{"id":49757,"date":"2024-05-14T08:00:50","date_gmt":"2024-05-14T00:00:50","guid":{"rendered":"\/\/www.gsbet888.com\/?p=49757"},"modified":"2024-05-13T13:51:23","modified_gmt":"2024-05-13T05:51:23","slug":"angew%ef%bc%9a%e9%9d%9e%e6%b4%bb%e5%8c%96%e6%9c%ab%e7%ab%af%e7%83%af%e7%83%83%e5%8f%82%e4%b8%8e%e7%9a%84%e5%af%b9%e6%98%a0%e9%80%89%e6%8b%a9%e6%80%a7%e6%b0%ae%e6%9d%82%e7%8e%af%e4%b8%99%e7%83%b7","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2024\/05\/angew%ef%bc%9a%e9%9d%9e%e6%b4%bb%e5%8c%96%e6%9c%ab%e7%ab%af%e7%83%af%e7%83%83%e5%8f%82%e4%b8%8e%e7%9a%84%e5%af%b9%e6%98%a0%e9%80%89%e6%8b%a9%e6%80%a7%e6%b0%ae%e6%9d%82%e7%8e%af%e4%b8%99%e7%83%b7.html","title":{"rendered":"Angew\uff1a\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3\u53c2\u4e0e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66"},"content":{"rendered":"<p style=\"text-align: justify;\">\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n<h4 style=\"text-align: justify;\">\u5bfc\u8bfb\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u8fd1\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u738b\u5b88\u56fd\u8bfe\u9898\u7ec4\u5728<em>Angew. Chem. Int. Ed.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684Cp<sup>x<\/sup>Rh(III) (cyclopentadienyl-rhodium(III))-\u50ac\u5316\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3\u4e0e<em>N<\/em>-pivalolyloxy sulfonamides (\u6c2e\u5bbe\u6e90)\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n<blockquote><p>Chiral Cp<sup>x<\/sup>Rhodium(III)-Catalyzed Enantioselective Aziridination of Unactivated Terminal Alkenes<\/p>\n<p>J. Wang, M. Luo, Y. Gu, Y. Liu, Y. Qin, S. Wang, <em>Angew. Chem. Int. Ed<\/em>. <strong>2024<\/strong>, ASAP. doi: <a href=\"https:\/\/doi.org\/10.1002\/anie.202400502\">10.1002\/anie.202400502<\/a><u>.<\/u><\/p><\/blockquote>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49759 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image002-3.png\" alt=\"\" width=\"1269\" height=\"244\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image002-3.png 1269w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image002-3-300x58.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image002-3-680x131.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image002-3-768x148.png 768w\" sizes=\"(max-width: 1269px) 100vw, 1269px\" \/><\/p>\n<h4 style=\"text-align: justify;\">\u6b63\u6587\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u624b\u6027Cp<sup>x<\/sup>Rh(III)-\u50ac\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u5df2\u6210\u4e3a\u5bf9\u6620\u9009\u62e9\u6027C-H\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u7684\u4e00\u79cd\u5f3a\u5927\u7b56\u7565<sup>[1]<\/sup>(Scheme 1A)\u3002\u540c\u65f6\uff0c\u624b\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u9aa8\u67b6\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u7c7b\u5929\u7136\u4ea7\u7269\u4ee5\u53ca\u751f\u7269\u6d3b\u6027\u5206\u5b50\u4e2d (Scheme 1E)\u3002\u8fd1\u5e74\u6765\uff0c\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u5df2\u7ecf\u6210\u529f\u8bbe\u8ba1\u51fa\u591a\u79cd\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u70ef\u70c3\u4e0e\u4e0d\u540c\u6c2e\u5bbe\u6e90\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[2]<\/sup> (Scheme 1B)\u3002\u7136\u800c\uff0c\u6b64\u7c7b\u53cd\u5e94\u4e3b\u8981\u96c6\u4e2d\u4e8e\u5728\u82ef\u4e59\u70ef\u3001<em>\u03b1<\/em>,<em>\u03b2<\/em>-\u4e0d\u9971\u548c\u7fb0\u57fa\u5316\u5408\u7269\u4ee5\u53ca\u4e00\u4e9b\u7279\u5b9a\u7684\u5e95\u7269\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u5bf9\u4e8e[Ind<sup>*<\/sup>RhCl<sub>2<\/sub>]<sub>2<\/sub>-\u50ac\u5316\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[3]<\/sup> (Scheme 1C)\u4ee5\u53caCp<sup>x<\/sup>Rh(III)-\u50ac\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66<sup>[4]<\/sup>\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u738b\u5b88\u56fd\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684Cp<sup>x<\/sup>Rh(III)-\u50ac\u5316\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3\u4e0e<em>N<\/em>-pivalolyloxy sulfonamides\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5206\u5b50\u7684\u6784\u5efa (Scheme 1D)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49760 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image003-3.png\" alt=\"\" width=\"1268\" height=\"1382\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image003-3.png 1268w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image003-3-275x300.png 275w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image003-3-680x741.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image003-3-768x837.png 768w\" sizes=\"(max-width: 1268px) 100vw, 1268px\" \/><\/p>\n<p style=\"text-align: justify;\">\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528<em>N<\/em>-pivaloyloxy tosylamide <strong>1<\/strong>\u4e0e\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3<strong>2a<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528<strong>1a<\/strong>\u4f5c\u4e3a\u5e95\u7269\uff0c<strong>Rh1<\/strong>\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cCs<sub>2<\/sub>CO<sub>3<\/sub>\u4f5c\u4e3a\u78b1\uff0c\u5728HFIP\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9790%\u6536\u7387\u7684\u4ea7\u7269<strong>3a <\/strong>(91%<em> ee<\/em>)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49761 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image004-3.png\" alt=\"\" width=\"1180\" height=\"1180\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image004-3.png 1180w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image004-3-300x300.