\u6709\u673a\u787c\u5316\u5408\u7269\u5728\u5316\u5b66\u3001\u6750\u6599\u5b66\u3001\u80fd\u6e90\u7814\u7a76\u548c\u836f\u7269\u5316\u5b66\u7b49\u9886\u57df\u4e2d\u5e94\u7528\u5e7f\u6cdb\u3002\u4f5c\u4e3a\u5173\u952e\u5408\u6210\u5207\u5757\uff0c\u6709\u673a\u787c\u5316\u7269\u5728\u5404\u79cd\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u6b64\u5916\uff0cC-B\u952e\u53ef\u4ee5\u901a\u8fc7\u6c27\u5316\u6216\u8d28\u5b50\u5316\u751f\u6210\u76f8\u5e94\u7684\u9187\u7c7b\u548c\u70c3\u7c7b\u5316\u5408\u7269\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u65b9\u6cd5\u6269\u5c55\u4e86\u6709\u673a\u787c\u5316\u5b66\u7684\u5e94\u7528\u8303\u56f4\uff0c\u4f46\u5b83\u4eec\u4e3b\u8981\u96c6\u4e2d\u5728\u787c\u7684\u591a\u6837\u6027\u5b98\u80fd\u56e2\u5316\u4e0a\u3002\u8fd1\u5e74\u6765\uff0c\u787c\u539f\u5b50\u4fdd\u7559\u7684\u6709\u673a\u53cd\u5e94\u53d7\u5230\u4e86\u5e7f\u6cdb\u5173\u6ce8\uff0c\u5176\u4e2d\u787c\u8fc1\u79fb\u7b56\u7565\u662f\u4e00\u79cd\u83b7\u53d6\u4fdd\u7559\u787c\u5316\u5408\u7269\u7684\u4fbf\u6377\u65b9\u6cd5\u3002\u76ee\u524d\uff0c\u867d\u7136\u5173\u4e8e1, 2-\u787c\u8fc1\u79fb\u7684\u62a5\u9053\u5f88\u591a\uff0c\u4f46\u81ea\u7531\u57fa\u8bf1\u5bfc\u76841, 2-\u787c\u8fc1\u79fb\u7814\u7a76\u76f8\u5bf9\u8f83\u5c11\uff0c\u4e14\u4e3b\u8981\u4ee5\u81ea\u7531\u57fa\u52a0\u6210\u548c\u5355\u7535\u5b50\u6c27\u5316\u4e24\u79cd\u7b56\u7565\u5b9e\u73b0\u81ea\u7531\u57fa\u8bf1\u5bfc\u76841, 2-\u787c\u8fc1\u79fb\uff0c\u56e0\u800c\u9650\u5236\u4e86\u8be5\u9886\u57df\u7684\u53d1\u5c55\u3002<\/p>\n

\u6700\u8fd1\uff0c\u6210\u90fd\u5927\u5b66\u674e\u4fca\u9f99\u6559\u6388\u56e2\u961f\u548c\u6210\u90fd\u4e2d\u533b\u836f\u5927\u5b66\u97e9\u6ce2\u6559\u6388\u56e2\u961f\u5408\u4f5c\uff0c\u63d0\u51fa\u4e86\u4e00\u79cd\u521b\u65b0\u7684\u5149\u4fc3\u8fdb<\/strong>NHC<\/strong>\u50ac\u5316\u81ea\u7531\u57fa\u8bf1\u5bfc\u7684<\/strong>1,2-<\/strong>\u787c\u8fc1\u79fb\u9170\u5316\u53cd\u5e94\u3002<\/strong><\/p>\n

