{"id":49485,"date":"2024-04-15T08:00:43","date_gmt":"2024-04-15T00:00:43","guid":{"rendered":"\/\/www.gsbet888.com\/?p=49485"},"modified":"2024-04-14T22:55:11","modified_gmt":"2024-04-14T14:55:11","slug":"green-chem-%ef%bc%9a%e7%94%b5%e5%8c%96%e5%ad%a6%e4%bf%83%e8%bf%9b%e5%92%aa%e5%94%91%e5%b9%b6%e5%90%a1%e5%95%b6%e4%b8%8e%e4%ba%8c%e7%94%b2%e5%9f%ba%e4%ba%9a%e7%a0%9c%e7%9a%84c3-%e7%94%b2%e7%a1%ab","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2024\/04\/green-chem-%ef%bc%9a%e7%94%b5%e5%8c%96%e5%ad%a6%e4%bf%83%e8%bf%9b%e5%92%aa%e5%94%91%e5%b9%b6%e5%90%a1%e5%95%b6%e4%b8%8e%e4%ba%8c%e7%94%b2%e5%9f%ba%e4%ba%9a%e7%a0%9c%e7%9a%84c3-%e7%94%b2%e7%a1%ab.html","title":{"rendered":"Green Chem.\uff1a\u7535\u5316\u5b66\u4fc3\u8fdb\u54aa\u5511\u5e76\u5421\u5576\u4e0e\u4e8c\u7532\u57fa\u4e9a\u781c\u7684C3-\u7532\u786b\u57fa\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66"},"content":{"rendered":"<p style=\"text-align: justify;\">\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n<h4 style=\"text-align: justify;\">\u5bfc\u8bfb\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u8fd1\u65e5\uff0c\u5357\u4eac\u5e08\u8303\u5927\u5b66\u7684\u5b59\u57f9\u57f9\u7b49\u4eba\u5728<em>Green Chem.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u7535\u5316\u5b66\u533a\u57df\u9009\u62e9\u6027\u54aa\u5511\u5e76\u5421\u5576\u884d\u751f\u7269 (imidazopyridines)\u4e0e\u4e8c\u7532\u57fa\u4e9a\u781c\u7684C3-\u7532\u786b\u57fa\u5316 (C3-methylthiolation)\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709C3-\u7532\u786b\u57fa\u5316\u53d6\u4ee3\u7684\u54aa\u5511\u5e76\u5421\u5576\u5206\u5b50\u7684\u6784\u5efa\u3002\u5176\u4e2d\uff0c\u4e8c\u7532\u57fa\u4e9a\u781c\u4f5c\u4e3a\u6eb6\u5242\u4e0e\u7532\u786b\u57fa\u5316\u8bd5\u5242\uff0cKI\u4f5c\u4e3a\u6c22\u539f\u5b50\u8f6c\u79fb\u8bd5\u5242\u4e0e\u652f\u6301\u7535\u89e3\u8d28\u3002<\/p>\n<blockquote><p>Electrochemical C3-methylthiolation of imidazopyridines with dimethyl sulfoxide<\/p>\n<p>Z. Feng, Y. Fan, C. Qiang, P. Liu, P. Sun, <em>Green Chem.<\/em> <strong>2024<\/strong>, ASAP. doi: <a href=\"https:\/\/doi.org\/10.1039\/D4GC00314D\">10.1039\/D4GC00314D<\/a><u>.<\/u><\/p><\/blockquote>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49487 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image002-5.jpg\" alt=\"\" width=\"554\" height=\"152\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image002-5.jpg 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image002-5-300x82.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image002-5-550x152.jpg 550w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<h4 style=\"text-align: justify;\">\u6b63\u6587\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u7532\u786b\u57fa\u5355\u5143\u5728\u751f\u7269\u5316\u5b66\u3001\u8367\u5149\u63a2\u9488\u4ee5\u53ca\u836f\u7269\u53d1\u73b0\u7b49\u9886\u57df\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u8fd1\u4e9b\u5e74\u6765\uff0c\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u5229\u7528\u4e8c\u7532\u57fa\u4e9a\u781c\u4f5c\u4e3a\u7532\u786b\u57fa\u5316\u8bd5\u5242\u5df2\u7ecf\u6210\u529f\u8ba1\u51fa\u591a\u79cd\u6742\u73af\u5316\u5408\u7269\u7684\u7532\u786b\u57fa\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[1]<\/sup> (Scheme 1a)\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u7535\u5316\u5b66\u4fc3\u8fdb\u54aa\u5511\u5e76\u5421\u5576\u7684C3-\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[2]-[3]<\/sup>(Schemes 1b-1c)\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u5357\u4eac\u5e08\u8303\u5927\u5b66\u7684\u5b59\u57f9\u57f9\u7b49\u4eba\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u7535\u5316\u5b66\u533a\u57df\u9009\u62e9\u6027\u54aa\u5511\u5e76\u5421\u5576\u884d\u751f\u7269\u4e0e\u4e8c\u7532\u57fa\u4e9a\u781c\u7684C3-\u7532\u786b\u57fa\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709C3-\u7532\u786b\u57fa\u5316\u53d6\u4ee3\u7684\u54aa\u5511\u5e76\u5421\u5576\u5206\u5b50\u7684\u6784\u5efa (Scheme 1d)\u3002<\/p>\n<p style=\"text-align: justify;\">\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49488 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image003-6.jpg\" alt=\"\" width=\"554\" height=\"474\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image003-6.jpg 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image003-6-300x257.jpg 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<p style=\"text-align: justify;\">\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u75282-phenylimidazo[1,2-<em>a<\/em>]pyridine (<strong>1a<\/strong>) \u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\uff0c\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528\u7532\u786b\u57fa\u5316\u8bd5\u5242\u5728\u4e8c\u7532\u57fa\u4e9a\u781c\u6eb6\u5242\u4e2d\uff0cKI\u4f5c\u4e3a\u6c22\u539f\u5b50\u8f6c\u79fb\u8bd5\u5242\u4e0e\u652f\u6301\u7535\u89e3\u8d28\uff0cGF(+)\/Pt(\u2212)\u4f5c\u4e3a\u7535\u6781\uff0c\u7535\u6d41\u4e3a15 mA\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a40 <sup>o<\/sup>C\uff0c\u5728\u65e0\u9694\u819c\u7535\u89e3\u69fd\u4e2d\u8fdb\u884c\u53cd\u5e94\uff0c\u6700\u7ec8\u83b7\u5f9786%\u6536\u7387\u7684\u4ea7\u7269<strong>2a<\/strong>\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49489 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image004-4.jpg\" alt=\"\" width=\"554\" height=\"613\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image004-4.jpg 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image004-4-271x300.jpg 271w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u54aa\u5511\u5e76\u5421\u5576\u884d\u751f\u7269\u5e95\u7269 (Scheme 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49490 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image005-4.jpg\" alt=\"\" width=\"554\" height=\"613\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image005-4.jpg 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image005-4-271x300.jpg 271w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49491 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image006-2.png\" alt=\"\" width=\"550\" height=\"331\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image006-2.png 550w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image006-2-300x181.png 300w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><\/p>\n<p style=\"text-align: justify;\">\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u7532\u786b\u57fa\u5316\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 3)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49492 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image007-4.jpg\" alt=\"\" width=\"554\" height=\"285\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image007-4.jpg 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image007-4-300x154.jpg 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<p style=\"text-align: justify;\">\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u7532\u786b\u57fa\u5316\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76 \u00a0(Scheme 4\u4e0eFig. 1)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49493 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image008-1.jpg\" alt=\"\" width=\"554\" height=\"439\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image008-1.jpg 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image008-1-300x238.jpg 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49494 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image009.png\" alt=\"\" width=\"521\" height=\"213\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image009.png 521w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image009-300x123.png 300w\" sizes=\"(max-width: 521px) 100vw, 521px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49495 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image010-2.jpg\" alt=\"\" width=\"554\" height=\"412\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image010-2.jpg 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image010-2-300x223.