{"id":55400,"date":"2025-04-16T08:00:07","date_gmt":"2025-04-16T00:00:07","guid":{"rendered":"\/\/www.gsbet888.com\/?p=55400"},"modified":"2025-04-16T08:15:04","modified_gmt":"2025-04-16T00:15:04","slug":"jacs%ef%bc%9a%e5%85%89%e6%b0%a7%e5%8c%96%e8%bf%98%e5%8e%9f-%e5%90%a1%e5%95%b6-n-%e6%b0%a7%e5%8c%96%e7%89%a9%e5%82%ac%e5%8c%96%ce%b1-%e7%83%af%e7%83%83%e7%9a%84carbohydroxylation%e4%b8%8e%e6%b0%a8","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2025\/04\/jacs%ef%bc%9a%e5%85%89%e6%b0%a7%e5%8c%96%e8%bf%98%e5%8e%9f-%e5%90%a1%e5%95%b6-n-%e6%b0%a7%e5%8c%96%e7%89%a9%e5%82%ac%e5%8c%96%ce%b1-%e7%83%af%e7%83%83%e7%9a%84carbohydroxylation%e4%b8%8e%e6%b0%a8.html","title":{"rendered":"JACS\uff1a\u5149\u6c27\u5316\u8fd8\u539f\/\u5421\u5576-N-\u6c27\u5316\u7269\u50ac\u5316\u03b1-\u70ef\u70c3\u7684Carbohydroxylation\u4e0e\u6c28\u7f9f\u5316\u53cd\u5e94"},"content":{"rendered":"<p style=\"text-align: justify;\">\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n<h4 style=\"text-align: justify;\">\u5bfc\u8bfb\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u8fd1\u65e5\uff0c\u7f8e\u56fdBinghamton\u5927\u5b66\u7684Mathew J. Vetticatt\u4e0eIndiana\u5927\u5b66\u7684Yongming Deng\u8bfe\u9898\u7ec4\u5728<em data-eusoft-scrollable-element=\"1\">J. Am. Chem. Soc.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u5149\u6c27\u5316\u8fd8\u539f\/\u5421\u5576-<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u5316\u7269\u50ac\u5316<em data-eusoft-scrollable-element=\"1\">\u03b1<\/em>-\u70ef\u70c3\u7684\u533a\u57df\u9009\u62e9\u6027carbohydroxylation\u4e0e\u6c28\u7f9f\u5316\u53cd\u5e94\u3002\u8be5\u65b9\u6cd5\u53ef\u5c06\u975e\u6d3b\u5316\u7684\u70ef\u70c3\u76f4\u63a5\u8f6c\u5316\u4e3a\u4e00\u7ea7\u9187\uff0c\u5305\u62ec\u542b\u6709<em data-eusoft-scrollable-element=\"1\">\u03b2<\/em>-\u5b63\u78b3\u4e2d\u5fc3\u4e0e<em data-eusoft-scrollable-element=\"1\">\u03b2<\/em>-\u6c28\u57fa\u9187\u7684\u4e00\u7ea7\u9187\u3002<em data-eusoft-scrollable-element=\"1\">\u03b1<\/em>-\u70ef\u70c3\u7684\u533a\u57df\u9009\u62e9\u6027\u53cc\u5b98\u80fd\u56e2\u5316\u662f\u901a\u8fc7\u5421\u5576-<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u81ea\u7531\u57fa(<em data-eusoft-scrollable-element=\"1\">N<\/em>-oxy radical)\u5bf9\u5176\u8fdb\u884c\u81ea\u7531\u57fa\u52a0\u6210\u5b9e\u73b0\uff0c\u8be5\u81ea\u7531\u57fa\u7531\u6613\u5f97\u7684\u5421\u5576-<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u5316\u7269\u7ecf\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u7684\u5355\u7535\u5b50\u6c27\u5316\u8fc7\u7a0b\u751f\u6210\u3002\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u53cd\u5e94\u6d89\u53ca\u4ea4\u7ec7\u7684\u81ea\u7531\u57fa\u6b65\u9aa4(interwoven radical steps)\u4e0e\u6781\u6027\u53d6\u4ee3\u7684\u8fc7\u7a0b\u3002\u6b64\u5916\uff0c\u901a\u8fc7carboetherification\u3001\u78b3\u916f\u5316\u53ca\u5185\u916f\u5f62\u6210\u7b49\u5b9e\u4f8b\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u8be5\u65b9\u6cd5\u5bf9<em data-eusoft-scrollable-element=\"1\">\u03b1<\/em>-\u70ef\u70c3\u533a\u57df\u9009\u62e9\u6027\u53cc\u5b98\u80fd\u56e2\u5316\u7684\u666e\u9002\u6027\u3002<\/p>\n<blockquote data-eusoft-scrollable-element=\"1\">\n<p style=\"text-align: justify;\">Photoredox\/Pyridine <em data-eusoft-scrollable-element=\"1\">N<\/em>\u2011Oxide Catalyzed Carbohydroxylation and Aminohydroxylation of <em data-eusoft-scrollable-element=\"1\">\u03b1<\/em>\u2011Olefins<\/p>\n<p>C. A. Pettenuzzo, D. R. Pradhan, J. Singh, L. Liu, G. Cuffel, M. J. Vetticatt, Y. Deng, <em data-eusoft-scrollable-element=\"1\">J. Am. Chem. Soc.<\/em> <strong data-eusoft-scrollable-element=\"1\">2025<\/strong>, ASAP. doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.4c17657\" data-eusoft-scrollable-element=\"1\">10.1021\/jacs.4c17657<\/a><u data-eusoft-scrollable-element=\"1\">.<\/u><\/p><\/blockquote>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55402 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/ce6e2814f207c9333f10785606c57df3-1.png\" alt=\"\" width=\"554\" height=\"177\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/ce6e2814f207c9333f10785606c57df3-1.png 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/ce6e2814f207c9333f10785606c57df3-1-300x96.