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image004-3-680x680.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image004-3-150x150.png 150w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image004-3-768x768.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image004-3-120x120.png 120w\" sizes=\"(max-width: 1180px) 100vw, 1180px\" \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3\u5e95\u7269 (Scheme 2)\u4ee5\u53ca<em>N<\/em>-pivalolyloxy sulfonamides\u5e95\u7269 (Scheme 3)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49762 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image005-3.png\" alt=\"\" width=\"1271\" height=\"908\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image005-3.png 1271w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image005-3-300x214.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image005-3-680x486.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image005-3-768x549.png 768w\" sizes=\"(max-width: 1271px) 100vw, 1271px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49766 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/4e34606e4ed87ab502ea0229df067715.png\" alt=\"\" width=\"663\" height=\"525\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/4e34606e4ed87ab502ea0229df067715.png 663w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/4e34606e4ed87ab502ea0229df067715-300x238.png 300w\" sizes=\"(max-width: 663px) 100vw, 663px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49763 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image007-2.png\" alt=\"\" width=\"1268\" height=\"678\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image007-2.png 1268w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image007-2-300x160.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image007-2-680x364.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image007-2-768x411.png 768w\" sizes=\"(max-width: 1268px) 100vw, 1268px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49767 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/6b5ea1321e7448bc174c5a2d3447241d.png\" alt=\"\" width=\"659\" height=\"362\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/6b5ea1321e7448bc174c5a2d3447241d.png 659w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/6b5ea1321e7448bc174c5a2d3447241d-300x165.png 300w\" sizes=\"(max-width: 659px) 100vw, 659px\" \/><\/p>\n<p style=\"text-align: justify;\">\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 4)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49764 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image009-2.png\" alt=\"\" width=\"1138\" height=\"1412\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image009-2.png 1138w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image009-2-242x300.png 242w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image009-2-680x844.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image009-2-768x953.png 768w\" sizes=\"(max-width: 1138px) 100vw, 1138px\" \/><\/p>\n<p style=\"text-align: justify;\">\u57fa\u4e8e\u4e0a\u8ff0\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053<sup>[3]<\/sup>\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 5A)\u3002\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76 \u00a0(Schemes 5B-5C)\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8fd8\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u7acb\u4f53\u5316\u5b66\u6a21\u578b (Scheme 5D)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49765 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image010-1.png\" alt=\"\" width=\"1184\" height=\"2208\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image010-1.png 1184w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image010-1-161x300.png 161w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image010-1-549x1024.png 549w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image010-1-768x1432.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image010-1-824x1536.png 824w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image010-1-1098x2048.png 1098w\" sizes=\"(max-width: 1184px) 100vw, 1184px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-49768 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/e861120735e6522f34d7190fadbf3104.png\" alt=\"\" width=\"627\" height=\"321\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/e861120735e6522f34d7190fadbf3104.png 627w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/e861120735e6522f34d7190fadbf3104-300x154.png 300w\" sizes=\"(max-width: 627px) 100vw, 627px\" \/><\/p>\n<p style=\"text-align: justify;\">\u603b\u7ed3\uff1a\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u738b\u5b88\u56fd\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684Cp<sup>x<\/sup>Rh(III)-\u50ac\u5316\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3\u4e0e<em>N<\/em>-pivalolyloxy sulfonamides\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5316\u5b66\u9009\u62e9\u6027\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n<h4 style=\"text-align: justify;\"><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ul style=\"text-align: justify;\">\n<li>[1] C. G. Newton, S. G. Wang, C. C. Oliveira, N. Cramer, <em>Chem. Rev. <\/em><strong>2017<\/strong>, 117, 8908. doi:<a href=\"https:\/\/doi.org\/10.1021\/acs.chemrev.6b00692\">10.1021\/acs.chemrev.6b00692<\/a>.