{"id":55370,"date":"2025-04-02T08:00:49","date_gmt":"2025-04-02T00:00:49","guid":{"rendered":"\/\/www.gsbet888.com\/?p=55370"},"modified":"2025-04-02T15:39:48","modified_gmt":"2025-04-02T07:39:48","slug":"nat-chem-%ef%bc%9a%e7%83%af%e7%83%83%e4%b8%8e%e9%a5%b1%e5%92%8c%e6%9d%82%e7%8e%af%e5%8c%96%e5%90%88%e7%89%a9%e7%9a%84%e7%9b%b4%e6%8e%a5%e7%ab%8b%e4%bd%93%e9%80%89%e6%8b%a9%e6%80%a7csp3-h","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2025\/04\/nat-chem-%ef%bc%9a%e7%83%af%e7%83%83%e4%b8%8e%e9%a5%b1%e5%92%8c%e6%9d%82%e7%8e%af%e5%8c%96%e5%90%88%e7%89%a9%e7%9a%84%e7%9b%b4%e6%8e%a5%e7%ab%8b%e4%bd%93%e9%80%89%e6%8b%a9%e6%80%a7csp3-h.html","title":{"rendered":"Nat. Chem.\uff1a\u70ef\u70c3\u4e0e\u9971\u548c\u6742\u73af\u5316\u5408\u7269\u7684\u76f4\u63a5\u7acb\u4f53\u9009\u62e9\u6027C(sp3)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94"},"content":{"rendered":"<p style=\"text-align: justify;\">\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n<h4 style=\"text-align: justify;\">\u5bfc\u8bfb\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u8fd1\u65e5\uff0c\u6b66\u6c49\u5927\u5b66\u7684\u5b54\u671b\u6e05\u8bfe\u9898\u7ec4\u5728<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">Nat. Chem.<\/i><\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u954d\u50ac\u5316\u9971\u548c\u6742\u73af\u5316\u5408\u7269\u4e0e\u70ef\u70c3\u7684\u5bf9\u6620\u9009\u62e9\u6027C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u4e3aC(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u952e\u7684\u7acb\u4f53\u9009\u62e9\u6027\u6784\u5efa\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u6548\u7684\u7b56\u7565\u3002\u5176\u4e2d\uff0c\u8be5\u7b56\u7565\u4f7f\u7528\u6613\u5f97\u4e0e\u7a33\u5b9a\u7684\u70ef\u70c3\u548c\u7b80\u5355\u7684\u9971\u548c\u6c2e\u548c\u6c27\u6742\u73af\u5316\u5408\u7269\u4f5c\u4e3a\u524d\u624b\u6027\u4eb2\u6838\u8bd5\u5242\uff0c\u5076\u8054\u53cd\u5e94\u53ef\u5728\u6e29\u548c\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c\uff0c\u5e76\u8868\u73b0\u51fa\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u4e0e\u9ad8\u5ea6\u7684\u5b98\u80fd\u56e2\u8010\u53d7\u6027\u3002\u5176\u6b21\uff0c\u4f5c\u8005\u8fd8\u5b9e\u73b0\u4e86\u9971\u548c\u70c3\u4e0e\u70ef\u57fa\u787c\u9178\u916f\u7684\u5bf9\u6620\u4e0e\u975e\u5bf9\u6620\u9009\u62e9\u6027C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5408\u6210\u4e86\u542b\u6709\u76f8\u90bb\u624b\u6027\u4e2d\u5fc3\u7684\u70f7\u57fa\u787c\u9178\u916f\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u5bf9\u5929\u7136\u4ea7\u7269\u4e0e\u836f\u7269\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\uff0c\u4ee5\u53ca\u4e00\u7cfb\u5217\u624b\u6027\u7ed3\u6784\u5355\u5143\u4e0e\u5929\u7136\u4ea7\u7269\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u53cd\u5e94\u7684\u5b9e\u7528\u6027\u3002<\/p>\n<blockquote data-eusoft-scrollable-element=\"1\">\n<p style=\"text-align: justify;\">Direct stereoselective C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H alkylation of\u00a0saturated heterocycles using olefins<\/p>\n<p style=\"text-align: justify;\">Z.Zhou, Y.Ke, R.\u00a0Miao, F.\u00a0Hu, X.\u00a0Wang,\u00a0Y.\u00a0Ping, S.\u00a0Xu,\u00a0W.\u00a0Kong, <i data-eusoft-scrollable-element=\"1\"> <\/i><em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">Chem.<\/i><\/em><strong data-eusoft-scrollable-element=\"1\">\u00a02025<\/strong>, <em data-eusoft-scrollable-element=\"1\">17<\/em>, 344. doi:\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41557-025-01747-6\" data-eusoft-scrollable-element=\"1\"><u data-eusoft-scrollable-element=\"1\">10.1038\/s41557-025-01747-6<\/u><u data-eusoft-scrollable-element=\"1\">.<\/u><\/a><\/p>\n<p style=\"text-align: justify;\">\n<\/blockquote>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55374 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504956738.jpg\" alt=\"\" width=\"1380\" height=\"333\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504956738.jpg 1380w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504956738-300x72.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504956738-680x164.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504956738-768x185.jpg 768w\" sizes=\"(max-width: 1380px) 100vw, 1380px\" \/><\/p>\n<h4 style=\"text-align: justify;\">\u6b63\u6587\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u901a\u8fc7C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u5b98\u80fd\u56e2\u5316\u5c06\u78b3\u6c22\u5316\u5408\u7269\u8f6c\u5316\u4e3a\u9ad8\u9644\u52a0\u503c\u7684\u624b\u6027\u5316\u5408\u7269\uff0c\u5177\u6709\u9ad8\u5ea6\u7684\u539f\u5b50\u4e0e\u6b65\u9aa4\u7ecf\u6d4e\u6027\uff0c\u4ece\u800c\u5907\u53d7\u5173\u6ce8\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5bf9\u6620\u9009\u62e9\u6027C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\uff0c\u5177\u6709\u4e00\u5b9a\u7684\u6311\u6218\u3002\u8fd1\u5e74\u6765\uff0c\u6c22\u539f\u5b50\u8f6c\u79fb(HAT, hydrogen atom\u00a0transfer)<sup data-eusoft-scrollable-element=\"1\">[1]<\/sup>\u4e0e\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u4ea4\u53c9\u5076\u8054<sup data-eusoft-scrollable-element=\"1\">[2]<\/sup>\u76f8\u7ed3\u5408\u7684\u7b56\u7565\uff0c\u5df2\u6210\u4e3a\u5b9e\u73b0C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u952e\u8fdb\u884c\u5bf9\u6620\u9009\u62e9\u6027\u5b98\u80fd\u56e2\u5316\u7684\u6709\u529b\u5de5\u5177\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u7f3a\u4e4f\u5bfc\u5411\u57fa\u56e2\u7684\u9971\u548c\u70c3\u901a\u8fc7\u5bf9\u6620\u9009\u62e9\u6027C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\u6784\u5efaC(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u952e\u7684\u65b9\u6cd5\uff0c\u4ecd\u5177\u6709\u96be\u5ea6(Fig. 1a)\u3002\u540c\u65f6\uff0c\u624b\u6027\u9971\u548c\u6c2e\u4e0e\u6c27\u6742\u73af\u9aa8\u67b6\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u7c7b\u751f\u7269\u6d3b\u6027\u5206\u5b50\u4e0e\u5929\u7136\u4ea7\u7269\u7b49\u4e2d\uff0c\u82e5\u80fd\u5bf9\u5176\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u4fee\u9970\uff0c\u5219\u66f4\u5177\u7814\u7a76\u4ef7\u503c\u3002\u76ee\u524d\uff0c\u5bf9\u4e8e\u5421\u54af\u70f7\u884d\u751f\u7269\u7684\u5bf9\u6620\u9009\u62e9\u6027C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\u4e3b\u8981\u4f9d\u8d56\u4e8e<em