{"id":51039,"date":"2024-08-28T08:00:00","date_gmt":"2024-08-28T00:00:00","guid":{"rendered":"\/\/www.gsbet888.com\/?p=51039"},"modified":"2024-08-28T08:02:13","modified_gmt":"2024-08-28T00:02:13","slug":"%e3%80%8cspotlight-research%e3%80%8d%e4%ba%ba%e5%b7%a5%e6%90%ad%e5%bb%ba%e8%87%aa%e7%94%b1%e5%9f%ba%e7%8e%af%e5%8c%96%e9%85%b6","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/interview\/2024\/08\/%e3%80%8cspotlight-research%e3%80%8d%e4%ba%ba%e5%b7%a5%e6%90%ad%e5%bb%ba%e8%87%aa%e7%94%b1%e5%9f%ba%e7%8e%af%e5%8c%96%e9%85%b6.html","title":{"rendered":"\u300cSpotlight Research\u300d\u4eba\u5de5\u642d\u5efa\u81ea\u7531\u57fa\u73af\u5316\u9176"},"content":{"rendered":"

\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/strong><\/p>\n

\u672c\u671f\u70ed\u70b9\u7814\u7a76\uff0c\u6211\u4eec\u9080\u8bf7\u5230\u4e86\u672c\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u6765\u81ea\u5df4\u585e\u5c14\u5927\u5b66\u7684\u535a\u58eb\u751f\u9648\u680b\u840d\u4e3a\u6211\u4eec\u5206\u4eab\u3002<\/p>\n

2024\u5e747\u670819\u65e5\uff0c Nature Chemistry<\/em>\u5728\u7ebf\u53d1\u8868\u4e86\u6765\u81ea\u745e\u58eb\u5df4\u585e\u5c14\u5927\u5b66\u7684Thomas R. Ward\u6559\u6388\u8bfe\u9898\u7ec4\u9898\u4e3a\u300cAn Evolved Artificial Radical Cyclase Enables the Construction of Bicyclic Terpenoid Scaffolds via an H-Atom Transfer Pathway\u300d\u7684\u7814\u7a76\u8bba\u6587\u3002\u57fa\u4e8e\u751f\u7269\u7d20\u548c\u94fe\u9709\u4eb2\u548c\u7d20\u7684\u5f3a\u4eb2\u548c\u529b\uff0c\u4f5c\u8005\u901a\u8fc7\u5728\u5de5\u7a0b\u5316\u6539\u9020\u7684\u5d4c\u5408\u94fe\u9709\u4eb2\u548c\u7d20\u4e2d\u951a\u5b9a\u751f\u7269\u7d20[Co(schiff-base)] \u7684\u4eba\u9020\u8f85\u56e0\u5b50\u800c\u6784\u5efa\u4e86\u4eba\u5de5\u81ea\u7531\u57fa\u73af\u5316\u9176\uff08ARCase\uff09\u3002\u7ecf\u8fc7\u8ba1\u7b97\u8f85\u52a9\u7684\u86cb\u767d\u6539\u9020\u4ee5\u53ca\u4e24\u8f6e\u5b9a\u5411\u8fdb\u5316\u83b7\u5f97\u7684\u6700\u4f73\u7a81\u53d8\u4f53\u53ef\u4ee5\u987a\u5229\u5730\u50ac\u5316\u81ea\u7531\u57fa\u73af\u5316\u53cd\u5e94\uff0c\u4e00\u6b65\u5408\u6210\u5177\u6709cis<\/em>-5-6-\u7a20\u73af\u7ed3\u6784\u548c\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u7684\u53cc\u73af\u4ea7\u7269\u3002QM\/MM\u8ba1\u7b97\u4ee5\u53ca\u5355\u6676\u7ed3\u6784\u8bc1\u660e\u7a81\u53d8\u5f15\u5165\u7684\u7ec4\u6c28\u9178\u6b8b\u57fa\u4e0e\u50ac\u5316\u4e2d\u5fc3\u7684\u94b4\u539f\u5b50\u5177\u6709\u914d\u4f4d\u4f5c\u7528\u3002\u901a\u8fc7\u5bf9\u53cd\u5e94\u8fc7\u7a0b\u7684\u5b9e\u65f6\u76d1\u6d4b\uff0c\u63ed\u9732\u4e86ARCase \u6210\u529f\u5730\u50ac\u5316\u4e86\u4e00\u4e2a\u5305\u542b\u4e24\u6b65\u53cd\u5e94\u7684\u7ea7\u8054\u8fc7\u7a0b\uff0c\u5373\u94b4\u6c22\u4ecb\u5bfc\u7684\u81ea\u7531\u57fa\u73af\u5316\u548c\u5171\u8f6d\u8fd8\u539f\u53cd\u5e94\u3002\u6b64\u5916\uff0cARCase\u5bf9\u4e8c\u70ef\u916e\u5e95\u7269\u7684\u53d8\u5316\u8868\u73b0\u51fa\u8f83\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u4e14\u7ed3\u5408\u5316\u5b66\u5408\u6210\u4e0e\u9176\u5408\u6210\u7b56\u7565\uff0c\u53ef\u4ee5\u5feb\u901f\u5b9e\u73b0\u841c\u7c7b\u5316\u5408\u7269\u4e2d\u7684\u4e09\u73af\u9aa8\u67b6\u7684\u624b\u6027\u6784\u5efa\uff0c \u5c55\u793a\u4e86\u5176\u5728\u590d\u6742\u841c\u7c7b\u5316\u5408\u7269\u751a\u81f3\u836f\u7269\u5206\u5b50\u5408\u6210\u4e2d\u7684\u6f5c\u529b\u3002<\/p>\n

