{"id":51829,"date":"2024-12-05T08:00:44","date_gmt":"2024-12-05T00:00:44","guid":{"rendered":"\/\/www.gsbet888.com\/?p=51829"},"modified":"2024-12-05T15:47:14","modified_gmt":"2024-12-05T07:47:14","slug":"%e6%af%9b%e6%b6%a6%e6%b3%bd%e5%9b%a2%e9%98%9fangew%ef%bc%9a-nadh%e7%b1%bb%e4%bc%bc%e7%89%a9%e4%bf%83%e8%bf%9b%e7%9a%84%e7%be%a7%e9%85%b8%e8%8d%af%e7%89%a9%e4%b8%8e%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2024\/12\/%e6%af%9b%e6%b6%a6%e6%b3%bd%e5%9b%a2%e9%98%9fangew%ef%bc%9a-nadh%e7%b1%bb%e4%bc%bc%e7%89%a9%e4%bf%83%e8%bf%9b%e7%9a%84%e7%be%a7%e9%85%b8%e8%8d%af%e7%89%a9%e4%b8%8e%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9.html","title":{"rendered":"\u6bdb\u6da6\u6cfd\u56e2\u961fAngew\uff1a  NADH\u7c7b\u4f3c\u7269\u4fc3\u8fdb\u7684\u7fa7\u9178\u836f\u7269\u4e0e\u5929\u7136\u4ea7\u7269\u540e\u671f\u5b98\u80fd\u5316\u7b56\u7565"},"content":{"rendered":"<p>\u4f5c\u8005\uff1a\u6bdb\u6da6\u6cfd\u535a\u58eb<\/p>\n<h4>\u5bfc\u8bfb\uff1a<\/h4>\n<p>\u8fd1\u65e5\uff0c<strong>\u6e05\u534e\u5927\u5b66<\/strong><strong>iBHE<\/strong><strong>\u6bdb\u6da6\u6cfd\u56e2\u961f\u8054\u5408\u6cb3\u5357\u79d1\u6280\u5b66\u9662\u6881\u78ca\u56e2\u961f<\/strong>\u5408\u4f5c\u53d1\u5c55\u4e86\u4e00\u79cd\u6e29\u548c\u6761\u4ef6\u4e0bNADH\u7c7b\u4f3c\u7269\u4fc3\u8fdb\u7684\u7fa7\u9178\u836f\u7269\u4e0e\u5929\u7136\u4ea7\u7269\u540e\u671f\u5b98\u80fd\u5316\u7b56\u7565\u3002\u8be5\u53cd\u5e94\u4f53\u7cfb\u64cd\u4f5c\u7b80\u4fbf\uff08\u5ba4\u6e29\u3001\u65e0\u5149\u7167\u3001\u65e0\u91d1\u5c5e\uff09\uff0c\u5c06\u7fa7\u9178\u9ad8\u7898\u916f\uff08ADs\uff09\uff0cNADH\u6a21\u62df\u7269\u548c\u5076\u8054\u8bd5\u5242\u6df7\u5408\u6405\u62cc\u53cd\u5e945\u5206\u949f\uff0c\u5373\u53ef\u5b9e\u73b0\u7fa7\u9178\u57fa\u56e2\u7684\u8f6c\u5316\uff08\u56fe2\uff09\u3002\u53cd\u5e94\u8fd8\u663e\u793a\u51fa\u4e86\u5e7f\u6cdb\u7684\u5e95\u7269\u666e\u9002\u6027\uff0c\u53ef\u7528\u4e8e\u6c28\u57fa\u9178\u3001\u836f\u7269\u5206\u5b50\u53ca\u5929\u7136\u4ea7\u7269\u7b49\u751f\u7269\u6d3b\u6027\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\uff0c\u4e3a\u751f\u7269\u6d3b\u6027\u5206\u5b50\u5316\u5408\u7269\u5e93\u7684\u5feb\u901f\u6784\u5efa\u63d0\u4f9b\u4e86\u4e00\u79cd\u9ad8\u6548\u7684\u624b\u6bb5\u3002<\/p>\n<blockquote><p>\u201cNADH Analogues Enable Metal- and Light-Free Decarboxylative Functionalization<\/p>\n<p>Lei Liang, Yue-Hui Wang, Cheng-Xing Cui, Xiao-Shan Deng, Song-Lin Wang, Hai-Ming Guo, Yingzi Li, Hong-Ying Niu, Runze Mao*<\/p>\n<p><em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2024<\/strong>, e202415131. Doi: <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202415131\">10.1002\/anie.202415131<\/a><\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<h4>\u6b63\u6587\uff1a<\/h4>\n<p>\u7fa7\u9178\u662f\u4e00\u7c7b\u6765\u6e90\u5e7f\u6cdb\u3001\u4ef7\u683c\u4f4e\u5ec9\u4e14\u53ef\u518d\u751f\u7684\u5316\u5b66\u539f\u6599\uff0c\u7b26\u5408\u53ef\u6301\u7eed\u5316\u5b66\u8f6c\u5316\u7684\u9700\u6c42\u3002\u7fa7\u9178\u57fa\u56e2\u5728\u836f\u7269\u548c\u5929\u7136\u4ea7\u7269\u4e2d\u5206\u5e03\u5e7f\u6cdb\uff0c\u5176\u540e\u671f\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u5177\u6709\u91cd\u8981\u5e94\u7528\u4ef7\u503c\u3002\u901a\u8fc7\u5fae\u8c03\u7fa7\u9178\u57fa\u56e2\uff0c\u53ef\u4f18\u5316\u836f\u7269\u7684\u5173\u952e\u836f\u7406\u6027\u8d28\uff08\u5982\u6eb6\u89e3\u5ea6\u3001\u4ee3\u8c22\u7a33\u5b9a\u6027\u548c\u53d7\u4f53\u4eb2\u548c\u529b\uff09\uff0c\u4ece\u800c\u52a0\u901f\u836f\u7269\u53d1\u73b0\uff1b\u6b64\u5916\uff0c\u901a\u8fc7\u6539\u9020\u5929\u7136\u4ea7\u7269\u9aa8\u67b6\u4ee5\u5f00\u53d1\u5177\u6709\u65b0\u6d3b\u6027\u7684\u884d\u751f\u7269\uff0c\u4e5f\u53ef\u62d3\u5c55\u5929\u7136\u4ea7\u7269\u7684\u529f\u80fd\u5e94\u7528\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-51831 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image002.jpg\" alt=\"\" width=\"692\" height=\"139\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image002.jpg 692w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image002-300x60.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image002-680x137.jpg 680w\" sizes=\"(max-width: 692px) 100vw, 692px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>1<\/strong> \u7fa7\u9178\u836f\u7269\u4e0e\u5929\u7136\u4ea7\u7269<\/p>\n<p>\u7136\u800c\uff0c\u7531\u4e8e\u7fa7\u9178\u672c\u8eab\u7684\u9ad8\u5316\u5b66\u7a33\u5b9a\u6027\uff0c\u8fd9\u7c7b\u53cd\u5e94\u901a\u5e38\u4f9d\u8d56\u91d1\u5c5e\u50ac\u5316\u5242\u6216\u5149\u50ac\u5316\u5242\u6765\u964d\u4f4e\u53cd\u5e94\u80fd\u5792\uff0c\u5e76\u901a\u8fc7\u5355\u7535\u5b50\u8f6c\u79fb\uff08SET\uff09\u673a\u5236\u5b9e\u73b0\u8131\u7fa7\u5076\u8054\u3002\u5149\u7167\u548c\u91d1\u5c5e\u7684\u4f7f\u7528\u867d\u7136\u6709\u6548\uff0c\u4f46\u4e5f\u589e\u52a0\u4e86\u53cd\u5e94\u6761\u4ef6\u7684\u82db\u523b\u6027\uff0c\u4f7f\u5f97\u7fa7\u9178\u7c7b\u836f\u7269\u5206\u5b50\u548c\u5929\u7136\u4ea7\u7269\u7684\u540e\u671f\u5b98\u80fd\u56e2\u5316\u53d8\u5f97\u590d\u6742\u4e14\u5177\u6709\u6311\u6218\u6027\u3002\u8fd1\u5e74\u6765\uff0c\u7814\u7a76\u8868\u660e\uff0cNADH\u7c7b\u4f3c\u7269\u7684\u7535\u5b50-\u4f9b\u4f53-\u53d7\u4f53\uff08EDA\uff09\u590d\u5408\u7269\u5728\u53ef\u89c1\u5149\u6fc0\u53d1\u4e0b\u53ef\u4ee5\u4ea7\u751f\u81ea\u7531\u57fa\uff0c\u5e76\u4e0e\u53d7\u4f53\u7ed3\u5408\u751f\u6210\u5076\u8054\u4ea7\u7269\uff08\u56fe1B\uff09\u3002\u867d\u7136\u8fd9\u4e00\u7b56\u7565\u907f\u514d\u4e86\u91d1\u5c5e\u50ac\u5316\u5242\u7684\u4f7f\u7528\uff0c\u4f46\u5bf9\u5149\u7167\u7684\u4f9d\u8d56\u4f9d\u7136\u662f\u4e00\u4e2a\u9650\u5236\u56e0\u7d20\u3002\u5728\u5de5\u4e1a\u5316\u5e94\u7528\u4e2d\uff0c\u5149\u7167\u9700\u6c42\u4e0d\u4ec5\u589e\u52a0\u4e86\u8bbe\u5907\u590d\u6742\u6027\uff0c\u8fd8\u63d0\u5347\u4e86\u80fd\u6e90\u6210\u672c\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u4e00\u79cd\u80fd\u591f\u5728\u6e29\u548c\u3001\u65e0\u5149\u6761\u4ef6\u4e0b\u5b9e\u73b0\u7fa7\u9178\u540e\u671f\u5b98\u80fd\u56e2\u5316\u7684\u65b0\u7b56\u7565\uff0c\u6210\u4e3a\u5408\u6210\u5316\u5b66\u548c\u836f\u7269\u5316\u5b66\u4e2d\u7684\u4e00\u4e2a\u5173\u952e\u8bfe\u9898\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-51832 