data-eusoft-scrollable-element=\"1\">N<\/em>-(\u53d4\u4e01\u6c27\u7fb0\u57fa)\u5421\u54af\u70f7\u7684<em data-eusoft-scrollable-element=\"1\">\u03b1<\/em>-\u9502\u5316\uff0c\u968f\u540e\u4e0e\u70f7\u57fa\u5364\u8fdb\u884cNegishi\u4ea4\u53c9\u5076\u8054<sup data-eusoft-scrollable-element=\"1\">[3]<\/sup>\uff0c\u4f46\u9700\u5728\u82db\u523b\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c\u53bb\u8d28\u5b50\u5316\uff0c\u5e76\u4e14\u5bf9\u4e00\u7ea7\u70f7\u57fa\u5364\u5177\u6709\u8f83\u4f4e\u7684\u5bf9\u6620\u9009\u62e9\u6027(Fig. 1b)\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u5bf9\u4e8e\u954d\u50ac\u5316\u8fc7\u6c27\u5316\u7269\u4ecb\u5bfcC(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u5b98\u80fd\u56e2\u5316<sup data-eusoft-scrollable-element=\"1\">[4]<\/sup>\u4e0eNiH-\u50ac\u5316\u70ef\u70c3\u52a0\u6c22\u70f7\u57fa\u5316\u53cd\u5e94<sup data-eusoft-scrollable-element=\"1\">[<\/sup><sup data-eusoft-scrollable-element=\"1\">5<\/sup><sup data-eusoft-scrollable-element=\"1\">]<\/sup>\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u6b66\u6c49\u5927\u5b66\u7684\u5b54\u671b\u6e05\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u954d\u50ac\u5316\u9971\u548c\u6742\u73af\u5316\u5408\u7269\u4e0e\u70ef\u70c3\u7684\u5bf9\u6620\u9009\u62e9\u6027C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5b9e\u73b0\u4e86C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u952e\u7684\u7acb\u4f53\u9009\u62e9\u6027\u6784\u5efa(Fig. 1c)\u3002\u540c\u65f6\uff0c\u901a\u8fc7\u5bf9\u5929\u7136\u4ea7\u7269\u4e0e\u836f\u7269\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\uff0c\u4ee5\u53ca\u4e00\u7cfb\u5217\u624b\u6027\u7ed3\u6784\u5355\u5143\u4e0e\u5929\u7136\u4ea7\u7269\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u53cd\u5e94\u7684\u5b9e\u7528\u6027(Fig. 1d)\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55375 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504946108.jpg\" alt=\"\" width=\"1268\" height=\"692\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504946108.jpg 1268w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504946108-300x164.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504946108-680x371.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504946108-768x419.jpg 768w\" sizes=\"(max-width: 1268px) 100vw, 1268px\" \/><\/p>\n<p style=\"text-align: justify;\">\u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528\u5421\u54af\u70f7\u884d\u751f\u7269<strong data-eusoft-scrollable-element=\"1\">1<\/strong>\u4e0e\u975e\u6d3b\u5316\u70ef\u70c3<strong data-eusoft-scrollable-element=\"1\">2<\/strong>\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528NiBr<sub data-eusoft-scrollable-element=\"1\">2<\/sub>\u00b7DME\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c<strong data-eusoft-scrollable-element=\"1\">L8<\/strong>\u4f5c\u4e3a\u624b\u6027\u914d\u4f53\uff0c\u8fc7\u6c27\u5316\u4e8c\u5f02\u4e19\u82ef(DCP)\u4f5c\u4e3aHAT\u8bd5\u5242\u4e0e\u6c27\u5316\u5242\uff0cKHCO<sub data-eusoft-scrollable-element=\"1\">3<\/sub>\u4f5c\u4e3a\u78b1\uff0cZn\u7c89\u4f5c\u4e3a\u8fd8\u539f\u5242\uff0c(MeO)<sub data-eusoft-scrollable-element=\"1\">3<\/sub>SiH\u4f5c\u4e3a\u6c22\u6e90\uff0c\u5728EA\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a0 <sup data-eusoft-scrollable-element=\"1\">o<\/sup>C\uff0c\u6700\u7ec8\u83b7\u5f9761%\u5206\u79bb\u6536\u7387\u7684\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">3<\/strong>(97% <em data-eusoft-scrollable-element=\"1\">ee<\/em>)\u3002\u5176\u4e2d\uff0c\u8be5\u53cd\u5e94\u6210\u529f\u7684\u5173\u952e\u662f\u627e\u5230\u4e00\u79cd\u5408\u9002\u7684HAT\u6c27\u5316\u5242\uff0c\u8be5\u6c27\u5316\u5242\u53ef\u4ee5\u4e0e\u78b3\u6c22\u5316\u5408\u7269\u5b9e\u73b0\u9ad8\u6548\u7684HAT\uff0c\u5e76\u5728\u954d\u50ac\u5316\u5faa\u73af\u4e2d\u80fd\u591f\u6c27\u5316\u954d\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55376 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504936272.jpg\" alt=\"\" width=\"1268\" height=\"1268\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504936272.jpg 1268w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504936272-300x300.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504936272-680x680.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504936272-150x150.jpg 150w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504936272-768x768.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504936272-120x120.jpg 120w\" sizes=\"(max-width: 1268px) 100vw, 1268px\" \/><\/p>\n<p style=\"text-align: justify;\"><strong data-eusoft-scrollable-element=\"1\">\u00a0<\/strong>\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u975e\u6d3b\u5316\u70ef\u70c3\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76(Table 2)\u3002\u9996\u5148\uff0c\u4e0a\u8ff0\u5408\u6210\u7684\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">3<\/strong>\u5728\u9178\u6027\u6761\u4ef6\u4e0b\uff0c\u5f88\u5bb9\u6613\u8fdb\u884c\u8131\u4fdd\u62a4\uff0c\u83b7\u5f97N-H\u5421\u54af\u70f7\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">5<\/strong>\u3002\u5176\u6b21\uff0c\u4e00\u7cfb\u5217\u4e0d\u540c\u53d6\u4ee3\u7684\u672b\u7aef\u70ef\u70c3\uff0c\u5747\u53ef\u4e0e\u5421\u54af\u70f7\u884d\u751f\u7269<strong data-eusoft-scrollable-element=\"1\">1<\/strong>\u8fdb\u884c\u53cd\u5e94\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">6<\/strong>&#8211;<strong data-eusoft-scrollable-element=\"1\">25<\/strong>\uff0c\u6536\u7387\u4e3a39-73%\uff0cee\u4e3a89-99%\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e00\u7cfb\u5217\u6d3b\u6027\u7684\u57fa\u56e2\uff0c\u5982\u5364\u7d20\u3001\u7845\u57fa\u3001\u70f7\u6c27\u7fb0\u57fa\u7b49\uff0c\u5747\u4e0e\u4f53\u7cfb\u517c\u5bb9\u3002\u7136\u800c\uff0c\u542b\u6709\u6e38\u79bb\u9187\u7684\u5e95\u7269\uff0c\u672a\u80fd\u6709\u6548\u7684\u8fdb\u884c\u53cd\u5e94\u3002\u540c\u65f6\uff0c\u975e\u5bf9\u79f0\u76841,1-\u4e8c\u53d6\u4ee3\u70ef\u70c3\u8fdb\u884c\u5076\u8054\u53cd\u5e94\u65f6\uff0c\u53ef\u83b7\u5f97\u5177\u67091,3-\u975e\u76f8\u90bb\u624b\u6027\u4e2d\u5fc3\u7684\u4ea7\u7269\uff0c\u5c3d\u7ba1\u975e\u5bf9\u6620\u9009\u62e9\u6027\u8f83\u5dee\uff0c\u4f46\u4e24\u79cd\u975e\u5bf9\u6620\u5f02\u6784\u4f53\u90fd\u5177\u6709\u51fa\u8272\u7684\u5bf9\u6620\u9009\u62e9\u6027\uff0c\u5982<strong