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\u5bfc\u8bfb\uff1a<\/strong><\/h4>\n

\u8fd1\u671f\uff0c\u534e\u4e2d\u5e08\u8303\u5927\u5b66\u5468\u6167\u8bfe\u9898\u7ec4<\/strong>\u53d1\u73b0\u4e86\u4e00\u79cdN<\/em>-\u5b98\u80fd\u5316\u7684\u7f9f\u80fa\u8bd5\u5242\uff0c\u5728\u78b1\u7684\u4f5c\u7528\u4e0b\u53ef\u539f\u4f4d\u751f\u6210\u4e9a\u80fa\u4e2d\u95f4\u4f53\uff0c\u4ece\u800c\u4e0e\u5ec9\u4ef7\u6613\u5f97\u7684\u5927\u5b97\u5316\u5b66\u54c1\u8fdb\u884c\u4eb2\u6838\u52a0\u6210\uff0c\u6210\u529f\u6784\u5efa\u4e86\u591a\u79cd\u5316\u5b66\u952e\u3002\u8be5\u65b9\u6cd5\u53ef\u4e00\u9505\u6cd5\u6784\u5efaalpha-\u624b\u6027\u6c28\u57fa\u9178\u884d\u751f\u7269\uff0c\u5e76\u4e3a\u6d3b\u6027\u836f\u7269\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u6548\u7684\u9014\u5f84\u3002\u76f8\u5173\u5de5\u4f5c\u53d1\u8868\u4e8e\u76f8\u5173\u5de5\u4f5c\u53d1\u8868\u4e8eNat. Commun. <\/em><\/strong>\u4e0a\u3002<\/p>\n

\n

\u201cNucleophilic addition of bulk chemicals with imines using N-functionalized hydroxylamine reagents as precursors.<\/p>\n

Wei Wang, Yuanyuan Peng, Yang Liu, Yanchun Lin, Fei Zhao, Qinlin Chen, Liangming Xuan, Qiongjiao Yan, Fen-Er Chen, and Hui Zhou*<\/p>\n

Nat Commun.,<\/em> 2025<\/strong>, 16<\/strong>, 168. Doi: 10.1038\/s41467-024-55488-0<\/a>\u201d<\/p>\n<\/blockquote>\n

\u6b63\u6587<\/strong>:<\/strong><\/h4>\n

\u00a0 \u00a0 \u00a0\u00a0\u6210\u952e\u53cd\u5e94\u662f\u6709\u673a\u5408\u6210\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u5de5\u5177\uff0c\u4e0d\u65ad\u63a8\u52a8\u6539\u8fdb\u4eba\u7c7b\u751f\u6d3b\u3002\u5982\u591a\u79cd\u591a\u6837\u7684\u5076\u8054\u53cd\u5e94\uff0c\u5df2\u88ab\u8bc1\u5b9e\u5728\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u3001\u6750\u6599\u79d1\u5b66\u7b49\u9886\u57df\u6709\u7740\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u5728\u6784\u5efa\u65b0\u5316\u5b66\u952e\u7684\u5173\u952e\u65b9\u6cd5\u4e2d\uff0c\u6d89\u53ca\u4e9a\u80fa\u7684\u4eb2\u6838\u52a0\u6210\u53cd\u5e94\u5360\u6709\u91cd\u8981\u5730\u4f4d\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5408\u6210\u548c\u50a8\u5b58\u4e9a\u80fa\u56fa\u6709\u7684\u6311\u6218\uff0c\u8bbe\u8ba1\u7a33\u5b9a\u7684\u4e9a\u80fa\u524d\u4f53\u4ee5\u5728\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u539f\u4f4d\u751f\u6210\u4e9a\u80fa\u5f15\u8d77\u4e86\u5e7f\u6cdb\u5173\u6ce8\u3002\u8fd1\u671f\uff0c\u534e\u4e2d\u5e08\u8303\u5927\u5b66\u5468\u6167\u8bfe\u9898\u7ec4<\/strong>\u53d1\u73b0\u4e86\u4e00\u79cdN<\/em>-\u5b98\u80fd\u5316\u7684\u7f9f\u80fa\u8bd5\u5242\uff0c\u5728\u78b1\u7684\u4f5c\u7528\u4e0b\u53ef\u539f\u4f4d\u751f\u6210\u4e9a\u80fa\u4e2d\u95f4\u4f53\uff0c\u4ece\u800c\u4e0e\u5ec9\u4ef7\u6613\u5f97\u7684\u5927\u5b97\u5316\u5b66\u54c1\u8fdb\u884c\u4eb2\u6838\u52a0\u6210\uff0c\u6210\u529f\u6784\u5efa\u4e86\u591a\u79cd\u5316\u5b66\u952e\u3002\u8be5\u65b9\u6cd5\u53ef\u4e00\u9505\u6cd5\u6784\u5efaalpha-\u624b\u6027\u6c28\u57fa\u9178\u884d\u751f\u7269\uff0c\u5e76\u4e3a\u6d3b\u6027\u836f\u7269\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u6548\u7684\u9014\u5f84\uff08\u56fe1\uff09\u3002<\/p>\n

