{"id":50338,"date":"2024-07-22T08:00:09","date_gmt":"2024-07-22T00:00:09","guid":{"rendered":"\/\/www.gsbet888.com\/?p=50338"},"modified":"2024-07-22T08:50:02","modified_gmt":"2024-07-22T00:50:02","slug":"jacs%ef%bc%9a%e5%a4%96%e6%b6%88%e6%97%8b2-%e5%8f%96%e4%bb%a3%e5%90%b2%e5%93%9a%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e6%b0%a2%e5%8c%96%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2024\/07\/jacs%ef%bc%9a%e5%a4%96%e6%b6%88%e6%97%8b2-%e5%8f%96%e4%bb%a3%e5%90%b2%e5%93%9a%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e6%b0%a2%e5%8c%96%e5%8f%8d%e5%ba%94%e6%96%b9%e6%b3%95%e5%ad%a6.html","title":{"rendered":"JACS\uff1a\u5916\u6d88\u65cb2-\u53d6\u4ee3\u5432\u54da\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66"},"content":{"rendered":"<p style=\"text-align: justify;\">\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n<h4 style=\"text-align: justify;\">\u5bfc\u8bfb\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u8fd1\u671f\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u6bb7\u52e4\u8bfe\u9898\u7ec4\u5728<em>J. Am. Chem. Soc.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u94af\u50ac\u5316\u5916\u6d88\u65cb<em>\u03b1<\/em>-\u70f7\u57fa\u6216\u82b3\u57fa\u53d6\u4ee3\u7684indole-2-acetates\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316 (asymmetric hydrogenation\uff0cAH)\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u73af\u5916\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u5432\u54da\u5549\u5206\u5b50\u7684\u6784\u5efa\uff0c\u6d89\u53ca\u9178\u8f85\u52a9\u52a8\u6001\u52a8\u529b\u5b66\u62c6\u5206(dynamic kinetic resolution\uff0cDKR)\u7684\u8fc7\u7a0b\u3002<\/p>\n<blockquote><p>Asymmetric Hydrogenation of Racemic 2\u2011Substituted Indoles via Dynamic Kinetic Resolution: An Easy Access to Chiral Indolines Bearing Vicinal Stereogenic Centers<\/p>\n<p>N. Rong, A. Zhou, M. Liang, S. Wang, Q. Yin, <em>J. Am. Chem. Soc.<\/em> <strong>2024<\/strong>, <em>146<\/em>, 5081. doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.4c00298\">10.1021\/jacs.4c00298<\/a><u>.<\/u><\/p><\/blockquote>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-50340 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image002-1.png\" alt=\"\" width=\"1106\" height=\"292\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image002-1.png 1106w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image002-1-300x79.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image002-1-680x180.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image002-1-768x203.png 768w\" sizes=\"(max-width: 1106px) 100vw, 1106px\" \/><\/p>\n<h4 style=\"text-align: justify;\">\u6b63\u6587\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u8fd1\u5e74\u6765\uff0c\u57fa\u4e8eDKR\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u662f\u5408\u6210\u5177\u6709\u8fde\u7eed\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u9187\u6216\u80fa\u7684\u91cd\u8981\u65b9\u6cd5<sup>[1]<\/sup>(Scheme 1a)\u3002\u7136\u800c\uff0c\u6b64\u7c7b\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u4e3b\u8981\u5c40\u9650\u4e8e\u53ef\u70ef\u9187\u5316\u7684\u916e\u6216\u6d3b\u5316\u7684\u4e9a\u80fa\u3002\u540c\u65f6\uff0c\u4e0e<em>N<\/em>-\u4fdd\u62a4\u7684\u5432\u54da\u76f8\u6bd4\uff0c<em>N<\/em>-\u975e\u4fdd\u62a4\u5432\u54da\u7684\u76f4\u63a5\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u76ee\u524d\u5374\u8f83\u5c11\u6709\u76f8\u5173\u7684\u7814\u7a76\u62a5\u9053<sup>[2]<\/sup>\uff0c\u5e76\u4e14\u4e3b\u8981\u5f62\u6210\u73af\u5185\u7acb\u4f53\u4e2d\u5fc3(Scheme 1b)\u3002\u8fd9\u91cc\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u6bb7\u52e4\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u94af\u50ac\u5316\u5916\u6d88\u65cb<em>\u03b1<\/em>-\u70f7\u57fa\u6216\u82b3\u57fa\u53d6\u4ee3\u7684indole-2-acetates\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u73af\u5916\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u5432\u54da\u5549\u5206\u5b50\u7684\u6784\u5efa (Scheme 1d)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-50341 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image003-11.jpg\" alt=\"\" width=\"1107\" height=\"386\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image003-11.jpg 1107w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image003-11-300x105.