{"id":49647,"date":"2024-04-28T08:00:50","date_gmt":"2024-04-28T00:00:50","guid":{"rendered":"\/\/www.gsbet888.com\/?p=49647"},"modified":"2024-04-27T20:54:25","modified_gmt":"2024-04-27T12:54:25","slug":"nat-commun-%ef%bc%9a%e6%9c%89%e6%9c%ba%e5%82%ac%e5%8c%96%e5%8e%bb%e5%af%b9%e7%a7%b0%e5%8c%96%e5%90%88%e6%88%90%e5%b9%b3%e9%9d%a2%e6%89%8b%e6%80%a72-2%e5%af%b9%e7%8e%af%e8%95%83%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2024\/04\/nat-commun-%ef%bc%9a%e6%9c%89%e6%9c%ba%e5%82%ac%e5%8c%96%e5%8e%bb%e5%af%b9%e7%a7%b0%e5%8c%96%e5%90%88%e6%88%90%e5%b9%b3%e9%9d%a2%e6%89%8b%e6%80%a72-2%e5%af%b9%e7%8e%af%e8%95%83%e5%8f%8d%e5%ba%94.html","title":{"rendered":"Nat. Commun.\uff1a\u6709\u673a\u50ac\u5316\u53bb\u5bf9\u79f0\u5316\u5408\u6210\u5e73\u9762\u624b\u6027[2.2]\u5bf9\u73af\u8543\u53cd\u5e94\u65b9\u6cd5\u5b66"},"content":{"rendered":"

\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n

\u5bfc\u8bfb\uff1a<\/h4>\n

\u8fd1\u65e5\uff0c\u6377\u514bCharles\u5927\u5b66\u7684Jan Vesel\u00fd\u8bfe\u9898\u7ec4\u5728Nat. Commun.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u6709\u673a\u50ac\u5316\u524d\u624b\u6027\u4e8c\u7532\u9170\u57fa[2.2]\u5bf9\u73af\u8543 (diformyl[2.2]paracyclophanes)\u4e0e\u9187\u7684\u53bb\u5bf9\u79f0\u5316\u916f\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u6d89\u53ca\u5173\u952e\u7684Breslow\u4e2d\u95f4\u4f53\u7684\u5f62\u6210\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5e73\u9762\u624b\u6027[2.2]\u5bf9\u73af\u8543(planar chiral [2.2]paracyclophanes)\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n

Organocatalytic desymmetrization provides access to planar chiral [2.2]paracyclophanes<\/p>\n

V. Do\u010dekal, F. Kouck\u00fd, I. C\u00edsa\u0159ov\u00e1, J. Vesel\u00fd, Nat. Commun.<\/em> 2024<\/strong>, 15<\/em>, 3090. doi: 10.1038\/s41467-024-47407-0<\/a>.<\/u><\/p><\/blockquote>\n

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\u6b63\u6587\uff1a<\/h4>\n

\u624b\u6027[2.2]\u5bf9\u73af\u8543\u9aa8\u67b6\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u7c7b\u914d\u4f53\u3001\u7ec6\u80de\u56e0\u5b50\u6291\u5236\u5242\u3001\u50ac\u5316\u5242\u3001\u5706\u504f\u632f\u5149\u53d1\u5c04\u4f53\u7b49\u7269\u8d28\u4e2d(Fig. 1)\u3002\u5e76\u4e14\uff0c\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u5df2\u7ecf\u6210\u529f\u8bbe\u8ba1\u51fa\u591a\u79cd\u5229\u7528\u5bf9\u6620\u4f53\u5206\u79bb\u6216\u5404\u79cd\u62c6\u5206\u65b9\u6cd5[1]<\/sup>\u6784\u5efa\u624b\u6027[2.2]\u5bf9\u73af\u8543\u5206\u5b50\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565\u3002\u7136\u800c\uff0c\u6b64\u7c7b\u7b56\u7565\u5b58\u5728\u5e95\u7269\u8303\u56f4\u7a84\u3001\u6536\u7387\u4f4e\u7b49\u5f0a\u7aef\u3002\u53d7\u5230\u948c\u50ac\u5316\u4e0d\u5bf9\u79f0\u8f6c\u79fb\u6c22\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[2]<\/sup>\u4ee5\u53ca\u624b\u6027N<\/em>-\u6742\u73af\u5361\u5bbe\u8bf1\u5bfc\u7684\u65e0\u91d1\u5c5e\u6709\u673a\u50ac\u5316\u53bb\u5bf9\u79f0\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[3]<\/sup>\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u6377\u514bCharles\u5927\u5b66\u7684Jan Vesel\u00fd\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u6709\u673a\u50ac\u5316\u524d\u624b\u6027\u4e8c\u7532\u9170\u57fa[2.2]\u5bf9\u73af\u8543\u4e0e\u9187\u7684\u53bb\u5bf9\u79f0\u5316\u916f\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5e73\u9762\u624b\u6027[2.2]\u5bf9\u73af\u8543\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n

\"\"<\/p>\n

\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528\u4e8c\u7532\u9170\u57fa[2.2]\u5bf9\u73af\u8543\u884d\u751f\u72691a<\/strong>\u4e0e\u9187\u884d\u751f\u72692<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528\u7532\u9187\u4f5c\u4e3a\u5e95\u7269\uff0cpre<\/em>–C1<\/strong>\u4f5c\u4e3a\u9884\u50ac\u5316\u5242\uff0cDQ (Kharash reagent, 3,3\u20195,5\u2019-tetra-tert<\/em>-butyldiphenoquinone)\u4f5c\u4e3a\u6c27\u5316\u5242\uff0cCs2<\/sub>CO3<\/sub>\u4f5c\u4e3a\u78b1\uff0c\u5728DCM\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9787%\u6536\u7387\u7684\u4ea7\u72693<\/strong> (99:1 er<\/em>)\u3002<\/p>\n

\"\"<\/p>\n

\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217pseudo<\/em>–para<\/em> derivative\u5e95\u7269 (Fig. 2)\u4ee5\u53capseudo<\/em>–gem<\/em> derivative\u5e95\u7269 (Fig. 3)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n

\"\" \"\" \"\" \"\"<\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u53bb\u5bf9\u79f0\u5316\u916f\u5316\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76 \u00a0(Fig. 4\u4e0eFig. 5)\u3002<\/p>\n

\"\" \"\" \"\" \"\"<\/p>\n

\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u5bf9\u79f0\u5316\u916f\u5316\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Fig. 6)\u3002<\/p>\n

\"\"<\/p>\n

\u603b\u7ed3\uff1a\u6377\u514bCharles\u5927\u5b66\u7684Jan Vesel\u00fd\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u6709\u673a\u50ac\u5316\u524d\u624b\u6027\u4e8c\u7532\u9170\u57fa[2.2]\u5bf9\u73af\u8543\u4e0e\u9187\u7684\u53bb\u5bf9\u79f0\u5316\u916f\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5e73\u9762\u624b\u6027[2.2]\u5bf9\u73af\u8543\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u53bb\u5bf9\u79f0\u5316\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u64cd\u4f5c\u7b80\u5355\u3001\u65e0\u9700\u91d1\u5c5e\u50ac\u5316\u5242\u3001\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u4ee5\u53ca\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n