\n

\u201cAn Evolved Artificial Radical Cyclase Enables the Construction of Bicyclic Terpenoid Scaffolds via an H-Atom Transfer Pathway.<\/p>\n

Dongping Chen\u2021, Xiang Zhang\u2021 Anastassia Andreevna Vorobieva, Ryo Tachibana, Alina Stein, Roman P. Jakob, Zhi Zou, Damian Alexander Graf, Ang Li, Timm Maier, Bruno E. Correia*, Thomas R. Ward*<\/p>\n

Nat.Chem.<\/em>\u00a02024<\/strong>. Doi: 10.1038\/s41557-024-01562-5\u201d<\/a><\/p>\n<\/blockquote>\n

\"\"<\/p>\n

Q1. <\/strong>\u8bf7\u5bf9<\/strong>\u201cAn Evolved Artificial Radical Cyclase Enables the Construction of Bicyclic Terpenoid Scaffolds via an H-Atom Transfer Pathway\u201d<\/strong>\u4f5c<\/strong>\u4e00\u4e2a\u7b80\u5355\u4ecb\u7ecd\u3002<\/strong><\/h4>\n

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Q3.<\/strong>\u672c\u6b21\u7814\u7a76\u4e3b\u4f53\uff0c\u6709\u6ca1\u6709\u4ec0\u4e48\u8ba9\u60a8\u611f\u89c9\u7279\u522b\u8f9b\u82e6\u548c\u70e7\u8111\u5462\uff1f<\/strong><\/h4>\n

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Q4. <\/strong>\u5c06\u6765\u60f3\u7ee7\u7eed\u7814\u7a76\u5316\u5b66\u7684\u54ea\u4e2a\u65b9\u5411\u5462\uff1f<\/strong><\/h4>\n

\u76ee\u524d\uff0c\u535a\u58eb\u5373\u5c06\u6bd5\u4e1a\u3002\u5e0c\u671b\u4ee5\u540e\u80fd\u591f\u4ece\u4e8b\u4eba\u5de5\u91d1\u5c5e\u9176\uff0c\u86cb\u767d\u8bbe\u8ba1\uff0c\u5408\u6210\u751f\u7269\u5b66\u7684\u76f8\u5173\u5de5\u4f5c\u3002<\/p>\n

Q5. <\/strong>\u6700\u540e\uff0c\u6709\u4ec0\u4e48\u60f3\u5bf9\u5404\u4f4d\u8bfb\u8005\u8bf4\u7684\u5417\uff1f<\/strong><\/h4>\n