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/ce6e2814f207c9333f10785606c57df3-1-550x177.png 550w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<h4>\u6b63\u6587\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u4e00\u7ea7\u9187\u5728\u5236\u836f\u3001\u519c\u7528\u5316\u5b66\u54c1\u4e0e\u7cbe\u7ec6\u5316\u5b66\u5de5\u4e1a\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u7528\u9014\u3002\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u5df2\u7ecf\u6210\u529f\u8bbe\u8ba1\u51fa\u591a\u79cd\u91c7\u7528\u70ef\u70c3\u6784\u5efa\u4e00\u7ea7\u9187\u5206\u5b50\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565<sup data-eusoft-scrollable-element=\"1\">[1]<\/sup>\uff0c\u4f46\u9700\u4f7f\u7528\u5316\u5b66\u8ba1\u91cf\u7684\u6c27\u5316\u5242\u6216\u8fd8\u539f\u5242\uff0c\u5e76\u6d89\u53ca\u591a\u6b65\u64cd\u4f5c(Figure 1A)\u30022011\u5e74\uff0cGrubbs\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u4e09\u91cd\u63a5\u529b\u50ac\u5316\u4f53\u7cfb\uff0c\u5b9e\u73b0\u4e86\u82ef\u4e59\u70ef\u4e0e\u6c34\u7684\u4e00\u9505<em data-eusoft-scrollable-element=\"1\">anti<\/em>-Markovnikov\u6c34\u5408\u53cd\u5e94<sup data-eusoft-scrollable-element=\"1\">[2]<\/sup>(Figure 1B)\u30022017\u5e74\uff0c\u96f7\u7231\u6587\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u57fa\u4e8e\u5416\u5576\u76d0(acridinium)\u5149\u50ac\u5316\u5242\u7684\u5149\u6c27\u5316\u8fd8\u539f\u7b56\u7565\uff0c\u901a\u8fc7\u82ef\u4e59\u70ef\u53ca\u591a\u53d6\u4ee3\u70ef\u70c3\u7684\u5355\u7535\u5b50\u6c27\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5408\u6210\u4e86\u4e00\u7ea7\u9187<sup data-eusoft-scrollable-element=\"1\">[3]<\/sup>(Figure 1B)\u3002\u5c3d\u7ba1\u53d6\u5f97\u4e86\u8fd9\u4e9b\u91cd\u8981\u8fdb\u5c55\uff0c\u4f46\u5df2\u62a5\u9053\u7684\u4e00\u7ea7\u9187\u5408\u6210\u50ac\u5316\u65b9\u6cd5\u666e\u904d\u53d7\u9650\u4e8e\u82ef\u4e59\u70ef\u6216\u591a\u53d6\u4ee3\u70ef\u70c3\u7c7b\u5e95\u7269\u3002\u6b64\u5916\uff0c\u975e\u5bf9\u79f0\u70ef\u70c3\u7684\u81ea\u7531\u57fa\u52a0\u6210\u53cd\u5e94\uff0c\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u6548\u7684\u66ff\u4ee3\u7b56\u7565\uff0c\u53ef\u5728\u70ef\u70c3\u4e2d\u8f83\u5c11\u53d6\u4ee3\u78b3\u4f4d\u70b9\u4e0a\u8fdb\u884c\u78b3-\u6742\u539f\u5b50\u952e\u7684\u53cd\u9a6c\u6c0f\u533a\u57df\u9009\u62e9\u6027\u6784\u5efa\u3002\u76ee\u524d\uff0c\u6b64\u7c7b\u7b56\u7565\u4e3b\u8981\u96c6\u4e2d\u4e8e\u6c2e\u3001\u786b\u4e0e\u5364\u7d20\u4e3a\u4e2d\u5fc3\u7684\u81ea\u7531\u57fa\u4ecb\u5bfc\u975e\u6d3b\u5316\u70ef\u70c3\u7684\u50ac\u5316<em data-eusoft-scrollable-element=\"1\">anti<\/em>-Markovnikov\u52a0\u6210\u53cd\u5e94<sup 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srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/7f88dbbcaa77a1d28f1e88164d4f6dcd-1.png 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/7f88dbbcaa77a1d28f1e88164d4f6dcd-1-285x300.png 285w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<p style=\"text-align: justify;\">\u4f5c\u8005\u63a8\u6d4b\uff0c\u57fa\u4e8e\u6301\u4e45\u81ea\u7531\u57fa\u6548\u5e94\u4e0e\u6709\u5229\u7684\u6781\u6027\u5339\u914d\uff0c\u5149\u50ac\u5316\u751f\u6210\u7684\u4eb2\u7535\u5421\u5576-<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u81ea\u7531\u57fa\u53ef\u80fd\u5f15\u53d1<em data-eusoft-scrollable-element=\"1\">\u03b1<\/em>-\u70ef\u70c3\u5728\u672b\u7aef\u78b3\u7684\u533a\u57df\u9009\u62e9\u6027\u52a0\u6210\uff0c\u751f\u6210\u66f4\u7a33\u5b9a\u7684\u78b3\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\uff0c\u5176\u53ef\u4e0e\u7f3a\u7535\u5b50\u70ef\u70c3\u8fdb\u884cGiese\u578b\u53cd\u5e94\uff0c\u751f\u6210<em data-eusoft-scrollable-element=\"1\">N<\/em>-alkoxypyridinium\u4e2d\u95f4\u4f53\u3002<em data-eusoft-scrollable-element=\"1\">N<\/em>-alkoxypyridinium\u4e2d\u95f4\u4f53\u53ef\u80fd\u901a\u8fc7\u6c34\u5206\u5b50\u53d6\u4ee3\u53cd\u5e94\u751f\u6210\u4e00\u7ea7\u9187\u4ea7\u7269\uff0c\u4ece\u800c\u5b9e\u73b0<em data-eusoft-scrollable-element=\"1\">\u03b1<\/em>-\u70ef\u70c3\u7684\u533a\u57df\u9009\u62e9\u6027carbohydroxylation(Figure 2)\u3002\u8fd9\u91cc\uff0c\u7f8e\u56fdBinghamton\u5927\u5b66\u7684Mathew J. 