data-eusoft-scrollable-element=\"1\">25<\/strong>\u3002\u6b64\u5916\uff0c\u73af\u70ef\u70c3\u4e5f\u662f\u5408\u9002\u7684\u5e95\u7269\uff0c\u53ef\u4ee541%\u7684\u6536\u7387\u5f97\u5230\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">26<\/b><\/strong>\uff0cee\u4e3a94%\u3002\u6709\u8da3\u7684\u662f\uff0c\u4f7f\u7528\u5185\u70ef\u70c3\u8fdb\u884cC(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u952e\u7684\u6784\u5efa\u65f6\uff0c\u53cd\u5e94\u53d1\u751f\u5728\u8fdc\u7aefC(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)-H\u952e\u800c\u4e0d\u662f<em data-eusoft-scrollable-element=\"1\">ipso<\/em>-\u4f4d(<strong data-eusoft-scrollable-element=\"1\">6<\/strong>\u3001<strong data-eusoft-scrollable-element=\"1\">27<\/strong>\u548c<strong data-eusoft-scrollable-element=\"1\">28<\/strong>)\uff0c\u4ece\u800c\u8868\u660e\u8be5\u53cd\u5e94\u6d89\u53ca\u954d\u6c22\u914d\u5408\u7269\u7684\u94fe\u884c\u8d70\u8fc7\u7a0b\u3002\u4f7f\u7528\u8f9b\u70ef<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">29<\/b><\/strong>\u7684\u6df7\u5408\u7269\u8fdb\u884c\u70f7\u57fa\u5316\u53cd\u5e94\u65f6\uff0c\u53ef\u83b7\u5f97\u5355\u4e00\u7684\u533a\u57df\u5f02\u6784\u4f53\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">9<\/strong>\uff0cee\u4e3a97%\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u975e\u6d3b\u53161,1,2-\u4e09\u53d6\u4ee3\u6216\u56db\u53d6\u4ee3\u70ef\u70c3\uff0c\u672a\u80fd\u83b7\u5f97\u9884\u671f\u4ea7\u7269(\u5982<strong data-eusoft-scrollable-element=\"1\">30<\/strong>)\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u7a7a\u95f4\u4f4d\u963b\u963b\u6b62\u4e86\u70ef\u70c3\u8fc1\u79fb\u63d2\u5165Ni-H\u914d\u5408\u7269\u5bfc\u81f4\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55377 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504922379.jpg\" alt=\"\" width=\"1268\" height=\"1550\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504922379.jpg 1268w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504922379-245x300.jpg 245w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504922379-680x831.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504922379-768x939.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504922379-1257x1536.jpg 1257w\" sizes=\"(max-width: 1268px) 100vw, 1268px\" \/><\/p>\n<p style=\"text-align: justify;\">\u5176\u6b21\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76(Table 3)\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5728\u4f18\u5316\u7684\u6761\u4ef6\u4e0b\uff0c\u5404\u79cd\u9971\u548c\u7684\u6c2e\u4e0e\u6c27\u6742\u73af\u5316\u5408\u7269\uff0c\u5747\u53ef\u987a\u5229\u8fdb\u884c\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u5177\u6709\u826f\u597d\u7684\u6536\u7387\u4ee5\u53ca\u4f18\u5f02\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3002\u5176\u4e2d\uff0c(<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">R<\/i><\/em>)-2-\u7532\u57fa-1-\u82ef\u7532\u9170\u57fa\u5421\u54af\u70f7(<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">33<\/b><\/strong>)\u5728\u7a7a\u95f4\u4f4d\u963b\u8f83\u5c0f\u7684C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u952e\u4e0a\u9009\u62e9\u6027\u8fdb\u884c\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u5177\u6709\u9ad8\u5ea6\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u3002\u7136\u800c\uff0c\u65e0\u73af<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">N<\/i><\/em>-\u70f7\u57fa\u82ef\u7532\u9170\u80fa\uff0c\u672a\u80fd\u83b7\u5f97\u9884\u671f\u7684\u70f7\u57fa\u5316\u4ea7\u7269\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8be5\u7b56\u7565\u8fd8\u53ef\u7528\u4e8e\u4e00\u4e9b\u5929\u7136\u4ea7\u7269\u4e0e\u836f\u7269\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\uff0c\u5982<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">47<\/b><\/strong>&#8211;<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">55<\/b><\/strong>\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55378 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504913931.jpg\" alt=\"\" width=\"1268\" height=\"1681\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504913931.jpg 1268w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504913931-226x300.jpg 226w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504913931-680x901.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504913931-768x1018.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504913931-1159x1536.jpg 1159w\" sizes=\"(max-width: 1268px) 100vw, 1268px\" \/><\/p>\n<p style=\"text-align: justify;\">\u6b64\u5916\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u5f53\u4ee5NiBr<sub data-eusoft-scrollable-element=\"1\">2<\/sub>\u00b7DME\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c<strong data-eusoft-scrollable-element=\"1\">L2<\/strong>\u4f5c\u4e3a\u624b\u6027\u914d\u4f53\uff0c\u8fc7\u6c27\u5316\u4e8c\u53d4\u4e01\u57fa(DTBP)\u4f5c\u4e3aHAT\u8bd5\u5242\u4e0e\u6c27\u5316\u5242\uff0cCs<sub data-eusoft-scrollable-element=\"1\">2<\/sub>CO<sub data-eusoft-scrollable-element=\"1\">3<\/sub>\u4f5c\u4e3a\u78b1\uff0c\u805a\u7532\u57fa\u6c22\u7845\u6c27\u70f7(PHMS)\u4f5c\u4e3a\u6c22\u6e90\uff0c\u53ef\u4fc3\u8fdb\u70ef\u57fa\u787c\u9178\u916f\u4e0eC(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u5e95\u7269\u7684\u5bf9\u6620\u4e0e\u975e\u5bf9\u6620\u9009\u62e9\u6027\u70f7\u57fa\u5316\u53cd\u5e94(Table 