\u8fd1\u5e74\u6765\uff0cNHC\u50ac\u5316\u7684\u81ea\u7531\u57fa\u53cd\u5e94\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u8be5\u7814\u7a76\u56e2\u961f\u4e00\u76f4\u81f4\u529b\u4e8eNHC\u6709\u673a\u5c0f\u5206\u5b50\u50ac\u5316\u7684\u81ea\u7531\u57fa\u53cd\u5e94\u7814\u7a76\uff08Nat. Catal. <\/em>2024<\/strong>, <\/em>doi: 10.1038\/s41929-024-01194-5; Angew. Chem. Int. Ed. <\/em>2022<\/strong>, 61,<\/em> e202116629; Angew. Chem. Int. Ed. <\/em>2022<\/strong>, 61,<\/em> e202207824;Angew. Chem. Int. Ed.<\/em>2020<\/strong>, 59, <\/em>1863-1870;Chem. Sci. <\/em>2022<\/strong>, 13, <\/em>2584-2590;ACS Catal. <\/em>2024<\/strong>, 14, <\/em>3181-3190.\uff09\u3002\u5c3d\u7ba1NHC\u50ac\u5316\u7684\u81ea\u7531\u57fa\u53cd\u5e94\u4e0e\u6c22\u539f\u5b50\u8fc1\u79fb\uff08HAT\uff09\u7b56\u7565\u7684\u7ed3\u5408\uff0c\u5df2\u7ecf\u6210\u4e3a\u5f00\u53d1\u5177\u6709\u6311\u6218\u6027\u5316\u5b66\u53cd\u5e94\u7684\u6709\u529b\u5de5\u5177\u3002\u7136\u800c\u9664\u6c22\u539f\u5b50\u5916\uff0c\u76ee\u524d\u5c1a\u65e0\u5173\u4e8eNHC\u50ac\u5316\u4ecb\u5bfc\u7684\u5176\u4ed6\u6742\u539f\u5b50\u57fa\u56e2\u8fc1\u79fb\u7684\u62a5\u9053\u3002\u672c\u9879\u7814\u7a76\u901a\u8fc7\u65b0\u5f00\u53d1\u7684\u5177\u6709\u7f3a\u7535\u5b50\u79bb\u53bb\u57fa\u56e2\u7684\u03b2-\u787c\u9178\u916f\u5e95\u7269\uff0c\u7ecf\u201c\u5355\u7535\u5b50\u8fd8\u539f\u7b56\u7565\u201d\u751f\u6210\u5173\u952e\u7684\u03b2-\u787c\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\uff0c\u968f\u540e\u901a\u8fc71, 2-\u787c\u8fc1\u79fb\u3001\u81ea\u7531\u57fa\u5076\u8054\u751f\u6210\u4e00\u7cfb\u5217\u03b2-\u9170\u57fa\u787c\u5316\u7269\u3002\u8be5\u50ac\u5316\u7b56\u7565\u540c\u6837\u9002\u7528\u4e8e\u836f\u7269\u5206\u5b50\u548c\u6d3b\u6027\u4ea7\u7269\u7684\u540e\u671f\u4fee\u9970\u3002\u901a\u8fc7\u4e00\u7cfb\u5217\u673a\u7406\u5b9e\u9a8c\u548c\u5bc6\u5ea6\u6cdb\u51fd\u7406\u8bba\uff08DFT\uff09\u8ba1\u7b97\uff0c\u7814\u7a76\u4e86\u53cd\u5e94\u7684\u521d\u6b65\u673a\u7406\u3002<\/p>\n

Fig. 1 Backgrounds of this study and research motivation.<\/strong><\/p>\n

\u8be5\u56e2\u961f\u9996\u5148\u4ee5\u5bf9\u6eb4\u82ef\u7532\u919b1a<\/strong>\u548c\u03b2-\u787c\u57fa-N-\u7f9f\u57fa\u90bb\u82ef\u4e8c\u7532\u9170\u4e9a\u80fa\uff08NHPI\uff09\u916f2<\/strong>\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u901a\u8fc7\u6761\u4ef6\u7b5b\u9009\u7ed3\u679c\u8868\u660e\uff1a\u4ee51a<\/strong>\u548cTCNHPI\u916f2b<\/strong>\u4e3a\u5e95\u7269\uff0cPC1<\/strong>\u4e3a\u5149\u50ac\u5316\u5242\uff0cN1<\/strong>\u4e3a\u6c2e\u6742\u73af\u5361\u5bbe\u50ac\u5316\u5242\uff0cCs_{2<\/sub>CO3<\/sub>\u4e3a\u78b1\uff0c\u4e8c\u6c2f\u7532\u70f7\/\u56db\u6c22\u544b\u5583\uff084:1\uff09\u4e3a\u6eb6\u5242\uff0c\u80fd\u591f\u4ee573%\u7684\u4ea7\u7387\u5f97\u52301, 2-\u787c\u8fc1\u79fb\u9170\u57fa\u5316\u4ea7\u72693a<\/strong>\u3002<\/p>\n}

Table 1. Optimization studies.<\/strong><\/p>\n

<\/p>\n

* Isolated yield of3a<\/strong>. \u2020 DCM\/THF = 1\/1. \u2021 DCM\/THF = 3\/2.^{||<\/sup> DCM\/THF = 4\/1. THF: tetrahydrofuran; DCM: dichloromethane; DBU: 1,8-diazabicyclo [5.4.0] undec-7-ene.<\/p>\n}