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data-eusoft-scrollable-element=\"1\">2<\/strong>\u3002\u5176\u4e2d\uff0c\u5f53\u4f7f\u7528\u5421\u5576<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u5316\u7269(<strong data-eusoft-scrollable-element=\"1\">1a<\/strong>)\u65f6\uff0c\u53ef\u4ee514%\u7684\u6536\u7387\u83b7\u5f97\u5177\u6709\u5b8c\u5168\u533a\u57df\u9009\u62e9\u6027\u7684\u4e00\u7ea7\u9187\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">2<\/strong>\uff0c\u540c\u65f6\u8fd8\u751f\u6210\u90bb\u4f4d\u70f7\u57fa\u5316\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">3<\/strong>(13%)(Figure 3B)\u3002\u5bf9\u4e8e\u5316\u5408\u7269<strong data-eusoft-scrollable-element=\"1\">3<\/strong>\u7684\u751f\u6210\uff0c\u6d89\u53ca\u5206\u5b50\u5185\u81ea\u7531\u57fa\u90bb\u4f4d\u52a0\u6210\u4ee5\u53ca\u968f\u540e\u7684<em data-eusoft-scrollable-element=\"1\">\u03b2<\/em>\u2212N\u2212O\u4e0e<em data-eusoft-scrollable-element=\"1\">\u03b2<\/em>\u2212C\u2212C\u952e\u65ad\u88c2\uff0c\u4ece\u800c\u91ca\u653e\u7532\u919b\u5355\u5143\u7684\u8fc7\u7a0b\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5f53\u4f7f\u75282,6-\u4e8c\u6eb4\u5421\u5576<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u5316\u7269<strong data-eusoft-scrollable-element=\"1\">1d<\/strong>\u65f6\uff0c1-\u5df1\u70ef\u4e0e\u82c4\u70ef\u4e19\u4e8c\u8148\u7684\u53cd\u5e94\uff0c\u53ef\u4ee534%\u7684\u6536\u7387\u83b7\u5f97\u70ef\u4e19\u57fa\u70f7\u57fa\u5316\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">4<\/strong>(Figure 3C)\u3002\u5316\u5408\u7269<strong data-eusoft-scrollable-element=\"1\">4<\/strong>\u662f\u901a\u8fc7\u4ee5<strong data-eusoft-scrollable-element=\"1\">1d<\/strong>\u4f5c\u4e3a\u6c22\u539f\u5b50\u8f6c\u79fb(HAT)\u8bd5\u5242\u5b9e\u73b0\u70ef\u4e19\u4f4dC-H\u5b98\u80fd\u56e2\u5316\u800c\u751f\u6210\uff0c\u800c\u91c7\u7528<strong data-eusoft-scrollable-element=\"1\">1b<\/strong>\u65f6\u672a\u68c0\u6d4b\u5230\u76f8\u5e94\u7684\u70f7\u57fa\u5316\u4ea7\u7269\u3002\u6b64\u5916\uff0c2-\u4e59\u57fa-1-\u4e01\u70ef\u4e0e\u82c4\u70ef\u4e19\u4e8c\u8148\u5728\u6807\u51c6\u6761\u4ef6\u4e0b\u53cd\u5e94(<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55405 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/b14210e1ee30421b0a34b345c1768a63-1.png\" alt=\"\" width=\"554\" height=\"700\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/b14210e1ee30421b0a34b345c1768a63-1.png 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/b14210e1ee30421b0a34b345c1768a63-1-237x300.png 237w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/>\u5373Condition A)\uff0c\u53ef\u4ee582%\u7684\u6536\u7387\u5f97\u5230\u4e00\u7ea7\u9187\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">5<\/strong>\u3002\u540c\u65f6\uff0c1-\u5df1\u70ef\u4e0e\u82c4\u70ef\u4e19\u4e8c\u8148\u7684\u53cd\u5e94\u4e2d\uff0c\u589e\u52a0\u50ac\u5316\u5242\u7684\u8d1f\u8f7d\u91cf(\u5373Condition B)\uff0c\u53ef\u8fdb\u4e00\u6b65\u63d0\u9ad8\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">2<\/strong>\u7684\u53cd\u5e94\u6536\u7387\u81f374%(Figure 3D)\u3002<\/p>\n<p style=\"text-align: justify;\">\u5728\u4e0a\u8ff0\u7684\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9 carbohydroxylation\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76(Figure 4)\u3002\u9996\u5148\uff0c\u5404\u79cd\u7f3a\u7535\u5b50\u7684\u70ef\u70c3\uff0c\u5747\u53ef\u987a\u5229\u8fdb\u884c\u53cd\u5e94\uff0c\u53ef\u4ee5\u826f\u597d\u81f3\u4e2d\u7b49\u7684\u6536\u7387\u83b7\u5f97\u76f8\u5e94\u7684\u4e00\u7ea7\u9187\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">6<\/strong>&#8211;<strong data-eusoft-scrollable-element=\"1\">12<\/strong>\u30022-\u7532\u57fa-1-\u620a\u70ef\u4e0eexomethylene\uff0c\u4e5f\u662f\u5408\u9002\u7684\u5e95\u7269\uff0c\u5206\u522b\u83b7\u5f97\u76f8\u5e94\u7684\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">13<\/strong>(81%)\u4e0e<strong data-eusoft-scrollable-element=\"1\">14<\/strong>(75%)\u3002\u5176\u6b21\uff0c\u542b\u6709\u7fb0\u57fa\u3001\u70f7\u6c27\u7fb0\u57fa\u3001\u8148\u4e0e\u6c2f\u53d6\u4ee3\u7684\u70ef\u70c3\uff0c\u4e5f\u4e0e\u4f53\u7cfb\u517c\u5bb9\uff0c\u53ef\u4ee5\u826f\u597d\u81f3\u4e2d\u7b49\u7684\u6536\u7387\u83b7\u5f97\u76f8\u5e94\u7684\u4e00\u7ea7\u9187\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">15<\/strong>&#8211;<strong