{"id":853,"date":"2014-03-29T12:38:48","date_gmt":"2014-03-29T04:38:48","guid":{"rendered":"\/\/www.gsbet888.com\/?p=853"},"modified":"2019-08-02T18:57:08","modified_gmt":"2019-08-02T10:57:08","slug":"%e7%a6%8f%e5%b1%b1%e5%90%b2%e5%93%9a%e5%90%88%e6%88%90%ef%bc%88fukuyama-indole-synthesis%ef%bc%89","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/%e7%8e%af%e5%8c%96%e5%8f%8d%e5%ba%94\/2014\/03\/%e7%a6%8f%e5%b1%b1%e5%90%b2%e5%93%9a%e5%90%88%e6%88%90%ef%bc%88fukuyama-indole-synthesis%ef%bc%89.html","title":{"rendered":"\u798f\u5c71\u5432\u54da\u5408\u6210\uff08Fukuyama Indole Synthesis\uff09"},"content":{"rendered":"<p>\u7b2c\u4e00\u4ee3\uff1a\u5f02\u8148\u6cd5<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"fukuyama_indole_1.gif\" src=\"http:\/\/www.chem-station.com\/odos\/images\/fukuyama_indole_1.gif\" width=\"492\" height=\"202\" \/><\/p>\n<p>\u7b2c\u4e8c\u4ee3\uff1a\u5f02\u786b\u6c30\u9178\u916f\u6cd5<\/p>\n<p><span class=\"mt-enclosure mt-enclosure-image\" style=\"margin: 0px;padding: 0px;font-family: Arial, Verdana, Helvetica, sans-serif;letter-spacing: 1px;line-height: 25px\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"fukuyama_indole_2.gif\" src=\"http:\/\/www.chem-station.com\/odos\/images\/fukuyama_indole_2.gif\" width=\"298\" height=\"75\" \/><\/span><\/p>\n<ul>\n<li>\u6982\u8981<\/li>\n<\/ul>\n<p>\u7531\u81ea\u7531\u57fa\u5f15\u53d1\u5242\u53ca\u4e09\u4e01\u57fa\u6c22\u5316\u9521\u3001\u662f\u5408\u62103-\u53d6\u4ee3\u548c2,3-\u4e8c\u53d6\u4ee3\u5432\u54da\u7684\u5f3a\u6709\u529b\u7684\u65b9\u6cd5\u3002<\/p>\n<p>\u7279\u522b\u662f\u7b2c\u4e8c\u4ee3\u65b9\u6cd5\uff0c\u662f\u5f15\u5165\u591a\u79cd\u53d6\u4ee3\u57fa\u7684\u6709\u6548\u65b9\u6cd5 \u3002\u57282\u4f4d\u7684sp<sup>3<\/sup>\u78b3\u539f\u5b50\u4e0a\u5f15\u5165\u57fa\u56e2\uff08\u901a\u8fc7\u5076\u8054\u53cd\u5e94\u901a\u5e38\u4e0d\u80fd\u5b9e\u73b0\uff09\u3002<\/p>\n<p>\u539f\u6599\u7684\u786b\u6c30\u9178\u916f\uff0c\u53ef\u7531\u55b9\u5549\u7684\u5f00\u73af\u53cd\u5e94\u5236\u5907\uff0c\u53cd\u5e94\u7b80\u4fbf\u6613\u884c\uff0c\u5e76\u80fd\u5e94\u7528\u4e8e\u5927\u91cf\u5408\u6210\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"fukuyama_indole_3.gif\" src=\"http:\/\/www.chem-station.com\/odos\/images\/fukuyama_indole_3.gif\" width=\"435\" height=\"98\" \/><\/p>\n<ul>\n<li>\u57fa\u672c\u6587\u732e<\/li>\n<\/ul>\n<p>\u30fbFukuyama, T.; Chen, X.; Peng, G.\u00a0<em>J. Am. Chem. Soc.<\/em>\u00a0<strong>1994<\/strong>,\u00a0<em>116<\/em>, 3127. DOI:<a href=\"http:\/\/dx.doi.org\/10.1021\/ja00086a054\">\u00a010.1021\/ja00086a054<\/a><br \/>\n\u30fbTokuyama, H.; Yamashita, T.; Reding, M. T.; Kaburagi, Y.; Fukuyama, T.