{"id":51291,"date":"2024-09-20T08:46:00","date_gmt":"2024-09-20T00:46:00","guid":{"rendered":"\/\/www.gsbet888.com\/?p=51291"},"modified":"2024-09-20T08:46:00","modified_gmt":"2024-09-20T00:46:00","slug":"%e6%b0%a7%e5%8c%96%e8%83%ba%e7%9a%84%e6%80%a7%e8%b4%a8%e4%bb%a5%e5%8f%8a%e5%9c%a8%e5%88%9b%e8%8d%af%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/molecule\/2024\/09\/%e6%b0%a7%e5%8c%96%e8%83%ba%e7%9a%84%e6%80%a7%e8%b4%a8%e4%bb%a5%e5%8f%8a%e5%9c%a8%e5%88%9b%e8%8d%af%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8.html","title":{"rendered":"\u6c27\u5316\u80fa\u7684\u6027\u8d28\u4ee5\u53ca\u5728\u521b\u836f\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"

\u8bd1\u81eaChem-Station\u7f51\u7ad9\u65e5\u672c\u7248 \u539f\u6587\u94fe\u63a5\uff1aN-\u30aa\u30ad\u30b7\u30c9\u306e\u6027\u8cea\u3068\u5275\u85ac\u306b\u304a\u3051\u308b\u6d3b\u7528 <\/a><\/p>\n

\u7ffb\u8bd1\uff1a\u70b8\u9e21<\/p>\n

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\u4eca\u5929\u6765\u770b\u770bJ. Med. Chem\u6742\u5fd7\u520a\u767b\u7684\u4e00\u7bc7\u5f00\u653e\u83b7\u53d6\u7efc\u8ff0 \u201cMedicinal Chemistry of Drugs with\u2002N<\/em>-Oxide Functionalities<\/a>\u201d \u3002<\/p>\n

\u8bba\u6587\u6982\u8981<\/h4>\n

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\u6c27\u5316\u80fa\u662f\u4ec0\u4e48\uff1f<\/h4>\n

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\"\"\u56fe<\/strong> 1 <\/strong>\u6c27\u5316\u80fa\u7684\u79cd\u7c7b\u4ee5\u53ca\u5176\u4ed6<\/strong>\u6c27\u5316\u6c2e\u5316\u7269<\/strong><\/p>\n

(\u539f\u8bba\u6587 Fig. 1)<\/p>\n

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\u6c27\u5316\u80fa\u7684\u5316\u5b66\u7279\u5f81<\/h4>\n

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(\u539f\u8bba\u6587 Fig. 2)<\/p>\n

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(\u539f\u8bba\u6587 Fig. 3)<\/p>\n

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(\u539f\u8bba\u6587 Fig. 4)<\/p>\n

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\"\"<\/p>\n

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(\u539f\u8bba\u6587 Fig. 6)<\/p>\n

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(\u6765\u81ea\u8bba\u6587Fig. 7)<\/p>\n

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\u5176\u4ed6\u5177\u6709\u751f\u7406\u6d3b\u6027\u7684\u6c27\u5316\u80fa\u5305\u62ecCarbadox\u548cOlaquindox\uff08\u56fe7 \u5de6\u548c\u4e2d\u592e\uff09\u3002\u8fd9\u4e9b\u662f\u5929\u7136\u4ea7\u7269\u5982\u4e54\u6797\u5b81<\/u>\u548c\u9ecf\u83cc\u7d20\u7684\u884d\u751f\u7269\u3002\u5b83\u4eec\u4e00\u76f4\u5728\u517d\u533b\u5b66\u9886\u57df\u5f53\u4f5c\u4fc3\u8fdb\u5bb6\u755c\u751f\u957f\u7684\u9972\u6599\u6dfb\u52a0\u5242\u3002\u8fd9\u4e9b\u836f\u7269\u90fd\u901a\u8fc7\u6291\u5236\u52a8\u7269\u6d88\u5316\u9053\u5185\u75c5\u539f\u6027\u7ec6\u83cc\u7684\u589e\u6b96\u6765\u4fc3\u8fdb\u751f\u957f\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u6709\u62a5\u544a\u6307\u51faOlaquindox\u4f1a\u5f15\u8d77\u5149\u654f\u6027\u53cd\u5e94\u3002\u867d\u7136\u8fd9\u4e24\u79cd\u836f\u7269\u7684\u4f5c\u7528\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u660e\u4e86\uff0c\u4f46\u666e\u904d\u8ba4\u4e3a\u5176\u6297\u83cc\u6d3b\u6027\u53ef\u80fd\u4e0e\u8fd8\u539f\u6027\u7684\u6d3b\u5316\u8fc7\u7a0b\u53ca\u53cd\u5e94\u6027\u81ea\u7531\u57fa\u7684\u5f62\u6210\u6709\u5173\u30024-\u4e19\u6c28\u9170\u5421\u5576-N-\u6c27\u5316\u7269\uff08\u56fe7 \u53f3\uff09\u4e5f\u88ab\u62a5\u9053\u5177\u6709\u6297\u83cc\u6d3b\u6027\uff0c\u636e\u4fe1\u5176\u6297\u83cc\u6d3b\u6027\u662f\u901a\u8fc7\u6291\u5236\u6240\u8c13\u7684\u7fa4\u4f53\u611f\u5e94\uff08Quorum Sensing\uff09\u73b0\u8c61\u6765\u5b9e\u73b0\u7684\uff0c\u4f46\u5176\u5177\u4f53\u7684\u4f5c\u7528\u673a\u5236\u4ecd\u4e0d\u660e\u786e\u3002\"\"<\/p>\n

