0c\u5e76\u4e14\u7ed3\u6784\u4e2d\u5305\u542b\u4e24\u4e2a\u989d\u5916\u7684E\u6784\u578b\u70ef\u70c3\u4ee5\u53ca\u73af\u72b6\u56db\u6c22\u544b\u5583\u73af\u7b49\u7ed3\u6784(Scheme 1A)\u3002\u57fa\u4e8e\u91d1\u50ac\u5316\u7094\u4e19\u57fa\u82c4\u57fa\u919a\u91cd\u6392\u53cd\u5e94<sup>[3]<\/sup> (Scheme 1B)\u3001\u91d1\u50ac\u5316\u8054\u70ef-\u70ef\u70c3\u901a\u8fc7\u620a\u4e8c\u70ef\u57fa\u9633\u79bb\u5b50\u4e2d\u95f4\u4f53\u53d1\u751f\u7535\u73af\u5316<sup>[4] <\/sup>(Scheme 1C)\u4ee5\u53ca(+)-Archangiumide(<strong>1<\/strong>)\u7684\u9aa8\u67b6\uff0c\u4f5c\u8005\u5bf9\u5176\u8fdb\u884c\u4e86\u76f8\u5173\u7684\u9006\u5408\u6210\u5206\u6790(Scheme 1A)\uff0c\u5373\u780c\u5757<strong>C-D<\/strong>\u83b7\u5f97\u4e2d\u95f4\u4f53<strong>B<\/strong><strong>\uff0c<\/strong><strong>B<\/strong>\u901a\u8fc7\u95ed\u73af\u590d\u5206\u89e3\u83b7\u5f97\u4e2d\u95f4\u4f53<strong>A<\/strong>\u3002\u6700\u540e<strong>A<\/strong>\u7ecf\u91d1\u50ac\u5316\u7094\u4e19\u57fa\u70f7\u57fa\u919a\u91cd\u6392\u53cd\u5e94\u5b8c\u6210\u5929\u7136\u4ea7\u7269(+)-Archangiumide(<strong>1<\/strong>)\u7684\u5168\u5408\u6210\u3002<\/p>\n<p style=\"text-align: justify;\">\u9996\u5148\uff0c\u4f5c\u8005\u5bf9\u780c\u5757<strong>6<\/strong>\uff0c<strong>11<\/strong>\u548c<strong>18<\/strong>\u8fdb\u884c\u4e86\u76f8\u5173\u5408\u6210\uff0c\u5982Scheme 2\u6240\u793a\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49287 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/03\/image003-1.gif\" alt=\"\" width=\"789\" height=\"1565\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49288 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/03\/image004-1.gif\" alt=\"\" width=\"1020\" height=\"701\" \/><\/p>\n<p style=\"text-align: justify;\">\u5176\u6b21\uff0c\u4f5c\u8005\u5bf9(+)-Archangiumide(<strong>1<\/strong>)\u5b8c\u6210\u4e86\u5168\u5408\u6210\u7684\u7814\u7a76\uff0c\u5982Scheme 3\u6240\u793a\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49289 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/03\/image005-1.gif\" alt=\"\" width=\"1107\" height=\"640\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49290 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/03\/image006-2.gif\" alt=\"\" width=\"1024\" height=\"272\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49291 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/03\/image007-1.gif\" alt=\"\" width=\"1108\" height=\"450\" \/><\/p>\n<p style=\"text-align: justify;\">\u6700\u540e\uff0c\u4f5c\u8005\u901a\u8fc7\u63a7\u5236\u5b9e\u9a8c\u5bf911-<em>epi<\/em>&#8211;<strong>20<\/strong>\u548c<strong>20<\/strong>\u5747\u53ef\u7ecf\u5386\u76f8\u540c\u5f97\u6b65\u9aa4\u5b8c\u6210(+)-Archangiumide(<strong>1<\/strong>)\u5f97\u5168\u5408\u6210\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5373\u4ee5\u624b\u6027\u5316\u5408\u7269<strong>27<\/strong>\u4e3a\u539f\u6599\uff0c\u6240\u5f97\u8054\u70ef28\u662f\u6d88\u65cb\u4f53\uff0c\u8fdb\u800c\u8868\u660e\u91d1\u50ac\u5316\u53cd\u5e94\u672c\u8eab\u662f\u7acb\u4f53\u6d88\u65cb\u8fc7\u7a0b\uff0c\u5e76\u4e14\u4e0d\u4f1a\u5b9e\u73b0\u624b\u6027\u7684\u4f20\u9012(\u4ece\u7094\u4e19\u57fa\u82c4\u57fa\u919a\u4e2d\u5fc3\u4f20\u9012\u5230\u6240\u5f97\u8054\u70ef\u7684\u624b\u6027\u8f74)<sup>[5]<\/sup>\u3002\u7279\u522b\u7684\u662f\uff0cArchangiumide (1) \u662f\u53d7\u70ed\u529b\u5b66\u63a7\u5236\u6765\u83b7\u5f97\u5355\u4e00\u975e\u5bf9\u6620\u5f02\u6784\u4f53\uff0c\u5176\u4e0e<strong>23<\/strong> \u621611-<em>epi<\/em>&#8211;<strong>23<\/strong> \u4f5c\u4e3a\u5e95\u7269\u65e0\u5173\uff0c\u5e76\u4e14\u51b3\u5b9a\u7acb\u4f53\u5316\u5b66\u53d7\u9aa8\u67b6\u4e2d\u516d\u4e2a\u7acb\u6784\u4e2d\u5fc3\u548c\u4e24\u4e2a<em>E<\/em>-\u70ef\u70c3\u6240\u63a7\u5236\u3002<\/p>\n<p style=\"text-align: justify;\">\u603b\u7ed3\uff0c Alois F\u00fcrstner\u6559\u6388\u56e2\u961f\u62a5\u9053\u4e86\u5929\u7136\u4ea7\u7269(+)-Archangiumide\u7684\u5168\u5408\u6210\u3002\u5176\u4e2d\u5173\u952e\u6b65\u9aa4\u6d89\u53ca\u91d1\u50ac\u5316\u7094\u4e19\u57fa\u82c4\u57fa\u919a\u91cd\u6392\u53cd\u5e94(Gold catalyzed rearrangement of propargyl benzyl ethers pioneered)\u4ee5\u53ca\u95ed\u73af\u590d\u5206\u89e3(ring closing alkyne metathesis (RCAM))\u3002<\/p>\n<h4 style=\"text-align: justify;\">\u53c2\u8003\u6587\u732e:<\/h4>\n<ul style=\"text-align: justify;\">\n<li>[1]\u00a0 A. Hoffmann-R\u00f6der, N. Krause, <em>Angew. Chem., Int. Ed. <\/em>2004, <em>43<\/em>, 1196. doi:<a href=\"https:\/\/doi.org\/10.1002\/anie.200300628\"> 10.1002\/anie.200300628<\/a>.<\/li>\n<li>[2]\u00a0 J.-Q. Hu, J.-J. Wang, Y.-L. Li, L. Zhuo, A. Zhang, H.-Y. Sui, X.-J. Li, T. Shen, Y. Yin, Z.-H. Wu, W. Hu, Y.-Z. Li, C. Wu, <em>Org. Lett. <\/em><strong>2021<\/strong>, <em>23<\/em>, 2114. doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.1c00265\">10.1021\/acs.orglett.1c00265.<\/a><\/li>\n<li>[3]\u00a0 B. Bolte, Y. Odabachian, F. Gagosz, <em>J. Am. Chem. Soc. <\/em><strong>2010<\/strong>, <em>132<\/em>, 7294. doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja1020469\">10.1021\/ja1020469.<\/a><\/li>\n<li>[4]\u00a0 J. H. Lee, F. D. Toste, <em>Angew. Chem., Int. Ed. <\/em><strong>2007<\/strong>, <em>46<\/em>, 912. doi:<a href=\"https:\/\/doi.org\/10.1002\/anie.200604006\">10.1002\/anie.200604006<\/a>.<\/li>\n<li>[5]\u00a0 A. F\u00fcrstner, <em>Acc. Chem. Res. <\/em><strong>2021<\/strong>, <em>54<\/em>, 861. doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.accounts.0c00759\">10.1021\/acs.accounts.0c00759.