{"id":864,"date":"2014-03-31T05:53:21","date_gmt":"2014-03-30T21:53:21","guid":{"rendered":"\/\/www.gsbet888.com\/?p=864"},"modified":"2019-08-02T18:57:07","modified_gmt":"2019-08-02T10:57:07","slug":"post-864","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2014\/03\/post-864.html","title":{"rendered":"Pinnick\u6c27\u5316(Pinnick oxidation)"},"content":{"rendered":"<ul>\n<li><strong>\u6982\u8981<\/strong><\/li>\n<\/ul>\n<p>\u5728\u6781\u5176\u6e29\u548c\u7684\u6761\u4ef6\u4e0b\uff0c\u919b\u88ab\u6c27\u5316\u6210\u9178\u7684\u53cd\u5e94\u3002<\/p>\n<p>\u4f7f\u7528Jones\u6c27\u5316\u3001PDC\u3001\u56db\u6c27\u5316\u948c\u7b49\u6c27\u5316\u5242\u53ef\u4ee5\u4e00\u6b65\u53cd\u5e94\u5c31\u628a\u9187\u6c27\u5316\u6210\u7fa7\u9178\uff0c\u4f46\u662f\u7531\u4e8e\u53cd\u5e94\u6761\u4ef6\u6bd4\u8f83\u5f3a\uff0c\u5bf9\u4e8e\u5168\u5408\u6210\u6765\u8bf4\uff0c\u5c24\u5176\u662f\u6709\u591a\u5b98\u80fd\u56e2\u7684\u5316\u5408\u7269\u7ecf\u5e38\u4e0d\u9002\u5408\u8fd9\u79cd\u592a\u5f3a\u7684\u6761\u4ef6\u3002\u6240\u4ee5\uff0c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u7ecf\u5e38\u5229\u7528\u4ece\u9187\u2192\u919b\u2192\u9178\u8fd9\u79cd\u5206\u4e24\u6b65\u7684\u6bd4\u8f83\u6e29\u548c\u7684\u53cd\u5e94\u65b9\u6cd5\u3002Pinnick\u6c27\u5316\u4e5f\u5728\u7b2c\u4e8c\u6b65(\u919b\u2192\u9178)\u7684\u6c27\u5316\u53cd\u5e94\u4e2d\u88ab\u4f7f\u7528\u3002<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u57fa\u672c\u6587\u732e<\/strong><\/li>\n<\/ul>\n<p>\u30fbKraus, G. A.; Roth, B. <em>J. Org. Chem.<\/em> <strong>1980<\/strong>,\u00a0\u00a0<em>45<\/em>, 4825. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jo01312a004\">10.1021\/jo01312a004<\/a><br \/>\n\u30fbKraus, G. A.; Taschner, M. J. <em>J. Org. Chem.<\/em> <strong>1980<\/strong>,\u00a0<em>45<\/em>, 1175. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jo01294a058\">10.1021\/jo01294a058<\/a><br \/>\n\u30fbBal, B. S.; Childers, W. E., Jr.; Pinnick, H. W. <em>Tetrahedron<\/em> <strong>1981<\/strong>, <em>37<\/em>, 2091. doi:<a href=\"http:\/\/dx.doi.org\/10.1016\/S0040-4020(01)97963-3\">10.1016\/S0040-4020(01)97963-3<\/a><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/li>\n<\/ul>\n<p>2-\u7532\u57fa-2-\u4e01\u70ef\u3001\u4f5c\u4e3a\u53cd\u5e94\u4e2d\u4f34\u968f\u751f\u6210\u7684\u6b21\u6c2f\u9178\u76d0\u548c\u78b1\u7684\u6e05\u9664\u5242\u3001\u9632\u6b62\u526f\u53cd\u5e94\u7684\u53d1\u751f\u3002 <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/www.chem-station.com\/odos\/images\/pinnick_2.gif\" alt=\"pinnick_2.gif\" width=\"435\" height=\"142\" \/><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u00a0\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/li>\n<\/ul>\n<p>\u8be5\u53cd\u5e94\u6700\u5927\u7684\u7279\u5f81\u5c31\u662f\u5f88\u5f3a\u7684\u591a\u5b98\u80fd\u56e2\u7684\u517c\u5bb9\u6027\u3002<br \/>\nNorzoanthamine\u7684\u5408\u6210[1] <img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.chem-station.com\/odos\/images\/pinnick_3.gif\" alt=\"pinnick_3.gif\" width=\"513\" height=\"119\" \/> Platensimycin\u7684\u5408\u6210[2] <img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.chem-station.com\/odos\/images\/pinnick_4.gif\" alt=\"pinnick_4.gif\" width=\"299\" height=\"110\" \/><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u5b9e\u9a8c\u6280\u5de7<\/strong><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>\u53c2\u8003\u6587\u732e<\/strong><\/li>\n<\/ul>\n[1] Miyashita, M.; Tanino, K. et al. <em>Science<\/em> <strong>2004<\/strong>,\u00a0<em>305<\/em>, 495. DOI:<a href=\"http:\/\/dx.doi.org\/10.1126\/science.1098851\">10.1126\/science.1098851<\/a><br \/>\n[2] (a) Nicolaou, K. C.; Li, A.; Edmonds, E. J.<em> Angew. Chem. Int.