4)\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u8868\u660e\uff0c\u70ef\u57fa-\u9891\u90a3\u9187\u787c\u70f7(\u70ef\u57fa-Bpin)\u5bf9\u4e8e\u8be5\u53cd\u5e94\u5177\u6709\u72ec\u7279\u4e4b\u5904\uff0c\u56e0\u4e3a\u5176\u4ed6\u6709\u673a\u787c\u8bd5\u5242\uff0c\u5982\u70ef\u57fa(1,8-\u8418\u4e8c\u6c28\u57fa)\u787c\u70f7\u548c9-\u70ef\u57fa-9-\u787c\u53cc\u73af[3.3.1]\u58ec\u70f7\uff0c\u672a\u80fd\u751f\u6210\u9884\u671f\u7684\u4ea7\u7269\u3002\u5176\u6b21\uff0c\u542b\u6709\u5404\u79cd\u5b98\u80fd\u56e2\u5316\u7684\u70ef\u70c3\uff0c\u5982\u919a\u3001TBS\u919a\u3001\u70f7\u6c27\u7fb0\u57fa\u3001\u90bb\u82ef\u4e8c\u7532\u9170\u4e9a\u80fa\u548c\u82b3\u57fa\u7b49\uff0c\u5747\u4e0e\u4f53\u7cfb\u517c\u5bb9\u3002\u6b64\u5916\uff0c\u5177\u6709\u5f3aC(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u952e\u7684\u73af\u70f7\u70c3\uff0c\u5982\u73af\u620a\u70f7(<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">69<\/b><\/strong>)\u548c\u73af\u5df1\u70f7(<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">70<\/b><\/strong>)\uff0c\u4e5f\u662f\u5408\u9002\u7684\u5e95\u7269\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55379 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504905474.jpg\" alt=\"\" width=\"1267\" height=\"1350\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504905474.jpg 1267w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504905474-282x300.jpg 282w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504905474-680x725.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504905474-768x818.jpg 768w\" sizes=\"(max-width: 1267px) 100vw, 1267px\" \/><\/p>\n<p style=\"text-align: justify;\">\u4e4b\u540e\uff0c\u4f5c\u8005\u5bf9\u53cd\u5e94\u7684\u5b9e\u7528\u6027\u8fdb\u884c\u4e86\u7814\u7a76 (Fig. 2)\u3002\u9996\u5148\uff0c\u4ee5\u5421\u54af\u70f7\u884d\u751f\u7269<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">1<\/b><\/strong>\u4e3a\u5e95\u7269\uff0c\u901a\u8fc7\u4e09\u6b65\u53cd\u5e94\uff0c\u53ef\u5206\u522b\u5b9e\u73b0(<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">R<\/i><\/em>)-Bgugaine\u3001(<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">R<\/i><\/em>)-Irnidine\u4e0e(\u2212)-Coniceine\u7684\u5168\u5408\u6210(Fig. 2a)\u3002\u5176\u6b21\uff0c\u4ee5\u4e19\u916e\u4fdd\u62a4\u76841,3-\u4e8c\u9187<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">77<\/b><\/strong>\u4e3a\u5e95\u7269\uff0c\u5229\u7528\u4e0a\u8ff0\u7684\u7b56\u7565\uff0c\u8fd8\u53ef\u5b9e\u73b0(<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">S<\/i><\/em>)-\u786b\u8f9b\u9178\u4e0e\u00a0(\u2212)-Tetrahydrolipstatin\u5173\u952e\u4e2d\u95f4\u4f53\u7684\u5408\u6210(Fig. 2b)\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u6210\u529f\u7684\u5c06\u4e0a\u8ff0\u7684\u7b56\u7565\u5e94\u7528\u4e8e(\u2212)-1-Hydroxypyrrolizidine, (\u2212)-Perhydro-8-indolizinol, (\u2212)-Trachelanthamidine \u4e0e\u00a0(\u2212)-Tashiromine\u7684\u5168\u5408\u6210\u4e2d\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u8be5\u7b56\u7565\u7684\u5b9e\u7528\u6027(Fig. 2c)\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55380 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504897729.jpg\" alt=\"\" width=\"1268\" height=\"1642\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504897729.jpg 1268w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504897729-232x300.jpg 232w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504897729-680x881.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504897729-768x995.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504897729-1186x1536.jpg 1186w\" sizes=\"(max-width: 1268px) 100vw, 1268px\" \/><\/p>\n<p style=\"text-align: justify;\">\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u53cd\u5e94\u7684\u673a\u7406\u8fdb\u884c\u4e86\u8fdb\u4e00\u6b65\u7814\u7a76\u00a0(Fig. 3)\u3002\u81ea\u7531\u57fa\u6355\u83b7\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u53d4\u4e01\u6c27\u57fa\u81ea\u7531\u57fa\u4eceC(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u5e95\u7269\u4e2d\u652b\u53d6\u4e00\u4e2a\u6c22\u539f\u5b50\uff0c\u5f62\u6210\u4e86\u76f8\u5e94\u7684\u78b3\u4e2d\u5fc3\u81ea\u7531\u57fa(Fig. 3a)\u3002\u540c\u65f6\uff0c\u901a\u8fc7\u70f7\u57fa\u7845\u70f7\u7684\u5bf9\u7167\u5b9e\u9a8c\u7ed3\u679c\uff0c\u6392\u9664\u4e86\u70ef\u70c3\u901a\u8fc7\u6c22\u7845\u5316\u5f62\u6210\u70f7\u57fa\u7845\u70f7\u4f5c\u4e3a\u5173\u952e\u4e2d\u95f4\u4f53\u7684\u53ef\u80fd\u6027(Fig. 3b)\u3002KIE\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u50ac\u5316\u53cd\u5e94\u4e2d\u7684\u5468\u8f6c\u9650\u901f\u6b65\u9aa4\u53ef\u80fd\u662f\u70f7\u6c27\u81ea\u7531\u57fa\u5bf9C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u952e\u7684\u65ad\u88c2\u200c(Fig. 3c\u4e0eFig. 3d)\u3002\u70f7\u57fa-Ni(II)\u914d\u5408\u7269<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">99<\/b><\/strong>\u7684\u5316\u5b66\u8ba1\u91cf\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0c\u70f7\u57fa-Ni(II)\u914d\u5408\u7269\u53ef\u80fd\u662f\u8fd9\u79cd\u8f6c\u5316\u4e2d\u7684\u53cd\u5e94\u6027\u4e2d\u95f4\u4f53(Fig. 3e)\u3002\u5229\u7528\u4e0d\u540c\u7684\u954d\u914d\u5408\u7269\u8fd8\u539fDCP\u7684\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0c<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">L8<\/b><\/strong>Ni(I)Br\u8fd8\u539f\u4e86DCP\uff0c\u5176\u7531Zn\u8fd8\u539f<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">L8<\/b><\/strong>Ni(II)Br<sub data-eusoft-scrollable-element=\"1\">2<\/sub>\u751f\u6210(Fig. 3f)\u3002\u70ef\u70c3\u5f02\u6784\u4f53\u6df7\u5408\u7269\u7684\u533a\u57df\u6c47\u805a\u6027\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0cNi\u2013H\u5bf9\u70ef\u70c3\u7684\u8fc1\u79fb\u63d2\u5165\u8fc7\u7a0b\u4e0d\u5177\u6709\u533a\u57df\u4e13\u4e00\u6027\uff0c\u652f\u94fe\u70f7\u57fa-\u954d\u4e2d\u95f4\u4f53\u4e0e\u5176\u7ebf\u6027\u5f02\u6784\u4f53\u4e4b\u95f4\u901a\u8fc7<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">\u03b2<\/i><\/em>-H\u6d88\u9664\u548c\u70ef\u70c3\u518d\u63d2\u5165\u5b9e\u73b0\u76f8\u4e92\u8f6c\u5316\u662f\u53ef\u884c\u7684\u200c(Fig. 3g)\u3002<\/p>\n<p style=\"text-align: justify;\">\u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Fig. 3h)\u3002\u9996\u5148\uff0c\u8fc7\u6c27\u5316\u7269\u6c27\u5316(RO)Ni(I)L*\u914d\u5408\u7269<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">A<\/b><\/strong>\u4f1a\u4ea7\u751f\u70ed\u529b\u5b66\u7a33\u5b9a\u7684L*Ni(II)(OR)<sub