\u5728\u6700\u4f18\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u53cd\u5e94\u7684\u666e\u9002\u6027\u8fdb\u884c\u4e86\u8003\u5bdf\u3002\u5bf9\u4e8e\u919b\u7c7b\u5e95\u7269\uff0c\u5e26\u6709\u5438\u7535\u5b50\u6216\u4f9b\u7535\u5b50\u53d6\u4ee3\u57fa\u7684\u5bf9\u4f4d\u548c\u95f4\u4f4d\u82ef\u7532\u919b\u90fd\u80fd\u4e0e\u8be5\u50ac\u5316\u4f53\u7cfb\u517c\u5bb9\uff1b\u90bb\u4f4d\u53d6\u4ee3\u7684\u82ef\u7532\u919b\u53cd\u5e94\u4e5f\u80fd\u987a\u5229\u8fdb\u884c\uff1b\u53cc\u53d6\u4ee3\u82b3\u919b\u3001\u7a20\u73af\u82b3\u919b\u548c\u5404\u79cd\u6742\u82b3\u9999\u919b\u540c\u6837\u9002\u7528\u8be5\u50ac\u5316\u4f53\u7cfb\u3002\u4ee5\u8102\u80aa\u919b\u4e3a\u5e95\u7269\u65f6\uff0c\u53cd\u5e94\u4e5f\u80fd\u987a\u5229\u8fdb\u884c\u3002\u5bf9\u4e8e\u03b2-\u787c\u57faTCNHPI\u916f\u7c7b\u5e95\u7269\uff0c\u82b3\u73af\u7684\u5bf9\u4f4d\u3001\u95f4\u4f4d\u6216\u90bb\u4f4d\u5f15\u5165\u5bcc\u7535\u5b50\u6216\u7f3a\u7535\u5b50\u53d6\u4ee3\u57fa\u65f6\uff0c\u8be5\u50ac\u5316\u4f53\u7cfb\u5747\u80fd\u517c\u5bb9\uff1b\u975e\u82c4\u57fa\u7684TCNHPI\u916f\u5e95\u7269\u4e5f\u80fd\u987a\u5229\u53c2\u4e0e\u53cd\u5e94\u3002\u5176\u4ed6\u787c\u6e90\uff08\u5982\uff1aBhex\u3001Bnep\u3001Boct\uff09\u4f5c\u4e3a1, 2-\u787c\u8fc1\u79fb\u7684\u57fa\u56e2\u65f6\uff0c\u540c\u6837\u80fd\u591f\u5f97\u5230\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n

Fig. 2 Substrate scope for the catalytic reactions.<\/strong><\/p>\n

\u8be5\u50ac\u5316\u4f53\u7cfb\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\uff0c\u53ef\u7528\u4e8e\u591a\u79cd\u836f\u7269\u9aa8\u67b6\u548c\u751f\u7269\u6d3b\u6027\u5206\u5b50\u7684\u540e\u671f\u5b98\u80fd\u5316\u3002\u4f8b\u5982\uff0c\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\u4e8c\u6c1f\u5c3c\u67f3\uff08Diflunisal\uff09\u3001\u6258\u9ea6\u6c40\uff08Tolmetin\uff09\u548c\u8418\u666e\u751f\uff08Naproxen\uff09\u3001\u964d\u8102\u7c7b\u836f\u7269\u73af\u4e19\u8d1d\u7279\uff08Ciprofibrate\uff09\u3001\u4ee5\u53ca\u751f\u7269\u6d3b\u6027\u5206\u5b50\u9999\u53f6\u9187\uff08Geraniol\uff09\u3001\u7d2b\u6a80\u82aa\uff08Pterostilbene\uff09\u3001\u59dc\u916e\uff08Zingerone\uff09\u7b49\u3002<\/p>\n

Fig. 3 Late-stage functionalization of the drug-derived or natural product-derived aldehydes.<\/strong><\/p>\n