data-eusoft-scrollable-element=\"1\">19<\/strong>\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u6eb4\u53d6\u4ee3\u7684\u70ef\u70c3\uff0c\u4ec5\u4ee532%\u7684\u6536\u7387\u5f97\u5230\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">20<\/strong>\u3002\u6b64\u5916\uff0c\u5185\u70ef\u70c3\u4e0e\u73af\u70ef\u70c3\uff0c\u4e5f\u80fd\u591f\u987a\u5229\u8fdb\u884c\u53cd\u5e94\uff0c\u53ef\u4ee5\u4e2d\u7b49\u7684\u6536\u7387\u83b7\u5f97\u76f8\u5e94\u7684\u9187\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">21<\/strong>&#8211;<strong data-eusoft-scrollable-element=\"1\">25<\/strong>\uff0c\u5c3d\u7ba1\u975e\u5bf9\u6620\u9009\u62e9\u6027\u8f83\u4f4e\u3002\u7531\u5df1-3-\u70ef\u4e8c\u9178\u4e8c\u7532\u916f\u751f\u6210\u7684\u9187\u4ea7\u7269\u7ecf\u5206\u5b50\u5185\u916f\u4ea4\u6362\u53cd\u5e94\uff0c\u53ef\u4ee536%\u7684\u6536\u7387\u5f97\u5230\u5185\u916f\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">26<\/strong>\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8be5\u7b56\u7565\u8fd8\u53ef\u7528\u4e8e\u83b0\u70ef\u4e0e\u5e03\u6d1b\u82ac\u884d\u751f\u7269\u7684\u540e\u671f\u884d\u751f\u5316\uff0c\u53ef\u4ee5\u826f\u597d\u7684\u6536\u7387\u83b7\u5f97\u76f8\u5e94\u7684\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">27<\/strong>\u4e0e<strong data-eusoft-scrollable-element=\"1\">28<\/strong>\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55406 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/de5bcf7d8eaea98b5a67b2b3883c44b3-1.png\" alt=\"\" width=\"554\" height=\"586\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/de5bcf7d8eaea98b5a67b2b3883c44b3-1.png 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/de5bcf7d8eaea98b5a67b2b3883c44b3-1-284x300.png 284w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<p style=\"text-align: justify;\">\u4e4b\u540e\uff0c\u4f5c\u8005\u91c7\u7528\u5076\u6c2e\u4e8c\u7532\u9178\u4e8c\u5f02\u4e19\u916f(DIAD)\u4f5c\u4e3a\u78b3\u81ea\u7531\u57fa\u6355\u83b7\u5242\uff0c\u5bf9\u6c28\u7f9f\u5316\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76(Figure 5)\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5404\u79cd<em data-eusoft-scrollable-element=\"1\">\u03b1<\/em>-\u70ef\u70c3\u5747\u53ef\u987a\u5229\u8fdb\u884c\u6c28\u7f9f\u5316\u53cd\u5e94\uff0c\u53ef\u4ee5\u826f\u597d\u7684\u6536\u7387\u83b7\u5f97\u76f8\u5e94\u7684\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">29<\/strong>&#8211;<strong data-eusoft-scrollable-element=\"1\">34<\/strong>\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u73af\u5df1\u70ef\u884d\u751f\u7269\uff0c\u70ef\u4e19\u57faC-H\u80fa\u5316\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">35<\/strong>\u4f5c\u4e3a\u4e3b\u8981\u7684\u4ea7\u7269(46%)\uff0c\u4ec5\u4ee5\u8f83\u4f4e\u7684\u6536\u7387(11%)\u83b7\u5f97\u76ee\u6807\u7684\u9187\u4ea7\u7269<strong data-eusoft-scrollable-element=\"1\">36<\/strong>\u3002\u6b64\u5916\uff0c\u5316\u5408\u7269<strong data-eusoft-scrollable-element=\"1\">29<\/strong>\u7ecf\u78b1\u4fc3\u8fdb\u7684\u73af\u5316\u53cd\u5e94\uff0c\u53ef\u5236\u5907\u5641\u5511\u70f7-2-\u916e\u5316\u5408\u7269<strong data-eusoft-scrollable-element=\"1\">37<\/strong>(67%)\uff0c\u5176\u53ef\u4e0e\u6eb4\u4e59\u9178\u7532\u916f\u53cd\u5e94\uff0c\u901a\u8fc7\u6c2e-\u6c2e\u952e\u65ad\u88c2\uff0c\u4ece\u800c\u83b7\u5f97\u5641\u5511\u70f7\u916e\u5316\u5408\u7269<strong data-eusoft-scrollable-element=\"1\">38<\/strong>\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u53cd\u5e94\u7684\u5b9e\u7528\u6027\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55407 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/aa3023e0288002c8592c3c8fc4194d66-1.png\" alt=\"\" width=\"554\" height=\"748\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/aa3023e0288002c8592c3c8fc4194d66-1.png 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/aa3023e0288002c8592c3c8fc4194d66-1-222x300.png 222w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/p>\n<p style=\"text-align: justify;\">\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u533a\u57df\u9009\u62e9\u6027carbohydroxylation\u4e0e\u6c28\u7f9f\u5316\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76(Figure 6)\u3002\u9996\u5148\uff0c\u5416\u5576\u76d0\u5149\u50ac\u5316\u5242\u3001\u5421\u5576<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u5316\u7269\u4e0e<em