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image010-2-265x197.jpg 265w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49496 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image011.png\" alt=\"\" width=\"554\" height=\"195\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image011.png 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image011-300x106.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image011-550x195.png 550w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<p style=\"text-align: justify;\">\u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053<sup>[3]<\/sup>\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 5)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49497 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image012-2.jpg\" alt=\"\" width=\"554\" height=\"606\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image012-2.jpg 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/04\/image012-2-274x300.jpg 274w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<p style=\"text-align: justify;\">\u603b\u7ed3\uff1a\u5357\u4eac\u5e08\u8303\u5927\u5b66\u7684\u5b59\u57f9\u57f9\u7b49\u4eba\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u7535\u5316\u5b66\u533a\u57df\u9009\u62e9\u6027\u54aa\u5511\u5e76\u5421\u5576\u884d\u751f\u7269\u4e0e\u4e8c\u7532\u57fa\u4e9a\u781c\u7684C3-\u7532\u786b\u57fa\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709C3-\u7532\u786b\u57fa\u5316\u53d6\u4ee3\u7684\u54aa\u5511\u5e76\u5421\u5576\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u7532\u786b\u57fa\u5316\u5408\u6210\u8f6c\u5316\u7b56\u7565\u65e0\u9700\u4f7f\u7528\u91d1\u5c5e\u50ac\u5316\u5242\u4e0e\u5316\u5b66\u6c27\u5316\u5242\uff0c\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u826f\u597d\u7684\u6536\u7387\u7b49\u4f18\u52bf\u3002<\/p>\n<h4 style=\"text-align: justify;\"><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ul style=\"text-align: justify;\">\n<li>[1] C. Ravi, D. C. Mohan, S. Adimurthy, <em>Org. Biomol. Chem.<\/em> <strong>2016<\/strong>, <em>14<\/em>, 2282. doi:<a href=\"https:\/\/doi.org\/10.1039\/C5OB02475G\">10.1039\/C5OB02475G<\/a>.<\/li>\n<li>[2] Y. Yuan, A. Lei, <em>Acc. Chem. Res.<\/em> <strong>2019<\/strong>, <em>52<\/em>, 3309. doi:<a href=\"https:\/\/doi.org\/10.1021\/acs.accounts.9b00512\">10.1021\/acs.accounts.9b00512<\/a>.<\/li>\n<li>[3] J. Wen, C. Niu, K. Yan, X. Cheng, R. Gong, M. Li, Y. Guo, J. Yang, H. Wang, <em>Green Chem.<\/em> <strong>2020<\/strong>, <em>22<\/em>, 1129. doi:<a href=\"https:\/\/doi.org\/10.1039\/C9GC04068D\">10.1039\/C9GC04068D<\/a>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u5357\u4eac\u5e08\u8303\u5927\u5b66\u7684\u5b59\u57f9\u57f9\u7b49\u4eba\u5728Green Chem.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u7535\u5316\u5b66\u533a\u57df\u9009\u62e9\u6027\u54aa\u5511\u5e76\u5421\u5576\u884d\u751f\u7269 (imidazopyridines)\u4e0e\u4e8c\u7532\u57fa\u4e9a\u781c\u7684C3-\u7532\u786b\u57fa\u5316 (C3-methylthiolation)\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709C3-\u7532\u786b\u57fa\u5316\u53d6\u4ee3\u7684\u54aa\u5511\u5e76\u5421\u5576\u5206\u5b50\u7684\u6784\u5efa\u3002\u5176\u4e2d\uff0c\u4e8c\u7532\u57fa\u4e9a\u781c\u4f5c\u4e3a\u6eb6\u5242\u4e0e\u7532\u786b\u57fa\u5316\u8bd5\u5242\uff0cKI\u4f5c\u4e3a\u6c22\u539f\u5b50\u8f6c\u79fb\u8bd5\u5242\u4e0e\u652f\u6301\u7535\u89e3\u8d28\u3002 Electrochemical