\u968f\u540e\uff0c\u901a\u8fc7\u653e\u5927\u53cd\u5e94\u548c\u5bf9\u787c\u8fc1\u79fb\u9170\u5316\u4ea7\u7269\u7684\u8fdb\u4e00\u6b65\u8f6c\u5316\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u542b\u787c\u5316\u5408\u7269\u5411\u5404\u79cd\u5b98\u80fd\u56e2\u7684\u884d\u751f\u5316\uff08\u5982\u5076\u8054\u3001\u4e59\u70ef\u57fa\u5316\u3001\u6c27\u5316\u3001\u6c1f\u787c\u9178\u94be\u7b49\uff09\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u6709\u673a\u787c\u5316\u5408\u7269\u7684\u6709\u7528\u6027\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u5229\u7528\u8bfe\u9898\u7ec4\u81ea\u4e3b\u8bbe\u8ba1\u5408\u6210\u7684\u624b\u6027\u567b\u5511\u9393NHC\u50ac\u5316\u5242N6<\/strong>\uff0c\u5bf9\u53cd\u5e94\u7684\u4e0d\u5bf9\u79f0\u63a7\u5236\u8fdb\u884c\u4e86\u521d\u6b65\u63a2\u7d22\uff0c\u53cd\u5e94\u80fd\u4ee5\u4e2d\u7b49\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u52301, 2-\u787c\u8fc1\u79fb\u9170\u5316\u4ea7\u72693a\u3002<\/strong><\/p>\n

Fig. 4 Scale-up reaction, synthetic elaboration, and the attempt for an asymmetric version.<\/strong><\/p>\n

\u4e3a\u4e86\u9610\u660e\u8be51, 2-\u787c\u8fc1\u79fb\u9170\u5316\u7684\u53cd\u5e94\u673a\u7406\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u8be6\u7ec6\u7684\u673a\u7406\u5b9e\u9a8c\u7814\u7a76\u3002\u9996\u5148\uff0c\u901a\u8fc7\u63a7\u5236\u5b9e\u9a8c\u53d1\u73b0\uff0c\u5728\u4e0d\u4f7f\u7528NHC\u50ac\u5316\u5242\u7684\u60c5\u51b5\u4e0b\uff0c\u65e0\u76ee\u6807\u4ea7\u7269\u751f\u6210\u3002\u5728\u5ba4\u6e29\u4e14\u6ca1\u6709\u5149\u50ac\u5316\u5242\u548c\u5149\u7167\u7684\u6761\u4ef6\u4e0b\uff0c\u65e0\u8bba\u662f\u4ee52a<\/strong>\u8fd8\u662f2b<\/strong>\u4e3a\u5e95\u7269\uff0c\u90fd\u65e0\u6cd5\u751f\u6210\u76ee\u6807\u4ea7\u7269\u3002\u572850\u00b0C\u4e14\u6ca1\u6709\u5149\u50ac\u5316\u5242\u548c\u5149\u7167\u7684\u6761\u4ef6\u4e0b\uff0c\u4ee52a<\/strong>\u4e3a\u5e95\u7269\u65f6\u6ca1\u6709\u4ea7\u751f\u4efb\u4f55\u4ea7\u7269\uff0c\u4f46\u4ee52b<\/strong>\u4e3a\u5e95\u7269\u65f6\u751f\u6210\u4e86\u76ee\u6807\u4ea7\u72693a<\/strong>\uff0c\u4ea7\u7387\u4e3a40%\u3002\u901a\u8fc7\u7d2b\u5916-\u53ef\u89c1\u5438\u6536\u5149\u8c31\u5b9e\u9a8c\uff0c\u8bc1\u5b9e\u5149\u50ac\u5316\u8fc7\u7a0b\u662f\u7531\u5149\u50ac\u5316\u5242\u7684\u6fc0\u53d1\u5f15\u53d1\u7684\u3002\u8367\u5149\u6dec\u706d\u5b9e\u9a8c\u8868\u660e\uff0c\u6fc0\u53d1\u6001\u7684PC1<\/strong>\u5f88\u5bb9\u6613\u88ab\u6d3b\u6027\u916f2b<\/strong>\u6dec\u706d\u3002\u901a\u8fc7\u5f00\u5173\u706f\u5b9e\u9a8c\u4ee5\u53ca\u91cf\u5b50\u4ea7\u7387\u7684\u6d4b\u5b9a\uff0c\u663e\u793a\u8be5\u53cd\u5e94\u662f\u50ac\u5316\u81ea\u7531\u57fa\u8fc7\u7a0b\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u6d4b\u5b9a\u4e862b<\/strong>\u7684\u8fd8\u539f\u7535\u4f4d\uff0c\u8868\u660e\u6fc0\u53d1\u6001\u5149\u50ac\u5316\u5242\u4e0e\u6d3b\u6027\u916f2b<\/strong>\u4e4b\u95f4\u7684\u5355\u7535\u5b50\u8f6c\u79fb\u662f\u53ef\u884c\u7684\u3002<\/p>\n