\u56fe<\/strong>7 <\/strong>\u6709\u82b3\u9999\u65cf\u6c27\u5316\u80fa\u7ed3\u6784\u7684\u6297\u83cc\u836f<\/strong><\/p>\n

(\u6765\u81ea\u8bba\u6587Fig. 8)<\/p>\n

\"\"\u56fe<\/strong>8 <\/strong>\u4e09\u73af\u7c7b\u6297\u6291\u90c1\u836f\u7684\u6c27\u5316\u80fa\u578b\u4ee3\u8c22\u7269<\/strong><\/p>\n

(\u6765\u81ea\u8bba\u6587 \u00a0Fig. 9)<\/p>\n

\u6b64\u5916\uff0c\u68c0\u6d4b\u5230\u4e09\u7ea7\u80fa\u6216\u542b\u6c2e\u82b3\u9999\u73af\u7684\u4e3b\u8981\u751f\u7269\u4f53\u5185\u4ee3\u8c22\u7269\u4e5f\u662f\u6c27\u5316\u80fa\u3002\u5f53\u6bcd\u4f53\u88ab\u6c27\u5316\u6210\u6c27\u5316\u80fa\u540e\uff0c\u542b\u6709\u6c27\u5316\u80fa\u8f83\u6bcd\u4f53\u5316\u5408\u7269\u7684\u6c34\u6eb6\u6027\u4f1a\u4e0a\u5347\uff0c\u66f4\u6613\u88ab\u6392\u6cc4\u51fa\u6765\u3002\u4f8b\u5982\u4f5c\u4e3a\u4e09\u73af\u7c7b\u6297\u6291\u90c1\u836f\u7684\u7c73\u5e15\u660e(Melipramine)\u548c\u963f\u7c73\u66ff\u6797(Amitriptyline)\u5728\u9ec4\u7d20\u5355\u6c27\u5316\u9176\uff08FMO\uff09\u7684\u6c27\u5316\u4f5c\u7528\u4e0b\uff0c\u5206\u522b\u53d8\u6210\u4e86\u56fe8\u4e2d\u7684\u4e24\u4e2a\u6c27\u5316\u80fa\u3002\u56fe8\u4e2d\u4e24\u4e2a\u6c27\u5316\u4ea7\u7269\u7686\u6bd4\u5404\u81ea\u7684\u6bcd\u4f53\u5316\u5408\u7269\u836f\u6548\u5feb\uff0c\u526f\u4f5c\u7528(\u55dc\u7761\u3001\u9547\u9759\u3001\u53e3\u5e72\u3001\u51fa\u6c57\u3001\u5934\u6655\u7b49)\u5c11\u3002\u8fd9\u4e9b\u6c27\u5316\u80fa\u6709\u65f6\u8fd8\u4f1a\u901a\u8fc7\u8fd8\u539f\u4ee3\u8c22\u8f6c\u5316\u4e3a\u6bcd\u4f53\u5316\u5408\u7269\u7684\u80fa\uff0c\u4f5c\u4e3a\u524d\u836f\u7684\u4f7f\u7528\u53ef\u80fd\u6027\u4e5f\u6b63\u5728\u7814\u7a76\u4e2d\u3002<\/p>\n