\"\"\u56fe1. \u53cd\u5e94\u7814\u7a76\u80cc\u666f\u3002\u56fe\u7247\u6765\u6e90\uff1aNat. Commun.<\/em><\/p>\n

<\/div>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u5728\u5e95\u7269\u62d3\u5c55\u65b9\u9762\uff0c\u4f5c\u8005\u8bc1\u5b9e\u4e86\u4e00\u7cfb\u5217O<\/span><\/i>–<\/span>\u4eb2\u6838\u8bd5\u5242\uff0cN<\/span><\/i>–<\/span>\u4eb2\u6838\u8bd5\u5242\uff0cS<\/span><\/i>–<\/span>\u4eb2\u6838\u8bd5\u5242\u4ee5\u53caC<\/span><\/i>–<\/span>\u4eb2\u6838\u8bd5\u5242\u5747\u53ef\u53d1\u751f\u53cd\u5e94\uff0c\u4ee5\u4e2d\u7b49\u5230\u4f18\u79c0\u7684\u4ea7\u7387\u7ed9\u51fa\u76f8\u5e94\u7684\u4ea7\u7269\uff0c\u5e76\u4e14\u8be5\u65b9\u6cd5\u7528\u4e8e\u591a\u79cd\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u548c\u836f\u7269\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\uff08\u56fe2<\/span>\uff09\u3002\"\"<\/p>\n

\u56fe2. \u90e8\u5206\u5e95\u7269\u62d3\u5c55\u7ed3\u679c\u3002\u56fe\u7247\u6765\u6e90\uff1aNat. Commun.<\/em><\/p>\n

\"\"\u56fe3. \u7279\u6b8a\u5e95\u7269\u62d3\u5c55\u7814\u7a76\u3002\u56fe\u7247\u6765\u6e90\uff1aNat. Commun.<\/em><\/p>\n

\u00a0 \u00a0 \u00a0 \u5bf9\u4e8e\u542b\u591a\u5b98\u80fd\u56e2\u7684\u5e95\u7269\uff0c\u4f5c\u8005\u89c2\u5bdf\u5230\u4e0d\u540c\u7684\u53cd\u5e94\u6027\uff08\u56fe3\uff09\uff0c\u4e14\u4e0d\u540c\u7684N-\u5b98\u80fd\u5316\u7684\u7f9f\u80fa\u8bd5\u5242\u5747\u53ef\u517c\u5bb9\u53cd\u5e94\uff0c\u53ef\u4e00\u6b65\u6784\u5efa\u591a\u79cdalpha-\u6c28\u57fa\u9178\u884d\u751f\u7269\u3002\u76f8\u5173\u7684\u514b\u7ea7\u5b9e\u9a8c\u4e5f\u8bf4\u660e\u4e86\u8be5\u65b9\u6cd5\u7684\u5b9e\u7528\u6027\u3002<\/p>\n