Fig. 5 Experimental mechanistic investigations.<\/strong> (A) Control experiments. (B) UV-vis absorption. (C) Luminescence quenching experiments. * At room temperature. \u2020 At 50^{o<\/sup>C.<\/p>\n}

\u4e3a\u4e86\u66f4\u6df1\u5165\u5730\u7406\u89e3\u8be5\u50ac\u5316\u7b56\u7565\u7684\u673a\u7406\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u901a\u8fc7\u5bc6\u5ea6\u6cdb\u51fd\u7406\u8bba\uff08DFT\uff09\u8ba1\u7b97\uff0c\u7814\u7a76\u4e86\u5404\u53cd\u5e94\u8def\u5f84\u7684\u80fd\u91cf\uff0c\u4e3a\u5149\u4fc3\u8fdb\u7684NHC\u50ac\u5316\u7684\u81ea\u7531\u57fa\u8bf1\u5bfc\u76841, 2-\u787c\u8fc1\u79fb\u9170\u5316\u673a\u7406\u63d0\u4f9b\u4e86\u53ef\u9760\u7684\u4f9d\u636e\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u5408\u7406\u7684\u53cd\u5e94\u9014\u5f84\uff1a\u9996\u5148\uff0c\u5149\u50ac\u5316\u5242\u5728\u5149\u7167\u6761\u4ef6\u4e0b\u88ab\u6fc0\u53d1\uff0c\u968f\u540e\u88ab\u6d3b\u6027\u916f\u6dec\u706d\uff0c\u53d1\u751f\u5355\u7535\u5b50\u8f6c\u79fb\uff0c\u751f\u6210\u70f7\u57fa\u81ea\u7531\u57faIV<\/strong>\u548c\u76f8\u5e94\u7684\u5149\u50ac\u5316\u5242Ir(IV)\u3002\u63a5\u4e0b\u6765\uff0c\u70f7\u57fa\u81ea\u7531\u57faIV<\/strong>\u901a\u8fc71, 2-\u787c\u8fc1\u79fb\uff0c\u8f6c\u5316\u4e3a\u66f4\u7a33\u5b9a\u7684\u81ea\u7531\u57faV<\/strong>\u3002\u540c\u65f6\uff0c\u5728\u78b1\u6027\u6761\u4ef6\u4e0b\uff0c\u919b\u4e0e\u5361\u5bbe\u50ac\u5316\u5242I<\/strong>\u7f29\u5408\u5f62\u6210\u53bb\u8d28\u5b50\u5316\u7684Breslow\u4e2d\u95f4\u4f53II<\/strong>\u3002\u5bcc\u7535\u5b50\u7684Breslow\u4e2d\u95f4\u4f53II<\/strong>\u4e0e\u5149\u50ac\u5316\u5242Ir(IV)\u53d1\u751f\u5355\u7535\u5b50\u8f6c\u79fb\uff0c\u518d\u751fIr(III)\u5149\u50ac\u5316\u5242\uff0c\u5e76\u751f\u6210Breslow\u4e2d\u95f4\u4f53\u884d\u751f\u7684\u916e\u81ea\u7531\u57fa\u7269\u79cdIII<\/strong>\u3002\u53e6\u4e00\u79cd\u53ef\u80fd\u7684\u9014\u5f84\u662f\uff0c\u52a0\u70ed\u6761\u4ef6\u53ef\u4ee5\u4fc3\u8fdbBreslow\u4e2d\u95f4\u4f53II<\/strong>\u548c\u6d3b\u6027\u916f2<\/strong>\u4e4b\u95f4\u7684\u76f4\u63a5\u5355\u7535\u5b50\u8f6c\u79fb\uff0c\u751f\u6210\u70f7\u57fa\u81ea\u7531\u57faIV<\/strong>\uff0c\u7136\u540e\u8f6c\u5316\u4e3a\u66f4\u7a33\u5b9a\u7684\u81ea\u7531\u57faV<\/strong>\u548c\u916e\u81ea\u7531\u57fa\u7269\u79cdIII<\/strong>\u3002\u916e\u81ea\u7531\u57fa\u7269\u79cdIII<\/strong>\u548c\u81ea\u7531\u57faV<\/strong>\u4e4b\u95f4\u53d1\u751f\u81ea\u7531\u57fa-\u81ea\u7531\u57fa\u4ea4\u53c9\u5076\u8054\u3002\u6700\u540e\uff0c\u91ca\u653e\u50ac\u5316\u5242\u5b8c\u6210\u50ac\u5316\u5faa\u73af\uff0c\u540c\u65f6\u751f\u6210\u76ee\u6807\u4ea7\u72693<\/strong>\u3002<\/p>\n