<\/li>\n<li>[2] A. Fanourakis, N. J. Hodson, A. R. Lit, R. J. Phipps, <em>J. Am. Chem. Soc. <\/em><strong>2023<\/strong>, <em>145<\/em>, 7516. doi:<a href=\"https:\/\/doi.org\/10.1021\/jacs.3c00693\">10.1021\/jacs.3c00693<\/a>.<\/li>\n<li>[3] S. Lee, H. Lei, T. Rovis, <em>J. Am. Chem. Soc. <\/em><strong>2019<\/strong>, <em>141<\/em>, 12536. doi:<a href=\"https:\/\/doi.org\/10.1021\/jacs.9b07012\">10.1021\/jacs.9b07012<\/a>.<\/li>\n<li>[4] S. Wang, N. Cramer, <em>Angew. Chem. Int. Ed. <\/em><strong>2019<\/strong>, <em>58<\/em>, 2514. doi:<a href=\"https:\/\/doi.org\/10.1002\/anie.201813953\">10.1002\/anie.201813953<\/a>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u738b\u5b88\u56fd\u8bfe\u9898\u7ec4\u5728Angew. Chem. Int. Ed.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684CpxRh(III) (cyclopentadienyl-rhodium(III))-\u50ac\u5316\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3\u4e0eN-pivalolyloxy sulfonamides (\u6c2e\u5bbe\u6e90)\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5206\u5b50\u7684\u6784\u5efa\u3002 Chiral CpxRhodium(III)-Catalyzed Enantioselective Aziridination of Unactivated Terminal Alkenes J. Wang, M. Luo, Y. Gu, Y. Liu, Y. Qin, S. Wang, Angew. Chem. Int. Ed. 2024, ASAP. doi: 10.1002\/anie.202400502. \u6b63\u6587\uff1a \u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u624b\u6027CpxRh(III)-\u50ac\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u5df2\u6210\u4e3a\u5bf9\u6620\u9009\u62e9\u6027C-H\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u7684\u4e00\u79cd\u5f3a\u5927\u7b56\u7565[1](Scheme 1A)\u3002\u540c\u65f6\uff0c\u624b\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u9aa8\u67b6\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u7c7b\u5929\u7136\u4ea7\u7269\u4ee5\u53ca\u751f\u7269\u6d3b\u6027\u5206\u5b50\u4e2d (Scheme 1E)\u3002\u8fd1\u5e74\u6765\uff0c\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u5df2\u7ecf\u6210\u529f\u8bbe\u8ba1\u51fa\u591a\u79cd\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u70ef\u70c3\u4e0e\u4e0d\u540c\u6c2e\u5bbe\u6e90\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[2] (Scheme 1B)\u3002\u7136\u800c\uff0c\u6b64\u7c7b\u53cd\u5e94\u4e3b\u8981\u96c6\u4e2d\u4e8e\u5728\u82ef\u4e59\u70ef\u3001\u03b1,\u03b2-\u4e0d\u9971\u548c\u7fb0\u57fa\u5316\u5408\u7269\u4ee5\u53ca\u4e00\u4e9b\u7279\u5b9a\u7684\u5e95\u7269\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u5bf9\u4e8e[Ind*RhCl2]2-\u50ac\u5316\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[3] (Scheme 1C)\u4ee5\u53caCpxRh(III)-\u50ac\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[4]\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u738b\u5b88\u56fd\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684CpxRh(III)-\u50ac\u5316\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3\u4e0eN-pivalolyloxy sulfonamides\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5206\u5b50\u7684\u6784\u5efa (Scheme 1D)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528N-pivaloyloxy tosylamide 1\u4e0e\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c32a\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u75281a\u4f5c\u4e3a\u5e95\u7269\uff0cRh1\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cCs2CO3\u4f5c\u4e3a\u78b1\uff0c\u5728HFIP\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9790%\u6536\u7387\u7684\u4ea7\u72693a (91% ee)\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3\u5e95\u7269 (Scheme 2)\u4ee5\u53caN-pivalolyloxy sulfonamides\u5e95\u7269 (Scheme 3)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 4)\u3002 \u57fa\u4e8e\u4e0a\u8ff0\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053[3]\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 5A)\u3002\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76 \u00a0(Schemes 5B-5C)\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8fd8\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u7acb\u4f53\u5316\u5b66\u6a21\u578b (Scheme 5D)\u3002 \u603b\u7ed3\uff1a\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u738b\u5b88\u56fd\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684CpxRh(III)-\u50ac\u5316\u975e\u6d3b\u5316\u672b\u7aef\u70ef\u70c3\u4e0eN-pivalolyloxy sulfonamides\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u6c2e\u6742\u73af\u4e19\u70f7\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u5316\u5b66\u9009\u62e9\u6027\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] C. G. Newton, S. G. Wang, C. C. Oliveira, N. Cramer, Chem. Rev. 2017, 117, 8908. doi:10.1021\/acs.chemrev.6b00692. [2] A. Fanourakis, N. J. Hodson, A. R. Lit, R. J. Phipps, J. Am. Chem. Soc. 2023, [&hellip;]","protected":false},"author":26,"featured_media":49758,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[4381],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/05\/image001-3.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-cWx","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/49757"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=49757"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/49757\/revisions"}],"predecessor-version":[{"id":49770,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/49757\/revisions\/49770"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/49758"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=49757"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=49757"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=49757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}