{"id":52065,"date":"2025-01-15T07:00:28","date_gmt":"2025-01-14T23:00:28","guid":{"rendered":"\/\/www.gsbet888.com\/?p=52065"},"modified":"2025-01-15T07:59:22","modified_gmt":"2025-01-14T23:59:22","slug":"umpolung-morita-baylis-hillman-reaction","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%9f%ba%e7%a1%80%e5%8c%96%e5%ad%a6\/2025\/01\/umpolung-morita-baylis-hillman-reaction.html","title":{"rendered":"Umpolung Morita\u2013Baylis\u2013Hillman Reaction"},"content":{"rendered":"

\u6982\u8981:<\/h4>\n

 <\/p>\n

\"\"<\/p>\n

Umpolung Morita\u2013Baylis\u2013Hillman\u53cd\u5e94(Umpolung Morita\u2013Baylis\u2013Hillman Reaction)\u662f\u6307\u4e0d\u9971\u548c\u70ef\u916e\u5728\u53d4\u80fa\u6216\u8005\u53d4\u81a6\u7684\u50ac\u5316\u4e0b\u9996\u5148\u53d1\u751f\u5171\u8f6d\u52a0\u6210\u53cd\u5e94\uff0c\u5f97\u5230\u7684\u4e2d\u95f4\u4f53\u7acb\u5373\u548c\u9ad8\u4ef7\u7898\u8bd5\u5242\u53cd\u5e94\u5f62\u6210\u4e00\u79cd\u4eb2\u7535\u6027\u7684MBH\u4e2d\u95f4\u4f53\uff0c\u6700\u7ec8\u88ab\u4e0d\u540c\u7684\u4eb2\u6838\u8bd5\u5242\u6240\u6355\u83b7\uff0c\u5f97\u5230\u4e00\u7cfb\u5217\u03b1\u4f4d\u5b98\u80fd\u56e2\u5316\u7684\u70ef\u916e\u884d\u751f\u7269\u3002\u901a\u8fc7\u9ad8\u4ef7\u7898\u8bd5\u5242\u7684\u534f\u540c\u53c2\u4e0e\uff0c\u6210\u529f\u5730\u9006\u8f6c\u4e86\u7ecf\u5178MBH\u53cd\u5e94\u7684\u5316\u5b66\u9009\u62e9\u6027\uff0c\u5f00\u8f9f\u4e86\u6781\u6027\u53cd\u8f6c\u539f\u7406\u5728\u7ecf\u5178MBH\u53cd\u5e94\u4e2d\u7684\u65b0\u5e94\u7528\u3002\u8be5\u53cd\u5e94\u7531\u4ee5\u8272\u5217\u963f\u91cc\u5c14\u5927\u5b66(Department of Chemical Sciences, Ariel University)\u7684(\u53f3A. M. Szpilman)\u8bfe\u9898\u7ec4\u57282020\u5e74\u9996\u6b21\u62a5\u9053[1]<\/sup>\u3002<\/p>\n

\u53cd\u5e94\u673a\u7406\uff1a<\/h4>\n

\"\"<\/p>\n

\u53cd\u5e94\u5b9e\u4f8b\uff1a<\/h4>\n

1,2-\u4e8c\u916e\u7684\u5408\u6210[1]<\/sup><\/p>\n

\"\"\u4ee5\u4e59\u9178\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\u53c2\u4e0e\u53cd\u5e94\u65f6\uff0c\u7531\u4e8e\u5f97\u5230\u7684\u03b1-\u4e59\u9170\u6c27\u57fa\u70ef\u916e\u5728\u7845\u80f6\u8272\u8c31\u67f1\u4e0a\u5177\u6709\u4e00\u5b9a\u7684\u4e0d\u7a33\u5b9a\u6027\uff0c\u6240\u4ee5\u4f5c\u8005\u901a\u8fc7\u78b1\u6027\u6c27\u5316\u94dd\u7684\u5feb\u901f\u8272\u8c31\u67f1\uff0c\u6210\u529f\u6c34\u89e3\u4e59\u9170\u6c27\u57fa\u5f97\u5230\u4e00\u7cfb\u52171,2-\u4e8c\u916e\u884d\u751f\u7269\uff0c\u8be5\u7c7b\u5316\u5408\u7269\u662f\u6784\u5efa\u5421\u55ea\u548c\u55b9\u5594\u5549\u6742\u73af\u9aa8\u67b6\u7684\u91cd\u8981\u4e2d\u95f4\u4f53\u3002<\/p>\n

\u03b1-\u7532\u82ef\u78fa\u9170\u6c27\u57fa\u70ef\u916e\u7684\u5408\u6210[1]<\/sup><\/p>\n