Fig. 6 DFT studies and proposed mechanism of the 1,2-boron migrative acylation.<\/strong><\/p>\n

\u603b\u7ed3\uff1a<\/strong><\/h4>\n

\u7efc\u4e0a\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u201c\u5149\u4fc3\u8fdb\u7684NHC\u81ea\u7531\u57fa\u50ac\u5316\u76841, 2-\u787c\u8fc1\u79fb\u9170\u5316\u201d\u53cd\u5e94\u3002\u901a\u8fc7\u8be5\u50ac\u5316\u7b56\u7565\uff0c\u53ef\u4ee5\u5728\u6e29\u548c\u6761\u4ef6\u4e0b\u5feb\u901f\u83b7\u5f97\u5404\u79cd\u03b2-\u787c\u57fa\u916e\u5316\u5408\u7269\uff0c\u53ef\u8fdb\u4e00\u6b65\u5c06C-B\u952e\u8fdb\u884c\u591a\u6837\u6027\u7684\u8f6c\u5316\u3002\u8be5\u65b9\u6cd5\u53ef\u7528\u4e8e\u836f\u7269\u5206\u5b50\u548c\u5929\u7136\u4ea7\u7269\u7684\u540e\u671f\u4fee\u9970\uff0c\u4f5c\u8005\u8fd8\u63a2\u7d22\u4e86\u8be5\u53cd\u5e94\u7684\u4e0d\u5bf9\u79f0\u7248\u672c\u7684\u53ef\u884c\u6027\uff0c\u5f97\u5230\u4e86\u4e2d\u7b49\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3002\u6700\u540e\uff0c\u4f5c\u8005\u901a\u8fc7\u63a7\u5236\u5b9e\u9a8c\u3001\u5149\u7269\u7406\u5b9e\u9a8c\u548cDFT\u8ba1\u7b97\uff0c\u8fdb\u4e00\u6b65\u9610\u660e\u4e86NHC\u50ac\u53161, 2-\u787c\u8fc1\u79fb\u9170\u5316\u7684\u53cd\u5e94\u673a\u7406\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a \u5bfc\u8bfb\uff1a \u6709\u673a\u787c\u5316\u5408\u7269\u5728\u5316\u5b66\u3001\u6750\u6599\u5b66\u3001\u80fd\u6e90\u7814\u7a76\u548c\u836f\u7269\u5316\u5b66\u7b49\u9886\u57df\u4e2d\u5e94\u7528\u5e7f\u6cdb\u3002\u4f5c\u4e3a\u5173\u952e\u5408\u6210\u5207\u5757\uff0c\u6709\u673a\u787c\u5316\u7269\u5728\u5404\u79cd\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u8fd1\u5e74\u6765\uff0c\u787c\u539f\u5b50\u4fdd\u7559\u7684\u6709\u673a\u53cd\u5e94\u53d7\u5230\u4e86\u5e7f\u6cdb\u5173\u6ce8\uff0c\u5176\u4e2d\u787c\u8fc1\u79fb\u7b56\u7565\u662f\u4e00\u79cd\u83b7\u53d6\u4fdd\u7559\u787c\u5316\u5408\u7269\u7684\u4fbf\u6377\u65b9\u6cd5\u3002\u76ee\u524d\uff0c\u867d\u7136\u5173\u4e8e1, 2-\u787c\u8fc1\u79fb\u7684\u62a5\u9053\u5f88\u591a\uff0c\u4f46\u81ea\u7531\u57fa\u8bf1\u5bfc\u76841, 2-\u787c\u8fc1\u79fb\u7814\u7a76\u76f8\u5bf9\u8f83\u5c11\uff0c\u4e14\u4e3b\u8981\u4ee5\u81ea\u7531\u57fa\u52a0\u6210\u548c\u5355\u7535\u5b50\u6c27\u5316\u4e24\u79cd\u7b56\u7565\u5b9e\u73b0\u81ea\u7531\u57fa\u8bf1\u5bfc\u76841, 2-\u787c\u8fc1\u79fb\uff0c\u56e0\u800c\u9650\u5236\u4e86\u8be5\u9886\u57df\u7684\u53d1\u5c55\u3002\u6700\u8fd1\uff0c\u6210\u90fd\u5927\u5b66\u674e\u4fca\u9f99\u6559\u6388\u56e2\u961f\u548c\u6210\u90fd\u4e2d\u533b\u836f\u5927\u5b66\u97e9\u6ce2\u6559\u6388\u56e2\u961f\u5408\u4f5c\uff0c\u63d0\u51fa\u4e86\u4e00\u79cd\u521b\u65b0\u7684\u5149\u4fc3\u8fdbNHC\u50ac\u5316\u81ea\u7531\u57fa\u8bf1\u5bfc\u76841, 