\u00a0<em>J. Am. Chem. Soc.<\/em>\u00a0<strong>1999<\/strong>,<em>121<\/em>, 3791. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/ja983681v\">10.1021\/ja983681v<\/a><\/p>\n<ul>\n<li>\u53cd\u5e94\u673a\u7406<\/li>\n<\/ul>\n<p>\u4e24\u79cd\u65b9\u6cd5\u90fd\u662f\u7531\u81ea\u7531\u57fa\u73af\u5316\u673a\u7406\u8fdb\u884c\u7684\u3002\u70ef\u70c3\u662f\u53cd\u5f0f\u6784\u578b\u65f6\uff0c\u70ed\u529b\u5b66\u7a33\u5b9a\u7684\u516d\u5143\u73af\u526f\u4ea7\u7269\uff08\u56db\u6c22\u55b9\u5549\uff09\u4f1a\u589e\u52a0\u3002<\/p>\n<div>\uff1c\u7b2c\u4e00\u4ee3\uff1e<\/div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"fukuyama_indole_4.gif\" src=\"http:\/\/www.chem-station.com\/odos\/images\/fukuyama_indole_4.gif\" width=\"354\" height=\"138\" \/><\/p>\n<div>\uff1c\u7b2c\u4e8c\u4ee3\uff1e<\/div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"fukuyama_indole_5.gif\" src=\"http:\/\/www.chem-station.com\/odos\/images\/fukuyama_indole_5.gif\" width=\"430\" height=\"155\" \/><\/p>\n<ul>\n<li>\u53cd\u5e94\u5b9e\u4f8b<\/li>\n<\/ul>\n<p>\u672c\u5432\u54da\u5408\u6210\u662f\u5408\u6210(+)-Vinblastine\u4e2d\u81f3\u5173\u91cd\u8981\u7684\u6b65\u9aa4[1]\u3001\u662f\u6709\u6a5f\u5408\u6210\u5316\u5b66\u91d1\u5b57\u5854\u4e2d\u7684\u4e00\u4e2a\u7ecf\u5178\u5b9e\u4f8b\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" alt=\"fukuyama_indole_6.gif\" src=\"http:\/\/www.chem-station.com\/odos\/images\/fukuyama_indole_6.gif\" width=\"552\" height=\"303\" \/><\/p>\n<ul>\n<li>\u5b9e\u9a8c\u6b65\u9aa4<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u5b9e\u9a8c\u6280\u5de7<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u53c2\u8003\u6587\u732e<\/li>\n<\/ul>\n[1] Yokoshima, S.; Ueda, T.; Kobayashi, S.; Sato, A.; Kuboyama, T.; Tokuyama, H.; Fukuyama, T.<em>J. Am. Chem. Soc.<\/em>\u00a0<strong>2002<\/strong>,\u00a0<em>124<\/em>, 2137. DOI:<a href=\"http:\/\/dx.doi.org\/10.1021\/ja0177049\">10.1021\/ja0177049<\/a><\/p>\n<p><span class=\"mt-enclosure mt-enclosure-image\" style=\"margin: 0px;padding: 0px;font-family: Arial, Verdana, Helvetica, sans-serif;letter-spacing: 1px;line-height: 25px\">\u00a0<\/span> <\/p>\n","protected":false},"excerpt":{"rendered":"\u7b2c\u4e00\u4ee3\uff1a\u5f02\u8148\u6cd5 \u7b2c\u4e8c\u4ee3\uff1a\u5f02\u786b\u6c30\u9178\u916f\u6cd5 \u6982\u8981 \u7531\u81ea\u7531\u57fa\u5f15\u53d1\u5242\u53ca\u4e09\u4e01\u57fa\u6c22\u5316\u9521\u3001\u662f\u5408\u62103-\u53d6\u4ee3\u548c2,3-\u4e8c\u53d6\u4ee3\u5432\u54da\u7684\u5f3a\u6709\u529b\u7684\u65b9\u6cd5\u3002 \u7279\u522b\u662f\u7b2c\u4e8c\u4ee3\u65b9\u6cd5\uff0c\u662f\u5f15\u5165\u591a\u79cd\u53d6\u4ee3\u57fa\u7684\u6709\u6548\u65b9\u6cd5 \u3002\u57282\u4f4d\u7684sp3\u78b3\u539f\u5b50\u4e0a\u5f15\u5165\u57fa\u56e2\uff08\u901a\u8fc7\u5076\u8054\u53cd\u5e94\u901a\u5e38\u4e0d\u80fd\u5b9e\u73b0\uff09\u3002 \u539f\u6599\u7684\u786b\u6c30\u9178\u916f\uff0c\u53ef\u7531\u55b9\u5549\u7684\u5f00\u73af\u53cd\u5e94\u5236\u5907\uff0c\u53cd\u5e94\u7b80\u4fbf\u6613\u884c\uff0c\u5e76\u80fd\u5e94\u7528\u4e8e\u5927\u91cf\u5408\u6210\u3002 \u57fa\u672c\u6587\u732e \u30fbFukuyama, T.; Chen, X.; Peng, G.\u00a0J. Am. Chem. Soc.\u00a01994,\u00a0116, 3127. DOI:\u00a010.1021\/ja00086a054 \u30fbTokuyama, H.; Yamashita, T.; Reding, M. T.; Kaburagi, Y.; Fukuyama, T.\u00a0J. Am. Chem. Soc.\u00a01999,121, 3791. DOI:\u00a010.1021\/ja983681v \u53cd\u5e94\u673a\u7406 \u4e24\u79cd\u65b9\u6cd5\u90fd\u662f\u7531\u81ea\u7531\u57fa\u73af\u5316\u673a\u7406\u8fdb\u884c\u7684\u3002\u70ef\u70c3\u662f\u53cd\u5f0f\u6784\u578b\u65f6\uff0c\u70ed\u529b\u5b66\u7a33\u5b9a\u7684\u516d\u5143\u73af\u526f\u4ea7\u7269\uff08\u56db\u6c22\u55b9\u5549\uff09\u4f1a\u589e\u52a0\u3002 \uff1c\u7b2c\u4e00\u4ee3\uff1e \uff1c\u7b2c\u4e8c\u4ee3\uff1e \u53cd\u5e94\u5b9e\u4f8b \u672c\u5432\u54da\u5408\u6210\u662f\u5408\u6210(+)-Vinblastine\u4e2d\u81f3\u5173\u91cd\u8981\u7684\u6b65\u9aa4[1]\u3001\u662f\u6709\u6a5f\u5408\u6210\u5316\u5b66\u91d1\u5b57\u5854\u4e2d\u7684\u4e00\u4e2a\u7ecf\u5178\u5b9e\u4f8b\u3002 \u5b9e\u9a8c\u6b65\u9aa4 &nbsp; \u5b9e\u9a8c\u6280\u5de7 &nbsp; \u53c2\u8003\u6587\u732e [1] Yokoshima, S.; Ueda, T.; Kobayashi, S.; Sato, A.; Kuboyama, T.; Tokuyama, H.; Fukuyama, T.J. Am. Chem. Soc.\u00a02002,\u00a0124, 2137. DOI:10.1021\/ja0177049 \u00a0","protected":false},"author":3,"featured_media":855,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[9,99],"tags":[114,111,110,109],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/03\/fukuyama_indole_2.gif","jetpack_shortlink":"https:\/\/wp.me\/p96op1-dL","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/853"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=853"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/853\/revisions"}],"predecessor-version":[{"id":28261,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/853\/revisions\/28261"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/855"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=853"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=853"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=853"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}