data-eusoft-scrollable-element=\"1\">\u03b1<\/em>-\u70ef\u70c3\u7684\u8367\u5149\u6dec\u706d\u5b9e\u9a8c\u4e0e\u7535\u5316\u5b66\u7814\u7a76\u8868\u660e\uff0c\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u901a\u8fc7\u5421\u5576<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u5316\u7269\u7684\u5355\u7535\u5b50\u6c27\u5316\u751f\u6210\u5421\u5576<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u81ea\u7531\u57fa\u3002\u540c\u65f6\uff0c\u5421\u5576<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u5316\u7269(<strong data-eusoft-scrollable-element=\"1\">1b<\/strong>)\u4f5c\u4e3a\u8fd8\u539f\u6dec\u706d\u5242(Figure 6A)\u3002\u5176\u6b21\uff0c1,6-\u5e9a\u4e8c\u70ef\u7684\u73af\u5316\/carbohydroxylation\u53cd\u5e94\u7ed3\u679c\u8868\u660e\uff0c\u53cd\u5e94\u6d89\u53ca<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u81ea\u7531\u57fa\u52a0\u6210\u5230\u70ef\u70c3\u751f\u6210\u78b3\u81ea\u7531\u57fa\u7684\u8fc7\u7a0b(Figure 6B)\u3002<sup data-eusoft-scrollable-element=\"1\">18<\/sup>O\u6c18\u4ee3\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\uff0c<em data-eusoft-scrollable-element=\"1\">N<\/em>-alkoxypyridinium\u4e0e\u6c34\u53d1\u751f\u7684\u4eb2\u6838\u53d6\u4ee3\u6b65\u9aa4\u53ef\u7528\u4e8e\u9187\u7c7b\u5408\u6210(Figure 6C)\u3002\u6b64\u5916\uff0c\u8be5\u7b56\u7565\u8fd8\u53ef\u8fdb\u4e00\u6b65\u6269\u5c55\u81f3\u533a\u57df\u9009\u62e9\u6027carboetherification\u4e0e\u78b3\u916f\u5316\u53cd\u5e94\uff0c\u5982<strong data-eusoft-scrollable-element=\"1\">40<\/strong>&#8211;<strong data-eusoft-scrollable-element=\"1\">42<\/strong>(Figure 6D)\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55408 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/e2f457ec632c1f6729839285dcf348ab-1.png\" alt=\"\" width=\"448\" height=\"930\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/e2f457ec632c1f6729839285dcf348ab-1.png 448w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/e2f457ec632c1f6729839285dcf348ab-1-145x300.png 145w\" sizes=\"(max-width: 448px) 100vw, 448px\" \/><\/p>\n<p style=\"text-align: justify;\">\u4e3a\u4e86\u8fdb\u4e00\u6b65\u4e86\u89e3\u53cd\u5e94\u7684\u673a\u7406\uff0c\u4f5c\u8005\u8fd8\u8fdb\u884c\u4e86\u76f8\u5173DFT\u8ba1\u7b97\u7814\u7a76(Figure 7)\u3002\u9996\u5148\uff0c\u5728\u70ed\u529b\u5b66\u4e0a\uff0c<strong data-eusoft-scrollable-element=\"1\">1b<\/strong>\u4e0e<strong data-eusoft-scrollable-element=\"1\">PC<\/strong><sub data-eusoft-scrollable-element=\"1\">2<\/sub>\u7ecfSET\u53ef\u751f\u6210<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u81ea\u7531\u57fa(<strong data-eusoft-scrollable-element=\"1\">1b<sup data-eusoft-scrollable-element=\"1\">\u2022<\/sup><\/strong>)\uff0c\u5176\u6613\u4e0e2-\u4e59\u57fa-1-\u4e01\u70ef\u8fdb\u884c\u52a0\u6210(<strong data-eusoft-scrollable-element=\"1\"><em data-eusoft-scrollable-element=\"1\">TS<\/em><sub data-eusoft-scrollable-element=\"1\">C-O<\/sub><\/strong>)\uff0c\u751f\u6210\u4e09\u7ea7\u78b3\u4e2d\u5fc3\u81ea\u7531\u57fa(<strong data-eusoft-scrollable-element=\"1\">Int1<\/strong>)\u3002\u5176\u6b21\uff0c<strong data-eusoft-scrollable-element=\"1\">Int1<\/strong>\u4e0e\u82c4\u70ef\u4e19\u4e8c\u8148\u7ecfGiese-\u578b\u52a0\u6210\u53cd\u5e94(<strong data-eusoft-scrollable-element=\"1\"><em data-eusoft-scrollable-element=\"1\">TS<\/em><sub data-eusoft-scrollable-element=\"1\">C\u2212C<\/sub><\/strong>)\uff0c\u751f\u6210\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\">Int2<\/strong>\u3002<strong data-eusoft-scrollable-element=\"1\">Int2<\/strong>\u7ecf\u5feb\u901fSET\u8fc7\u7a0b\uff0c\u53ef\u751f\u6210\u78b3\u8d1f\u79bb\u5b50\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\">Int3<\/strong>\u3002\u5728TFA\u5b58\u5728\u4e0b\uff0c\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\">Int3<\/strong>\u53ef\u8fdb\u884c\u5feb\u901f\u8d28\u5b50\u5316(<strong data-eusoft-scrollable-element=\"1\"><em data-eusoft-scrollable-element=\"1\">TS<\/em><sub data-eusoft-scrollable-element=\"1\">Prot<\/sub><\/strong>)\uff0c\u751f\u6210\u4e2d\u95f4\u4f53<strong data-eusoft-scrollable-element=\"1\">Int4<\/strong>\u3002\u6700\u540e\uff0c<strong data-eusoft-scrollable-element=\"1\">Int4<\/strong>\u4e2d\u5421\u5576<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u5316\u7269\u901a\u8fc7\u6c34\u53d6\u4ee3\u8fc7\u7a0b(<strong data-eusoft-scrollable-element=\"1\"><em data-eusoft-scrollable-element=\"1\">TS<\/em><sub data-eusoft-scrollable-element=\"1\">Sub<\/sub><\/strong>)\uff0c\u4ece\u800c\u83b7\u5f97\u76ee\u6807\u9187\u4ea7\u7269\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-55409 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/bf2e94a56e16c6af677e3aceb39de97e-1.png\" alt=\"\" width=\"1269\" height=\"791\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/bf2e94a56e16c6af677e3aceb39de97e-1.png 1269w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/bf2e94a56e16c6af677e3aceb39de97e-1-300x187.