2-\u787c\u8fc1\u79fb\u9170\u5316\u53cd\u5e94\u3002\u5e76\u53d1\u8868\u4e8eScience Advances\u4e0a \u201cN-Heterocyclic carbene catalytic 1,2- boron migrative acylation accelerated by photocatalysis. Hua Huang, Zhao-Yuan Yu, Lu- Yao Han, Yi-Qi Wu, Lu Jiang, Qing- Zhu Li, Wei Huang, Bo Han*, Jun- Long Li* Sci. Adv. 2024, 10, eadn8401. Doi: 10.1126\/sciadv.adn8401\u201d \u6b63\u6587\uff1a \u6709\u673a\u787c\u5316\u5408\u7269\u5728\u5316\u5b66\u3001\u6750\u6599\u5b66\u3001\u80fd\u6e90\u7814\u7a76\u548c\u836f\u7269\u5316\u5b66\u7b49\u9886\u57df\u4e2d\u5e94\u7528\u5e7f\u6cdb\u3002\u4f5c\u4e3a\u5173\u952e\u5408\u6210\u5207\u5757\uff0c\u6709\u673a\u787c\u5316\u7269\u5728\u5404\u79cd\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u6b64\u5916\uff0cC-B\u952e\u53ef\u4ee5\u901a\u8fc7\u6c27\u5316\u6216\u8d28\u5b50\u5316\u751f\u6210\u76f8\u5e94\u7684\u9187\u7c7b\u548c\u70c3\u7c7b\u5316\u5408\u7269\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u65b9\u6cd5\u6269\u5c55\u4e86\u6709\u673a\u787c\u5316\u5b66\u7684\u5e94\u7528\u8303\u56f4\uff0c\u4f46\u5b83\u4eec\u4e3b\u8981\u96c6\u4e2d\u5728\u787c\u7684\u591a\u6837\u6027\u5b98\u80fd\u56e2\u5316\u4e0a\u3002\u8fd1\u5e74\u6765\uff0c\u787c\u539f\u5b50\u4fdd\u7559\u7684\u6709\u673a\u53cd\u5e94\u53d7\u5230\u4e86\u5e7f\u6cdb\u5173\u6ce8\uff0c\u5176\u4e2d\u787c\u8fc1\u79fb\u7b56\u7565\u662f\u4e00\u79cd\u83b7\u53d6\u4fdd\u7559\u787c\u5316\u5408\u7269\u7684\u4fbf\u6377\u65b9\u6cd5\u3002\u76ee\u524d\uff0c\u867d\u7136\u5173\u4e8e1, 2-\u787c\u8fc1\u79fb\u7684\u62a5\u9053\u5f88\u591a\uff0c\u4f46\u81ea\u7531\u57fa\u8bf1\u5bfc\u76841, 2-\u787c\u8fc1\u79fb\u7814\u7a76\u76f8\u5bf9\u8f83\u5c11\uff0c\u4e14\u4e3b\u8981\u4ee5\u81ea\u7531\u57fa\u52a0\u6210\u548c\u5355\u7535\u5b50\u6c27\u5316\u4e24\u79cd\u7b56\u7565\u5b9e\u73b0\u81ea\u7531\u57fa\u8bf1\u5bfc\u76841, 2-\u787c\u8fc1\u79fb\uff0c\u56e0\u800c\u9650\u5236\u4e86\u8be5\u9886\u57df\u7684\u53d1\u5c55\u3002 \u6700\u8fd1\uff0c\u6210\u90fd\u5927\u5b66\u674e\u4fca\u9f99\u6559\u6388\u56e2\u961f\u548c\u6210\u90fd\u4e2d\u533b\u836f\u5927\u5b66\u97e9\u6ce2\u6559\u6388\u56e2\u961f\u5408\u4f5c\uff0c\u63d0\u51fa\u4e86\u4e00\u79cd\u521b\u65b0\u7684\u5149\u4fc3\u8fdbNHC\u50ac\u5316\u81ea\u7531\u57fa\u8bf1\u5bfc\u76841,2-\u787c\u8fc1\u79fb\u9170\u5316\u53cd\u5e94\u3002 \u8fd1\u5e74\u6765\uff0cNHC\u50ac\u5316\u7684\u81ea\u7531\u57fa\u53cd\u5e94\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u8be5\u7814\u7a76\u56e2\u961f\u4e00\u76f4\u81f4\u529b\u4e8eNHC\u6709\u673a\u5c0f\u5206\u5b50\u50ac\u5316\u7684\u81ea\u7531\u57fa\u53cd\u5e94\u7814\u7a76\uff08Nat. Catal. 