\u00a0Ed.<\/em> <strong>2006<\/strong>, <em>45<\/em>, 7086. doi:<a href=\"http:\/\/dx.doi.org\/10.1002\/anie.200603892\">10.1002\/anie.200603892<\/a>\u00a0(b) Nicoalou, K. C.; Edmonds, E. J.; Li, A.; Tria, G. S. <em>Angew.\u00a0Chem. Int. Ed.<\/em> <strong>2007<\/strong>, <em>46<\/em>, 3942. doi:<a href=\"http:\/\/dx.doi.org\/10.1002\/anie.200700586\">10.1002\/anie.200700586<\/a><\/p>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<\/strong><a href=\"\/\/www.gsbet888.com\/\"><strong>Chem-Station\u5316\u5b66\u7a7a\u95f4<\/strong><\/a><strong>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 \u5728\u6781\u5176\u6e29\u548c\u7684\u6761\u4ef6\u4e0b\uff0c\u919b\u88ab\u6c27\u5316\u6210\u9178\u7684\u53cd\u5e94\u3002 \u4f7f\u7528Jones\u6c27\u5316\u3001PDC\u3001\u56db\u6c27\u5316\u948c\u7b49\u6c27\u5316\u5242\u53ef\u4ee5\u4e00\u6b65\u53cd\u5e94\u5c31\u628a\u9187\u6c27\u5316\u6210\u7fa7\u9178\uff0c\u4f46\u662f\u7531\u4e8e\u53cd\u5e94\u6761\u4ef6\u6bd4\u8f83\u5f3a\uff0c\u5bf9\u4e8e\u5168\u5408\u6210\u6765\u8bf4\uff0c\u5c24\u5176\u662f\u6709\u591a\u5b98\u80fd\u56e2\u7684\u5316\u5408\u7269\u7ecf\u5e38\u4e0d\u9002\u5408\u8fd9\u79cd\u592a\u5f3a\u7684\u6761\u4ef6\u3002\u6240\u4ee5\uff0c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u7ecf\u5e38\u5229\u7528\u4ece\u9187\u2192\u919b\u2192\u9178\u8fd9\u79cd\u5206\u4e24\u6b65\u7684\u6bd4\u8f83\u6e29\u548c\u7684\u53cd\u5e94\u65b9\u6cd5\u3002Pinnick\u6c27\u5316\u4e5f\u5728\u7b2c\u4e8c\u6b65(\u919b\u2192\u9178)\u7684\u6c27\u5316\u53cd\u5e94\u4e2d\u88ab\u4f7f\u7528\u3002 &nbsp; \u57fa\u672c\u6587\u732e \u30fbKraus, G. A.; Roth, B. J. Org. Chem. 1980,\u00a0\u00a045, 4825. DOI: 10.1021\/jo01312a004 \u30fbKraus, G. A.; Taschner, M. J. J. Org. Chem. 1980,\u00a045, 1175. DOI: 10.1021\/jo01294a058 \u30fbBal, B. S.; Childers, W. E., Jr.; Pinnick, H. W. Tetrahedron 1981, 37, 2091. doi:10.1016\/S0040-4020(01)97963-3 &nbsp; \u53cd\u5e94\u673a\u7406 2-\u7532\u57fa-2-\u4e01\u70ef\u3001\u4f5c\u4e3a\u53cd\u5e94\u4e2d\u4f34\u968f\u751f\u6210\u7684\u6b21\u6c2f\u9178\u76d0\u548c\u78b1\u7684\u6e05\u9664\u5242\u3001\u9632\u6b62\u526f\u53cd\u5e94\u7684\u53d1\u751f\u3002 &nbsp; \u00a0\u53cd\u5e94\u5b9e\u4f8b &nbsp; \u5b9e\u9a8c\u6b65\u9aa4 \u8be5\u53cd\u5e94\u6700\u5927\u7684\u7279\u5f81\u5c31\u662f\u5f88\u5f3a\u7684\u591a\u5b98\u80fd\u56e2\u7684\u517c\u5bb9\u6027\u3002 Norzoanthamine\u7684\u5408\u6210[1] Platensimycin\u7684\u5408\u6210[2] &nbsp; \u5b9e\u9a8c\u6280\u5de7 &nbsp; \u53c2\u8003\u6587\u732e [1] Miyashita, M.; Tanino, K. et al. Science 2004,\u00a0305, 495. DOI:10.1126\/science.1098851 [2] (a) Nicolaou, K. C.; Li, A.; Edmonds, E. J. Angew. Chem. Int.\u00a0Ed. 2006, 45, 7086. doi:10.1002\/anie.200603892\u00a0(b) Nicoalou, K. C.; Edmonds, E. J.; Li, A.; Tria, G. S. Angew.\u00a0Chem. Int. Ed. 2007, 46, 3942. doi:10.1002\/anie.200700586 \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d","protected":false},"author":5,"featured_media":865,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2,8],"tags":[431,125],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/03\/pinnick_1.gif","jetpack_shortlink":"https:\/\/wp.me\/p96op1-dW","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/864"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=864"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/864\/revisions"}],"predecessor-version":[{"id":28259,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/864\/revisions\/28259"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/865"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=864"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=864"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=864"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}