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/bf2e94a56e16c6af677e3aceb39de97e-1-680x424.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/bf2e94a56e16c6af677e3aceb39de97e-1-768x479.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2025\/04\/bf2e94a56e16c6af677e3aceb39de97e-1-233x144.png 233w\" sizes=\"(max-width: 1269px) 100vw, 1269px\" \/><\/p>\n<h4 style=\"text-align: justify;\">\u603b\u7ed3\uff1a<\/h4>\n<p style=\"text-align: justify;\">\u7f8e\u56fdBinghamton\u5927\u5b66\u7684Mathew J. Vetticatt\u4e0eIndiana\u5927\u5b66\u7684Yongming Deng\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u5149\u6c27\u5316\u8fd8\u539f\/\u5421\u5576-<em data-eusoft-scrollable-element=\"1\">N<\/em>-\u6c27\u5316\u7269\u50ac\u5316<em data-eusoft-scrollable-element=\"1\">\u03b1<\/em>-\u70ef\u70c3\u7684\u533a\u57df\u9009\u62e9\u6027carbohydroxylation\u4e0e\u6c28\u7f9f\u5316\u53cd\u5e94\u3002\u540c\u65f6\uff0c\u8be5\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u3001\u826f\u597d\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u5e7f\u6cdb\u7684\u5b9e\u7528\u6027\u7b49\u7279\u70b9\u3002\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u53cd\u5e94\u6d89\u53ca\u4ea4\u7ec7\u7684\u81ea\u7531\u57fa\u6b65\u9aa4\u4e0e\u6781\u6027\u53d6\u4ee3\u7684\u8fc7\u7a0b\u3002<\/p>\n<h4 style=\"text-align: justify;\"><strong data-eusoft-scrollable-element=\"1\">\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ul>\n<li style=\"text-align: justify;\">[1] H. C. Brown, G. Zweifel, <em data-eusoft-scrollable-element=\"1\">J. Am. Chem. Soc. <\/em><strong data-eusoft-scrollable-element=\"1\">1959<\/strong>, <em data-eusoft-scrollable-element=\"1\">81<\/em>, 247. doi:<a href=\"https:\/\/doi.org\/10.1021\/ja01510a059\" data-eusoft-scrollable-element=\"1\">10.1021\/ja01510a059<\/a>.<\/li>\n<li style=\"text-align: justify;\">[2] G. Dong, P. Teo, Z. K. Wickens, R. H. Grubbs, <em data-eusoft-scrollable-element=\"1\">Science <\/em><strong data-eusoft-scrollable-element=\"1\">2011<\/strong>, <em data-eusoft-scrollable-element=\"1\">333<\/em>, 1609. doi: <a href=\"https:\/\/doi.org\/10.1126\/science.1208685\" data-eusoft-scrollable-element=\"1\">10.1126\/science.1208685<\/a>.<\/li>\n<li style=\"text-align: justify;\">[3] X. Hu, G. Zhang, F. Bu, A. Lei, <em data-eusoft-scrollable-element=\"1\">ACS Catal. <\/em><strong data-eusoft-scrollable-element=\"1\">2017<\/strong>, <em data-eusoft-scrollable-element=\"1\">7<\/em>, 1432. doi:<a href=\"https:\/\/doi.org\/10.1021\/acscatal.6b03388\" data-eusoft-scrollable-element=\"1\">10.1021\/acscatal.6b03388<\/a>.<\/li>\n<li style=\"text-align: justify;\">[4] C. Pratley, S. Fenner, J. A. Murphy, <em data-eusoft-scrollable-element=\"1\">Chem. Rev. <\/em><strong data-eusoft-scrollable-element=\"1\">2022<\/strong>, <em data-eusoft-scrollable-element=\"1\">122<\/em>, 8181.<a href=\"https:\/\/doi.org\/10.1021\/acs.chemrev.1c00831\" data-eusoft-scrollable-element=\"1\">10.1021\/acs.chemrev.1c00831<\/a>.<\/li>\n<li style=\"text-align: justify;\">[5] G. Tan, F. Paulus, A\u0301. Renteria-Gomez, R. F. Lalisse, C. G. Daniliuc, O. Gutierrez, F. Glorius, <em data-eusoft-scrollable-element=\"1\">J. Am. <\/em><em data-eusoft-scrollable-element=\"1\">Chem. Soc. <\/em><strong data-eusoft-scrollable-element=\"1\">2022<\/strong>, <em data-eusoft-scrollable-element=\"1\">144<\/em>, 21664. doi:<a href=\"https:\/\/doi.org\/10.1021\/jacs.2c09244\" data-eusoft-scrollable-element=\"1\">10.1021\/jacs.2c09244<\/a>.<\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n<p>\u5173\u6ce8Chem-Station\u6296\u97f3\u53f7\uff1a79473891841<\/p>\n<h5>\u8bf7\u767b\u9646TCI\u8bd5\u5242\u5b98\u7f51\u67e5\u770b\u66f4\u591a\u5185\u5bb9<\/h5>\n<h5>https:\/\/www.tcichemicals.com\/CN\/zh\/<\/h5>\n<p style=\"text-align: justify;\">\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u65e5\uff0c\u7f8e\u56fdBinghamton\u5927\u5b66\u7684Mathew J. Vetticatt\u4e0eIndiana\u5927\u5b66\u7684Yongming Deng\u8bfe\u9898\u7ec4\u5728J. Am. Chem. Soc.