data-eusoft-scrollable-element=\"1\">2<\/sub>\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">B<\/b><\/strong>\u548c\u70f7\u6c27\u57fa\u81ea\u7531\u57fa\u3002\u5728\u950c\u7c89\u7684\u5b58\u5728\u4e0b\uff0cNi(II)\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">B<\/b><\/strong>\u53ef\u8fd8\u539f\u4e3aNi(I)\u914d\u5408\u7269<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">A<\/b><\/strong>\u3002\u5176\u4e2d\uff0c<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">B<\/b><\/strong>\u548c<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">A<\/b><\/strong>\u4e4b\u95f4\u76f8\u4e92\u8f6c\u5316\u53ef\u589e\u52a0\u70f7\u6c27\u57fa\u81ea\u7531\u57fa\u7684\u6d53\u5ea6\uff0c\u4ece\u800c\u63d0\u9ad8HAT\u8fc7\u7a0b\u7684\u6548\u7387\u3002\u5176\u6b21\uff0cNi(II)\u914d\u5408\u7269<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">B<\/b><\/strong>\u4e0e\u7845\u70f7\u53d1\u751f\u8f6c\u91d1\u5c5e\u5316\u53cd\u5e94\uff0c\u751f\u6210\u6c22\u5316\u954d(II)\u914d\u5408\u7269<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">C<\/b><\/strong>\u3002\u5185\u70ef\u70c3\u5728Ni-H\u914d\u5408\u7269\u4e2d\u7684\u5feb\u901f\u8fc1\u79fb\u63d2\u5165\uff0c\u751f\u6210\u70f7\u57fa\u954d(II)\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">D<\/b><\/strong>\u3002\u7136\u540e\uff0c\u652f\u94fe\u70f7\u57fa-\u954d(II)\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">D<\/b><\/strong>\u901a\u8fc7<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">\u03b2<\/i><\/em>-H\u6d88\u9664\u548c\u70ef\u70c3\u91cd\u65b0\u63d2\u5165\u7684\u76f8\u4e92\u8f6c\u5316\uff0c\u53ef\u751f\u6210\u76f8\u5e94\u7684\u76f4\u94fe\u5f02\u6784\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">E<\/b><\/strong>\u3002\u4ece\u9971\u548c\u6742\u73af\u5316\u5408\u7269\u5230\u70f7\u6c27\u57fa\u81ea\u7531\u57fa\u7684HAT\u751f\u6210\u70f7\u57fa\u81ea\u7531\u57fa<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">F<\/b><\/strong>\uff0c\u5176\u53ef\u88ab\u76f4\u94fe\u70f7\u57fa-Ni(II)\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">E<\/b><\/strong>\u6355\u83b7\uff0c\u751f\u6210Ni(III)\u914d\u5408\u7269<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">G<\/b><\/strong>\u3002Ni(III)\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">G<\/b><\/strong>\u7ecf\u8fd8\u539f\u6d88\u9664\uff0c\u53ef\u751f\u6210\u6240\u9700\u7684C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u70f7\u57fa\u5316\u4ea7\u7269\uff0c\u5e76\u518d\u751f\u50ac\u5316\u6d3b\u6027(RO)Ni(I)\u914d\u5408\u7269<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">A<\/b><\/strong>\u3002\u6b64\u5916\uff0c\u652f\u94fe\u70f7\u57fa-\u954d\u4e2d\u95f4\u4f53\u8f6c\u5316\u4e3a\u76f4\u94fe\u70f7\u57fa-\u954d\u914d\u5408\u7269\u7684\u9a71\u52a8\u529b\u53ef\u80fd\u662f\u7a7a\u95f4\u4f4d\u963b\uff0c\u81ea\u7531\u57fa<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">F<\/b><\/strong>\u4f18\u5148\u653b\u51fb\u76f4\u94fe\u70f7\u57fa-\u954d<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">E<\/b><\/strong>\u5f62\u6210Ni(III)\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">G<\/b><\/strong>\uff0c\u800c\u4e0d\u662f\u652f\u94fe\u70f7\u57fa-\u954d<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">D<\/b><\/strong>\u5f62\u6210Ni(III)\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">H<\/b><\/strong>\u3002<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">\u03b1<\/i><\/em>-\u787c\u57fa\u5bfc\u5411\u57fa\u56e2\u53ef\u4ee5\u7a33\u5b9a\u70ef\u57fa\u787c\u9178\u916f\u5e95\u7269\u7ecf\u6c22\u954d\u5316\u751f\u6210\u7684\u652f\u94fe\u6709\u673a\u954d\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">I<\/b><\/strong>\uff0c\u540c\u65f6\u907f\u514d\u94fe\u884c\u8d70\u83b7\u5f97\u76f4\u94fe\u6709\u673a\u954d\u4e2d\u95f4\u4f53\u3002\u81ea\u7531\u57fa<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">F<\/b><\/strong>\u4e0e\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">I<\/b><\/strong>\u53cd\u5e94\u751f\u6210Ni(III)\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">J<\/b><\/strong>\uff0c\u7136\u540e\u7ecf\u8fd8\u539f\u6d88\u9664\uff0c\u53ef\u83b7\u5f97\u542b\u6709\u4e24\u4e2a\u8fde\u7eed\u624b\u6027\u4e2d\u5fc3\u7684\u787c\u9178\u70f7\u57fa\u916f\u3002<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55381 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504887426.jpg\" alt=\"\" width=\"1268\" height=\"1548\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504887426.jpg 1268w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504887426-246x300.jpg 246w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504887426-680x830.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504887426-768x938.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/1743504887426-1258x1536.jpg 1258w\" sizes=\"(max-width: 1268px) 100vw, 1268px\" \/><\/p>\n<h4 style=\"text-align: justify;\">\u603b\u7ed3\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u6b66\u6c49\u5927\u5b66\u7684\u5b54\u671b\u6e05\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u954d\u50ac\u5316\u9971\u548c\u6742\u73af\u5316\u5408\u7269\u4e0e\u70ef\u70c3\u7684\u5bf9\u6620\u9009\u62e9\u6027C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u9ad8\u6548\u5b9e\u73b0\u4e86C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u952e\u7684\u7acb\u4f53\u9009\u62e9\u6027\u6784\u5efa\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8fd8\u5f00\u53d1\u4e86\u4e00\u79cd\u9971\u548c\u70c3\u4e0e\u70ef\u57fa\u787c\u9178\u916f\u7684\u5bf9\u6620\u4e0e\u975e\u5bf9\u6620\u9009\u62e9\u6027C(<em data-eusoft-scrollable-element=\"1\">sp<\/em><sup data-eusoft-scrollable-element=\"1\">3<\/sup>)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5408\u6210\u4e86\u542b\u6709\u76f8\u90bb\u624b\u6027\u4e2d\u5fc3\u7684\u70f7\u57fa\u787c\u9178\u916f\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u5bf9\u5929\u7136\u4ea7\u7269\u4e0e\u836f\u7269\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\uff0c\u4ee5\u53ca\u4e00\u7cfb\u5217\u624b\u6027\u7ed3\u6784\u5355\u5143\u4e0e\u5929\u7136\u4ea7\u7269\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u53cd\u5e94\u7684\u5b9e\u7528\u6027\u3002<\/p>\n<h4 style=\"text-align: justify;\"><strong data-eusoft-scrollable-element=\"1\">\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ul>\n<li style=\"text-align: justify;\">[1]\u00a0L.