\u00a0 \u00a0 \u00a0 \u4e9a\u80fa\u7684\u4e0d\u7a33\u5b9a\u6027\uff0c\u4ee5\u53ca\u5206\u79bb\u3001\u7eaf\u5316\u548c\u50a8\u5b58\u7684\u6311\u6218\uff0c\u8fd1\u5e74\u6765\u7814\u7a76\u5de5\u4f5c\u8005\u4eec\u5f00\u53d1\u4e86\u591a\u79cd\u7528\u4e8e\u4eb2\u6838\u52a0\u6210\u53cd\u5e94\u7684\u4e9a\u80fa\u524d\u4f53\u3002\u4e3a\u8bc4\u4f30\u65b0\u5f00\u53d1\u7684N-\u529f\u80fd\u5316\u7f9f\u80fa\u8bd5\u5242\u7684\u9002\u7528\u6027\u548c\u4f18\u52bf\uff0c\u4f5c\u8005\u6d4b\u8bd5\u4e86\u4e00\u7cfb\u5217\u4f20\u7edf\u4e9a\u80fa\u524d\u4f53\u4e0e\u5e38\u89c1\u4eb2\u6838\u8bd5\u5242\u7684\u53cd\u5e94\u3002\u5982\u56fe4\u6240\u793a\uff0c\u4f5c\u8005\u5c1d\u8bd5\u4f7f\u7528\u4e09\u6c1f\u7532\u57fa\u4e9a\u80fa\u524d\u4f53\u3001\u82b3\u57fa\u4e9a\u80fa\u524d\u4f53\u548c\u7094\u57fa\u4e9a\u80fa\u524d\u4f53\u5206\u522b\u7528\u4e8e\u6784\u5efaC\u2013O\u3001C\u2013S\u548cC\u2013N\u952e\u3002\u7136\u800c\uff0c\u5373\u4f7f\u5728\u591a\u79cd\u78b1\u548c\u6eb6\u5242\u4e2d\u5c06\u6e29\u5ea6\u5347\u9ad8\u81f370 \u00b0C\uff0c\u4e5f\u672a\u89c2\u5bdf\u5230\u76f8\u5e94\u7684\u52a0\u6210\u4ea7\u7269\u3002\u8fd9\u4e9b\u7ed3\u679c\u51f8\u663e\u4e86\u4f5c\u8005\u65b0\u5f00\u53d1\u7684N-\u529f\u80fd\u5316\u7f9f\u80fa\u8bd5\u5242\u7684\u5f3a\u5927\uff0c\u786e\u7acb\u4e86\u5176\u4f5c\u4e3a\u529f\u80fd\u5316\u4e9a\u80fa\u524d\u4f53\u7684\u6f5c\u529b\u3002\u4e3a\u4e86\u9610\u660e\u53cd\u5e94\u673a\u5236\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u7cfb\u5217\u5bf9\u7167\u5b9e\u9a8c\u3002\u9996\u5148\u7814\u7a76\u4e86\u8be5\u8f6c\u5316\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u6d89\u53ca\u7684\u526f\u53cd\u5e94\u3002\u5f53\u4ee54-\u7532\u57fa\u82ef\u915a2a<\/strong>\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\u4e0eN<\/em>-\u4e09\u6c1f\u4e59\u57fa\u7f9f\u80fa\u5e95\u72691b<\/strong>\u53cd\u5e94\u65f6\uff0c\u9664\u4e86\u76ee\u6807\u4ea7\u7269\u5916\uff0c\u8fd8\u89c2\u5bdf\u5230\u526f\u4ea7\u7269\u916f\u548c\u7f9f\u80fa\u7684\u751f\u6210\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u8868\u660e\uff0c\u7f9f\u80fa\u5e76\u4e0d\u662f\u4e3b\u53cd\u5e94\u4e2d\u7684\u6d3b\u6027\u4e2d\u95f4\u4f53\u3002\u7136\u800c\uff0c\u5f53\u526f\u4ea7\u7269\u916f\u548c\u7f9f\u80fa\u5728\u78b3\u9178\u94ef\u548c\u4e59\u8148\u5b58\u5728\u4e0b\u91cd\u65b0\u52a0\u5165\u53cd\u5e94\u65f6\uff0c\u6210\u529f\u76d1\u6d4b\u5230\u4e86\u76ee\u6807\u4ea7\u7269\u3002\u8fd9\u8868\u660e\u751f\u6210\u916f\u548c\u7f9f\u80fa\u7684\u526f\u53cd\u5e94\u662f\u53ef\u9006\u7684\uff0c\u6700\u7ec8\u56de\u5f52\u5230\u4e3b\u53cd\u5e94\u8def\u5f84\u3002\u4e3a\u8fdb\u4e00\u6b65\u63a2\u8ba8\u4e9a\u80fa\u7684\u53cd\u5e94\u673a\u5236\uff0c\u4f5c\u8005\u5c1d\u8bd5\u5206\u79bb\u5f97\u5230\u4e86\u76f8\u5e94\u7684\u916f\u53d6\u4ee3\u7684N-Boc\u4e9a\u80fa\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8be5\u4e9a\u80fa\u4e2d\u95f4\u4f53\u53ef\u5728\u6700\u4f73\u6761\u4ef6\u4e0b\u4e0e\u591a\u79cd\u4eb2\u6838\u8bd5\u5242\u53cd\u5e94\uff0c\u751f\u6210\u76f8\u5e94\u7684\u52a0\u6210\u4ea7\u7269\uff0c\u800c\u5728\u65e0\u78b1\u6761\u4ef6\u4e0b\u672a\u68c0\u6d4b\u5230\u76ee\u6807\u4ea7\u7269\u3002\u4e0a\u8ff0\u7ed3\u679c\u8868\u660e\uff0c\u78b1\u4ecb\u5bfc\u751f\u6210\u7684\u4e9a\u80fa\u786e\u5b9e\u662f\u53cd\u5e94\u7684\u6d3b\u6027\u4e2d\u95f4\u4f53\u3002\u6700\u540e\uff0c\u4f5c\u8005\u4f7f\u7528\u5b8c\u5168\u6c18\u4ee3\u915a\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\u8fdb\u884c\u6c18\u6807\u8bb0\u5b9e\u9a8c\uff0c\u8fd9\u4e9b\u53d1\u73b0\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u8be5\u53cd\u5e94\u901a\u8fc7\u539f\u4f4d\u751f\u6210\u4e9a\u80fa\uff0c\u5e76\u8fdb\u884c\u4eb2\u6838\u52a0\u6210\u8def\u5f84\u7684\u5047\u8bbe\u3002<\/p>\n