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u5149\u6c27\u5316\u8fd8\u539f\/\u5421\u5576-N-\u6c27\u5316\u7269\u50ac\u5316\u03b1-\u70ef\u70c3\u7684\u533a\u57df\u9009\u62e9\u6027carbohydroxylation\u4e0e\u6c28\u7f9f\u5316\u53cd\u5e94\u3002\u8be5\u65b9\u6cd5\u53ef\u5c06\u975e\u6d3b\u5316\u7684\u70ef\u70c3\u76f4\u63a5\u8f6c\u5316\u4e3a\u4e00\u7ea7\u9187\uff0c\u5305\u62ec\u542b\u6709\u03b2-\u5b63\u78b3\u4e2d\u5fc3\u4e0e\u03b2-\u6c28\u57fa\u9187\u7684\u4e00\u7ea7\u9187\u3002\u03b1-\u70ef\u70c3\u7684\u533a\u57df\u9009\u62e9\u6027\u53cc\u5b98\u80fd\u56e2\u5316\u662f\u901a\u8fc7\u5421\u5576-N-\u6c27\u81ea\u7531\u57fa(N-oxy radical)\u5bf9\u5176\u8fdb\u884c\u81ea\u7531\u57fa\u52a0\u6210\u5b9e\u73b0\uff0c\u8be5\u81ea\u7531\u57fa\u7531\u6613\u5f97\u7684\u5421\u5576-N-\u6c27\u5316\u7269\u7ecf\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u7684\u5355\u7535\u5b50\u6c27\u5316\u8fc7\u7a0b\u751f\u6210\u3002\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u53cd\u5e94\u6d89\u53ca\u4ea4\u7ec7\u7684\u81ea\u7531\u57fa\u6b65\u9aa4(interwoven radical steps)\u4e0e\u6781\u6027\u53d6\u4ee3\u7684\u8fc7\u7a0b\u3002\u6b64\u5916\uff0c\u901a\u8fc7carboetherification\u3001\u78b3\u916f\u5316\u53ca\u5185\u916f\u5f62\u6210\u7b49\u5b9e\u4f8b\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u8be5\u65b9\u6cd5\u5bf9\u03b1-\u70ef\u70c3\u533a\u57df\u9009\u62e9\u6027\u53cc\u5b98\u80fd\u56e2\u5316\u7684\u666e\u9002\u6027\u3002 Photoredox\/Pyridine N\u2011Oxide Catalyzed Carbohydroxylation and Aminohydroxylation of \u03b1\u2011Olefins C. A. Pettenuzzo, D. R. Pradhan, J. Singh, L. Liu, G. Cuffel, M. J. Vetticatt, Y. Deng, J. Am. Chem. Soc. 2025, ASAP. doi: 10.1021\/jacs.4c17657. \u6b63\u6587\uff1a \u4e00\u7ea7\u9187\u5728\u5236\u836f\u3001\u519c\u7528\u5316\u5b66\u54c1\u4e0e\u7cbe\u7ec6\u5316\u5b66\u5de5\u4e1a\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u7528\u9014\u3002\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u5df2\u7ecf\u6210\u529f\u8bbe\u8ba1\u51fa\u591a\u79cd\u91c7\u7528\u70ef\u70c3\u6784\u5efa\u4e00\u7ea7\u9187\u5206\u5b50\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565[1]\uff0c\u4f46\u9700\u4f7f\u7528\u5316\u5b66\u8ba1\u91cf\u7684\u6c27\u5316\u5242\u6216\u8fd8\u539f\u5242\uff0c\u5e76\u6d89\u53ca\u591a\u6b65\u64cd\u4f5c(Figure 1A)\u30022011\u5e74\uff0cGrubbs\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u4e09\u91cd\u63a5\u529b\u50ac\u5316\u4f53\u7cfb\uff0c\u5b9e\u73b0\u4e86\u82ef\u4e59\u70ef\u4e0e\u6c34\u7684\u4e00\u9505anti-Markovnikov\u6c34\u5408\u53cd\u5e94[2](Figure 1B)\u30022017\u5e74\uff0c\u96f7\u7231\u6587\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u57fa\u4e8e\u5416\u5576\u76d0(acridinium)\u5149\u50ac\u5316\u5242\u7684\u5149\u6c27\u5316\u8fd8\u539f\u7b56\u7565\uff0c\u901a\u8fc7\u82ef\u4e59\u70ef\u53ca\u591a\u53d6\u4ee3\u70ef\u70c3\u7684\u5355\u7535\u5b50\u6c27\u5316\u53cd\u5e94\uff0c\u4ece\u800c\u5408\u6210\u4e86\u4e00\u7ea7\u9187[3](Figure 1B)\u3002\u5c3d\u7ba1\u53d6\u5f97\u4e86\u8fd9\u4e9b\u91cd\u8981\u8fdb\u5c55\uff0c\u4f46\u5df2\u62a5\u9053\u7684\u4e00\u7ea7\u9187\u5408\u6210\u50ac\u5316\u65b9\u6cd5\u666e\u904d\u53d7\u9650\u4e8e\u82ef\u4e59\u70ef\u6216\u591a\u53d6\u4ee3\u70ef\u70c3\u7c7b\u5e95\u7269\u3002\u6b64\u5916\uff0c\u975e\u5bf9\u79f0\u70ef\u70c3\u7684\u81ea\u7531\u57fa\u52a0\u6210\u53cd\u5e94\uff0c\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u6548\u7684\u66ff\u4ee3\u7b56\u7565\uff0c\u53ef\u5728\u70ef\u70c3\u4e2d\u8f83\u5c11\u53d6\u4ee3\u78b3\u4f4d\u70b9\u4e0a\u8fdb\u884c\u78b3-\u6742\u539f\u5b50\u952e\u7684\u53cd\u9a6c\u6c0f\u533a\u57df\u9009\u62e9\u6027\u6784\u5efa\u3002\u76ee\u524d\uff0c\u6b64\u7c7b\u7b56\u7565\u4e3b\u8981\u96c6\u4e2d\u4e8e\u6c2e\u3001\u786b\u4e0e\u5364\u7d20\u4e3a\u4e2d\u5fc3\u7684\u81ea\u7531\u57fa\u4ecb\u5bfc\u975e\u6d3b\u5316\u70ef\u70c3\u7684\u50ac\u5316anti-Markovnikov\u52a0\u6210\u53cd\u5e94[4]\uff0c\u5bf9\u4e8e\u6d89\u53ca\u6c27\u4e3a\u4e2d\u5fc3\u7684\u81ea\u7531\u57fa\u4ecb\u5bfc\u53cd\u5e94\u4ecd\u7136\u96be\u4ee5\u6349\u6478\u3002\u6700\u8fd1\uff0cHan\u7b49\u56e2\u961f\u5206\u522b\u5f00\u53d1\u4e86\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u7684\u6c27\u4e2d\u5fc3\u81ea\u7531\u57fa\u4ecb\u5bfc\u7684\u975e\u6d3b\u5316\u70ef\u70c3\u7684anti-Markovnikov