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image003-11-680x237.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image003-11-768x268.jpg 768w\" sizes=\"(max-width: 1107px) 100vw, 1107px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-50342 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image004-11.jpg\" alt=\"\" width=\"1108\" height=\"532\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image004-11.jpg 1108w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image004-11-300x144.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image004-11-680x326.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image004-11-768x369.jpg 768w\" sizes=\"(max-width: 1108px) 100vw, 1108px\" \/><\/p>\n<p style=\"text-align: justify;\">\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528\u5432\u54da\u884d\u751f\u7269<strong>1a<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528Pd(CF<sub>3<\/sub>CO<sub>2<\/sub>)<sub>2<\/sub>\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c<strong>L5<\/strong>\u4f5c\u4e3a\u914d\u4f53\uff0cTFA\u4f5c\u4e3a\u6dfb\u52a0\u5242\uff0cH<sub>2<\/sub> (60 bar)\u4f5c\u4e3a\u8fd8\u539f\u5242\uff0c\u5728DCM\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9789%\u6536\u7387\u7684\u4ea7\u7269<strong>2a <\/strong>(&gt;20:1<em> dr<\/em>\u4ee5\u53ca94% <em>ee<\/em>)\u3002<\/p>\n<p style=\"text-align: justify;\">\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-50343 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image005-2.png\" alt=\"\" width=\"1091\" height=\"1861\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image005-2.png 1091w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image005-2-176x300.png 176w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image005-2-600x1024.png 600w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image005-2-768x1310.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image005-2-900x1536.png 900w\" sizes=\"(max-width: 1091px) 100vw, 1091px\" \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u5916\u6d88\u65cb2-\u53d6\u4ee3\u5432\u54da\u5e95\u7269 (Scheme 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-50344 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image006-4.jpg\" alt=\"\" width=\"1108\" height=\"1220\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image006-4.jpg 1108w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image006-4-272x300.jpg 272w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image006-4-680x749.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image006-4-768x846.jpg 768w\" sizes=\"(max-width: 1108px) 100vw, 1108px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-50345 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image007-4.png\" alt=\"\" width=\"1093\" height=\"726\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image007-4.png 1093w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image007-4-300x199.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image007-4-680x452.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image007-4-768x510.png 768w\" sizes=\"(max-width: 1093px) 100vw, 1093px\" \/><\/p>\n<p style=\"text-align: justify;\">\u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 3)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-50346 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image008-4.jpg\" alt=\"\" width=\"1107\" height=\"1009\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image008-4.jpg 1107w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image008-4-300x273.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image008-4-680x620.