\"\"\u5f53\u4eb2\u6838\u8bd5\u5242\u66f4\u6362\u4e3aPPTS\u65f6\uff0c\u6240\u5f97\u5230\u4ea7\u7269\u03b1-\u7532\u82ef\u78fa\u9170\u6c27\u57fa\u70ef\u916e\u662f\u6781\u5176\u7a33\u5b9a\u7684\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8be5\u7c7b\u5316\u5408\u7269\u53ef\u4ee5\u4f5c\u4e3a\u4eb2\u7535\u8bd5\u5242\u53c2\u4e0e\u5230\u4e00\u4e9b\u7ecf\u5178\u7684\u5076\u8054\u53cd\u5e94\u4e2d\uff0c\u4f8b\u5982Kumada, Heck, Negishi, Stille, Suzuki, and Sonigashira couplings\u3002<\/p>\n

\u03b1-\u6c2f\u70ef\u916e\u7684\u5408\u6210[1]<\/sup><\/p>\n

\"\"\u8fd9\u662f\u4f5c\u8005\u505a\u4e86\u4e00\u4e2a\u7b80\u5355\u7684\u673a\u7406\u7814\u7a76\uff0c\u901a\u8fc7\u5421\u5576\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\uff0c\u539f\u4f4d\u6838\u78c1\u786e\u5b9e\u8868\u5f81\u5230\u4e86\u7ecf\u5178MBH\u53cd\u5e94\u52a0\u6210\u7684\u4e2d\u95f4\u4f53\uff0c\u968f\u540e\u5411\u53cd\u5e94\u4f53\u7cfb\u4e2d\u52a0\u5165PIDA\uff0c\u8be5\u4e2d\u95f4\u4f53\u7acb\u5373\u5b9a\u91cf\u5730\u8f6c\u5316\u4e3a\u03b1-\u6c2f\u70ef\u916e\uff0c\u8fd9\u4e5f\u8bc1\u5b9ePIDA\u5bf9\u540e\u7eed\u7684\u6781\u6027\u53cd\u8f6c\u8d77\u5230\u4e86\u5173\u952e\u6027\u7684\u4f5c\u7528\u3002<\/p>\n

