{"id":890,"date":"2014-04-04T11:57:09","date_gmt":"2014-04-04T03:57:09","guid":{"rendered":"\/\/www.gsbet888.com\/?p=890"},"modified":"2019-08-02T18:57:06","modified_gmt":"2019-08-02T10:57:06","slug":"%e6%96%bd%e9%99%b6%e4%b8%81%e6%a0%bc%e5%8f%8d%e5%bf%9c-staudinger-reaction","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/%e8%bf%98%e5%8e%9f%e5%8f%8d%e5%ba%94\/2014\/04\/%e6%96%bd%e9%99%b6%e4%b8%81%e6%a0%bc%e5%8f%8d%e5%bf%9c-staudinger-reaction.html","title":{"rendered":"\u65bd\u9676\u4e01\u683c\u53cd\u5fdc Staudinger Reaction"},"content":{"rendered":"<ul>\n<li>\u6982\u8981<\/li>\n<\/ul>\n<p>\u53e0\u6c2e\u76d0\u5316\u5408\u7269\u4e0e\u4e09\u4ef7\u7684\u81a6\u5316\u5408\u7269\u53cd\u5e94\u3001\u751f\u6210\u4e9a\u80fa\u57fa\u81a6(aza-phosphine ylide)\u4e2d\u95f4\u4f53\u3002\u901a\u8fc7\u6c34\u89e3\u5f97\u5230\u4f2f\u80fa\u7684\u53cd\u5e94\u53eb\u505aStaudinger\u53cd\u5e94\u3002\u4e9a\u80fa\u57fa\u81a6\u662f\u53ef\u7528\u4f5c\u591a\u79cd\u5316\u5b66\u53cd\u5e94\u7684\u4e2d\u95f4\u4f53\u3002\u4e5f\u53ef\u4e0e\u7fb0\u57fa\u53cd\u5e94\u751f\u6210\u4e9a\u80fa(<a href=\"http:\/\/www.chem-station.com\/user-cgi-bin\/odoos\/ps_search.cgi?act=jump&amp;access=1&amp;url=http%3a%2f%2fwww%2echem%2dstation%2ecom%2fodos%2f2009%2f07%2faza%2dwittig%2ehtml\">aza-Wittig\u53cd\u5fdc<\/a>)\u3002\u542b\u6709\u70ef\u70c3\u7684\u4f2f\u80fa\u5316\u5408\u7269\u3001\u901a\u8fc7\u785d\u57fa\u5316\u7269Pd\u50ac\u5316<a href=\"http:\/\/www.chem-station.com\/user-cgi-bin\/odoos\/ps_search.cgi?act=jump&amp;access=1&amp;url=http%3a%2f%2fwww%2echem%2dstation%2ecom%2fodos%2f2009%2f07%2f%2dheterogeneous%2dhydrogenation%2ehtml\">\u52a0\u6c22<\/a>\u8fd8\u539f\u4e0d\u80fd\u5236\u5907\u65f6\uff0c\u8be5\u65b9\u6cd5\u975e\u5e38\u6709\u6548\u3002<\/p>\n<ul>\n<li>\u57fa\u672c\u6587\u732e<\/li>\n<\/ul>\n<p>\u30fbStaudinger, H.; Meyer, J.\u00a0<em>Helv. Chim. Acta<\/em>\u00a0<strong>1919<\/strong>,\u00a0<em>2<\/em>, 635. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1002\/hlca.19190020164\">10.1002\/hlca.19190020164<\/a><br \/>\n\u30fbGololobov, Y. G.; Zhmurova, I. N.; Kasukhin, L. F.\u00a0<em>Tetrahedron<\/em>\u00a0<strong>1981<\/strong>,\u00a0<em>37<\/em>, 437.doi:<a href=\"http:\/\/dx.doi.org\/10.1016\/S0040-4020(01)92417-2\">10.1016\/S0040-4020(01)92417-2<\/a><br \/>\n\u30fbScriven, E. F. V.; Turnbull, K.\u00a0<em>Chem. Rev.<\/em>\u00a0<strong>1988<\/strong>,\u00a0<em>88<\/em>, 297. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/cr00084a001\">10.1021\/cr00084a001<\/a><br \/>\n\u30fbGololobov, Y. G.; Kasukhin, L. F.\u00a0<em>Tetrahedron<\/em>\u00a0<strong>1992<\/strong>,\u00a0<em>48<\/em>, 1353. doi:<a href=\"http:\/\/dx.doi.org\/10.1016\/S0040-4020(01)92229-X\">10.1016\/S0040-4020(01)92229-X<\/a><br \/>\n\u30fbReview: Shah, S.;Protasiewicz\uff0cJ. D.\u00a0<em>Coord. Chem. Rev.<\/em>\u00a0<strong>2000<\/strong>,\u00a0<em>210<\/em>, 181.\u00a0doi:<a href=\"http:\/\/dx.doi.org\/10.1016\/S0010-8545(00)00311-8\">10.1016\/S0010-8545(00)00311-8<\/a><br \/>\n\u30fbKohn, M.; Breinbauer, R.\u00a0<em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2004<\/strong>,\u00a0<em>43<\/em>, 3106. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1002\/anie.200401744\">10.1002\/anie.200401744<\/a><\/p>\n<ul>\n<li>\u53cd\u5e94\u673a\u7406<\/li>\n<\/ul>\n<p>\u53c2\u8003\uff1a<em><a href=\"http:\/\/dx.doi.org\/10.1021\/jo049702n\">J. Org. Chem.<\/a><\/em>\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/jo049702n\"><strong>2004<\/strong>,\u00a0<em>69<\/em>\u00a0, 4299.<\/a>\u00a0<em><a href=\"http:\/\/dx.doi.org\/10.1021\/ja044461m\">J. Am. Chem. Soc.<\/a><\/em>\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/ja044461m\"><strong>2005<\/strong>, 127, 2686.<\/a><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/www.chem-station.com\/odos\/images\/staudinger_2.gif\" alt=\"staudinger_2.gif\" width=\"469\" height=\"114\" \/><\/p>\n<ul>\n<li>\u53cd\u5e94\u5b9e\u4f8b<\/li>\n<\/ul>\n<p><strong>Staudinger-Bertozzi\u914d\u5408<\/strong><sup>[1]<\/sup>\uff1a<a href=\"http:\/\/www.chem-station.com\/chemist-db\/archives\/2007\/11\/-carolyne-r-bertozzi.php\">Bertozzi<\/a>\u7b49\u5c06\u53e0\u6c2e\u5316\u7269\u4e0e\u4ee5\u4e0b\u7684\u81a6\u8bd5\u5242\u53cd\u5e94\uff0c\u6210\u529f\u5c06\u8367\u5149\u8bd5\u5242\u4e0e\u5f3a\u56fa\u7684\u9170\u80fa\u8fde\u63a5\u3002\u8fd9\u4e00\u5316\u5b66\u4fee\u9970\u6cd5\u4ee5\u9ad8\u53ce\u7387\u3001\u9ad8\u5316\u5b66\u9009\u62e9\u6027\u8fdb\u884c\u3001\u80fd\u7528\u4e8e\u591a\u79cd\u751f\u7269\u5316\u5b66\u7814\u7a76<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/www.chem-station.com\/odos\/images\/staudinger_3.gif\" alt=\"staudinger_3.gif\" width=\"548\" height=\"82\" \/><\/p>\n<p>Traceless Staudinger Ligation<sup>[2]<\/sup>\uff1a\u9700\u8981Cys\u6b8b\u57fa\u7ec4<a href=\"http:\/\/www.chem-station.com\/odos\/2010\/01\/-native-chemical-ligation-ncl.html\">Native Chemical Ligation<\/a>\u6ca1\u6709\u7279\u522b\u7684\u5236\u7ea6\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/www.chem-station.com\/odos\/images\/staudinger_4.gif\" alt=\"staudinger_4.gif\" width=\"507\" height=\"128\" \/><\/p>\n<ul>\n<li>\u5b9e\u9a8c\u6b65\u9aa4<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u5b9e\u9a8c\u6280\u5de7<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u53c2\u8003\u6587\u732e<\/li>\n<\/ul>\n[1] Saxon, E.; Bertozzi, C.R.\u00a0<em>Science<\/em>\u00a0<strong>2000<\/strong>,\u00a0<em>287<\/em>, 2007. doi:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1126\/science.287.5460.2007\">10.1126\/science.287.5460.2007<\/a><br \/>\n[2] (a) Saxon, E.; Armstrong, C.R.; Bertozzi, C.R.\u00a0<em>Org. Lett.<\/em>\u00a0<strong>2000<\/strong>,\u00a0<em>2<\/em>, 2141. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/ol006054v\">10.1021\/ol006054v<\/a>\u00a0(b) Nilsson, B.L.; Kiessling, L.L.; Raines, R.T.\u00a0<em>Org. Lett.<\/em>\u00a0<strong>2000<\/strong>,\u00a0<em>2<\/em>, 1939. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/ol0060174\">10.1021\/ol0060174<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 \u53e0\u6c2e\u76d0\u5316\u5408\u7269\u4e0e\u4e09\u4ef7\u7684\u81a6\u5316\u5408\u7269\u53cd\u5e94\u3001\u751f\u6210\u4e9a\u80fa\u57fa\u81a6(aza-phosphine ylide)\u4e2d\u95f4\u4f53\u3002\u901a\u8fc7\u6c34\u89e3\u5f97\u5230\u4f2f\u80fa\u7684\u53cd\u5e94\u53eb\u505aStaudinger\u53cd\u5e94\u3002\u4e9a\u80fa\u57fa\u81a6\u662f\u53ef\u7528\u4f5c\u591a\u79cd\u5316\u5b66\u53cd\u5e94\u7684\u4e2d\u95f4\u4f53\u3002\u4e5f\u53ef\u4e0e\u7fb0\u57fa\u53cd\u5e94\u751f\u6210\u4e9a\u80fa(aza-Wittig\u53cd\u5fdc)\u3002\u542b\u6709\u70ef\u70c3\u7684\u4f2f\u80fa\u5316\u5408\u7269\u3001\u901a\u8fc7\u785d\u57fa\u5316\u7269Pd\u50ac\u5316\u52a0\u6c22\u8fd8\u539f\u4e0d\u80fd\u5236\u5907\u65f6\uff0c\u8be5\u65b9\u6cd5\u975e\u5e38\u6709\u6548\u3002 \u57fa\u672c\u6587\u732e \u30fbStaudinger, H.; Meyer, J.\u00a0Helv. Chim. Acta\u00a01919,\u00a02, 635. DOI:\u00a010.1002\/hlca.19190020164 \u30fbGololobov, Y. G.; Zhmurova, I. N.; Kasukhin, L. F.\u00a0Tetrahedron\u00a01981,\u00a037, 437.doi:10.1016\/S0040-4020(01)92417-2 \u30fbScriven, E. F. V.; Turnbull, K.\u00a0Chem. Rev.\u00a01988,\u00a088, 297. DOI:\u00a010.1021\/cr00084a001 \u30fbGololobov, Y. G.; Kasukhin, L. F.\u00a0Tetrahedron\u00a01992,\u00a048, 1353. doi:10.1016\/S0040-4020(01)92229-X \u30fbReview: Shah, S.;Protasiewicz\uff0cJ. D.\u00a0Coord. Chem. Rev.\u00a02000,\u00a0210, 181.\u00a0doi:10.1016\/S0010-8545(00)00311-8 \u30fbKohn, M.; Breinbauer, R.\u00a0Angew. Chem. Int. Ed.\u00a02004,\u00a043, 3106. DOI:\u00a010.1002\/anie.200401744 \u53cd\u5e94\u673a\u7406 \u53c2\u8003\uff1aJ. Org. Chem.\u00a02004,\u00a069\u00a0, 4299.\u00a0J. Am. Chem. Soc.\u00a02005, 127, 2686. \u53cd\u5e94\u5b9e\u4f8b Staudinger-Bertozzi\u914d\u5408[1]\uff1aBertozzi\u7b49\u5c06\u53e0\u6c2e\u5316\u7269\u4e0e\u4ee5\u4e0b\u7684\u81a6\u8bd5\u5242\u53cd\u5e94\uff0c\u6210\u529f\u5c06\u8367\u5149\u8bd5\u5242\u4e0e\u5f3a\u56fa\u7684\u9170\u80fa\u8fde\u63a5\u3002\u8fd9\u4e00\u5316\u5b66\u4fee\u9970\u6cd5\u4ee5\u9ad8\u53ce\u7387\u3001\u9ad8\u5316\u5b66\u9009\u62e9\u6027\u8fdb\u884c\u3001\u80fd\u7528\u4e8e\u591a\u79cd\u751f\u7269\u5316\u5b66\u7814\u7a76 Traceless Staudinger Ligation[2]\uff1a\u9700\u8981Cys\u6b8b\u57fa\u7ec4Native Chemical Ligation\u6ca1\u6709\u7279\u522b\u7684\u5236\u7ea6\u3002 \u5b9e\u9a8c\u6b65\u9aa4 &nbsp; \u5b9e\u9a8c\u6280\u5de7 &nbsp; \u53c2\u8003\u6587\u732e [1] Saxon, E.; Bertozzi, C.R.\u00a0Science\u00a02000,\u00a0287, 2007. doi:\u00a010.1126\/science.287.5460.2007 [2] (a) Saxon, E.; Armstrong, C.R.; Bertozzi, C.R.\u00a0Org. Lett.\u00a02000,\u00a02, 2141. DOI:\u00a010.1021\/ol006054v\u00a0(b) Nilsson, B.L.; Kiessling, L.L.; Raines, R.T.\u00a0Org. Lett.\u00a02000,\u00a02, 1939. DOI:\u00a010.1021\/ol0060174","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":true,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[91],"tags":[127,126,128],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p96op1-em","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/890"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=890"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/890\/revisions"}],"predecessor-version":[{"id":28255,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/890\/revisions\/28255"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=890"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=890"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=890"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}