\u00a0Capaldo, D. Ravelli, M. Fagnoni, <em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">Chem. Rev. <\/i><\/em><strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">2022<\/b><\/strong>, <em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">122<\/i><\/em>, 1875.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/acs.chemrev.1c00263\" data-eusoft-scrollable-element=\"1\"><u data-eusoft-scrollable-element=\"1\">10.1021\/acs.chemrev.1c00263<\/u><\/a>.<\/li>\n<li style=\"text-align: justify;\">[2] N.\u00a0Holmberg-Douglas, D. A. Nicewicz, <em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">Chem. Rev. <\/i><\/em><strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">2022<\/b><\/strong>, <em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">122<\/i><\/em>, 1925.\u00a0doi:<a href=\"https:\/\/doi.org\/10.1021\/acs.chemrev.1c00311\" data-eusoft-scrollable-element=\"1\"><u data-eusoft-scrollable-element=\"1\">10.1021\/acs.chemrev.1c00311<\/u><\/a>.<\/li>\n<li style=\"text-align: justify;\">[3]\u00a0C. J.\u00a0Cordier, R. J. Lundgren, G. C. Fu, <em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">J. Am. Chem. Soc.<\/i><\/em>\u00a0<strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">2013<\/b><\/strong>,<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">\u00a0<\/i><\/em><em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">135<\/i><\/em>,\u00a010946.\u00a0doi:<a href=\"https:\/\/doi.org\/10.1021\/ja4054114\" data-eusoft-scrollable-element=\"1\"><u data-eusoft-scrollable-element=\"1\">10.1021\/ja4054114<\/u><\/a>.<\/li>\n<li style=\"text-align: justify;\">[4] M.\u00a0Chen, A.\u00a0M. Ventura, S.\u00a0Das, A.\u00a0F. Ibrahim, P.\u00a0M. Zimmerman, J.\u00a0Montgomery,\u00a0<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">J. Am. <\/i><\/em><em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">Chem. Soc.<\/i><\/em><strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">\u00a02023<\/b><\/strong>,<em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">\u00a0145<\/i><\/em>, 20176.\u00a0doi:<a href=\"https:\/\/doi.org\/10.1021\/jacs.3c06532\" data-eusoft-scrollable-element=\"1\"><u data-eusoft-scrollable-element=\"1\">10.1021\/jacs.3c06532<\/u><\/a>.<\/li>\n<li style=\"text-align: justify;\">[5]\u00a0Y.\u00a0He, Y. Cai, S. Zhu, <em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">J. Am. Chem. Soc. <\/i><\/em><strong data-eusoft-scrollable-element=\"1\"><b data-eusoft-scrollable-element=\"1\">2017<\/b><\/strong>, <em data-eusoft-scrollable-element=\"1\"><i data-eusoft-scrollable-element=\"1\">139<\/i><\/em>, 1061.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1021\/jacs.6b11962\" data-eusoft-scrollable-element=\"1\"><u data-eusoft-scrollable-element=\"1\">10.1021\/jacs.6b11962<\/u><\/a>.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n<p>\u5173\u6ce8Chem-Station\u6296\u97f3\u53f7\uff1a79473891841<\/p>\n<h5>\u8bf7\u767b\u9646TCI\u8bd5\u5242\u5b98\u7f51\u67e5\u770b\u66f4\u591a\u5185\u5bb9<\/h5>\n<h5>https:\/\/www.tcichemicals.com\/CN\/zh\/<\/h5>\n<p style=\"text-align: justify;\">\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u6b66\u6c49\u5927\u5b66\u7684\u5b54\u671b\u6e05\u8bfe\u9898\u7ec4\u5728Nat. Chem.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u954d\u50ac\u5316\u9971\u548c\u6742\u73af\u5316\u5408\u7269\u4e0e\u70ef\u70c3\u7684\u5bf9\u6620\u9009\u62e9\u6027C(sp3)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u4e3aC(sp3)\u2013C(sp3)\u952e\u7684\u7acb\u4f53\u9009\u62e9\u6027\u6784\u5efa\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u6548\u7684\u7b56\u7565\u3002\u5176\u4e2d\uff0c\u8be5\u7b56\u7565\u4f7f\u7528\u6613\u5f97\u4e0e\u7a33\u5b9a\u7684\u70ef\u70c3\u548c\u7b80\u5355\u7684\u9971\u548c\u6c2e\u548c\u6c27\u6742\u73af\u5316\u5408\u7269\u4f5c\u4e3a\u524d\u624b\u6027\u4eb2\u6838\u8bd5\u5242\uff0c\u5076\u8054\u53cd\u5e94\u53ef\u5728\u6e29\u548c\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c\uff0c\u5e76\u8868\u73b0\u51fa\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u4e0e\u9ad8\u5ea6\u7684\u5b98\u80fd\u56e2\u8010\u53d7\u6027\u3002\u5176\u6b21\uff0c\u4f5c\u8005\u8fd8\u5b9e\u73b0\u4e86\u9971\u548c\u70c3\u4e0e\u70ef\u57fa\u787c\u9178\u916f\u7684\u5bf9\u6620\u4e0e\u975e\u5bf9\u6620\u9009\u62e9\u6027C(sp3)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5408\u6210\u4e86\u542b\u6709\u76f8\u90bb\u624b\u6027\u4e2d\u5fc3\u7684\u70f7\u57fa\u787c\u9178\u916f\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u5bf9\u5929\u7136\u4ea7\u7269\u4e0e\u836f\u7269\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\uff0c\u4ee5\u53ca\u4e00\u7cfb\u5217\u624b\u6027\u7ed3\u6784\u5355\u5143\u4e0e\u5929\u7136\u4ea7\u7269\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u53cd\u5e94\u7684\u5b9e\u7528\u6027\u3002 Direct stereoselective C(sp3)\u2013H alkylation of\u00a0saturated heterocycles using olefins Z.Zhou, Y.Ke, R.\u00a0Miao, F.\u00a0Hu, X.\u00a0Wang,\u00a0Y.\u00a0Ping, S.\u00a0Xu,\u00a0W.\u00a0Kong, Chem.\u00a02025, 17, 344. doi:\u00a010.1038\/s41557-025-01747-6. \u6b63\u6587\uff1a \u901a\u8fc7C(sp3)\u2013H\u5b98\u80fd\u56e2\u5316\u5c06\u78b3\u6c22\u5316\u5408\u7269\u8f6c\u5316\u4e3a\u9ad8\u9644\u52a0\u503c\u7684\u624b\u6027\u5316\u5408\u7269\uff0c\u5177\u6709\u9ad8\u5ea6\u7684\u539f\u5b50\u4e0e\u6b65\u9aa4\u7ecf\u6d4e\u6027\uff0c\u4ece\u800c\u5907\u53d7\u5173\u6ce8\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5bf9\u6620\u9009\u62e9\u6027C(sp3)\u2013H\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\uff0c\u5177\u6709\u4e00\u5b9a\u7684\u6311\u6218\u3002\u8fd1\u5e74\u6765\uff0c\u6c22\u539f\u5b50\u8f6c\u79fb(HAT, hydrogen atom\u00a0transfer)[1]\u4e0e\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u4ea4\u53c9\u5076\u8054[2]\u76f8\u7ed3\u5408\u7684\u7b56\u7565\uff0c\u5df2\u6210\u4e3a\u5b9e\u73b0C(sp3)\u2013H\u952e\u8fdb\u884c\u5bf9\u6620\u9009\u62e9\u6027\u5b98\u80fd\u56e2\u5316\u7684\u6709\u529b\u5de5\u5177\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u7f3a\u4e4f\u5bfc\u5411\u57fa\u56e2\u7684\u9971\u548c\u70c3\u901a\u8fc7\u5bf9\u6620\u9009\u62e9\u6027C(sp3)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\u6784\u5efaC(sp3)\u2013C(sp3)\u952e\u7684\u65b9\u6cd5\uff0c\u4ecd\u5177\u6709\u96be\u5ea6(Fig. 