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image003-1.png\" alt=\"\" width=\"691\" height=\"118\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image003-1.png 691w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image003-1-300x51.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image003-1-680x116.png 680w\" sizes=\"(max-width: 691px) 100vw, 691px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>2<\/strong> \u975e\u5149\u7167\u6761\u4ef6\u4e0bNADH\u7c7b\u4f3c\u7269\u4fc3\u8fdb\u7684\u8131\u7fa7\u8f6c\u5316<\/p>\n<p><strong>\u9488\u5bf9\u4e0a\u8ff0\u6311\u6218\uff0c\u6e05\u534e\u5927\u5b66<\/strong><strong>iBHE<\/strong><strong>\u6bdb\u6da6\u6cfd\u56e2\u961f\u8054\u5408\u6cb3\u5357\u79d1\u6280\u5b66\u9662\u6881\u78ca\u56e2\u961f<\/strong>\u5408\u4f5c\u53d1\u5c55\u4e86\u4e00\u79cd\u6e29\u548c\u6761\u4ef6\u4e0bNADH\u7c7b\u4f3c\u7269\u4fc3\u8fdb\u7684\u7fa7\u9178\u836f\u7269\u4e0e\u5929\u7136\u4ea7\u7269\u540e\u671f\u5b98\u80fd\u5316\u7b56\u7565\u3002\u8be5\u53cd\u5e94\u4f53\u7cfb\u64cd\u4f5c\u7b80\u4fbf\uff08\u5ba4\u6e29\u3001\u65e0\u5149\u7167\u3001\u65e0\u91d1\u5c5e\uff09\uff0c\u5c06\u7fa7\u9178\u9ad8\u7898\u916f\uff08ADs\uff09\uff0cNADH\u6a21\u62df\u7269\u548c\u5076\u8054\u8bd5\u5242\u6df7\u5408\u6405\u62cc\u53cd\u5e945\u5206\u949f\uff0c\u5373\u53ef\u5b9e\u73b0\u7fa7\u9178\u57fa\u56e2\u7684\u8f6c\u5316\uff08\u56fe2\uff09\u3002\u53cd\u5e94\u8fd8\u663e\u793a\u51fa\u4e86\u5e7f\u6cdb\u7684\u5e95\u7269\u666e\u9002\u6027\uff0c\u53ef\u7528\u4e8e\u6c28\u57fa\u9178\u3001\u836f\u7269\u5206\u5b50\u53ca\u5929\u7136\u4ea7\u7269\u7b49\u751f\u7269\u6d3b\u6027\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\uff0c\u4e3a\u751f\u7269\u6d3b\u6027\u5206\u5b50\u5316\u5408\u7269\u5e93\u7684\u5feb\u901f\u6784\u5efa\u63d0\u4f9b\u4e86\u4e00\u79cd\u9ad8\u6548\u7684\u624b\u6bb5\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-51833 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image004.png\" alt=\"\" width=\"689\" height=\"553\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image004.png 689w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image004-300x241.