2024, doi: 10.1038\/s41929-024-01194-5; Angew. Chem. Int. Ed. 2022, 61, e202116629; Angew. Chem. Int. Ed. 2022, 61, e202207824; Angew. Chem. Int. Ed. 2020, 59, 1863-1870; Chem. Sci. 2022, 13, 2584-2590; ACS Catal. 2024, 14, 3181-3190.\uff09\u3002\u5c3d\u7ba1NHC\u50ac\u5316\u7684\u81ea\u7531\u57fa\u53cd\u5e94\u4e0e\u6c22\u539f\u5b50\u8fc1\u79fb\uff08HAT\uff09\u7b56\u7565\u7684\u7ed3\u5408\uff0c\u5df2\u7ecf\u6210\u4e3a\u5f00\u53d1\u5177\u6709\u6311\u6218\u6027\u5316\u5b66\u53cd\u5e94\u7684\u6709\u529b\u5de5\u5177\u3002\u7136\u800c\u9664\u6c22\u539f\u5b50\u5916\uff0c\u76ee\u524d\u5c1a\u65e0\u5173\u4e8eNHC\u50ac\u5316\u4ecb\u5bfc\u7684\u5176\u4ed6\u6742\u539f\u5b50\u57fa\u56e2\u8fc1\u79fb\u7684\u62a5\u9053\u3002\u672c\u9879\u7814\u7a76\u901a\u8fc7\u65b0\u5f00\u53d1\u7684\u5177\u6709\u7f3a\u7535\u5b50\u79bb\u53bb\u57fa\u56e2\u7684\u03b2-\u787c\u9178\u916f\u5e95\u7269\uff0c\u7ecf\u201c\u5355\u7535\u5b50\u8fd8\u539f\u7b56\u7565\u201d\u751f\u6210\u5173\u952e\u7684\u03b2-\u787c\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\uff0c\u968f\u540e\u901a\u8fc71, 2-\u787c\u8fc1\u79fb\u3001\u81ea\u7531\u57fa\u5076\u8054\u751f\u6210\u4e00\u7cfb\u5217\u03b2-\u9170\u57fa\u787c\u5316\u7269\u3002\u8be5\u50ac\u5316\u7b56\u7565\u540c\u6837\u9002\u7528\u4e8e\u836f\u7269\u5206\u5b50\u548c\u6d3b\u6027\u4ea7\u7269\u7684\u540e\u671f\u4fee\u9970\u3002\u901a\u8fc7\u4e00\u7cfb\u5217\u673a\u7406\u5b9e\u9a8c\u548c\u5bc6\u5ea6\u6cdb\u51fd\u7406\u8bba\uff08DFT\uff09\u8ba1\u7b97\uff0c\u7814\u7a76\u4e86\u53cd\u5e94\u7684\u521d\u6b65\u673a\u7406\u3002 Fig. 1 Backgrounds of this study and research motivation. \u8be5\u56e2\u961f\u9996\u5148\u4ee5\u5bf9\u6eb4\u82ef\u7532\u919b1a\u548c\u03b2-\u787c\u57fa-N-\u7f9f\u57fa\u90bb\u82ef\u4e8c\u7532\u9170\u4e9a\u80fa\uff08NHPI\uff09\u916f2\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u901a\u8fc7\u6761\u4ef6\u7b5b\u9009\u7ed3\u679c\u8868\u660e\uff1a\u4ee51a\u548cTCNHPI\u916f2b\u4e3a\u5e95\u7269\uff0cPC1\u4e3a\u5149\u50ac\u5316\u5242\uff0cN1\u4e3a\u6c2e\u6742\u73af\u5361\u5bbe\u50ac\u5316\u5242\uff0cCs2CO3\u4e3a\u78b1\uff0c\u4e8c\u6c2f\u7532\u70f7\/\u56db\u6c22\u544b\u5583\uff084:1\uff09\u4e3a\u6eb6\u5242\uff0c\u80fd\u591f\u4ee573%\u7684\u4ea7\u7387\u5f97\u52301, 2-\u787c\u8fc1\u79fb\u9170\u57fa\u5316\u4ea7\u72693a\u3002 Table 1. 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