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image008-4-768x700.jpg 768w\" sizes=\"(max-width: 1107px) 100vw, 1107px\" \/><\/p>\n<p style=\"text-align: justify;\">\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u4e0d\u5bf9\u79f0\u6c22\u5316\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76 \u00a0(Scheme 4)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-50347 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image009-2.png\" alt=\"\" width=\"1106\" height=\"466\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image009-2.png 1106w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image009-2-300x126.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image009-2-680x287.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image009-2-768x324.png 768w\" sizes=\"(max-width: 1106px) 100vw, 1106px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-50348 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image010-3.png\" alt=\"\" width=\"1050\" height=\"942\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image010-3.png 1050w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image010-3-300x269.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image010-3-680x610.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image010-3-768x689.png 768w\" sizes=\"(max-width: 1050px) 100vw, 1050px\" \/><\/p>\n<p style=\"text-align: justify;\">\u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053<sup>[2]-[3]<\/sup>\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 5)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-50349 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image011-2.png\" alt=\"\" width=\"1106\" height=\"500\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image011-2.png 1106w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image011-2-300x136.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image011-2-680x307.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/07\/image011-2-768x347.png 768w\" sizes=\"(max-width: 1106px) 100vw, 1106px\" \/><\/p>\n<p style=\"text-align: justify;\">\u603b\u7ed3\uff1a\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u6bb7\u52e4\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u94af\u50ac\u5316\u5916\u6d88\u65cb<em>\u03b1<\/em>-\u70f7\u57fa\u6216\u82b3\u57fa\u53d6\u4ee3\u7684indole-2-acetates\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u73af\u5916\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u5432\u54da\u5549\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u5f02\u7684\u4ea7\u7387\u3001\u975e\u5bf9\u6620\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n<h4 style=\"text-align: justify;\"><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ul style=\"text-align: justify;\">\n<li>[1] Z. Zhang, N. A. Butt, W. Zhang, <em>Chem. Rev. <\/em><strong>2016<\/strong>, <em>116<\/em>, 14769. doi:<a href=\"https:\/\/doi.org\/10.1021\/acs.chemrev.6b00564\">10.1021\/acs.chemrev.6b00564<\/a>.<\/li>\n<li>[2] T. Touge, T. Arai, <em>J. Am. Chem. Soc. <\/em><strong>2016<\/strong>, <em>138<\/em>, 11299. doi:<a href=\"https:\/\/doi.org\/10.1021\/jacs.6b06295\">10.1021\/jacs.6b06295<\/a>.<\/li>\n<li>[3] G. Liu, L. Zheng, K. Tian, H. Wang, L. Chung, X. Zhang, X. Dong, <em>CCS Chem. <\/em><strong>2023<\/strong>, <em>5<\/em>, 1398. doi:<a href=\"https:\/\/doi.org\/10.31635\/ccschem.022.202101643\">10.31635\/ccschem.022.202101643<\/a>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u671f\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u6bb7\u52e4\u8bfe\u9898\u7ec4\u5728J. Am. Chem. Soc.