{"id":50273,"date":"2024-07-18T08:00:00","date_gmt":"2024-07-18T00:00:00","guid":{"rendered":"\/\/www.gsbet888.com\/?p=50273"},"modified":"2024-07-17T22:05:36","modified_gmt":"2024-07-17T14:05:36","slug":"jacs%ef%bc%9a%e8%bd%b4%e6%89%8b%e6%80%a7%e5%8f%af%e8%b0%83%e7%9a%84%e8%bd%b4%e6%89%8b%e6%80%a7%e5%92%aa%e5%94%91%e5%9f%bapn-%e9%85%8d%e4%bd%93%e4%bf%83%e8%bf%9b%e7%82%94%e7%83%83%e4%b8%8e%e7%a1%9d","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2024\/07\/jacs%ef%bc%9a%e8%bd%b4%e6%89%8b%e6%80%a7%e5%8f%af%e8%b0%83%e7%9a%84%e8%bd%b4%e6%89%8b%e6%80%a7%e5%92%aa%e5%94%91%e5%9f%bapn-%e9%85%8d%e4%bd%93%e4%bf%83%e8%bf%9b%e7%82%94%e7%83%83%e4%b8%8e%e7%a1%9d.html","title":{"rendered":"JACS\uff1a\u8f74\u624b\u6027\u53ef\u8c03\u7684\u8f74\u624b\u6027\u54aa\u5511\u57faP,N-\u914d\u4f53\u4fc3\u8fdb\u7094\u70c3\u4e0e\u785d\u916e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66"},"content":{"rendered":"

\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n

\u5bfc\u8bfb\uff1a<\/h4>\n

\u8fd1\u671f\uff0c\u7f8e\u56fdFlorida\u5927\u5b66\u7684Aaron Aponick\u8bfe\u9898\u7ec4\u5728J. Am. Chem. Soc.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5229\u7528\u8f74\u624b\u6027\u53ef\u8c03\u7684\u8f74\u624b\u6027\u54aa\u5511\u57faP,N-\u914d\u4f53\uff0c\u5b9e\u73b0\u4e86\u94dc\u50ac\u5316\u7094\u70c3\u4e0e\u785d\u916e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u7094\u4e19\u57faN<\/em>-\u7f9f\u80fa\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n

Catalytic Enantioselective Alkyne Addition to Nitrones Enabled by Tunable Axially Chiral Imidazole-Based P,N-Ligands<\/p>\n

S. Yin, K. N. Weeks, A. Aponick, J. Am. Chem. Soc.<\/em> 2024<\/strong>, 146<\/em>, 7185. doi: 10.1021\/jacs.4c00873<\/a>.<\/u><\/p><\/blockquote>\n

\"\"<\/p>\n

\u6b63\u6587\uff1a<\/h4>\n

\u7094\u70c3\u4e0e\u785d\u916e\u7684\u7acb\u4f53\u9009\u62e9\u6027\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\u662f\u6784\u5efa\u624b\u6027\u7094\u4e19\u57faN<\/em>-\u7f9f\u80fa\u5206\u5b50\u7684\u6709\u6548\u7b56\u7565\u3002\u7136\u800c\uff0c\u901a\u8fc7\u7094\u70c3\u4e0e\u785d\u916e\u53c2\u4e0e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u76ee\u524d\u5374\u8f83\u5c11\u6709\u76f8\u5173\u7684\u7814\u7a76\u62a5\u9053 (Figure 1A)[1]<\/sup>\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u91c7\u7528\u4e0d\u540c\u7684\u8f74\u624b\u6027P,N-\u914d\u4f53\u4fc3\u8fdb\u94dc\u50ac\u5316\u7094\u70c3\u4e0e\u4e9a\u80fa\u79bb\u5b50\u7684\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66(Figure 1B)[2]<\/sup>\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u7f8e\u56fdFlorida\u5927\u5b66\u7684Aaron Aponick\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5229\u7528\u8f74\u624b\u6027\u53ef\u8c03\u7684\u8f74\u624b\u6027\u54aa\u5511\u57faP,N-\u914d\u4f53\uff0c\u5b9e\u73b0\u4e86\u94dc\u50ac\u5316\u7094\u70c3\u4e0e\u785d\u916e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u7094\u4e19\u57faN<\/em>-\u7f9f\u80fa\u5206\u5b50\u7684\u6784\u5efa (Figure 1C)\u3002<\/p>\n