<\/a><\/li>\n<\/ul>\n<p style=\"text-align: justify;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u5fb7\u56fd\u9a6c\u514b\u65af\u666e\u6717\u514b\u7164\u70ad\u7814\u7a76\u6240\u7684Alois F\u00fcrstner\u6559\u6388\u56e2\u961f\u5728J. Am. Chem. Soc.\u4e0a\uff0c\u4ee5 \u201cTotal Synthesis of the Allenic Macrolide (+)-Archangiumide\u201d \u4e3a\u9898\uff0c\u62a5\u9053\u4e86\u5929\u7136\u4ea7\u7269(+)-Archangiumide\u7684\u5168\u5408\u6210\u3002\u5176\u4e2d\u5173\u952e\u6b65\u9aa4\u6d89\u53ca\u91d1\u50ac\u5316\u7094\u4e19\u57fa\u82c4\u57fa\u919a\u91cd\u6392\u53cd\u5e94(Gold catalyzed rearrangement of propargyl benzyl ethers pioneered)\u4ee5\u53ca\u95ed\u73af\u7094\u70c3\u590d\u5206\u89e3(ring closing alkyne metathesis (RCAM)) \u201cTotal Synthesis of the Allenic Macrolide (+)-Archangiumide Jack L. Sutro and Alois F\u00fcrstner* J. Am. Chem. Soc., 2024, ASAP. doi: 10.1021\/jacs.3c13304\u201d \u6b63\u6587 \u542b\u6709\u8054\u70ef\u7ed3\u6784\u7684\u5929\u7136\u4ea7\u7269\u7279\u522b\u7a00\u5c11[1]\uff0c\u5c24\u5176\u662f\u8054\u70ef\u4f5c\u4e3a\u5927\u73af\u5929\u7136\u4ea7\u7269\u7ec4\u6210\u90e8\u5206\u7684\u4f8b\u5b50\u66f4\u52a0\u7a00\u5c11\u3002\u5927\u73af\u5185\u916f(+)-Archangiumide(1)\u662f\u7531\u5c71\u4e1c\u5927\u5b66\u5434\u957f\u751f\u6559\u6388\u53ca\u5176\u540c\u4e8b\u4ece\u5c71\u4e1c\u7701\u7684\u7c98\u6746\u83ccArchangium violaceum SDU8\u4e2d\u5206\u79bb\u83b7\u5f97[2]\uff0c\u5e76\u901a\u8fc7\u57fa\u56e0\u7ec4\u6316\u6398\u548c\u57fa\u4e8e\u6838\u78c1\u5171\u632f\u7684\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\u76f8\u7ed3\u5408\uff0c\u5c06\u5176\u4f5c\u4e3a\u6b21\u7ea7\u4ee3\u8c22\u7269\u7684\u6f5c\u5728\u6765\u6e90\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8be5\u5c0f\u7ec4\u5bf9\u5176\u6297\u83cc\u3001\u6297\u771f\u83cc\u3001\u6297\u764c\u3001\u6297\u6c27\u5316\u548c\u6297\u708e\u6d3b\u6027\u8fdb\u884c\u4e86\u6df1\u5165\u7684\u7814\u7a76\uff0c\u4f46\u5e76\u6ca1\u6709\u53d1\u73b0\u5176\u663e\u8457\u7684\u6548\u679c\u3002\u867d\u7136\u5176\u5728\u751f\u7269\u6d3b\u6027\u65b9\u9762\u5e76\u4e0d\u786e\u5b9a\uff0c\u4f46(+)-Archangiumide(1)\u4f5c\u4e3a\u4e00\u7c7b\u65b0\u7684\u5fae\u751f\u7269\u6b21\u7ea7\u4ee3\u8c22\u7269\u7684\u539f\u578b\u503c\u5f97\u5173\u6ce8\u3002\u8fd1\u65e5\uff0c\u5fb7\u56fd\u9a6c\u514b\u65af\u666e\u6717\u514b\u7164\u70ad\u7814\u7a76\u6240\u7684Alois F\u00fcrstner\u6559\u6388\u56e2\u961f\u62a5\u9053\u4e86\u5929\u7136\u4ea7\u7269(+)-Archangiumide\u7684\u5168\u5408\u6210\u3002\u5e76\u53d1\u8868\u4e8eJ. Am. Chem. Soc.