\u03b1-\u6c1f\u70ef\u916e\u7684\u5408\u6210[2]<\/sup><\/p>\n

\"\"<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/h4>\n
    \n
  1. S. Arava, S. K. Santra, G. K. Pathe, R. Kapanaiah, A. M. Szpilman, Angew. Chem. Int. Ed.<\/i> 2020<\/b>, 59<\/i>, 15171-15175. doi: 10.1002\/anie.202005286<\/a><\/li>\n
  2. S. Maity, A. M. Szpilman, Org. Lett.<\/i> 2023<\/b>, 25<\/i>, 1218-1222. doi: 10.1021\/acs.orglett.3c00313<\/a><\/li>\n<\/ol>\n
    \u8bf7\u767b\u9646TCI\u8bd5\u5242\u5b98\u7f51\u67e5\u770b\u66f4\u591a\u5185\u5bb9<\/h5>\n
    https:\/\/www.tcichemicals.com\/CN\/zh\/<\/h5>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981:   Umpolung Morita\u2013Baylis\u2013Hillman\u53cd\u5e94(Umpolung Morita\u2013Baylis\u2013Hillman Reaction)\u662f\u6307\u4e0d\u9971\u548c\u70ef\u916e\u5728\u53d4\u80fa\u6216\u8005\u53d4\u81a6\u7684\u50ac\u5316\u4e0b\u9996\u5148\u53d1\u751f\u5171\u8f6d\u52a0\u6210\u53cd\u5e94\uff0c\u5f97\u5230\u7684\u4e2d\u95f4\u4f53\u7acb\u5373\u548c\u9ad8\u4ef7\u7898\u8bd5\u5242\u53cd\u5e94\u5f62\u6210\u4e00\u79cd\u4eb2\u7535\u6027\u7684MBH\u4e2d\u95f4\u4f53\uff0c\u6700\u7ec8\u88ab\u4e0d\u540c\u7684\u4eb2\u6838\u8bd5\u5242\u6240\u6355\u83b7\uff0c\u5f97\u5230\u4e00\u7cfb\u5217\u03b1\u4f4d\u5b98\u80fd\u56e2\u5316\u7684\u70ef\u916e\u884d\u751f\u7269\u3002\u901a\u8fc7\u9ad8\u4ef7\u7898\u8bd5\u5242\u7684\u534f\u540c\u53c2\u4e0e\uff0c\u6210\u529f\u5730\u9006\u8f6c\u4e86\u7ecf\u5178MBH\u53cd\u5e94\u7684\u5316\u5b66\u9009\u62e9\u6027\uff0c\u5f00\u8f9f\u4e86\u6781\u6027\u53cd\u8f6c\u539f\u7406\u5728\u7ecf\u5178MBH\u53cd\u5e94\u4e2d\u7684\u65b0\u5e94\u7528\u3002\u8be5\u53cd\u5e94\u7531\u4ee5\u8272\u5217\u963f\u91cc\u5c14\u5927\u5b66(Department of Chemical Sciences, Ariel University)\u7684(\u53f3A. M. Szpilman)\u8bfe\u9898\u7ec4\u57282020\u5e74\u9996\u6b21\u62a5\u9053[1]\u3002 \u53cd\u5e94\u673a\u7406\uff1a \u53cd\u5e94\u5b9e\u4f8b\uff1a 1,2-\u4e8c\u916e\u7684\u5408\u6210[1] \u4ee5\u4e59\u9178\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\u53c2\u4e0e\u53cd\u5e94\u65f6\uff0c\u7531\u4e8e\u5f97\u5230\u7684\u03b1-\u4e59\u9170\u6c27\u57fa\u70ef\u916e\u5728\u7845\u80f6\u8272\u8c31\u67f1\u4e0a\u5177\u6709\u4e00\u5b9a\u7684\u4e0d\u7a33\u5b9a\u6027\uff0c\u6240\u4ee5\u4f5c\u8005\u901a\u8fc7\u78b1\u6027\u6c27\u5316\u94dd\u7684\u5feb\u901f\u8272\u8c31\u67f1\uff0c\u6210\u529f\u6c34\u89e3\u4e59\u9170\u6c27\u57fa\u5f97\u5230\u4e00\u7cfb\u52171,2-\u4e8c\u916e\u884d\u751f\u7269\uff0c\u8be5\u7c7b\u5316\u5408\u7269\u662f\u6784\u5efa\u5421\u55ea\u548c\u55b9\u5594\u5549\u6742\u73af\u9aa8\u67b6\u7684\u91cd\u8981\u4e2d\u95f4\u4f53\u3002 \u03b1-\u7532\u82ef\u78fa\u9170\u6c27\u57fa\u70ef\u916e\u7684\u5408\u6210[1] \u5f53\u4eb2\u6838\u8bd5\u5242\u66f4\u6362\u4e3aPPTS\u65f6\uff0c\u6240\u5f97\u5230\u4ea7\u7269\u03b1-\u7532\u82ef\u78fa\u9170\u6c27\u57fa\u70ef\u916e\u662f\u6781\u5176\u7a33\u5b9a\u7684\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8be5\u7c7b\u5316\u5408\u7269\u53ef\u4ee5\u4f5c\u4e3a\u4eb2\u7535\u8bd5\u5242\u53c2\u4e0e\u5230\u4e00\u4e9b\u7ecf\u5178\u7684\u5076\u8054\u53cd\u5e94\u4e2d\uff0c\u4f8b\u5982Kumada, Heck, Negishi, Stille, Suzuki, and Sonigashira couplings\u3002 \u03b1-\u6c2f\u70ef\u916e\u7684\u5408\u6210[1] \u8fd9\u662f\u4f5c\u8005\u505a\u4e86\u4e00\u4e2a\u7b80\u5355\u7684\u673a\u7406\u7814\u7a76\uff0c\u901a\u8fc7\u5421\u5576\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\uff0c\u539f\u4f4d\u6838\u78c1\u786e\u5b9e\u8868\u5f81\u5230\u4e86\u7ecf\u5178MBH\u53cd\u5e94\u52a0\u6210\u7684\u4e2d\u95f4\u4f53\uff0c\u968f\u540e\u5411\u53cd\u5e94\u4f53\u7cfb\u4e2d\u52a0\u5165PIDA\uff0c\u8be5\u4e2d\u95f4\u4f53\u7acb\u5373\u5b9a\u91cf\u5730\u8f6c\u5316\u4e3a\u03b1-\u6c2f\u70ef\u916e\uff0c\u8fd9\u4e5f\u8bc1\u5b9ePIDA\u5bf9\u540e\u7eed\u7684\u6781\u6027\u53cd\u8f6c\u8d77\u5230\u4e86\u5173\u952e\u6027\u7684\u4f5c\u7528\u3002 \u03b1-\u6c1f\u70ef\u916e\u7684\u5408\u6210[2] \u53c2\u8003\u6587\u732e\uff1a S. Arava, S. K. Santra, G. K. Pathe, R. Kapanaiah, A. M. Szpilman, Angew. Chem. Int. Ed. 2020, 59, 15171-15175. doi: 10.1002\/anie.202005286 S. Maity, A. M. Szpilman, Org. Lett. 2023, 25, 1218-1222. doi: 10.1021\/acs.orglett.3c00313 \u8bf7\u767b\u9646TCI\u8bd5\u5242\u5b98\u7f51\u67e5\u770b\u66f4\u591a\u5185\u5bb9 https:\/\/www.tcichemicals.com\/CN\/zh\/","protected":false},"author":26,"featured_media":52066,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[4310],"tags":[4453,4454,981],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/01\/WechatIMG19.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-dxL","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/52065"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=52065"}],"version-history":[{"count":6,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/52065\/revisions"}],"predecessor-version":[{"id":52079,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/52065\/revisions\/52079"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/52066"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=52065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=52065"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=52065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}