\u79d1\u5b66\u7814\u7a76\u662f\u4e00\u4e2a\u9700\u8981\u4e0d\u65ad\u8bd5\u9519\u3001\u4e0d\u65ad\u63a2\u7d22\u7684\u65c5\u9014\uff0c\u5927\u90e8\u5206\u65f6\u95f4\u5e76\u4e0d\u4e00\u5b9a\u80fd\u591f\u5982\u5df1\u6240\u613f\uff0c\u4f46\u8d35\u5728\u575a\u6301\uff0c\u6211\u4eec\u53ef\u4ee5\u4ece\u8fd9\u4e2a\u65c5\u9014\u4e2d\u5f97\u5230\u591a\u4e2a\u7ef4\u5ea6\u7684\u8bad\u7ec3\uff0c\u800c\u8fd9\u4e9b\u7ecf\u9a8c\u6559\u8bad\u5bf9\u4ee5\u540e\u7684\u7814\u7a76\u5de5\u4f5c\u6765\u8bf4\u662f\u4e00\u4e2a\u5b9d\u8d35\u7684\u8d22\u5bcc\u3002\u6211\u5f88\u611f\u6fc0\u5728\u8fd9\u4e2a\u9879\u76ee\u7684\u63a2\u7d22\u8fc7\u7a0b\u4e2d\uff0c\u6211\u7684\u5bfc\u5e08Prof. Thomas R. Ward\u5bf9\u6211\u7684\u8010\u5fc3\u6307\u5bfc\uff0c\u65e0\u6761\u4ef6\u5730\u652f\u6301\u548c\u6781\u5927\u7684\u9f13\u52b1\uff0c\u4fc3\u4f7f\u6211\u5feb\u901f\u6210\u957f\u5e76\u79ef\u6781\u63a8\u52a8\u8bfe\u9898\u524d\u8fdb\u3002\u5f88\u611f\u6fc0\u6211\u4eec\u56e2\u961f\u91cc\u7684\u6bcf\u4e00\u4e2a\u6210\u5458\u7684\u52aa\u529b\uff0c\u4ed6\u4eec\u4e5f\u4e3a\u8fd9\u4efd\u5de5\u4f5c\u7684\u53d1\u8868\u505a\u51fa\u4e86\u5de8\u5927\u8d21\u732e\u3002\u8fd9\u4efd\u5de5\u4f5c\u5c06\u4f1a\u6210\u4e3a\u6211\u7684\u4e2a\u4eba\u6210\u957f\u548c\u804c\u4e1a\u53d1\u5c55\u4e2d\u975e\u5e38\u91cd\u8981\u7684\u7ecf\u5386\u3002<\/p>\n

\u4f5c\u8005\u6559\u80b2\u80cc\u666f\u7b80\u4ecb<\/strong><\/h4>\n

\"\"<\/strong><\/p>\n

\u6559\u80b2\u80cc\u666f\uff1a<\/strong><\/h4>\n

2020.08-\u73b0\u5728\uff0c\u535a\u58eb\u5728\u8bfb\uff0c\u5df4\u585e\u5c14\u5927\u5b66\uff0c Prof. Thomas R Ward<\/p>\n

2014.09-2017.07\uff0c \u7855\u58eb\uff0c\u4e0a\u6d77\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\uff0c \u6c64\u6587\u519b\u7814\u7a76\u5458<\/p>\n

2010.09-2014.06\uff0c\u5b66\u58eb\uff0c\u5357\u4eac\u5de5\u4e1a\u5927\u5b66<\/p>\n