1a)\u3002\u540c\u65f6\uff0c\u624b\u6027\u9971\u548c\u6c2e\u4e0e\u6c27\u6742\u73af\u9aa8\u67b6\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u7c7b\u751f\u7269\u6d3b\u6027\u5206\u5b50\u4e0e\u5929\u7136\u4ea7\u7269\u7b49\u4e2d\uff0c\u82e5\u80fd\u5bf9\u5176\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u4fee\u9970\uff0c\u5219\u66f4\u5177\u7814\u7a76\u4ef7\u503c\u3002\u76ee\u524d\uff0c\u5bf9\u4e8e\u5421\u54af\u70f7\u884d\u751f\u7269\u7684\u5bf9\u6620\u9009\u62e9\u6027C(sp3)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\u4e3b\u8981\u4f9d\u8d56\u4e8eN-(\u53d4\u4e01\u6c27\u7fb0\u57fa)\u5421\u54af\u70f7\u7684\u03b1-\u9502\u5316\uff0c\u968f\u540e\u4e0e\u70f7\u57fa\u5364\u8fdb\u884cNegishi\u4ea4\u53c9\u5076\u8054[3]\uff0c\u4f46\u9700\u5728\u82db\u523b\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c\u53bb\u8d28\u5b50\u5316\uff0c\u5e76\u4e14\u5bf9\u4e00\u7ea7\u70f7\u57fa\u5364\u5177\u6709\u8f83\u4f4e\u7684\u5bf9\u6620\u9009\u62e9\u6027(Fig. 1b)\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u5bf9\u4e8e\u954d\u50ac\u5316\u8fc7\u6c27\u5316\u7269\u4ecb\u5bfcC(sp3)\u2013H\u5b98\u80fd\u56e2\u5316[4]\u4e0eNiH-\u50ac\u5316\u70ef\u70c3\u52a0\u6c22\u70f7\u57fa\u5316\u53cd\u5e94[5]\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u6b66\u6c49\u5927\u5b66\u7684\u5b54\u671b\u6e05\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u954d\u50ac\u5316\u9971\u548c\u6742\u73af\u5316\u5408\u7269\u4e0e\u70ef\u70c3\u7684\u5bf9\u6620\u9009\u62e9\u6027C(sp3)\u2013H\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5b9e\u73b0\u4e86C(sp3)\u2013C(sp3)\u952e\u7684\u7acb\u4f53\u9009\u62e9\u6027\u6784\u5efa(Fig. 1c)\u3002\u540c\u65f6\uff0c\u901a\u8fc7\u5bf9\u5929\u7136\u4ea7\u7269\u4e0e\u836f\u7269\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\uff0c\u4ee5\u53ca\u4e00\u7cfb\u5217\u624b\u6027\u7ed3\u6784\u5355\u5143\u4e0e\u5929\u7136\u4ea7\u7269\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u53cd\u5e94\u7684\u5b9e\u7528\u6027(Fig. 1d)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u7528\u5421\u54af\u70f7\u884d\u751f\u72691\u4e0e\u975e\u6d3b\u5316\u70ef\u70c32\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528NiBr2\u00b7DME\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cL8\u4f5c\u4e3a\u624b\u6027\u914d\u4f53\uff0c\u8fc7\u6c27\u5316\u4e8c\u5f02\u4e19\u82ef(DCP)\u4f5c\u4e3aHAT\u8bd5\u5242\u4e0e\u6c27\u5316\u5242\uff0cKHCO3\u4f5c\u4e3a\u78b1\uff0cZn\u7c89\u4f5c\u4e3a\u8fd8\u539f\u5242\uff0c(MeO)3SiH\u4f5c\u4e3a\u6c22\u6e90\uff0c\u5728EA\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a0 oC\uff0c\u6700\u7ec8\u83b7\u5f9761%\u5206\u79bb\u6536\u7387\u7684\u4ea7\u72693(97% ee)\u3002\u5176\u4e2d\uff0c\u8be5\u53cd\u5e94\u6210\u529f\u7684\u5173\u952e\u662f\u627e\u5230\u4e00\u79cd\u5408\u9002\u7684HAT\u6c27\u5316\u5242\uff0c\u8be5\u6c27\u5316\u5242\u53ef\u4ee5\u4e0e\u78b3\u6c22\u5316\u5408\u7269\u5b9e\u73b0\u9ad8\u6548\u7684HAT\uff0c\u5e76\u5728\u954d\u50ac\u5316\u5faa\u73af\u4e2d\u80fd\u591f\u6c27\u5316\u954d\u3002 \u00a0\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u975e\u6d3b\u5316\u70ef\u70c3\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76(Table 2)\u3002\u9996\u5148\uff0c\u4e0a\u8ff0\u5408\u6210\u7684\u4ea7\u72693\u5728\u9178\u6027\u6761\u4ef6\u4e0b\uff0c\u5f88\u5bb9\u6613\u8fdb\u884c\u8131\u4fdd\u62a4\uff0c\u83b7\u5f97N-H\u5421\u54af\u70f7\u4ea7\u72695\u3002\u5176\u6b21\uff0c\u4e00\u7cfb\u5217\u4e0d\u540c\u53d6\u4ee3\u7684\u672b\u7aef\u70ef\u70c3\uff0c\u5747\u53ef\u4e0e\u5421\u54af\u70f7\u884d\u751f\u72691\u8fdb\u884c\u53cd\u5e94\uff0c\u83b7\u5f97\u76f8\u5e94\u7684\u4ea7\u72696&#8211;25\uff0c\u6536\u7387\u4e3a39-73%\uff0cee\u4e3a89-99%\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e00\u7cfb\u5217\u6d3b\u6027\u7684\u57fa\u56e2\uff0c\u5982\u5364\u7d20\u3001\u7845\u57fa\u3001\u70f7\u6c27\u7fb0\u57fa\u7b49\uff0c\u5747\u4e0e\u4f53\u7cfb\u517c\u5bb9\u3002\u7136\u800c\uff0c\u542b\u6709\u6e38\u79bb\u9187\u7684\u5e95\u7269\uff0c\u672a\u80fd\u6709\u6548\u7684\u8fdb\u884c\u53cd\u5e94\u3002\u540c\u65f6\uff0c\u975e\u5bf9\u79f0\u76841,1-\u4e8c\u53d6\u4ee3\u70ef\u70c3\u8fdb\u884c\u5076\u8054\u53cd\u5e94\u65f6\uff0c\u53ef\u83b7\u5f97\u5177\u67091,3-\u975e\u76f8\u90bb\u624b\u6027\u4e2d\u5fc3\u7684\u4ea7\u7269\uff0c\u5c3d\u7ba1\u975e\u5bf9\u6620\u9009\u62e9\u6027\u8f83\u5dee\uff0c\u4f46\u4e24\u79cd\u975e\u5bf9\u6620\u5f02\u6784\u4f53\u90fd\u5177\u6709\u51fa\u8272\u7684\u5bf9\u6620\u9009\u62e9\u6027\uff0c\u598225\u3002\u6b64\u5916\uff0c\u73af\u70ef\u70c3\u4e5f\u662f\u5408\u9002\u7684\u5e95\u7269\uff0c\u53ef\u4ee541%\u7684\u6536\u7387\u5f97\u5230\u4ea7\u726926\uff0cee\u4e3a94%\u3002\u6709\u8da3\u7684\u662f\uff0c\u4f7f\u7528\u5185\u70ef\u70c3\u8fdb\u884cC(sp3)\u2013C(sp3)\u952e\u7684\u6784\u5efa\u65f6\uff0c\u53cd\u5e94\u53d1\u751f\u5728\u8fdc\u7aefC(sp3)-H\u952e\u800c\u4e0d\u662fipso-\u4f4d(6\u300127\u548c28)\uff0c\u4ece\u800c\u8868\u660e\u8be5\u53cd\u5e94\u6d89\u53ca\u954d\u6c22\u914d\u5408\u7269\u7684\u94fe\u884c\u8d70\u8fc7\u7a0b\u3002\u4f7f\u7528\u8f9b\u70ef29\u7684\u6df7\u5408\u7269\u8fdb\u884c\u70f7\u57fa\u5316\u53cd\u5e94\u65f6\uff0c\u53ef\u83b7\u5f97\u5355\u4e00\u7684\u533a\u57df\u5f02\u6784\u4f53\u4ea7\u72699\uff0cee\u4e3a97%\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u975e\u6d3b\u53161,1,2-\u4e09\u53d6\u4ee3\u6216\u56db\u53d6\u4ee3\u70ef\u70c3\uff0c\u672a\u80fd\u83b7\u5f97\u9884\u671f\u4ea7\u7269(\u598230)\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u7a7a\u95f4\u4f4d\u963b\u963b\u6b62\u4e86\u70ef\u70c3\u8fc1\u79fb\u63d2\u5165Ni-H\u914d\u5408\u7269\u5bfc\u81f4\u3002 \u5176\u6b21\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217C(sp3)\u2013H\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76(Table 