\u8865\u5145<\/h4>\n

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\u7ed3\u675f\u8bed<\/h4>\n

\u539f\u8bba\u6587\u00a0\u201cMedicinal Chemistry of Drugs with\u2002N-Oxide Functionalities\u201d\u662f\u5f00\u53d1\u8d44\u6e90\uff0c\u5bf9\u8bba\u6587\u6709\u5174\u8da3\u7684\u8bfb\u8005\u8bf7\u4e00\u5b9a\u8981\u9605\u8bfb\u539f\u6587\u3002\u7b14\u8005\u4e2a\u4eba\u7684\u8bfb\u540e\u611f\u662f\u867d\u7136\u6c27\u5316\u80fa\u7684\u6f5c\u5728\u6bd2\u6027\u548c\u5728\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u4e2d\u7684\u4e0d\u7a33\u5b9a\u6027\u8ba9\u521b\u836f\u7814\u7a76\u5bf9\u5b83\u6709\u6240\u987e\u8651\uff0c\u4f46\u4e0d\u53ef\u5426\u8ba4\u7684\u662f\u82e5\u662f\u8fd0\u7528\u6c27\u5316\u80fa\u5f97\u5f53\uff0c\u4f1a\u8ba9\u6c27\u5316\u80fa\u53d1\u6325\u51fa\u610f\u60f3\u4e0d\u5230\u7684\u6548\u679c\uff0c\u5f85\u5f7b\u5e95\u5f04\u6e05\u6c27\u5316\u80fa\u7684\u6027\u8d28\u548c\u5408\u6210\u65b9\u6cd5\u540e\uff0c\u6c27\u5316\u80fa\u6216\u8bb8\u4f1a\u6210\u4e3a\u4e00\u5458”\u731b\u5c06”\u3002<\/p>\n

\u8bf7\u767b\u9646TCI\u8bd5\u5242\u5b98\u7f51\u67e5\u770b\u66f4\u591a\u5185\u5bb9<\/h5>\n
https:\/\/www.tcichemicals.com\/CN\/zh\/<\/h5>\n","protected":false},"excerpt":{"rendered":"\u8bd1\u81eaChem-Station\u7f51\u7ad9\u65e5\u672c\u7248 \u539f\u6587\u94fe\u63a5\uff1aN-\u30aa\u30ad\u30b7\u30c9\u306e\u6027\u8cea\u3068\u5275\u85ac\u306b\u304a\u3051\u308b\u6d3b\u7528 \u7ffb\u8bd1\uff1a\u70b8\u9e21 \u6c27\u5316\u80fa\u5b58\u5728\u4e8e\u4e00\u90e8\u5206\u7684\u5929\u7136\u7269\u4e2d\u4ee5\u53ca\u4e00\u4e9b\u98df\u54c1\u836f\u54c1\u5728\u751f\u547d\u4f53\u7684\u4ee3\u8c22\u7269\u4e2d\uff0c\u6b64\u5916\uff0c\u6c27\u5316\u80fa\u7ed3\u6784\u4e5f\u5e7f\u6cdb\u5b58\u5728\u4e8e\u533b\u836f\u54c1\u4e2d\u3002 \u4eca\u5929\u6765\u770b\u770bJ. Med. Chem\u6742\u5fd7\u520a\u767b\u7684\u4e00\u7bc7\u5f00\u653e\u83b7\u53d6\u7efc\u8ff0 \u201cMedicinal Chemistry of Drugs with\u2002N-Oxide Functionalities\u201d \u3002 \u8bba\u6587\u6982\u8981 \u6c27\u5316\u80fa\u80fd\u589e\u52a0\u836f\u7269\u7684\u6c34\u6eb6\u6027\uff0c\u964d\u4f4e\u7ec6\u80de\u819c\u900f\u8fc7\u6027\u548c\u51cf\u5c11\u514d\u75ab\u6297\u539f\u53cd\u5e94\u3002\u6c27\u5316\u80fa\u7ed3\u6784\u8fd8\u5177\u6709\u7279\u6b8a\u7684\u6c27\u5316\u8fd8\u539f\u6027\uff0c\u5728\u836f\u7269\u7684\u9776\u5411\u5316\u548c\u7ec6\u80de\u6bd2\u6027\u7b49\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u6c27\u5316\u80fa\u8fd9\u4e00\u7cfb\u5217\u7279\u6b8a\u6027\u8d28\u80cc\u540e\u7684\u90e8\u5206\u539f\u7406\u6700\u8fd1\u9010\u6e10\u88ab\u63ed\u5f00\uff0c\u5728\u836f\u7269\u548c\u4fdd\u5065\u9886\u57df\uff0c\u6c27\u5316\u80fa\u51fa\u573a\u7684\u9891\u7387\u6b63\u5728\u589e\u52a0\u3002\u672c\u7bc7\u7efc\u8ff0\u5c06\u7b80\u8981\u9648\u8ff0\u6c27\u5316\u80fa\u7684\u7279\u6027\u4ee5\u53ca\u5408\u6210\uff0c\u5e76\u5217\u4e3e\u73b0\u5728\u6c27\u5316\u80fa\u5728\u751f\u7269\u533b\u836f\u9886\u57df\u7684\u5e94\u7528\u5e76\u8bb2\u89e3\u5176\u4e2d\u6c27\u5316\u80fa\u53d1\u6325\u7684\u751f\u7269\u6d3b\u6027\u673a\u80fd\u80cc\u540e\u7684\u5206\u5b50\u673a\u7406\u3002 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