\"\"<\/p>\n

\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528\u785d\u916e\u884d\u751f\u72691a<\/strong>\u4e0e\u82ef\u4e59\u70942a<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528CuBr\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cL6<\/strong>\u4f5c\u4e3a\u624b\u6027\u914d\u4f53\uff0cTMSBr\u4f5c\u4e3a\u6d3b\u5316\u8bd5\u5242\uff0ci<\/em>Pr2<\/sub>NEt\u4f5c\u4e3a\u78b1\uff0c\u5728\u7532\u82ef\u4e0e\u4e8c\u6c2f\u7532\u70f7\u7684\u6df7\u5408\u53cd\u5e94\u6eb6\u5242 (\u6bd4\u4f8b\u4e3a1:1)\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a-40o<\/sup>C\uff0c\u5e76\u5728TsOH\/MeOH\u6761\u4ef6\u4e0b\u8fdb\u884c\u8131\u7845\u57fa\uff0c\u6700\u7ec8\u83b7\u5f9792%\u6536\u7387\u7684\u4ea7\u72693a <\/strong>(93% ee<\/em>)\u3002<\/p>\n

\"\"<\/p>\n

\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217\u7094\u70c3\u5e95\u7269\u53ca\u785d\u916e\u5e95\u7269 (Table 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n

\"\" \"\"<\/p>\n

\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6210\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 1)\u3002<\/p>\n

\"\"<\/p>\n

\u603b\u7ed3\uff1a\u7f8e\u56fdFlorida\u5927\u5b66\u7684Aaron Aponick\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5229\u7528\u8f74\u624b\u6027\u53ef\u8c03\u7684\u8f74\u624b\u6027\u54aa\u5511\u57faP,N-\u914d\u4f53\uff0c\u5b9e\u73b0\u4e86\u94dc\u50ac\u5316\u7094\u70c3\u4e0e\u785d\u916e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u7094\u4e19\u57faN<\/em>-\u7f9f\u80fa\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n

[1] R. Fassler, D. E. Frantz, J. Oetiker, E. M. Carreira, Angew. Chem. Int. Ed. <\/em>2002<\/strong>, 41<\/em>, 3054. doi: 10.1002\/1521-3773(20020816)41:16<3054::AID-ANIE3054>3.0.CO;2-B<\/a>.<\/p>\n