3)\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5728\u4f18\u5316\u7684\u6761\u4ef6\u4e0b\uff0c\u5404\u79cd\u9971\u548c\u7684\u6c2e\u4e0e\u6c27\u6742\u73af\u5316\u5408\u7269\uff0c\u5747\u53ef\u987a\u5229\u8fdb\u884c\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u5177\u6709\u826f\u597d\u7684\u6536\u7387\u4ee5\u53ca\u4f18\u5f02\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3002\u5176\u4e2d\uff0c(R)-2-\u7532\u57fa-1-\u82ef\u7532\u9170\u57fa\u5421\u54af\u70f7(33)\u5728\u7a7a\u95f4\u4f4d\u963b\u8f83\u5c0f\u7684C(sp3)\u2013H\u952e\u4e0a\u9009\u62e9\u6027\u8fdb\u884c\u70f7\u57fa\u5316\u53cd\u5e94\uff0c\u5177\u6709\u9ad8\u5ea6\u7684\u975e\u5bf9\u6620\u9009\u62e9\u6027\u3002\u7136\u800c\uff0c\u65e0\u73afN-\u70f7\u57fa\u82ef\u7532\u9170\u80fa\uff0c\u672a\u80fd\u83b7\u5f97\u9884\u671f\u7684\u70f7\u57fa\u5316\u4ea7\u7269\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8be5\u7b56\u7565\u8fd8\u53ef\u7528\u4e8e\u4e00\u4e9b\u5929\u7136\u4ea7\u7269\u4e0e\u836f\u7269\u5206\u5b50\u7684\u540e\u671f\u4fee\u9970\uff0c\u598247&#8211;55\u3002 \u6b64\u5916\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u5f53\u4ee5NiBr2\u00b7DME\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cL2\u4f5c\u4e3a\u624b\u6027\u914d\u4f53\uff0c\u8fc7\u6c27\u5316\u4e8c\u53d4\u4e01\u57fa(DTBP)\u4f5c\u4e3aHAT\u8bd5\u5242\u4e0e\u6c27\u5316\u5242\uff0cCs2CO3\u4f5c\u4e3a\u78b1\uff0c\u805a\u7532\u57fa\u6c22\u7845\u6c27\u70f7(PHMS)\u4f5c\u4e3a\u6c22\u6e90\uff0c\u53ef\u4fc3\u8fdb\u70ef\u57fa\u787c\u9178\u916f\u4e0eC(sp3)\u2013H\u5e95\u7269\u7684\u5bf9\u6620\u4e0e\u975e\u5bf9\u6620\u9009\u62e9\u6027\u70f7\u57fa\u5316\u53cd\u5e94(Table 4)\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u8868\u660e\uff0c\u70ef\u57fa-\u9891\u90a3\u9187\u787c\u70f7(\u70ef\u57fa-Bpin)\u5bf9\u4e8e\u8be5\u53cd\u5e94\u5177\u6709\u72ec\u7279\u4e4b\u5904\uff0c\u56e0\u4e3a\u5176\u4ed6\u6709\u673a\u787c\u8bd5\u5242\uff0c\u5982\u70ef\u57fa(1,8-\u8418\u4e8c\u6c28\u57fa)\u787c\u70f7\u548c9-\u70ef\u57fa-9-\u787c\u53cc\u73af[3.3.1]\u58ec\u70f7\uff0c\u672a\u80fd\u751f\u6210\u9884\u671f\u7684\u4ea7\u7269\u3002\u5176\u6b21\uff0c\u542b\u6709\u5404\u79cd\u5b98\u80fd\u56e2\u5316\u7684\u70ef\u70c3\uff0c\u5982\u919a\u3001TBS\u919a\u3001\u70f7\u6c27\u7fb0\u57fa\u3001\u90bb\u82ef\u4e8c\u7532\u9170\u4e9a\u80fa\u548c\u82b3\u57fa\u7b49\uff0c\u5747\u4e0e\u4f53\u7cfb\u517c\u5bb9\u3002\u6b64\u5916\uff0c\u5177\u6709\u5f3aC(sp3)\u2013H\u952e\u7684\u73af\u70f7\u70c3\uff0c\u5982\u73af\u620a\u70f7(69)\u548c\u73af\u5df1\u70f7(70)\uff0c\u4e5f\u662f\u5408\u9002\u7684\u5e95\u7269\u3002 \u4e4b\u540e\uff0c\u4f5c\u8005\u5bf9\u53cd\u5e94\u7684\u5b9e\u7528\u6027\u8fdb\u884c\u4e86\u7814\u7a76 (Fig. 2)\u3002\u9996\u5148\uff0c\u4ee5\u5421\u54af\u70f7\u884d\u751f\u72691\u4e3a\u5e95\u7269\uff0c\u901a\u8fc7\u4e09\u6b65\u53cd\u5e94\uff0c\u53ef\u5206\u522b\u5b9e\u73b0(R)-Bgugaine\u3001(R)-Irnidine\u4e0e(\u2212)-Coniceine\u7684\u5168\u5408\u6210(Fig. 2a)\u3002\u5176\u6b21\uff0c\u4ee5\u4e19\u916e\u4fdd\u62a4\u76841,3-\u4e8c\u918777\u4e3a\u5e95\u7269\uff0c\u5229\u7528\u4e0a\u8ff0\u7684\u7b56\u7565\uff0c\u8fd8\u53ef\u5b9e\u73b0(S)-\u786b\u8f9b\u9178\u4e0e\u00a0(\u2212)-Tetrahydrolipstatin\u5173\u952e\u4e2d\u95f4\u4f53\u7684\u5408\u6210(Fig. 2b)\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u6210\u529f\u7684\u5c06\u4e0a\u8ff0\u7684\u7b56\u7565\u5e94\u7528\u4e8e(\u2212)-1-Hydroxypyrrolizidine, (\u2212)-Perhydro-8-indolizinol, (\u2212)-Trachelanthamidine \u4e0e\u00a0(\u2212)-Tashiromine\u7684\u5168\u5408\u6210\u4e2d\uff0c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u8be5\u7b56\u7565\u7684\u5b9e\u7528\u6027(Fig. 2c)\u3002 \u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u53cd\u5e94\u7684\u673a\u7406\u8fdb\u884c\u4e86\u8fdb\u4e00\u6b65\u7814\u7a76\u00a0(Fig. 3)\u3002\u81ea\u7531\u57fa\u6355\u83b7\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u53d4\u4e01\u6c27\u57fa\u81ea\u7531\u57fa\u4eceC(sp3)\u2013H\u5e95\u7269\u4e2d\u652b\u53d6\u4e00\u4e2a\u6c22\u539f\u5b50\uff0c\u5f62\u6210\u4e86\u76f8\u5e94\u7684\u78b3\u4e2d\u5fc3\u81ea\u7531\u57fa(Fig. 3a)\u3002\u540c\u65f6\uff0c\u901a\u8fc7\u70f7\u57fa\u7845\u70f7\u7684\u5bf9\u7167\u5b9e\u9a8c\u7ed3\u679c\uff0c\u6392\u9664\u4e86\u70ef\u70c3\u901a\u8fc7\u6c22\u7845\u5316\u5f62\u6210\u70f7\u57fa\u7845\u70f7\u4f5c\u4e3a\u5173\u952e\u4e2d\u95f4\u4f53\u7684\u53ef\u80fd\u6027(Fig. 3b)\u3002KIE\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u50ac\u5316\u53cd\u5e94\u4e2d\u7684\u5468\u8f6c\u9650\u901f\u6b65\u9aa4\u53ef\u80fd\u662f\u70f7\u6c27\u81ea\u7531\u57fa\u5bf9C(sp3)\u2013H\u952e\u7684\u65ad\u88c2\u200c(Fig. 3c\u4e0eFig. 3d)\u3002\u70f7\u57fa-Ni(II)\u914d\u5408\u726999\u7684\u5316\u5b66\u8ba1\u91cf\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0c\u70f7\u57fa-Ni(II)\u914d\u5408\u7269\u53ef\u80fd\u662f\u8fd9\u79cd\u8f6c\u5316\u4e2d\u7684\u53cd\u5e94\u6027\u4e2d\u95f4\u4f53(Fig. 3e)\u3002\u5229\u7528\u4e0d\u540c\u7684\u954d\u914d\u5408\u7269\u8fd8\u539fDCP\u7684\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0cL8Ni(I)Br\u8fd8\u539f\u4e86DCP\uff0c\u5176\u7531Zn\u8fd8\u539fL8Ni(II)Br2\u751f\u6210(Fig. 3f)\u3002\u70ef\u70c3\u5f02\u6784\u4f53\u6df7\u5408\u7269\u7684\u533a\u57df\u6c47\u805a\u6027\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0cNi\u2013H\u5bf9\u70ef\u70c3\u7684\u8fc1\u79fb\u63d2\u5165\u8fc7\u7a0b\u4e0d\u5177\u6709\u533a\u57df\u4e13\u4e00\u6027\uff0c\u652f\u94fe\u70f7\u57fa-\u954d\u4e2d\u95f4\u4f53\u4e0e\u5176\u7ebf\u6027\u5f02\u6784\u4f53\u4e4b\u95f4\u901a\u8fc7\u03b2-H\u6d88\u9664\u548c\u70ef\u70c3\u518d\u63d2\u5165\u5b9e\u73b0\u76f8\u4e92\u8f6c\u5316\u662f\u53ef\u884c\u7684\u200c(Fig. 3g)\u3002 \u57fa\u4e8e\u4e0a\u8ff0\u7684\u5b9e\u9a8c\u7814\u7a76\uff0c\u4f5c\u8005\u63d0\u51fa\u5982\u4e0b\u5408\u7406\u7684\u53cd\u5e94\u673a\u7406 (Fig. 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Ravelli, M. Fagnoni, Chem. Rev. 2022, 122, 1875.\u00a0doi:\u00a010.1021\/acs.chemrev.1c00263. [2] N.\u00a0Holmberg-Douglas, D. A. Nicewicz, Chem. Rev. 2022, 122, 1925.\u00a0doi:10.1021\/acs.chemrev.1c00311. [3]\u00a0C. J.\u00a0Cordier, R. J. Lundgren, G. C. Fu, J. Am. Chem. Soc.\u00a02013,\u00a0135,\u00a010946.\u00a0doi:10.1021\/ja4054114. [4] M.\u00a0Chen, A.\u00a0M. Ventura, S.\u00a0Das, A.\u00a0F. Ibrahim, P.\u00a0M. Zimmerman, J.\u00a0Montgomery,\u00a0J. Am. Chem. 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