C3-methylthiolation of imidazopyridines with dimethyl sulfoxide Z. Feng, Y. Fan, C. Qiang, P. Liu, P. Sun, Green Chem. 2024, ASAP. doi: 10.1039\/D4GC00314D. \u6b63\u6587\uff1a \u7532\u786b\u57fa\u5355\u5143\u5728\u751f\u7269\u5316\u5b66\u3001\u8367\u5149\u63a2\u9488\u4ee5\u53ca\u836f\u7269\u53d1\u73b0\u7b49\u9886\u57df\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u8fd1\u4e9b\u5e74\u6765\uff0c\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u5229\u7528\u4e8c\u7532\u57fa\u4e9a\u781c\u4f5c\u4e3a\u7532\u786b\u57fa\u5316\u8bd5\u5242\u5df2\u7ecf\u6210\u529f\u8ba1\u51fa\u591a\u79cd\u6742\u73af\u5316\u5408\u7269\u7684\u7532\u786b\u57fa\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[1] (Scheme 1a)\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u7535\u5316\u5b66\u4fc3\u8fdb\u54aa\u5511\u5e76\u5421\u5576\u7684C3-\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[2]-[3](Schemes 1b-1c)\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u5357\u4eac\u5e08\u8303\u5927\u5b66\u7684\u5b59\u57f9\u57f9\u7b49\u4eba\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u7535\u5316\u5b66\u533a\u57df\u9009\u62e9\u6027\u54aa\u5511\u5e76\u5421\u5576\u884d\u751f\u7269\u4e0e\u4e8c\u7532\u57fa\u4e9a\u781c\u7684C3-\u7532\u786b\u57fa\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709C3-\u7532\u786b\u57fa\u5316\u53d6\u4ee3\u7684\u54aa\u5511\u5e76\u5421\u5576\u5206\u5b50\u7684\u6784\u5efa (Scheme 1d)\u3002 \u00a0 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u75282-phenylimidazo[1,2-a]pyridine (1a) \u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\uff0c\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528\u7532\u786b\u57fa\u5316\u8bd5\u5242\u5728\u4e8c\u7532\u57fa\u4e9a\u781c\u6eb6\u5242\u4e2d\uff0cKI\u4f5c\u4e3a\u6c22\u539f\u5b50\u8f6c\u79fb\u8bd5\u5242\u4e0e\u652f\u6301\u7535\u89e3\u8d28\uff0cGF(+)\/Pt(\u2212)\u4f5c\u4e3a\u7535\u6781\uff0c\u7535\u6d41\u4e3a15 mA\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a40 oC\uff0c\u5728\u65e0\u9694\u819c\u7535\u89e3\u69fd\u4e2d\u8fdb\u884c\u53cd\u5e94\uff0c\u6700\u7ec8\u83b7\u5f9786%\u6536\u7387\u7684\u4ea7\u72692a\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u54aa\u5511\u5e76\u5421\u5576\u884d\u751f\u7269\u5e95\u7269 (Scheme 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u7532\u786b\u57fa\u5316\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 3)\u3002 \u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u7532\u786b\u57fa\u5316\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76 \u00a0(Scheme 4\u4e0eFig. 1)\u3002 \u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053[3]\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 5)\u3002 \u603b\u7ed3\uff1a\u5357\u4eac\u5e08\u8303\u5927\u5b66\u7684\u5b59\u57f9\u57f9\u7b49\u4eba\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u7535\u5316\u5b66\u533a\u57df\u9009\u62e9\u6027\u54aa\u5511\u5e76\u5421\u5576\u884d\u751f\u7269\u4e0e\u4e8c\u7532\u57fa\u4e9a\u781c\u7684C3-\u7532\u786b\u57fa\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709C3-\u7532\u786b\u57fa\u5316\u53d6\u4ee3\u7684\u54aa\u5511\u5e76\u5421\u5576\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u7532\u786b\u57fa\u5316\u5408\u6210\u8f6c\u5316\u7b56\u7565\u65e0\u9700\u4f7f\u7528\u91d1\u5c5e\u50ac\u5316\u5242\u4e0e\u5316\u5b66\u6c27\u5316\u5242\uff0c\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u826f\u597d\u7684\u6536\u7387\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] C. Ravi, D. C. Mohan, S. Adimurthy, Org. Biomol. Chem. 2016, 14, 2282. doi:10.1039\/C5OB02475G. [2] Y. Yuan, A. Lei, Acc. Chem. Res. 2019, 52, 3309. doi:10.1021\/acs.accounts.9b00512. [3] J. Wen, C. Niu, K. Yan, X. Cheng, R. Gong, M. Li, Y. Guo, J. Yang, H. Wang, Green Chem. 2020, 22, 1129. 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