\"\"\u56fe4. \u63a7\u5236\u5b9e\u9a8c\u3002\u56fe\u7247\u6765\u6e90\uff1aNat. Commun.<\/em><\/p>\n

\u603b\u7ed3<\/strong><\/h4>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u65e0\u9700\u8fc7\u6e21\u91d1\u5c5e\u7684\u4eb2\u6838\u52a0\u6210\u5e73\u53f0\uff0c\u53ef\u7528\u4e8e\u6784\u5efaC\u2013O\u3001C\u2013C\u3001C\u2013S\u548cC\u2013N\u952e\uff0c\u76f8\u8f83\u4e8e\u4f9d\u8d56\u8fc7\u6e21\u91d1\u5c5e\u7684\u65b9\u6cd5\u5177\u6709\u53ef\u6301\u7eed\u6027\u7684\u4f18\u52bf\u3002\u5177\u4f53\u800c\u8a00\uff0c\u4f5c\u8005\u4f7f\u7528\u4e86N<\/em>-\u529f\u80fd\u5316\u7f9f\u80fa\u8bd5\u5242\u4f5c\u4e3a\u4e9a\u80fa\u7684\u7a33\u5b9a\u524d\u4f53\uff0c\u4e0e\u5305\u62ec\u6c34\u548c\u6c28\u5728\u5185\u7684\u5ec9\u4ef7\u6613\u5f97\u7684\u4eb2\u6838\u8bd5\u5242\u53cd\u5e94\u3002\u8be5\u65b9\u6cd5\u53ef\u6269\u5c55\u81f3\u03b1-\u6c28\u57fa\u9178\u884d\u751f\u7269\u7684\u5408\u6210\uff0c\u5e76\u901a\u8fc7\u5728\u5404\u79cd\u7ed3\u6784\u590d\u6742\u7684\u5929\u7136\u4ea7\u7269\u548c\u836f\u7269\u4e0a\u7684\u53cd\u5e94\u5c55\u793a\u5176\u6f5c\u5728\u5e94\u7528\u4ef7\u503c\u3002\u8be5\u53cd\u5e94\u5177\u6709\u64cd\u4f5c\u7b80\u4fbf\u3001\u5e95\u7269\u8303\u56f4\u5e7f\u3001\u9009\u62e9\u6027\u9ad8\u4ee5\u53ca\u4f18\u5f02\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u7b49\u7279\u70b9\u3002\u6b64\u5916\uff0c\u57fa\u4e8e\u7cfb\u7edf\u7684\u5bf9\u7167\u5b9e\u9a8c\u548c\u8ba1\u7b97\u7814\u7a76\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u5408\u7406\u7684\u53cd\u5e94\u673a\u5236\u3002\u9274\u4e8e\u5176\u5e7f\u6cdb\u7684\u591a\u6837\u6027\uff0c\u8fd9\u79cd\u7b80\u5355\u4e14\u6e29\u548c\u7684\u65e0\u8fc7\u6e21\u91d1\u5c5e\u4eb2\u6838\u52a0\u6210\u7b56\u7565\u5c06\u5728\u751f\u7269\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u3001\u836f\u7269\u5316\u5b66\u548c\u6750\u6599\u79d1\u5b66\u9886\u57df\u4e2d\u5f97\u5230\u5e7f\u6cdb\u5e94\u7528\u3002<\/p>\n

(\u975e\u5e38\u611f\u8c22\u5468\u6167\u6559\u6388\u6559\u6388\u5bf9Chem-Station<\/em>\u7684\u652f\u6301)<\/p>\n

\u5173\u6ce8Chem-Station\u6296\u97f3\u53f7\uff1a79473891841<\/p>\n

\u8bf7\u767b\u9646TCI\u8bd5\u5242\u5b98\u7f51\u67e5\u770b\u66f4\u591a\u5185\u5bb9<\/h5>\n
https:\/\/www.tcichemicals.com\/CN\/zh\/<\/h5>\n

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