\u83b7\u5956\u7ecf\u5386\uff1a<\/strong><\/h4>\n

2024\uff0c Swiss Chemistry Travel Award<\/p>\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a \u672c\u671f\u70ed\u70b9\u7814\u7a76\uff0c\u6211\u4eec\u9080\u8bf7\u5230\u4e86\u672c\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u6765\u81ea\u5df4\u585e\u5c14\u5927\u5b66\u7684\u535a\u58eb\u751f\u9648\u680b\u840d\u4e3a\u6211\u4eec\u5206\u4eab\u3002 2024\u5e747\u670819\u65e5\uff0c Nature Chemistry\u5728\u7ebf\u53d1\u8868\u4e86\u6765\u81ea\u745e\u58eb\u5df4\u585e\u5c14\u5927\u5b66\u7684Thomas R. Ward\u6559\u6388\u8bfe\u9898\u7ec4\u9898\u4e3a\u300cAn Evolved Artificial Radical Cyclase Enables the Construction of Bicyclic Terpenoid Scaffolds via an H-Atom Transfer Pathway\u300d\u7684\u7814\u7a76\u8bba\u6587\u3002\u57fa\u4e8e\u751f\u7269\u7d20\u548c\u94fe\u9709\u4eb2\u548c\u7d20\u7684\u5f3a\u4eb2\u548c\u529b\uff0c\u4f5c\u8005\u901a\u8fc7\u5728\u5de5\u7a0b\u5316\u6539\u9020\u7684\u5d4c\u5408\u94fe\u9709\u4eb2\u548c\u7d20\u4e2d\u951a\u5b9a\u751f\u7269\u7d20[Co(schiff-base)] \u7684\u4eba\u9020\u8f85\u56e0\u5b50\u800c\u6784\u5efa\u4e86\u4eba\u5de5\u81ea\u7531\u57fa\u73af\u5316\u9176\uff08ARCase\uff09\u3002\u7ecf\u8fc7\u8ba1\u7b97\u8f85\u52a9\u7684\u86cb\u767d\u6539\u9020\u4ee5\u53ca\u4e24\u8f6e\u5b9a\u5411\u8fdb\u5316\u83b7\u5f97\u7684\u6700\u4f73\u7a81\u53d8\u4f53\u53ef\u4ee5\u987a\u5229\u5730\u50ac\u5316\u81ea\u7531\u57fa\u73af\u5316\u53cd\u5e94\uff0c\u4e00\u6b65\u5408\u6210\u5177\u6709cis-5-6-\u7a20\u73af\u7ed3\u6784\u548c\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u7684\u53cc\u73af\u4ea7\u7269\u3002QM\/MM\u8ba1\u7b97\u4ee5\u53ca\u5355\u6676\u7ed3\u6784\u8bc1\u660e\u7a81\u53d8\u5f15\u5165\u7684\u7ec4\u6c28\u9178\u6b8b\u57fa\u4e0e\u50ac\u5316\u4e2d\u5fc3\u7684\u94b4\u539f\u5b50\u5177\u6709\u914d\u4f4d\u4f5c\u7528\u3002\u901a\u8fc7\u5bf9\u53cd\u5e94\u8fc7\u7a0b\u7684\u5b9e\u65f6\u76d1\u6d4b\uff0c\u63ed\u9732\u4e86ARCase \u6210\u529f\u5730\u50ac\u5316\u4e86\u4e00\u4e2a\u5305\u542b\u4e24\u6b65\u53cd\u5e94\u7684\u7ea7\u8054\u8fc7\u7a0b\uff0c\u5373\u94b4\u6c22\u4ecb\u5bfc\u7684\u81ea\u7531\u57fa\u73af\u5316\u548c\u5171\u8f6d\u8fd8\u539f\u53cd\u5e94\u3002\u6b64\u5916\uff0cARCase\u5bf9\u4e8c\u70ef\u916e\u5e95\u7269\u7684\u53d8\u5316\u8868\u73b0\u51fa\u8f83\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u4e14\u7ed3\u5408\u5316\u5b66\u5408\u6210\u4e0e\u9176\u5408\u6210\u7b56\u7565\uff0c\u53ef\u4ee5\u5feb\u901f\u5b9e\u73b0\u841c\u7c7b\u5316\u5408\u7269\u4e2d\u7684\u4e09\u73af\u9aa8\u67b6\u7684\u624b\u6027\u6784\u5efa\uff0c \u5c55\u793a\u4e86\u5176\u5728\u590d\u6742\u841c\u7c7b\u5316\u5408\u7269\u751a\u81f3\u836f\u7269\u5206\u5b50\u5408\u6210\u4e2d\u7684\u6f5c\u529b\u3002 \u201cAn Evolved Artificial Radical Cyclase Enables the Construction of Bicyclic Terpenoid Scaffolds via an H-Atom Transfer Pathway. 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