[2] C. Zhao, D. Seidel, J. Am. Chem. Soc. <\/em>2015<\/strong>, 137<\/em>, 4650. doi: 10.1021\/jacs.5b02071<\/a>.<\/p>\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u671f\uff0c\u7f8e\u56fdFlorida\u5927\u5b66\u7684Aaron Aponick\u8bfe\u9898\u7ec4\u5728J. Am. Chem. Soc.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5229\u7528\u8f74\u624b\u6027\u53ef\u8c03\u7684\u8f74\u624b\u6027\u54aa\u5511\u57faP,N-\u914d\u4f53\uff0c\u5b9e\u73b0\u4e86\u94dc\u50ac\u5316\u7094\u70c3\u4e0e\u785d\u916e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u7094\u4e19\u57faN-\u7f9f\u80fa\u5206\u5b50\u7684\u6784\u5efa\u3002 Catalytic Enantioselective Alkyne Addition to Nitrones Enabled by Tunable Axially Chiral Imidazole-Based P,N-Ligands S. Yin, K. N. Weeks, A. Aponick, J. Am. Chem. Soc. 2024, 146, 7185. doi: 10.1021\/jacs.4c00873. \u6b63\u6587\uff1a \u7094\u70c3\u4e0e\u785d\u916e\u7684\u7acb\u4f53\u9009\u62e9\u6027\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\u662f\u6784\u5efa\u624b\u6027\u7094\u4e19\u57faN-\u7f9f\u80fa\u5206\u5b50\u7684\u6709\u6548\u7b56\u7565\u3002\u7136\u800c\uff0c\u901a\u8fc7\u7094\u70c3\u4e0e\u785d\u916e\u53c2\u4e0e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u76ee\u524d\u5374\u8f83\u5c11\u6709\u76f8\u5173\u7684\u7814\u7a76\u62a5\u9053 (Figure 1A)[1]\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u91c7\u7528\u4e0d\u540c\u7684\u8f74\u624b\u6027P,N-\u914d\u4f53\u4fc3\u8fdb\u94dc\u50ac\u5316\u7094\u70c3\u4e0e\u4e9a\u80fa\u79bb\u5b50\u7684\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66(Figure 1B)[2]\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u7f8e\u56fdFlorida\u5927\u5b66\u7684Aaron Aponick\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5229\u7528\u8f74\u624b\u6027\u53ef\u8c03\u7684\u8f74\u624b\u6027\u54aa\u5511\u57faP,N-\u914d\u4f53\uff0c\u5b9e\u73b0\u4e86\u94dc\u50ac\u5316\u7094\u70c3\u4e0e\u785d\u916e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u7094\u4e19\u57faN-\u7f9f\u80fa\u5206\u5b50\u7684\u6784\u5efa (Figure 1C)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528\u785d\u916e\u884d\u751f\u72691a\u4e0e\u82ef\u4e59\u70942a\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528CuBr\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cL6\u4f5c\u4e3a\u624b\u6027\u914d\u4f53\uff0cTMSBr\u4f5c\u4e3a\u6d3b\u5316\u8bd5\u5242\uff0ciPr2NEt\u4f5c\u4e3a\u78b1\uff0c\u5728\u7532\u82ef\u4e0e\u4e8c\u6c2f\u7532\u70f7\u7684\u6df7\u5408\u53cd\u5e94\u6eb6\u5242 (\u6bd4\u4f8b\u4e3a1:1)\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a-40oC\uff0c\u5e76\u5728TsOH\/MeOH\u6761\u4ef6\u4e0b\u8fdb\u884c\u8131\u7845\u57fa\uff0c\u6700\u7ec8\u83b7\u5f9792%\u6536\u7387\u7684\u4ea7\u72693a (93% ee)\u3002 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5206\u522b\u5bf9\u4e00\u7cfb\u5217\u7094\u70c3\u5e95\u7269\u53ca\u785d\u916e\u5e95\u7269 (Table 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6210\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 1)\u3002 \u603b\u7ed3\uff1a\u7f8e\u56fdFlorida\u5927\u5b66\u7684Aaron Aponick\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\u4e00\u79cd\u5229\u7528\u8f74\u624b\u6027\u53ef\u8c03\u7684\u8f74\u624b\u6027\u54aa\u5511\u57faP,N-\u914d\u4f53\uff0c\u5b9e\u73b0\u4e86\u94dc\u50ac\u5316\u7094\u70c3\u4e0e\u785d\u916e\u7684\u5bf9\u6620\u9009\u62e9\u6027\u52a0\u6210\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u624b\u6027\u7094\u4e19\u57faN-\u7f9f\u80fa\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] R. Fassler, D. E. Frantz, J. Oetiker, E. M. Carreira, Angew. Chem. Int. Ed. 2002, 41, 3054. doi: 10.1002\/1521-3773(20020816)41:16<3054::AID-ANIE3054>3.0.CO;2-B. [2] C. Zhao, D. Seidel, J. Am. Chem. Soc. 2015, 137, 4650. doi: 10.1021\/jacs.5b02071. \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.","protected":false},"author":26,"featured_media":50274,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image001-8.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-d4R","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50273"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=50273"}],"version-history":[{"count":3,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50273\/revisions"}],"predecessor-version":[{"id":50283,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50273\/revisions\/50283"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/50274"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=50273"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=50273"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=50273"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}