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u94af\u50ac\u5316\u5916\u6d88\u65cb\u03b1-\u70f7\u57fa\u6216\u82b3\u57fa\u53d6\u4ee3\u7684indole-2-acetates\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316 (asymmetric hydrogenation\uff0cAH)\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u73af\u5916\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u5432\u54da\u5549\u5206\u5b50\u7684\u6784\u5efa\uff0c\u6d89\u53ca\u9178\u8f85\u52a9\u52a8\u6001\u52a8\u529b\u5b66\u62c6\u5206(dynamic kinetic resolution\uff0cDKR)\u7684\u8fc7\u7a0b\u3002 Asymmetric Hydrogenation of Racemic 2\u2011Substituted Indoles via Dynamic Kinetic Resolution: An Easy Access to Chiral Indolines Bearing Vicinal Stereogenic Centers N. Rong, A. Zhou, M. Liang, S. Wang, Q. Yin, J. Am. Chem. Soc. 2024, 146, 5081. doi: 10.1021\/jacs.4c00298. \u6b63\u6587\uff1a \u8fd1\u5e74\u6765\uff0c\u57fa\u4e8eDKR\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u662f\u5408\u6210\u5177\u6709\u8fde\u7eed\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u9187\u6216\u80fa\u7684\u91cd\u8981\u65b9\u6cd5[1](Scheme 1a)\u3002\u7136\u800c\uff0c\u6b64\u7c7b\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u4e3b\u8981\u5c40\u9650\u4e8e\u53ef\u70ef\u9187\u5316\u7684\u916e\u6216\u6d3b\u5316\u7684\u4e9a\u80fa\u3002\u540c\u65f6\uff0c\u4e0eN-\u4fdd\u62a4\u7684\u5432\u54da\u76f8\u6bd4\uff0cN-\u975e\u4fdd\u62a4\u5432\u54da\u7684\u76f4\u63a5\u5bf9\u6620\u9009\u62e9\u6027\u6c22\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u76ee\u524d\u5374\u8f83\u5c11\u6709\u76f8\u5173\u7684\u7814\u7a76\u62a5\u9053[2]\uff0c\u5e76\u4e14\u4e3b\u8981\u5f62\u6210\u73af\u5185\u7acb\u4f53\u4e2d\u5fc3(Scheme 1b)\u3002\u8fd9\u91cc\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u6bb7\u52e4\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u94af\u50ac\u5316\u5916\u6d88\u65cb\u03b1-\u70f7\u57fa\u6216\u82b3\u57fa\u53d6\u4ee3\u7684indole-2-acetates\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u73af\u5916\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u5432\u54da\u5549\u5206\u5b50\u7684\u6784\u5efa (Scheme 1d)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528\u5432\u54da\u884d\u751f\u72691a\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528Pd(CF3CO2)2\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cL5\u4f5c\u4e3a\u914d\u4f53\uff0cTFA\u4f5c\u4e3a\u6dfb\u52a0\u5242\uff0cH2 (60 bar)\u4f5c\u4e3a\u8fd8\u539f\u5242\uff0c\u5728DCM\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a\u5ba4\u6e29\uff0c\u6700\u7ec8\u83b7\u5f9789%\u6536\u7387\u7684\u4ea7\u72692a (&gt;20:1 dr\u4ee5\u53ca94% ee)\u3002 \u00a0 \u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u5916\u6d88\u65cb2-\u53d6\u4ee3\u5432\u54da\u5e95\u7269 (Scheme 2)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u4e4b\u540e\uff0c\u8be5\u5c0f\u7ec4\u901a\u8fc7\u5982\u4e0b\u7684\u4e00\u7cfb\u5217\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0c\u8fd9\u4e00\u5168\u65b0\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u7b56\u7565\u5177\u6709\u6f5c\u5728\u7684\u5408\u6210\u5e94\u7528\u4ef7\u503c (Scheme 3)\u3002 \u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u4e0d\u5bf9\u79f0\u6c22\u5316\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76 \u00a0(Scheme 4)\u3002 \u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\u4ee5\u53ca\u524d\u671f\u76f8\u5173\u7684\u6587\u732e\u62a5\u9053[2]-[3]\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Scheme 5)\u3002 \u603b\u7ed3\uff1a\u4e2d\u56fd\u79d1\u5b66\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u6bb7\u52e4\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u94af\u50ac\u5316\u5916\u6d88\u65cb\u03b1-\u70f7\u57fa\u6216\u82b3\u57fa\u53d6\u4ee3\u7684indole-2-acetates\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u5177\u6709\u73af\u5916\u7acb\u4f53\u4e2d\u5fc3\u7684\u624b\u6027\u5432\u54da\u5549\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u5f02\u7684\u4ea7\u7387\u3001\u975e\u5bf9\u6620\u4e0e\u5bf9\u6620\u9009\u62e9\u6027\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] Z. Zhang, N. A. Butt, W. Zhang, Chem. Rev. 2016, 116, 14769. doi:10.1021\/acs.chemrev.6b00564. [2] T. Touge, T. Arai, J. Am. Chem. Soc. 2016, 138, 11299. doi:10.1021\/jacs.6b06295. [3] G. Liu, L. 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