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image004-680x546.png 680w\" sizes=\"(max-width: 689px) 100vw, 689px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>3<\/strong> \u751f\u7269\u6d3b\u6027\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970<\/p>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u901a\u8fc7\u4f7f\u7528\u5176\u5b83\u7c7b\u578b\u7684\u5076\u8054\u8bd5\u5242\uff0c\u539f\u6709\u53cd\u5e94\u4f53\u7cfb\u8fd8\u53ef\u4ee5\u5e94\u7528\u4e8e\u5176\u5b83\u591a\u79cd\u5316\u5b66\u952e\u7684\u6784\u7b51\uff0c\u5305\u62ecC\u2013X\u952e\uff08X = S\u3001Se\u3001SCF<sub>3<\/sub>\u548cCN\uff09\u3001C\u2013C(sp)\u952e\u3001C\u2013C(sp\u00b2)\u952e\u4ee5\u53caC\u2013C(sp\u00b3)\u952e\uff08\u56fe4\uff09\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-51834 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image005.png\" alt=\"\" width=\"668\" height=\"353\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image005.png 668w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image005-300x159.png 300w\" sizes=\"(max-width: 668px) 100vw, 668px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>4<\/strong> \u591a\u7c7b\u578b\u5b98\u80fd\u56e2\u8f6c\u5316<\/p>\n<p>\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u81ea\u7531\u57fa\u6355\u83b7\u3001\u81ea\u7531\u57fa\u949f\u3001\u73af\u4e19\u70f7\u5f00\u73af\u3001\u5173\u952e\u4e2d\u95f4\u4f53\u5206\u79bb\u3001\u5bc6\u5ea6\u6cdb\u51fd\u7406\u8bba\uff08DFT\uff09\u8ba1\u7b97\u548c\u5faa\u73af\u4f0f\u5b89\u6cd5\u6d4b\u8bd5\u7b49\u624b\u6bb5\u5bf9\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5e76\u63d0\u51fa\u4e86\u53ef\u80fd\u7684\u53cd\u5e94\u673a\u5236\u3002\u8be6\u7ec6\u5185\u5bb9\u8bf7\u53c2\u8003\u539f\u6587\u3002<\/p>\n<p style=\"text-align: center;\"><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-51835 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image006.png\" alt=\"\" width=\"693\" height=\"222\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image006.png 693w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image006-300x96.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2024\/12\/image006-680x218.png 680w\" sizes=\"(max-width: 693px) 100vw, 693px\" \/>\u56fe<\/strong><strong>5 <\/strong>\u63d0\u51fa\u7684\u673a\u7406<\/p>\n<p>\u76f8\u5173\u7814\u7a76\u4ee5\u201cNADH Analogues Enable Metal- and Light-Free Decarboxylative Functionalization\u201d\u4e3a\u9898\u53d1\u8868\u5728\u300aAngewandte Chemie International Edition\u300b\uff08\u300a\u5fb7\u56fd\u5e94\u7528\u5316\u5b66\u300b\uff09\u4e0a\u3002\u8be5\u5de5\u4f5c\u7684\u901a\u8baf\u4f5c\u8005\u662f\u6e05\u534e\u5927\u5b66iBHE\u52a9\u7406\u6559\u6388\/\u535a\u58eb\u751f\u5bfc\u5e08\u6bdb\u6da6\u6cfd\uff0c\u7b2c\u4e00\u4f5c\u8005\u662f\u6e05\u534e\u5927\u5b66iBHE\u8bbf\u95ee\u5b66\u8005\/\u6cb3\u5357\u79d1\u6280\u5b66\u9662\u526f\u6559\u6388\u6881\u78ca\u3002<\/p>\n<p>\uff08<strong>\u975e\u5e38\u611f\u8c22\u6bdb\u6da6\u6cfd\u535a\u58eb\u5bf9<\/strong><strong>Chem-Station<\/strong><strong>\u7684\u652f\u6301<\/strong>\uff09<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6bdb\u6da6\u6cfd\u535a\u58eb \u5bfc\u8bfb\uff1a 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