\u4e0a\u3002 (+)-Archangiumide(1)\u662f\u4e00\u79cd\u8054\u70ef\u7ed3\u6784\u768417\u5143\u5927\u73af\u5185\u916f\uff0c\u5e76\u4e14\u7ed3\u6784\u4e2d\u5305\u542b\u4e24\u4e2a\u989d\u5916\u7684E\u6784\u578b\u70ef\u70c3\u4ee5\u53ca\u73af\u72b6\u56db\u6c22\u544b\u5583\u73af\u7b49\u7ed3\u6784(Scheme 1A)\u3002\u57fa\u4e8e\u91d1\u50ac\u5316\u7094\u4e19\u57fa\u82c4\u57fa\u919a\u91cd\u6392\u53cd\u5e94[3] (Scheme 1B)\u3001\u91d1\u50ac\u5316\u8054\u70ef-\u70ef\u70c3\u901a\u8fc7\u620a\u4e8c\u70ef\u57fa\u9633\u79bb\u5b50\u4e2d\u95f4\u4f53\u53d1\u751f\u7535\u73af\u5316[4] (Scheme 1C)\u4ee5\u53ca(+)-Archangiumide(1)\u7684\u9aa8\u67b6\uff0c\u4f5c\u8005\u5bf9\u5176\u8fdb\u884c\u4e86\u76f8\u5173\u7684\u9006\u5408\u6210\u5206\u6790(Scheme 1A)\uff0c\u5373\u780c\u5757C-D\u83b7\u5f97\u4e2d\u95f4\u4f53B\uff0cB\u901a\u8fc7\u95ed\u73af\u590d\u5206\u89e3\u83b7\u5f97\u4e2d\u95f4\u4f53A\u3002\u6700\u540eA\u7ecf\u91d1\u50ac\u5316\u7094\u4e19\u57fa\u70f7\u57fa\u919a\u91cd\u6392\u53cd\u5e94\u5b8c\u6210\u5929\u7136\u4ea7\u7269(+)-Archangiumide(1)\u7684\u5168\u5408\u6210\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u5bf9\u780c\u57576\uff0c11\u548c18\u8fdb\u884c\u4e86\u76f8\u5173\u5408\u6210\uff0c\u5982Scheme 2\u6240\u793a\u3002 \u5176\u6b21\uff0c\u4f5c\u8005\u5bf9(+)-Archangiumide(1)\u5b8c\u6210\u4e86\u5168\u5408\u6210\u7684\u7814\u7a76\uff0c\u5982Scheme 3\u6240\u793a\u3002 \u6700\u540e\uff0c\u4f5c\u8005\u901a\u8fc7\u63a7\u5236\u5b9e\u9a8c\u5bf911-epi&#8211;20\u548c20\u5747\u53ef\u7ecf\u5386\u76f8\u540c\u5f97\u6b65\u9aa4\u5b8c\u6210(+)-Archangiumide(1)\u5f97\u5168\u5408\u6210\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5373\u4ee5\u624b\u6027\u5316\u5408\u726927\u4e3a\u539f\u6599\uff0c\u6240\u5f97\u8054\u70ef28\u662f\u6d88\u65cb\u4f53\uff0c\u8fdb\u800c\u8868\u660e\u91d1\u50ac\u5316\u53cd\u5e94\u672c\u8eab\u662f\u7acb\u4f53\u6d88\u65cb\u8fc7\u7a0b\uff0c\u5e76\u4e14\u4e0d\u4f1a\u5b9e\u73b0\u624b\u6027\u7684\u4f20\u9012(\u4ece\u7094\u4e19\u57fa\u82c4\u57fa\u919a\u4e2d\u5fc3\u4f20\u9012\u5230\u6240\u5f97\u8054\u70ef\u7684\u624b\u6027\u8f74)[5]\u3002\u7279\u522b\u7684\u662f\uff0cArchangiumide (1) \u662f\u53d7\u70ed\u529b\u5b66\u63a7\u5236\u6765\u83b7\u5f97\u5355\u4e00\u975e\u5bf9\u6620\u5f02\u6784\u4f53\uff0c\u5176\u4e0e23 \u621611-epi&#8211;23 \u4f5c\u4e3a\u5e95\u7269\u65e0\u5173\uff0c\u5e76\u4e14\u51b3\u5b9a\u7acb\u4f53\u5316\u5b66\u53d7\u9aa8\u67b6\u4e2d\u516d\u4e2a\u7acb\u6784\u4e2d\u5fc3\u548c\u4e24\u4e2aE-\u70ef\u70c3\u6240\u63a7\u5236\u3002 \u603b\u7ed3\uff0c Alois F\u00fcrstner\u6559\u6388\u56e2\u961f\u62a5\u9053\u4e86\u5929\u7136\u4ea7\u7269(+)-Archangiumide\u7684\u5168\u5408\u6210\u3002\u5176\u4e2d\u5173\u952e\u6b65\u9aa4\u6d89\u53ca\u91d1\u50ac\u5316\u7094\u4e19\u57fa\u82c4\u57fa\u919a\u91cd\u6392\u53cd\u5e94(Gold catalyzed rearrangement of propargyl benzyl ethers pioneered)\u4ee5\u53ca\u95ed\u73af\u590d\u5206\u89e3(ring closing alkyne metathesis (RCAM))\u3002 \u53c2\u8003\u6587\u732e: [1]\u00a0 A. Hoffmann-R\u00f6der, N. Krause, Angew. Chem., Int. Ed. 2004, 43, 1196. doi: 10.1002\/anie.200300628. [2]\u00a0 J.-Q. Hu, J.-J. Wang, Y.-L. Li, L. Zhuo, A. 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