hydrooxygenation[5](Figure 1C)\u3002\u7136\u800c\uff0c\u8be5\u7b56\u7565\u9700\u5bf9\u5e95\u7269\u8fdb\u884c\u9884\u5b98\u80fd\u56e2\u5316\uff0c\u5e76\u9700\u4f7f\u7528\u5316\u5b66\u8ba1\u91cf\u7684\u6c27\u81ea\u7531\u57fa\u524d\u4f53\u3002 \u4f5c\u8005\u63a8\u6d4b\uff0c\u57fa\u4e8e\u6301\u4e45\u81ea\u7531\u57fa\u6548\u5e94\u4e0e\u6709\u5229\u7684\u6781\u6027\u5339\u914d\uff0c\u5149\u50ac\u5316\u751f\u6210\u7684\u4eb2\u7535\u5421\u5576-N-\u6c27\u81ea\u7531\u57fa\u53ef\u80fd\u5f15\u53d1\u03b1-\u70ef\u70c3\u5728\u672b\u7aef\u78b3\u7684\u533a\u57df\u9009\u62e9\u6027\u52a0\u6210\uff0c\u751f\u6210\u66f4\u7a33\u5b9a\u7684\u78b3\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\uff0c\u5176\u53ef\u4e0e\u7f3a\u7535\u5b50\u70ef\u70c3\u8fdb\u884cGiese\u578b\u53cd\u5e94\uff0c\u751f\u6210N-alkoxypyridinium\u4e2d\u95f4\u4f53\u3002N-alkoxypyridinium\u4e2d\u95f4\u4f53\u53ef\u80fd\u901a\u8fc7\u6c34\u5206\u5b50\u53d6\u4ee3\u53cd\u5e94\u751f\u6210\u4e00\u7ea7\u9187\u4ea7\u7269\uff0c\u4ece\u800c\u5b9e\u73b0\u03b1-\u70ef\u70c3\u7684\u533a\u57df\u9009\u62e9\u6027carbohydroxylation(Figure 2)\u3002\u8fd9\u91cc\uff0c\u7f8e\u56fdBinghamton\u5927\u5b66\u7684Mathew J. Vetticatt\u4e0eIndiana\u5927\u5b66\u7684Yongming Deng\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u5149\u6c27\u5316\u8fd8\u539f\/\u5421\u5576-N-\u6c27\u5316\u7269\u50ac\u5316\u03b1-\u70ef\u70c3\u7684\u533a\u57df\u9009\u62e9\u6027carbohydroxylation\u4e0e\u6c28\u7f9f\u5316\u53cd\u5e94 (Scheme 1)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u75281-\u5df1\u70ef\u4e0e\u82c4\u70ef\u4e19\u4e8c\u8148(\u81ea\u7531\u57fa\u6355\u83b7\u5242)\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Figure 3A)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u75281b\u4f5c\u4e3a\u6700\u4f73\u7684N-\u6c27\u5316\u7269\uff0cPC2\u4f5c\u4e3a\u5149\u50ac\u5316\u5242\uff0cTFA\u4f5c\u4e3a\u6dfb\u52a0\u5242\uff0c\u6c34\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\uff0c\u84dd\u8272LED(456 nm)\u4f5c\u4e3a\u5149\u6e90\uff0c\u5728\u4e19\u916e\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u53cd\u5e94\u6e29\u5ea6\u4e3a40-45 oC\uff0c\u6700\u7ec8\u83b7\u5f9774%\u6536\u7387\u7684\u4ea7\u72692\u3002\u5176\u4e2d\uff0c\u5f53\u4f7f\u7528\u5421\u5576N-\u6c27\u5316\u7269(1a)\u65f6\uff0c\u53ef\u4ee514%\u7684\u6536\u7387\u83b7\u5f97\u5177\u6709\u5b8c\u5168\u533a\u57df\u9009\u62e9\u6027\u7684\u4e00\u7ea7\u9187\u4ea7\u72692\uff0c\u540c\u65f6\u8fd8\u751f\u6210\u90bb\u4f4d\u70f7\u57fa\u5316\u4ea7\u72693(13%)(Figure 3B)\u3002\u5bf9\u4e8e\u5316\u5408\u72693\u7684\u751f\u6210\uff0c\u6d89\u53ca\u5206\u5b50\u5185\u81ea\u7531\u57fa\u90bb\u4f4d\u52a0\u6210\u4ee5\u53ca\u968f\u540e\u7684\u03b2\u2212N\u2212O\u4e0e\u03b2\u2212C\u2212C\u952e\u65ad\u88c2\uff0c\u4ece\u800c\u91ca\u653e\u7532\u919b\u5355\u5143\u7684\u8fc7\u7a0b\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5f53\u4f7f\u75282,6-\u4e8c\u6eb4\u5421\u5576N-\u6c27\u5316\u72691d\u65f6\uff0c1-\u5df1\u70ef\u4e0e\u82c4\u70ef\u4e19\u4e8c\u8148\u7684\u53cd\u5e94\uff0c\u53ef\u4ee534%\u7684\u6536\u7387\u83b7\u5f97\u70ef\u4e19\u57fa\u70f7\u57fa\u5316\u4ea7\u72694(Figure 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Vetticatt\u4e0eIndiana\u5927\u5b66\u7684Yongming Deng\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u5149\u6c27\u5316\u8fd8\u539f\/\u5421\u5576-N-\u6c27\u5316\u7269\u50ac\u5316\u03b1-\u70ef\u70c3\u7684\u533a\u57df\u9009\u62e9\u6027carbohydroxylation\u4e0e\u6c28\u7f9f\u5316\u53cd\u5e94\u3002\u540c\u65f6\uff0c\u8be5\u7b56\u7565\u5177\u6709\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u3001\u826f\u597d\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u5e7f\u6cdb\u7684\u5b9e\u7528\u6027\u7b49\u7279\u70b9\u3002\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u53cd\u5e94\u6d89\u53ca\u4ea4\u7ec7\u7684\u81ea\u7531\u57fa\u6b65\u9aa4\u4e0e\u6781\u6027\u53d6\u4ee3\u7684\u8fc7\u7a0b\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] H. C. Brown, G. Zweifel, J. Am. Chem. Soc. 1959, 81, 247. doi:10.1021\/ja01510a059. [2] G. Dong, P. Teo, Z. K. 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